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Protein

Epididymal-specific lipocalin-9

Gene

LCN9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000148386-MONOMER.
ReactomeiR-HSA-804914. Transport of fatty acids.

Names & Taxonomyi

Protein namesi
Recommended name:
Epididymal-specific lipocalin-9
Alternative name(s):
MUP-like lipocalin
Gene namesi
Name:LCN9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:17442. LCN9.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000148386.
PharmGKBiPA134879860.

Polymorphism and mutation databases

BioMutaiLCN9.
DMDMi338817980.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 15Sequence analysisAdd BLAST15
ChainiPRO_000001791816 – 176Epididymal-specific lipocalin-9Add BLAST161

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi68N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi83 ↔ 161By similarity
Glycosylationi129N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8WX39.
PRIDEiQ8WX39.

PTM databases

iPTMnetiQ8WX39.
PhosphoSitePlusiQ8WX39.

Expressioni

Gene expression databases

CleanExiHS_LCN9.
ExpressionAtlasiQ8WX39. baseline and differential.

Organism-specific databases

HPAiCAB026061.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000277526.

Structurei

3D structure databases

ProteinModelPortaliQ8WX39.
SMRiQ8WX39.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the calycin superfamily. Lipocalin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JBWS. Eukaryota.
ENOG4111AS1. LUCA.
GeneTreeiENSGT00530000063356.
HOGENOMiHOG000231458.
HOVERGENiHBG000215.
InParanoidiQ8WX39.
OMAiWYSIFMA.
TreeFamiTF338197.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR022272. Lipocalin_CS.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
IPR002971. Maj_urinary.
[Graphical view]
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR01221. MAJORURINARY.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00213. LIPOCALIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8WX39-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALLLLSLGL SLIAAQEFDP HTVMQRNYNV ARVSGVWYSI FMASDDLNRI
60 70 80 90 100
KENGDLRVFV RNIEHLKNGS LIFDFEYMVQ GECVAVVVVC EKTEKNGEYS
110 120 130 140 150
INYEGQNTVA VSETDYRLFI TFHLQNFRNG TETHTLALYE TCEKYGLGSQ
160 170
NIIDLTNKDP CYSKHYRSPP RPPMRW
Length:176
Mass (Da):20,285
Last modified:June 28, 2011 - v3
Checksum:iF15525B66B909180
GO

Sequence cautioni

The sequence CAD13244 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05616765H → Y.Corresponds to variant rs12352552dbSNPEnsembl.1
Natural variantiVAR_05616890C → F.Corresponds to variant rs7875283dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY301270 mRNA. Translation: AAQ81975.1.
AL158822 Genomic DNA. Translation: CAD13244.1. Sequence problems.
CCDSiCCDS56593.1.
RefSeqiNP_001001676.1. NM_001001676.1.
UniGeneiHs.532679.

Genome annotation databases

EnsembliENST00000277526; ENSP00000277526; ENSG00000148386.
GeneIDi392399.
KEGGihsa:392399.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY301270 mRNA. Translation: AAQ81975.1.
AL158822 Genomic DNA. Translation: CAD13244.1. Sequence problems.
CCDSiCCDS56593.1.
RefSeqiNP_001001676.1. NM_001001676.1.
UniGeneiHs.532679.

3D structure databases

ProteinModelPortaliQ8WX39.
SMRiQ8WX39.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000277526.

PTM databases

iPTMnetiQ8WX39.
PhosphoSitePlusiQ8WX39.

Polymorphism and mutation databases

BioMutaiLCN9.
DMDMi338817980.

Proteomic databases

PaxDbiQ8WX39.
PRIDEiQ8WX39.

Protocols and materials databases

DNASUi392399.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000277526; ENSP00000277526; ENSG00000148386.
GeneIDi392399.
KEGGihsa:392399.

Organism-specific databases

CTDi392399.
GeneCardsiLCN9.
HGNCiHGNC:17442. LCN9.
HPAiCAB026061.
MIMi612903. gene.
neXtProtiNX_Q8WX39.
OpenTargetsiENSG00000148386.
PharmGKBiPA134879860.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JBWS. Eukaryota.
ENOG4111AS1. LUCA.
GeneTreeiENSGT00530000063356.
HOGENOMiHOG000231458.
HOVERGENiHBG000215.
InParanoidiQ8WX39.
OMAiWYSIFMA.
TreeFamiTF338197.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000148386-MONOMER.
ReactomeiR-HSA-804914. Transport of fatty acids.

Miscellaneous databases

GenomeRNAii392399.
PROiQ8WX39.
SOURCEiSearch...

Gene expression databases

CleanExiHS_LCN9.
ExpressionAtlasiQ8WX39. baseline and differential.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR022272. Lipocalin_CS.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
IPR002971. Maj_urinary.
[Graphical view]
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR01221. MAJORURINARY.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00213. LIPOCALIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLCN9_HUMAN
AccessioniPrimary (citable) accession number: Q8WX39
Secondary accession number(s): C9J5F0, Q6JVE7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: June 28, 2011
Last modified: November 2, 2016
This is version 110 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.