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Protein

Selenoprotein M

Gene

SELENOM

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May function as a thiol-disulfide oxidoreductase that participates in disulfide bond formation.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei45NucleophileBy similarity1
Active sitei48NucleophileBy similarity1

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Selenoprotein M1 Publication
Short name:
SelM1 Publication
Gene namesi
Name:SELENOM1 PublicationImported
Synonyms:SELM2 Publications
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:30397. SELENOM.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Golgi apparatus

Pathology & Biotechi

Organism-specific databases

DisGeNETi140606.
OpenTargetsiENSG00000198832.

Polymorphism and mutation databases

BioMutaiSELM.
DMDMi189034058.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000002229824 – 145Selenoprotein MAdd BLAST122

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki45 ↔ 48Cysteinyl-selenocysteine (Cys-Sec)Sequence analysis

Proteomic databases

EPDiQ8WWX9.
MaxQBiQ8WWX9.
PaxDbiQ8WWX9.
PeptideAtlasiQ8WWX9.
PRIDEiQ8WWX9.

PTM databases

PhosphoSitePlusiQ8WWX9.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Organism-specific databases

HPAiHPA019601.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi126635. 4 interactors.
IntActiQ8WWX9. 7 interactors.
STRINGi9606.ENSP00000383155.

Structurei

3D structure databases

ProteinModelPortaliQ8WWX9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the selenoprotein M/F family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IZY6. Eukaryota.
ENOG4112CA8. LUCA.
GeneTreeiENSGT00390000001255.
HOGENOMiHOG000168390.
HOVERGENiHBG108468.
InParanoidiQ8WWX9.
OMAiTFRPDWN.
PhylomeDBiQ8WWX9.

Family and domain databases

InterProiView protein in InterPro
IPR014912. Sep15_SelM.
IPR012336. Thioredoxin-like_fold.
PfamiView protein in Pfam
PF08806. Sep15_SelM. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8WWX9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLLLPPLAL LLLLAALVAP ATAATAYRPD WNRLSGLTRA RVETCGGUQL
60 70 80 90 100
NRLKEVKAFV TQDIPFYHNL VMKHLPGADP ELVLLGRRYE ELERIPLSEM
110 120 130 140
TREEINALVQ ELGFYRKAAP DAQVPPEYVW APAKPPEETS DHADL
Length:145
Mass (Da):16,232
Last modified:February 26, 2008 - v3
Checksum:i556A41B02EF694BE
GO

Non-standard residue

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-standard residuei48Selenocysteine1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY043487 mRNA. Translation: AAK95397.1.
AC005005 Genomic DNA. No translation available.
BC013421 mRNA. Translation: AAH13421.1.
BC030236 mRNA. Translation: AAH30236.1.
BC068004 mRNA. Translation: AAH68004.1.
CCDSiCCDS43003.1.
RefSeqiNP_536355.1. NM_080430.3.
UniGeneiHs.55940.

Genome annotation databases

EnsembliENST00000400299; ENSP00000383155; ENSG00000198832.
ENST00000402395; ENSP00000384564; ENSG00000198832.
GeneIDi140606.
KEGGihsa:140606.

Keywords - Coding sequence diversityi

Selenocysteine

Similar proteinsi

Entry informationi

Entry nameiSELM_HUMAN
AccessioniPrimary (citable) accession number: Q8WWX9
Secondary accession number(s): A8MPZ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 17, 2003
Last sequence update: February 26, 2008
Last modified: August 30, 2017
This is version 119 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families