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Protein

WAP four-disulfide core domain protein 12

Gene

WFDC12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Antibacterial protein. Putative acid-stable proteinase inhibitor.

GO - Molecular functioni

  • serine-type endopeptidase inhibitor activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Protease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI17.003.

Names & Taxonomyi

Protein namesi
Recommended name:
WAP four-disulfide core domain protein 12
Alternative name(s):
Putative protease inhibitor WAP12
Whey acidic protein 2
Gene namesi
Name:WFDC12
Synonyms:C20orf122, WAP2
ORF Names:UNQ544/PRO844
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:16115. WFDC12.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25663.

Polymorphism and mutation databases

BioMutaiWFDC12.
DMDMi24212610.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Chaini24 – 11188WAP four-disulfide core domain protein 12PRO_0000041390Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi34 ↔ 62PROSITE-ProRule annotation
Disulfide bondi41 ↔ 66PROSITE-ProRule annotation
Disulfide bondi49 ↔ 61PROSITE-ProRule annotation
Disulfide bondi55 ↔ 70PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ8WWY7.
PeptideAtlasiQ8WWY7.
PRIDEiQ8WWY7.

PTM databases

iPTMnetiQ8WWY7.
PhosphoSiteiQ8WWY7.

Expressioni

Tissue specificityi

Highly expressed in prostate, skin, lung and esophagus. Weakly expressed in skeletal muscle, epididymis, kidney, trachea, salivary gland, testis and seminal vesicle.

Gene expression databases

BgeeiQ8WWY7.
CleanExiHS_WFDC12.
GenevisibleiQ8WWY7. HS.

Interactioni

Protein-protein interaction databases

BioGridi126126. 1 interaction.
STRINGi9606.ENSP00000361871.

Structurei

3D structure databases

ProteinModelPortaliQ8WWY7.
SMRiQ8WWY7. Positions 29-73.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 7448WAPPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 WAP domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JHHC. Eukaryota.
ENOG41119G0. LUCA.
GeneTreeiENSGT00390000012286.
HOGENOMiHOG000133110.
HOVERGENiHBG055877.
InParanoidiQ8WWY7.
OMAiDPPQCHT.
OrthoDBiEOG72RN27.
PhylomeDBiQ8WWY7.
TreeFamiTF338375.

Family and domain databases

Gene3Di4.10.75.10. 1 hit.
InterProiIPR008197. WAP_dom.
[Graphical view]
PfamiPF00095. WAP. 1 hit.
[Graphical view]
PRINTSiPR00003. 4DISULPHCORE.
SMARTiSM00217. WAP. 1 hit.
[Graphical view]
SUPFAMiSSF57256. SSF57256. 1 hit.
PROSITEiPS51390. WAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8WWY7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSSSFLVLM VSLVLVTLVA VEGVKEGIEK AGVCPADNVR CFKSDPPQCH
60 70 80 90 100
TDQDCLGERK CCYLHCGFKC VIPVKELEEG GNKDEDVSRP YPEPGWEAKC
110
PGSSSTRCPQ K
Length:111
Mass (Da):12,050
Last modified:March 1, 2002 - v1
Checksum:i2DFB39043F1A0997
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY037803 mRNA. Translation: AAK68848.1.
AY358678 mRNA. Translation: AAQ89041.1.
Z93016 Genomic DNA. Translation: CAI19817.1.
CCDSiCCDS13343.1.
RefSeqiNP_543145.1. NM_080869.1.
UniGeneiHs.352180.

Genome annotation databases

EnsembliENST00000372785; ENSP00000361871; ENSG00000168703.
GeneIDi128488.
KEGGihsa:128488.
UCSCiuc002xnf.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY037803 mRNA. Translation: AAK68848.1.
AY358678 mRNA. Translation: AAQ89041.1.
Z93016 Genomic DNA. Translation: CAI19817.1.
CCDSiCCDS13343.1.
RefSeqiNP_543145.1. NM_080869.1.
UniGeneiHs.352180.

3D structure databases

ProteinModelPortaliQ8WWY7.
SMRiQ8WWY7. Positions 29-73.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126126. 1 interaction.
STRINGi9606.ENSP00000361871.

Protein family/group databases

MEROPSiI17.003.

PTM databases

iPTMnetiQ8WWY7.
PhosphoSiteiQ8WWY7.

Polymorphism and mutation databases

BioMutaiWFDC12.
DMDMi24212610.

Proteomic databases

PaxDbiQ8WWY7.
PeptideAtlasiQ8WWY7.
PRIDEiQ8WWY7.

Protocols and materials databases

DNASUi128488.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372785; ENSP00000361871; ENSG00000168703.
GeneIDi128488.
KEGGihsa:128488.
UCSCiuc002xnf.2. human.

Organism-specific databases

CTDi128488.
GeneCardsiWFDC12.
HGNCiHGNC:16115. WFDC12.
MIMi609872. gene.
neXtProtiNX_Q8WWY7.
PharmGKBiPA25663.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JHHC. Eukaryota.
ENOG41119G0. LUCA.
GeneTreeiENSGT00390000012286.
HOGENOMiHOG000133110.
HOVERGENiHBG055877.
InParanoidiQ8WWY7.
OMAiDPPQCHT.
OrthoDBiEOG72RN27.
PhylomeDBiQ8WWY7.
TreeFamiTF338375.

Miscellaneous databases

GenomeRNAii128488.
PROiQ8WWY7.
SOURCEiSearch...

Gene expression databases

BgeeiQ8WWY7.
CleanExiHS_WFDC12.
GenevisibleiQ8WWY7. HS.

Family and domain databases

Gene3Di4.10.75.10. 1 hit.
InterProiIPR008197. WAP_dom.
[Graphical view]
PfamiPF00095. WAP. 1 hit.
[Graphical view]
PRINTSiPR00003. 4DISULPHCORE.
SMARTiSM00217. WAP. 1 hit.
[Graphical view]
SUPFAMiSSF57256. SSF57256. 1 hit.
PROSITEiPS51390. WAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a novel protease inhibitor gene that is highly expressed in the prostate."
    Lundwall A., Clauss A.
    Biochem. Biophys. Res. Commun. 290:452-456(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiWFD12_HUMAN
AccessioniPrimary (citable) accession number: Q8WWY7
Secondary accession number(s): Q5H980, Q9BR31
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: March 1, 2002
Last modified: July 6, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.