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Q8WWZ7

- ABCA5_HUMAN

UniProt

Q8WWZ7 - ABCA5_HUMAN

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Protein
ATP-binding cassette sub-family A member 5
Gene
ABCA5, KIAA1888
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

May play a role in the processing of autolysosomes By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi514 – 5218ATP 1 Reviewed prediction
Nucleotide bindingi1333 – 13408ATP 2 Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ATPase activity Source: InterPro

GO - Biological processi

  1. cholesterol efflux Source: BHF-UCL
  2. high-density lipoprotein particle remodeling Source: BHF-UCL
  3. negative regulation of macrophage derived foam cell differentiation Source: BHF-UCL
  4. reverse cholesterol transport Source: BHF-UCL
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Protein family/group databases

TCDBi3.A.1.211.9. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family A member 5
Gene namesi
Name:ABCA5
Synonyms:KIAA1888
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:35. ABCA5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei32 – 5221Helical; Reviewed prediction
Add
BLAST
Transmembranei220 – 24021Helical; Reviewed prediction
Add
BLAST
Transmembranei264 – 28421Helical; Reviewed prediction
Add
BLAST
Transmembranei297 – 31721Helical; Reviewed prediction
Add
BLAST
Transmembranei328 – 34821Helical; Reviewed prediction
Add
BLAST
Transmembranei355 – 37521Helical; Reviewed prediction
Add
BLAST
Transmembranei396 – 41621Helical; Reviewed prediction
Add
BLAST
Transmembranei866 – 88621Helical; Reviewed prediction
Add
BLAST
Transmembranei967 – 98721Helical; Reviewed prediction
Add
BLAST
Transmembranei1021 – 104121Helical; Reviewed prediction
Add
BLAST
Transmembranei1071 – 109121Helical; Reviewed prediction
Add
BLAST
Transmembranei1102 – 112221Helical; Reviewed prediction
Add
BLAST
Transmembranei1139 – 115921Helical; Reviewed prediction
Add
BLAST
Transmembranei1169 – 118921Helical; Reviewed prediction
Add
BLAST
Transmembranei1207 – 122721Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. late endosome Source: BHF-UCL
  4. late endosome membrane Source: UniProtKB-SubCell
  5. lysosomal membrane Source: UniProtKB-SubCell
  6. lysosome Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Golgi apparatus, Lysosome, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24380.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 16421642ATP-binding cassette sub-family A member 5
PRO_0000250669Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi86 – 861N-linked (GlcNAc...) Reviewed prediction
Glycosylationi458 – 4581N-linked (GlcNAc...) Reviewed prediction
Glycosylationi996 – 9961N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

N-glycosylated By similarity.

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8WWZ7.
PRIDEiQ8WWZ7.

PTM databases

PhosphoSiteiQ8WWZ7.

Expressioni

Tissue specificityi

Ubiquitously expressed. Highly expressed in testis, skeletal muscle, kidney, liver and placenta.2 Publications

Developmental stagei

Expressed in fetal liver, kidney and brain.1 Publication

Gene expression databases

ArrayExpressiQ8WWZ7.
BgeeiQ8WWZ7.
CleanExiHS_ABCA5.
GenevestigatoriQ8WWZ7.

Organism-specific databases

HPAiHPA022032.

Interactioni

Protein-protein interaction databases

BioGridi117024. 2 interactions.
IntActiQ8WWZ7. 2 interactions.
STRINGi9606.ENSP00000319766.

Structurei

3D structure databases

ProteinModelPortaliQ8WWZ7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini478 – 713236ABC transporter 1
Add
BLAST
Domaini1290 – 1533244ABC transporter 2
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1131.
HOGENOMiHOG000231057.
HOVERGENiHBG079884.
KOiK05648.
OrthoDBiEOG73Z2SB.
PhylomeDBiQ8WWZ7.
TreeFamiTF105192.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR026082. ABC_A.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR19229. PTHR19229. 1 hit.
PfamiPF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTi