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Q8WWZ7

- ABCA5_HUMAN

UniProt

Q8WWZ7 - ABCA5_HUMAN

Protein

ATP-binding cassette sub-family A member 5

Gene

ABCA5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 2 (03 Oct 2006)
      Previous versions | rss
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    Functioni

    May play a role in the processing of autolysosomes.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi514 – 5218ATP 1PROSITE-ProRule annotation
    Nucleotide bindingi1333 – 13408ATP 2PROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATPase activity Source: InterPro
    2. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. cholesterol efflux Source: BHF-UCL
    2. high-density lipoprotein particle remodeling Source: BHF-UCL
    3. negative regulation of macrophage derived foam cell differentiation Source: BHF-UCL
    4. reverse cholesterol transport Source: BHF-UCL

    Keywords - Biological processi

    Transport

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Protein family/group databases

    TCDBi3.A.1.211.9. the atp-binding cassette (abc) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATP-binding cassette sub-family A member 5
    Gene namesi
    Name:ABCA5
    Synonyms:KIAA1888
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:35. ABCA5.

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. late endosome Source: BHF-UCL
    4. late endosome membrane Source: UniProtKB-SubCell
    5. lysosomal membrane Source: UniProtKB-SubCell
    6. lysosome Source: BHF-UCL

    Keywords - Cellular componenti

    Endosome, Golgi apparatus, Lysosome, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA24380.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 16421642ATP-binding cassette sub-family A member 5PRO_0000250669Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi86 – 861N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi458 – 4581N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi996 – 9961N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    N-glycosylated.By similarity

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ8WWZ7.
    PRIDEiQ8WWZ7.

    PTM databases

    PhosphoSiteiQ8WWZ7.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed. Highly expressed in testis, skeletal muscle, kidney, liver and placenta.2 Publications

    Developmental stagei

    Expressed in fetal liver, kidney and brain.1 Publication

    Gene expression databases

    ArrayExpressiQ8WWZ7.
    BgeeiQ8WWZ7.
    CleanExiHS_ABCA5.
    GenevestigatoriQ8WWZ7.

    Organism-specific databases

    HPAiHPA022032.

    Interactioni

    Protein-protein interaction databases

    BioGridi117024. 2 interactions.
    IntActiQ8WWZ7. 2 interactions.
    STRINGi9606.ENSP00000319766.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8WWZ7.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei32 – 5221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei220 – 24021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei264 – 28421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei297 – 31721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei328 – 34821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei355 – 37521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei396 – 41621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei866 – 88621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei967 – 98721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1021 – 104121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1071 – 109121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1102 – 112221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1139 – 115921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1169 – 118921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1207 – 122721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini478 – 713236ABC transporter 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini1290 – 1533244ABC transporter 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 2 ABC transporter domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1131.
    HOGENOMiHOG000231057.
    HOVERGENiHBG079884.
    KOiK05648.
    OrthoDBiEOG73Z2SB.
    PhylomeDBiQ8WWZ7.
    TreeFamiTF105192.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    InterProiIPR003593. AAA+_ATPase.
    IPR026082. ABC_A.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PANTHERiPTHR19229. PTHR19229. 1 hit.
    PfamiPF00005. ABC_tran. 2 hits.
    [Graphical view]
    SMARTiSM00382. AAA. 2 hits.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 2 hits.
    PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
    PS50893. ABC_TRANSPORTER_2. 2 hits.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8WWZ7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSTAIREVGV WRQTRTLLLK NYLIKCRTKK SSVQEILFPL FFLFWLILIS     50
    MMHPNKKYEE VPNIELNPMD KFTLSNLILG YTPVTNITSS IMQKVSTDHL 100
    PDVIITEEYT NEKEMLTSSL SKPSNFVGVV FKDSMSYELR FFPDMIPVSS 150
    IYMDSRAGCS KSCEAAQYWS SGFTVLQASI DAAIIQLKTN VSLWKELEST 200
    KAVIMGETAV VEIDTFPRGV ILIYLVIAFS PFGYFLAIHI VAEKEKKIKE 250
    FLKIMGLHDT AFWLSWVLLY TSLIFLMSLL MAVIATASLL FPQSSSIVIF 300
    LLFFLYGLSS VFFALMLTPL FKKSKHVGIV EFFVTVAFGF IGLMIILIES 350
    FPKSLVWLFS PFCHCTFVIG IAQVMHLEDF NEGASFSNLT AGPYPLIITI 400
    IMLTLNSIFY VLLAVYLDQV IPGEFGLRRS SLYFLKPSYW SKSKRNYEEL 450
    SEGNVNGNIS FSEIIEPVSS EFVGKEAIRI SGIQKTYRKK GENVEALRNL 500
    SFDIYEGQIT ALLGHSGTGK STLMNILCGL CPPSDGFASI YGHRVSEIDE 550
    MFEARKMIGI CPQLDIHFDV LTVEENLSIL ASIKGIPANN IIQEVQKVLL 600
    DLDMQTIKDN QAKKLSGGQK RKLSLGIAVL GNPKILLLDE PTAGMDPCSR 650
    HIVWNLLKYR KANRVTVFST HFMDEADILA DRKAVISQGM LKCVGSSMFL 700
    KSKWGIGYRL SMYIDKYCAT ESLSSLVKQH IPGATLLQQN DQQLVYSLPF 750
    KDMDKFSGLF SALDSHSNLG VISYGVSMTT LEDVFLKLEV EAEIDQADYS 800
    VFTQQPLEEE MDSKSFDEME QSLLILSETK AALVSTMSLW KQQMYTIAKF 850
    HFFTLKRESK SVRSVLLLLL IFFTVQIFMF LVHHSFKNAV VPIKLVPDLY 900
    FLKPGDKPHK YKTSLLLQNS ADSDISDLIS FFTSQNIMVT MINDSDYVSV 950
    APHSAALNVM HSEKDYVFAA VFNSTMVYSL PILVNIISNY YLYHLNVTET 1000
    IQIWSTPFFQ EITDIVFKIE LYFQAALLGI IVTAMPPYFA MENAENHKIK 1050
    AYTQLKLSGL LPSAYWIGQA VVDIPLFFII LILMLGSLLA FHYGLYFYTV 1100
    KFLAVVFCLI GYVPSVILFT YIASFTFKKI LNTKEFWSFI YSVAALACIA 1150
    ITEITFFMGY TIATILHYAF CIIIPIYPLL GCLISFIKIS WKNVRKNVDT 1200
    YNPWDRLSVA VISPYLQCVL WIFLLQYYEK KYGGRSIRKD PFFRNLSTKS 1250
    KNRKLPEPPD NEDEDEDVKA ERLKVKELMG CQCCEEKPSI MVSNLHKEYD 1300
    DKKDFLLSRK VKKVATKYIS FCVKKGEILG LLGPNGAGKS TIINILVGDI 1350
    EPTSGQVFLG DYSSETSEDD DSLKCMGYCP QINPLWPDTT LQEHFEIYGA 1400
    VKGMSASDMK EVISRITHAL DLKEHLQKTV KKLPAGIKRK LCFALSMLGN 1450
    PQITLLDEPS TGMDPKAKQH MWRAIRTAFK NRKRAAILTT HYMEEAEAVC 1500
    DRVAIMVSGQ LRCIGTVQHL KSKFGKGYFL EIKLKDWIEN LEVDRLQREI 1550
    QYIFPNASRQ ESFSSILAYK IPKEDVQSLS QSFFKLEEAK HAFAIEEYSF 1600
    SQATLEQVFV ELTKEQEEED NSCGTLNSTL WWERTQEDRV VF 1642
    Length:1,642
    Mass (Da):186,508
    Last modified:October 3, 2006 - v2
    Checksum:i608809E8539804BF
    GO
    Isoform 2 (identifier: Q8WWZ7-2) [UniParc]FASTAAdd to Basket

    Also known as: V20+16

    The sequence of this isoform differs from the canonical sequence as follows:
         922-925: DSDI → GESV
         926-1642: Missing.

    Show »
    Length:925
    Mass (Da):104,364
    Checksum:iEF5D6A281832CE47
    GO
    Isoform 3 (identifier: Q8WWZ7-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-777: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:865
    Mass (Da):99,273
    Checksum:iF0A7BF87007E321F
    GO

    Sequence cautioni

    The sequence BAB71700.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1215 – 12151Y → H in BAB71208. (PubMed:14702039)Curated
    Sequence conflicti1357 – 13571V → I in CAB93535. (PubMed:12504089)Curated
    Sequence conflicti1366 – 13661T → S in CAB93535. (PubMed:12504089)Curated
    Sequence conflicti1371 – 13711D → G in BAB71208. (PubMed:14702039)Curated
    Sequence conflicti1419 – 14191A → G in BAB71208. (PubMed:14702039)Curated
    Sequence conflicti1523 – 15231K → R in BAB71208. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti93 – 931Q → K.
    Corresponds to variant rs12383 [ dbSNP | Ensembl ].
    VAR_027571
    Natural varianti178 – 1781A → T.1 Publication
    Corresponds to variant rs11544715 [ dbSNP | Ensembl ].
    VAR_048128
    Natural varianti484 – 4841Q → R.1 Publication
    Corresponds to variant rs17686569 [ dbSNP | Ensembl ].
    VAR_027572
    Natural varianti753 – 7531M → V.
    Corresponds to variant rs9898003 [ dbSNP | Ensembl ].
    VAR_027573
    Natural varianti832 – 8321A → S.3 Publications
    Corresponds to variant rs536009 [ dbSNP | Ensembl ].
    VAR_027574
    Natural varianti960 – 9601M → V.1 Publication
    Corresponds to variant rs557491 [ dbSNP | Ensembl ].
    VAR_027575
    Natural varianti1260 – 12601D → G.
    Corresponds to variant rs11544716 [ dbSNP | Ensembl ].
    VAR_048129

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 777777Missing in isoform 3. 1 PublicationVSP_020690Add
    BLAST
    Alternative sequencei922 – 9254DSDI → GESV in isoform 2. 1 PublicationVSP_020691
    Alternative sequencei926 – 1642717Missing in isoform 2. 1 PublicationVSP_020692Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY028897 mRNA. Translation: AAK30022.1.
    AJ275973 mRNA. Translation: CAB93535.3.
    AJ512612 mRNA. Translation: CAD54757.1.
    AK056533 mRNA. Translation: BAB71208.1.
    AK058170 mRNA. Translation: BAB71700.1. Different initiation.
    AB067475 mRNA. Translation: BAB67781.1.
    CCDSiCCDS11685.1. [Q8WWZ7-1]
    RefSeqiNP_061142.2. NM_018672.4. [Q8WWZ7-1]
    NP_758424.1. NM_172232.3. [Q8WWZ7-1]
    UniGeneiHs.731824.

    Genome annotation databases

    EnsembliENST00000392676; ENSP00000376443; ENSG00000154265. [Q8WWZ7-1]
    ENST00000588877; ENSP00000467882; ENSG00000154265. [Q8WWZ7-1]
    GeneIDi23461.
    KEGGihsa:23461.
    UCSCiuc002jib.2. human. [Q8WWZ7-3]
    uc002jic.2. human. [Q8WWZ7-1]
    uc002jih.2. human. [Q8WWZ7-2]

    Polymorphism databases

    DMDMi115503762.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    ABCMdb

    Database for mutations in ABC proteins

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY028897 mRNA. Translation: AAK30022.1 .
    AJ275973 mRNA. Translation: CAB93535.3 .
    AJ512612 mRNA. Translation: CAD54757.1 .
    AK056533 mRNA. Translation: BAB71208.1 .
    AK058170 mRNA. Translation: BAB71700.1 . Different initiation.
    AB067475 mRNA. Translation: BAB67781.1 .
    CCDSi CCDS11685.1. [Q8WWZ7-1 ]
    RefSeqi NP_061142.2. NM_018672.4. [Q8WWZ7-1 ]
    NP_758424.1. NM_172232.3. [Q8WWZ7-1 ]
    UniGenei Hs.731824.

    3D structure databases

    ProteinModelPortali Q8WWZ7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117024. 2 interactions.
    IntActi Q8WWZ7. 2 interactions.
    STRINGi 9606.ENSP00000319766.

    Chemistry

    DrugBanki DB00864. Tacrolimus.

    Protein family/group databases

    TCDBi 3.A.1.211.9. the atp-binding cassette (abc) superfamily.

    PTM databases

    PhosphoSitei Q8WWZ7.

    Polymorphism databases

    DMDMi 115503762.

    Proteomic databases

    PaxDbi Q8WWZ7.
    PRIDEi Q8WWZ7.

    Protocols and materials databases

    DNASUi 23461.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000392676 ; ENSP00000376443 ; ENSG00000154265 . [Q8WWZ7-1 ]
    ENST00000588877 ; ENSP00000467882 ; ENSG00000154265 . [Q8WWZ7-1 ]
    GeneIDi 23461.
    KEGGi hsa:23461.
    UCSCi uc002jib.2. human. [Q8WWZ7-3 ]
    uc002jic.2. human. [Q8WWZ7-1 ]
    uc002jih.2. human. [Q8WWZ7-2 ]

    Organism-specific databases

    CTDi 23461.
    GeneCardsi GC17M067240.
    HGNCi HGNC:35. ABCA5.
    HPAi HPA022032.
    MIMi 612503. gene.
    neXtProti NX_Q8WWZ7.
    PharmGKBi PA24380.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1131.
    HOGENOMi HOG000231057.
    HOVERGENi HBG079884.
    KOi K05648.
    OrthoDBi EOG73Z2SB.
    PhylomeDBi Q8WWZ7.
    TreeFami TF105192.

    Miscellaneous databases

    ChiTaRSi ABCA5. human.
    GenomeRNAii 23461.
    NextBioi 45765.
    PROi Q8WWZ7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8WWZ7.
    Bgeei Q8WWZ7.
    CleanExi HS_ABCA5.
    Genevestigatori Q8WWZ7.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    InterProi IPR003593. AAA+_ATPase.
    IPR026082. ABC_A.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    PANTHERi PTHR19229. PTHR19229. 1 hit.
    Pfami PF00005. ABC_tran. 2 hits.
    [Graphical view ]
    SMARTi SM00382. AAA. 2 hits.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 2 hits.
    PROSITEi PS00211. ABC_TRANSPORTER_1. 1 hit.
    PS50893. ABC_TRANSPORTER_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identifying and characterizing a five-gene cluster of ATP-binding cassette transporters mapping to human chromosome 17q24: a new subgroup within the ABCA subfamily."
      Arnould I., Schriml L.M., Prades C., Lachtermacher-Triunfol M., Schneider T., Maintoux C., Lemoine C., Debono D., Devaud C., Naudin L., Bauche S., Annat M., Annilo T., Allikmets R., Gold B., Denefle P., Rosier M., Dean M.
      GeneScreen 1:157-164(2001)
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT SER-832, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
      Tissue: Testis.
    2. "Cloning of human and rat ABCA5/Abca5 and detection of a human splice variant."
      Petry F., Kotthaus A., Hirsch-Ernst K.I.
      Biochem. Biophys. Res. Commun. 300:343-350(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY, VARIANTS THR-178; ARG-484 AND SER-832.
      Tissue: Hepatoma and Testis.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1187-1642 (ISOFORM 1), VARIANT SER-832.
      Tissue: Teratocarcinoma and Testis.
    4. "Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins."
      Nagase T., Kikuno R., Ohara O.
      DNA Res. 8:179-187(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 906-1642 (ISOFORM 1), VARIANT VAL-960.
      Tissue: Brain.

    Entry informationi

    Entry nameiABCA5_HUMAN
    AccessioniPrimary (citable) accession number: Q8WWZ7
    Secondary accession number(s): Q8IVJ2
    , Q96LJ1, Q96MS4, Q96PZ9, Q9NY14
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 3, 2006
    Last sequence update: October 3, 2006
    Last modified: October 1, 2014
    This is version 96 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3