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Protein

Epididymal-specific lipocalin-9

Gene

LCN9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiR-HSA-804914. Transport of fatty acids.

Names & Taxonomyi

Protein namesi
Recommended name:
Epididymal-specific lipocalin-9
Alternative name(s):
MUP-like lipocalin
Gene namesi
Name:LCN9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:17442. LCN9.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134879860.

Polymorphism and mutation databases

BioMutaiLCN9.
DMDMi338817980.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1515Sequence analysisAdd
BLAST
Chaini16 – 176161Epididymal-specific lipocalin-9PRO_0000017918Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi68 – 681N-linked (GlcNAc...)Sequence analysis
Disulfide bondi83 ↔ 161By similarity
Glycosylationi129 – 1291N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8WX39.
PRIDEiQ8WX39.

PTM databases

iPTMnetiQ8WX39.

Expressioni

Gene expression databases

CleanExiHS_LCN9.
ExpressionAtlasiQ8WX39. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000277526.

Structurei

3D structure databases

ProteinModelPortaliQ8WX39.
SMRiQ8WX39. Positions 29-161.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the calycin superfamily. Lipocalin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JBWS. Eukaryota.
ENOG4111AS1. LUCA.
HOGENOMiHOG000231458.
HOVERGENiHBG000215.
InParanoidiQ8WX39.
OMAiWYSIFMA.
OrthoDBiEOG77WWF8.
TreeFamiTF338197.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR022272. Lipocalin_CS.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
IPR002971. Maj_urinary.
[Graphical view]
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR01221. MAJORURINARY.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00213. LIPOCALIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8WX39-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALLLLSLGL SLIAAQEFDP HTVMQRNYNV ARVSGVWYSI FMASDDLNRI
60 70 80 90 100
KENGDLRVFV RNIEHLKNGS LIFDFEYMVQ GECVAVVVVC EKTEKNGEYS
110 120 130 140 150
INYEGQNTVA VSETDYRLFI TFHLQNFRNG TETHTLALYE TCEKYGLGSQ
160 170
NIIDLTNKDP CYSKHYRSPP RPPMRW
Length:176
Mass (Da):20,285
Last modified:June 28, 2011 - v3
Checksum:iF15525B66B909180
GO

Sequence cautioni

The sequence CAD13244.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti65 – 651H → Y.
Corresponds to variant rs12352552 [ dbSNP | Ensembl ].
VAR_056167
Natural varianti90 – 901C → F.
Corresponds to variant rs7875283 [ dbSNP | Ensembl ].
VAR_056168

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY301270 mRNA. Translation: AAQ81975.1.
AL158822 Genomic DNA. Translation: CAD13244.1. Sequence problems.
CCDSiCCDS56593.1.
RefSeqiNP_001001676.1. NM_001001676.1.
UniGeneiHs.532679.

Genome annotation databases

EnsembliENST00000277526; ENSP00000277526; ENSG00000148386.
GeneIDi392399.
KEGGihsa:392399.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY301270 mRNA. Translation: AAQ81975.1.
AL158822 Genomic DNA. Translation: CAD13244.1. Sequence problems.
CCDSiCCDS56593.1.
RefSeqiNP_001001676.1. NM_001001676.1.
UniGeneiHs.532679.

3D structure databases

ProteinModelPortaliQ8WX39.
SMRiQ8WX39. Positions 29-161.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000277526.

PTM databases

iPTMnetiQ8WX39.

Polymorphism and mutation databases

BioMutaiLCN9.
DMDMi338817980.

Proteomic databases

PaxDbiQ8WX39.
PRIDEiQ8WX39.

Protocols and materials databases

DNASUi392399.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000277526; ENSP00000277526; ENSG00000148386.
GeneIDi392399.
KEGGihsa:392399.

Organism-specific databases

CTDi392399.
GeneCardsiLCN9.
HGNCiHGNC:17442. LCN9.
MIMi612903. gene.
neXtProtiNX_Q8WX39.
PharmGKBiPA134879860.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JBWS. Eukaryota.
ENOG4111AS1. LUCA.
HOGENOMiHOG000231458.
HOVERGENiHBG000215.
InParanoidiQ8WX39.
OMAiWYSIFMA.
OrthoDBiEOG77WWF8.
TreeFamiTF338197.

Enzyme and pathway databases

ReactomeiR-HSA-804914. Transport of fatty acids.

Miscellaneous databases

GenomeRNAii392399.
PROiQ8WX39.
SOURCEiSearch...

Gene expression databases

CleanExiHS_LCN9.
ExpressionAtlasiQ8WX39. baseline and differential.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR022272. Lipocalin_CS.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
IPR002971. Maj_urinary.
[Graphical view]
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR01221. MAJORURINARY.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00213. LIPOCALIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular evolution of epididymal lipocalin genes localized on mouse chromosome 2."
    Suzuki K., Lareyre J.-J., Sanchez D., Gutierrez G., Araki Y., Matusik R.J., Orgebin-Crist M.-C.
    Gene 339:49-59(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiLCN9_HUMAN
AccessioniPrimary (citable) accession number: Q8WX39
Secondary accession number(s): C9J5F0, Q6JVE7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: June 28, 2011
Last modified: June 8, 2016
This is version 107 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.