Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

ATP-binding cassette sub-family A member 10

Gene

ABCA10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Probable transporter which may play a role in macrophage lipid homeostasis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi427 – 434ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1239 – 1246ATP 2PROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000154263-MONOMER.
ReactomeiR-HSA-1369062. ABC transporters in lipid homeostasis.

Protein family/group databases

TCDBi3.A.1.211.17. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family A member 10
Gene namesi
Name:ABCA10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:30. ABCA10.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei83 – 103HelicalSequence analysisAdd BLAST21
Transmembranei135 – 155HelicalSequence analysisAdd BLAST21
Transmembranei185 – 205HelicalSequence analysisAdd BLAST21
Transmembranei210 – 230HelicalSequence analysisAdd BLAST21
Transmembranei240 – 260HelicalSequence analysisAdd BLAST21
Transmembranei264 – 284HelicalSequence analysisAdd BLAST21
Transmembranei310 – 330HelicalSequence analysisAdd BLAST21
Transmembranei774 – 794HelicalSequence analysisAdd BLAST21
Transmembranei890 – 910HelicalSequence analysisAdd BLAST21
Transmembranei926 – 946HelicalSequence analysisAdd BLAST21
Transmembranei985 – 1005HelicalSequence analysisAdd BLAST21
Transmembranei1014 – 1034HelicalSequence analysisAdd BLAST21
Transmembranei1046 – 1066HelicalSequence analysisAdd BLAST21
Transmembranei1073 – 1093HelicalSequence analysisAdd BLAST21
Transmembranei1113 – 1133HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10349.
OpenTargetsiENSG00000154263.
PharmGKBiPA24374.

Polymorphism and mutation databases

BioMutaiABCA10.
DMDMi296439455.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002535721 – 1543ATP-binding cassette sub-family A member 10Add BLAST1543

Proteomic databases

EPDiQ8WWZ4.
PaxDbiQ8WWZ4.
PeptideAtlasiQ8WWZ4.
PRIDEiQ8WWZ4.

PTM databases

iPTMnetiQ8WWZ4.
PhosphoSitePlusiQ8WWZ4.

Expressioni

Tissue specificityi

Widely expressed. Highly expressed in skeletal muscle, heart, brain and gastrointestinal tract.2 Publications

Inductioni

Down-regulated by cholesterol loading of macrophages.1 Publication

Gene expression databases

BgeeiENSG00000154263.
CleanExiHS_ABCA10.
ExpressionAtlasiQ8WWZ4. baseline and differential.

Organism-specific databases

HPAiHPA014535.

Interactioni

Protein-protein interaction databases

BioGridi115630. 2 interactors.
STRINGi9606.ENSP00000269081.

Structurei

3D structure databases

ProteinModelPortaliQ8WWZ4.
SMRiQ8WWZ4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini391 – 626ABC transporter 1PROSITE-ProRule annotationAdd BLAST236
Domaini1206 – 1440ABC transporter 2PROSITE-ProRule annotationAdd BLAST235

Sequence similaritiesi

Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0059. Eukaryota.
COG1131. LUCA.
GeneTreeiENSGT00760000118965.
HOVERGENiHBG079884.
InParanoidiQ8WWZ4.
KOiK05652.
OMAiEWFIFIC.
OrthoDBiEOG091G00AG.
PhylomeDBiQ8WWZ4.
TreeFamiTF105192.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR026082. ABC_A.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR19229. PTHR19229. 1 hit.
PfamiPF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WWZ4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNKMALASFM KGRTVIGTPD EETMDIELPK KYHEMVGVIF SDTFSYRLKF
60 70 80 90 100
NWGYRIPVIK EHSEYTEHCW AMHGEIFCYL AKYWLKGFVA FQAAINAAII
110 120 130 140 150
EVTTNHSVME ELTSVIGINM KIPPFISKGE IMNEWFHFTC LVSFSSFIYF
160 170 180 190 200
ASLNVARERG KFKKLMTVMG LRESAFWLSW GLTYICFIFI MSIFMALVIT
210 220 230 240 250
SIPIVFHTGF MVIFTLYSLY GLSLIALAFL MSVLIRKPML AGLAGFLFTV
260 270 280 290 300
FWGCLGFTVL YRQLPLSLGW VLSLLSPFAF TAGMAQITHL DNYLSGVIFP
310 320 330 340 350
DPSGDSYKMI ATFFILAFDT LFYLIFTLYF ERVLPDKDGH GDSPLFFLKS
360 370 380 390 400
SFWSKHQNTH HEIFENEINP EHSSDDSFEP VSPEFHGKEA IRIRNVIKEY
410 420 430 440 450
NGKTGKVEAL QGIFFDIYEG QITAILGHNG AGKSTLLNIL SGLSVSTEGS
460 470 480 490 500
ATIYNTQLSE ITDMEEIRKN IGFCPQFNFQ FDFLTVRENL RVFAKIKGIQ
510 520 530 540 550
PKEVEQEVKR IIMELDMQSI QDIIAKKLSG GQKRKLTLGI AILGDPQVLL
560 570 580 590 600
LDEPTAGLDP FSRHRVWSLL KEHKVDRLIL FSTQFMDEAD ILADRKVFLS
610 620 630 640 650
NGKLKCAGSS LFLKRKWGIG YHLSLHRNEM CDTEKITSLI KQHIPDAKLT
660 670 680 690 700
TESEEKLVYS LPLEKTNKFP DLYSDLDKCS DQGIRNYAVS VTSLNEVFLN
710 720 730 740 750
LEGKSAIDEP DFDIGKQEKI HVTRNTGDES EMEQVLCSLP ETRKAVSSAA
760 770 780 790 800
LWRRQIYAVA TLRFLKLRRE RRALLCLLLV LGIAFIPIIL EKIMYKVTRE
810 820 830 840 850
THCWEFSPSM YFLSLEQIPK TPLTSLLIVN NTGSNIEDLV HSLKCQDIVL
860 870 880 890 900
EIDDFRNRNG SDDPSYNGAI IVSGDQKDYR FSVACNTKKL NCFPVLMGIV
910 920 930 940 950
SNALMGIFNF TELIQMESTS FSRDDIVLDL GFIDGSIFLL LITNCVSPFI
960 970 980 990 1000
GMSSISDYKK NVQSQLWISG LWPSAYWCGQ ALVDIPLYFL ILFSIHLIYY
1010 1020 1030 1040 1050
FIFLGFQLSW ELMFVLVVCI IGCAVSLIFL TYVLSFIFRK WRKNNGFWSF
1060 1070 1080 1090 1100
GFFIILICVS TIMVSTQYEK LNLILCMIFI PSFTLLGYVM LLIQLDFMRN
1110 1120 1130 1140 1150
LDSLDNRINE VNKTILLTTL IPYLQSVIFL FVIRCLEMKY GNEIMNKDPV
1160 1170 1180 1190 1200
FRISPRSRET HPNPEEPEEE DEDVQAERVQ AANALTAPNL EEEPVITASC
1210 1220 1230 1240 1250
LHKEYYETKK SCFSTRKKKI AIRNVSFCVK KGEVLGLLGH NGAGKSTSIK
1260 1270 1280 1290 1300
MITGCTKPTA GVVVLQGSRA SVRQQHDNSL KFLGYCPQEN SLWPKLTMKE
1310 1320 1330 1340 1350
HLELYAAVKG LGKEDAALSI SRLVEALKLQ EQLKAPVKTL SEGIKRKLCF
1360 1370 1380 1390 1400
VLSILGNPSV VLLDEPFTGM DPEGQQQMWQ ILQATVKNKE RGTLLTTHYM
1410 1420 1430 1440 1450
SEAEAVCDRM AMMVSGTLRC IGSIQHLKNK FGRDYLLEIK MKEPTQVEAL
1460 1470 1480 1490 1500
HTEILKLFPQ AAWQERYSSL MAYKLPVEDV HPLSRAFFKL EAMKQTFNLE
1510 1520 1530 1540
EYSLSQATLE QVFLELCKEQ ELGNVDDKID TTVEWKLLPQ EDP
Length:1,543
Mass (Da):175,790
Last modified:May 18, 2010 - v3
Checksum:i47E932434314B538
GO
Isoform 2 (identifier: Q8WWZ4-2) [UniParc]FASTAAdd to basket
Also known as: ABCA10delta+82

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: Missing.

Show »
Length:1,520
Mass (Da):173,280
Checksum:i53F733EF3885790F
GO
Isoform 3 (identifier: Q8WWZ4-3) [UniParc]FASTAAdd to basket
Also known as: ABCA10delta-104

The sequence of this isoform differs from the canonical sequence as follows:
     67-67: E → GHNKSFCNGGVDISYWNKYEDTTFHF
     68-1543: Missing.

Show »
Length:92
Mass (Da):10,828
Checksum:i947A319F99231651
GO
Isoform 4 (identifier: Q8WWZ4-4) [UniParc]FASTAAdd to basket
Also known as: ABCA10delta-176

The sequence of this isoform differs from the canonical sequence as follows:
     450-450: S → KKNYNGIRHAKHSRHYC
     451-1543: Missing.

Show »
Length:466
Mass (Da):53,113
Checksum:i636FB6EEBF278210
GO
Isoform 5 (identifier: Q8WWZ4-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     413-452: IFFDIYEGQI...LSVSTEGSAT → SEERLCPAAH...PCPAATPSGN
     453-1543: Missing.

Note: No experimental confirmation available.
Show »
Length:452
Mass (Da):51,478
Checksum:iD3583F1419B5AC38
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti140C → Y in CAD89903 (PubMed:17974005).Curated1
Sequence conflicti159R → G in CAD89903 (PubMed:17974005).Curated1
Sequence conflicti187F → S in CAD89903 (PubMed:17974005).Curated1
Sequence conflicti324L → S in CAD89903 (PubMed:17974005).Curated1
Sequence conflicti364F → L in CAD89903 (PubMed:17974005).Curated1
Sequence conflicti1216R → I in AAO72160 (PubMed:12821155).Curated1
Sequence conflicti1216R → I in AAO72161 (PubMed:12821155).Curated1
Sequence conflicti1216R → I in AAH51320 (PubMed:16625196).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_028384203P → S.3 PublicationsCorresponds to variant rs9909216dbSNPEnsembl.1
Natural variantiVAR_028385287I → V.3 PublicationsCorresponds to variant rs11657804dbSNPEnsembl.1
Natural variantiVAR_028386916M → T.1 PublicationCorresponds to variant rs4968849dbSNPEnsembl.1
Natural variantiVAR_0554691322R → W.Corresponds to variant rs10491178dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0210611 – 23Missing in isoform 2. CuratedAdd BLAST23
Alternative sequenceiVSP_02106267E → GHNKSFCNGGVDISYWNKYE DTTFHF in isoform 3. Curated1
Alternative sequenceiVSP_02106368 – 1543Missing in isoform 3. CuratedAdd BLAST1476
Alternative sequenceiVSP_021064413 – 452IFFDI…EGSAT → SEERLCPAAHRLRCGERLCP AAHHLGCEERPCPAATPSGN in isoform 5. 1 PublicationAdd BLAST40
Alternative sequenceiVSP_021065450S → KKNYNGIRHAKHSRHYC in isoform 4. Curated1
Alternative sequenceiVSP_021066451 – 1543Missing in isoform 4. CuratedAdd BLAST1093
Alternative sequenceiVSP_021067453 – 1543Missing in isoform 5. 1 PublicationAdd BLAST1091

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY028900 mRNA. Translation: AAK30025.1.
AY247065 mRNA. Translation: AAO72161.1.
AY247105
, AY247069, AY247070, AY247071, AY247072, AY247073, AY247074, AY247075, AY247076, AY247077, AY247078, AY247079, AY247080, AY247081, AY247082, AY247083, AY247084, AY247085, AY247086, AY247087, AY247088, AY247089, AY247090, AY247091, AY247092, AY247093, AY247094, AY247095, AY247096, AY247097, AY247098, AY247099, AY247100, AY247101, AY247102, AY247103, AY247104 Genomic DNA. Translation: AAO72160.1.
AL832004 mRNA. Translation: CAD89903.1.
AC005495 Genomic DNA. No translation available.
BC031026 mRNA. Translation: AAH31026.1.
BC051320 mRNA. Translation: AAH51320.1.
CCDSiCCDS11684.1. [Q8WWZ4-1]
RefSeqiNP_525021.3. NM_080282.3. [Q8WWZ4-1]
UniGeneiHs.25377.

Genome annotation databases

EnsembliENST00000269081; ENSP00000269081; ENSG00000154263. [Q8WWZ4-1]
ENST00000522406; ENSP00000429853; ENSG00000154263. [Q8WWZ4-5]
ENST00000523512; ENSP00000429945; ENSG00000154263. [Q8WWZ4-3]
GeneIDi10349.
KEGGihsa:10349.
UCSCiuc010dfa.2. human. [Q8WWZ4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

ABCMdb

Database for mutations in ABC proteins

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY028900 mRNA. Translation: AAK30025.1.
AY247065 mRNA. Translation: AAO72161.1.
AY247105
, AY247069, AY247070, AY247071, AY247072, AY247073, AY247074, AY247075, AY247076, AY247077, AY247078, AY247079, AY247080, AY247081, AY247082, AY247083, AY247084, AY247085, AY247086, AY247087, AY247088, AY247089, AY247090, AY247091, AY247092, AY247093, AY247094, AY247095, AY247096, AY247097, AY247098, AY247099, AY247100, AY247101, AY247102, AY247103, AY247104 Genomic DNA. Translation: AAO72160.1.
AL832004 mRNA. Translation: CAD89903.1.
AC005495 Genomic DNA. No translation available.
BC031026 mRNA. Translation: AAH31026.1.
BC051320 mRNA. Translation: AAH51320.1.
CCDSiCCDS11684.1. [Q8WWZ4-1]
RefSeqiNP_525021.3. NM_080282.3. [Q8WWZ4-1]
UniGeneiHs.25377.

3D structure databases

ProteinModelPortaliQ8WWZ4.
SMRiQ8WWZ4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115630. 2 interactors.
STRINGi9606.ENSP00000269081.

Protein family/group databases

TCDBi3.A.1.211.17. the atp-binding cassette (abc) superfamily.

PTM databases

iPTMnetiQ8WWZ4.
PhosphoSitePlusiQ8WWZ4.

Polymorphism and mutation databases

BioMutaiABCA10.
DMDMi296439455.

Proteomic databases

EPDiQ8WWZ4.
PaxDbiQ8WWZ4.
PeptideAtlasiQ8WWZ4.
PRIDEiQ8WWZ4.

Protocols and materials databases

DNASUi10349.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000269081; ENSP00000269081; ENSG00000154263. [Q8WWZ4-1]
ENST00000522406; ENSP00000429853; ENSG00000154263. [Q8WWZ4-5]
ENST00000523512; ENSP00000429945; ENSG00000154263. [Q8WWZ4-3]
GeneIDi10349.
KEGGihsa:10349.
UCSCiuc010dfa.2. human. [Q8WWZ4-1]

Organism-specific databases

CTDi10349.
DisGeNETi10349.
GeneCardsiABCA10.
HGNCiHGNC:30. ABCA10.
HPAiHPA014535.
MIMi612508. gene.
neXtProtiNX_Q8WWZ4.
OpenTargetsiENSG00000154263.
PharmGKBiPA24374.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0059. Eukaryota.
COG1131. LUCA.
GeneTreeiENSGT00760000118965.
HOVERGENiHBG079884.
InParanoidiQ8WWZ4.
KOiK05652.
OMAiEWFIFIC.
OrthoDBiEOG091G00AG.
PhylomeDBiQ8WWZ4.
TreeFamiTF105192.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000154263-MONOMER.
ReactomeiR-HSA-1369062. ABC transporters in lipid homeostasis.

Miscellaneous databases

ChiTaRSiABCA10. human.
GenomeRNAii10349.
PROiQ8WWZ4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000154263.
CleanExiHS_ABCA10.
ExpressionAtlasiQ8WWZ4. baseline and differential.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR026082. ABC_A.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR19229. PTHR19229. 1 hit.
PfamiPF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiABCAA_HUMAN
AccessioniPrimary (citable) accession number: Q8WWZ4
Secondary accession number(s): C9JZH2
, C9K035, Q6PIQ6, Q7Z2I9, Q7Z7P7, Q86TD2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: May 18, 2010
Last modified: November 2, 2016
This is version 116 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.