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Protein

Oncoprotein-induced transcript 3 protein

Gene

OIT3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in hepatocellular function and development.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Oncoprotein-induced transcript 3 protein
Alternative name(s):
Liver-specific zona pellucida domain-containing protein
Gene namesi
Name:OIT3
Synonyms:LZP
ORF Names:UNQ826/PRO1753
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:29953. OIT3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi170392.
OpenTargetsiENSG00000138315.
PharmGKBiPA142671231.

Polymorphism and mutation databases

BioMutaiOIT3.
DMDMi74730985.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000029893123 – 545Oncoprotein-induced transcript 3 proteinAdd BLAST523

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi89N-linked (GlcNAc...)Sequence analysis1
Glycosylationi116N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi186 ↔ 197By similarity
Disulfide bondi193 ↔ 206By similarity
Disulfide bondi208 ↔ 221By similarity
Glycosylationi291N-linked (GlcNAc...)1 Publication1
Glycosylationi299N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8WWZ8.
PeptideAtlasiQ8WWZ8.
PRIDEiQ8WWZ8.

PTM databases

iPTMnetiQ8WWZ8.
PhosphoSitePlusiQ8WWZ8.

Expressioni

Tissue specificityi

Liver-specific. Expressed only in the hepatocytes. Down-regulated in hepatocellular carcinoma (HCC) and HCC cell lines.1 Publication

Gene expression databases

BgeeiENSG00000138315.
CleanExiHS_OIT3.
GenevisibleiQ8WWZ8. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MEOX2A4D1275EBI-10277776,EBI-10172134

Protein-protein interaction databases

BioGridi128002. 1 interactor.
IntActiQ8WWZ8. 2 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ8WWZ8.
SMRiQ8WWZ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini182 – 222EGF-like; calcium-bindingSequence analysisAdd BLAST41
Domaini261 – 516ZPPROSITE-ProRule annotationAdd BLAST256

Sequence similaritiesi

Contains 1 EGF-like domain.Curated
Contains 1 ZP domain.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Signal

Phylogenomic databases

eggNOGiENOG410IHDE. Eukaryota.
ENOG4110JPJ. LUCA.
GeneTreeiENSGT00530000063244.
HOGENOMiHOG000115262.
HOVERGENiHBG097756.
InParanoidiQ8WWZ8.
OMAiDRQTCFD.
OrthoDBiEOG091G03XV.
PhylomeDBiQ8WWZ8.
TreeFamiTF330284.

Family and domain databases

InterProiIPR001881. EGF-like_Ca-bd_dom.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR001507. ZP_dom.
[Graphical view]
PfamiPF00100. Zona_pellucida. 1 hit.
[Graphical view]
PRINTSiPR00023. ZPELLUCIDA.
SMARTiSM00181. EGF. 3 hits.
SM00179. EGF_CA. 2 hits.
SM00241. ZP. 1 hit.
[Graphical view]
PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
PS01187. EGF_CA. 1 hit.
PS51034. ZP_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WWZ8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPPFLLLTCL FITGTSVSPV ALDPCSAYIS LNEPWRNTDH QLDESQGPPL
60 70 80 90 100
CDNHVNGEWY HFTGMAGDAM PTFCIPENHC GTHAPVWLNG SHPLEGDGIV
110 120 130 140 150
QRQACASFNG NCCLWNTTVE VKACPGGYYV YRLTKPSVCF HVYCGHFYDI
160 170 180 190 200
CDEDCHGSCS DTSECTCAPG TVLGPDRQTC FDENECEQNN GGCSEICVNL
210 220 230 240 250
KNSYRCECGV GRVLRSDGKT CEDVEGCHNN NGGCSHSCLG SEKGYQCECP
260 270 280 290 300
RGLVLSEDNH TCQVPVLCKS NAIEVNIPRE LVGGLELFLT NTSCRGVSNG
310 320 330 340 350
THVNILFSLK TCGTVVDVVN DKIVASNLVT GLPKQTPGSS GDFIIRTSKL
360 370 380 390 400
LIPVTCEFPR LYTISEGYVP NLRNSPLEIM SRNHGIFPFT LEIFKDNEFE
410 420 430 440 450
EPYREALPTL KLRDSLYFGI EPVVHVSGLE SLVESCFATP TSKIDEVLKY
460 470 480 490 500
YLIRDGCVSD DSVKQYTSRD HLAKHFQVPV FKFVGKDHKE VFLHCRVLVC
510 520 530 540
GVLDERSRCA QGCHRRMRRG AGGEDSAGLQ GQTLTGGPIR IDWED
Length:545
Mass (Da):60,022
Last modified:July 5, 2004 - v2
Checksum:iE4BDE126213484B0
GO
Isoform 2 (identifier: Q8WWZ8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     318-321: VVND → LCFR
     322-545: Missing.

Show »
Length:321
Mass (Da):34,911
Checksum:i9AF8C61098ED67A4
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034742237S → P.Corresponds to variant rs35089256dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_027482318 – 321VVND → LCFR in isoform 2. 1 Publication4
Alternative sequenceiVSP_027483322 – 545Missing in isoform 2. 1 PublicationAdd BLAST224

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY013707 mRNA. Translation: AAG40096.2.
AY358339 mRNA. Translation: AAQ88705.1.
AK096435 mRNA. Translation: BAC04788.1.
BC126440 mRNA. Translation: AAI26441.1.
CCDSiCCDS7318.1. [Q8WWZ8-1]
RefSeqiNP_689848.1. NM_152635.2. [Q8WWZ8-1]
UniGeneiHs.8366.

Genome annotation databases

EnsembliENST00000334011; ENSP00000333900; ENSG00000138315. [Q8WWZ8-1]
ENST00000622652; ENSP00000479787; ENSG00000138315. [Q8WWZ8-2]
GeneIDi170392.
KEGGihsa:170392.
UCSCiuc001jte.2. human. [Q8WWZ8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY013707 mRNA. Translation: AAG40096.2.
AY358339 mRNA. Translation: AAQ88705.1.
AK096435 mRNA. Translation: BAC04788.1.
BC126440 mRNA. Translation: AAI26441.1.
CCDSiCCDS7318.1. [Q8WWZ8-1]
RefSeqiNP_689848.1. NM_152635.2. [Q8WWZ8-1]
UniGeneiHs.8366.

3D structure databases

ProteinModelPortaliQ8WWZ8.
SMRiQ8WWZ8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128002. 1 interactor.
IntActiQ8WWZ8. 2 interactors.

PTM databases

iPTMnetiQ8WWZ8.
PhosphoSitePlusiQ8WWZ8.

Polymorphism and mutation databases

BioMutaiOIT3.
DMDMi74730985.

Proteomic databases

PaxDbiQ8WWZ8.
PeptideAtlasiQ8WWZ8.
PRIDEiQ8WWZ8.

Protocols and materials databases

DNASUi170392.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334011; ENSP00000333900; ENSG00000138315. [Q8WWZ8-1]
ENST00000622652; ENSP00000479787; ENSG00000138315. [Q8WWZ8-2]
GeneIDi170392.
KEGGihsa:170392.
UCSCiuc001jte.2. human. [Q8WWZ8-1]

Organism-specific databases

CTDi170392.
DisGeNETi170392.
GeneCardsiOIT3.
HGNCiHGNC:29953. OIT3.
MIMi609330. gene.
neXtProtiNX_Q8WWZ8.
OpenTargetsiENSG00000138315.
PharmGKBiPA142671231.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHDE. Eukaryota.
ENOG4110JPJ. LUCA.
GeneTreeiENSGT00530000063244.
HOGENOMiHOG000115262.
HOVERGENiHBG097756.
InParanoidiQ8WWZ8.
OMAiDRQTCFD.
OrthoDBiEOG091G03XV.
PhylomeDBiQ8WWZ8.
TreeFamiTF330284.

Miscellaneous databases

GenomeRNAii170392.
PROiQ8WWZ8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000138315.
CleanExiHS_OIT3.
GenevisibleiQ8WWZ8. HS.

Family and domain databases

InterProiIPR001881. EGF-like_Ca-bd_dom.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR001507. ZP_dom.
[Graphical view]
PfamiPF00100. Zona_pellucida. 1 hit.
[Graphical view]
PRINTSiPR00023. ZPELLUCIDA.
SMARTiSM00181. EGF. 3 hits.
SM00179. EGF_CA. 2 hits.
SM00241. ZP. 1 hit.
[Graphical view]
PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
PS01187. EGF_CA. 1 hit.
PS51034. ZP_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOIT3_HUMAN
AccessioniPrimary (citable) accession number: Q8WWZ8
Secondary accession number(s): A0AVP3, Q8N1M8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.