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Protein

Epididymal-specific lipocalin-9

Gene

LCN9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Keywordsi

Biological processTransport

Enzyme and pathway databases

ReactomeiR-HSA-804914. Transport of fatty acids.

Names & Taxonomyi

Protein namesi
Recommended name:
Epididymal-specific lipocalin-9
Alternative name(s):
MUP-like lipocalin
Gene namesi
Name:LCN9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000148386.9.
HGNCiHGNC:17442. LCN9.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134879860.

Chemistry databases

DrugBankiDB03087. 2-(Sec-Butyl)Thiazole.
DB04512. 2-Isobutyl-3-Methoxypyrazine.
DB01760. 2-Methoxy-3-Isopropylpyrazine.
DB03711. 6-Hydroxy-6-Methyl-Heptan-3-One.

Polymorphism and mutation databases

BioMutaiLCN9.
DMDMi338817980.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 15Sequence analysisAdd BLAST15
ChainiPRO_000001791816 – 176Epididymal-specific lipocalin-9Add BLAST161

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi68N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi83 ↔ 161By similarity
Glycosylationi129N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8WX39.
PeptideAtlasiQ8WX39.
PRIDEiQ8WX39.

PTM databases

iPTMnetiQ8WX39.
PhosphoSitePlusiQ8WX39.

Expressioni

Gene expression databases

BgeeiENSG00000148386.
CleanExiHS_LCN9.
ExpressionAtlasiQ8WX39. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000277526.

Structurei

3D structure databases

ProteinModelPortaliQ8WX39.
SMRiQ8WX39.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the calycin superfamily. Lipocalin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JBWS. Eukaryota.
ENOG4111AS1. LUCA.
GeneTreeiENSGT00530000063356.
HOGENOMiHOG000231458.
HOVERGENiHBG000215.
InParanoidiQ8WX39.
OMAiWYSIFMA.
TreeFamiTF338197.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiView protein in InterPro
IPR012674. Calycin.
IPR022272. Lipocalin_CS.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
IPR002971. Maj_urinary.
PfamiView protein in Pfam
PF00061. Lipocalin. 1 hit.
PRINTSiPR01221. MAJORURINARY.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiView protein in PROSITE
PS00213. LIPOCALIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8WX39-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALLLLSLGL SLIAAQEFDP HTVMQRNYNV ARVSGVWYSI FMASDDLNRI
60 70 80 90 100
KENGDLRVFV RNIEHLKNGS LIFDFEYMVQ GECVAVVVVC EKTEKNGEYS
110 120 130 140 150
INYEGQNTVA VSETDYRLFI TFHLQNFRNG TETHTLALYE TCEKYGLGSQ
160 170
NIIDLTNKDP CYSKHYRSPP RPPMRW
Length:176
Mass (Da):20,285
Last modified:June 28, 2011 - v3
Checksum:iF15525B66B909180
GO

Sequence cautioni

Q8WX39: The sequence CAD13244 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05616765H → Y. Corresponds to variant dbSNP:rs12352552Ensembl.1
Natural variantiVAR_05616890C → F. Corresponds to variant dbSNP:rs7875283Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY301270 mRNA. Translation: AAQ81975.1.
AL158822 Genomic DNA. Translation: CAD13244.1. Sequence problems.
CCDSiCCDS56593.1.
RefSeqiNP_001001676.1. NM_001001676.1.
UniGeneiHs.532679.

Genome annotation databases

EnsembliENST00000277526; ENSP00000277526; ENSG00000148386.
GeneIDi392399.
KEGGihsa:392399.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiLCN9_HUMAN
AccessioniPrimary (citable) accession number: Q8WX39
Secondary accession number(s): C9J5F0, Q6JVE7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: June 28, 2011
Last modified: September 27, 2017
This is version 117 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families