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Q8WWX0

- ASB5_HUMAN

UniProt

Q8WWX0 - ASB5_HUMAN

Protein

Ankyrin repeat and SOCS box protein 5

Gene

ASB5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. May play a role in the initiation of arteriogenesis By similarity.By similarity

    Pathwayi

    GO - Biological processi

    1. intracellular signal transduction Source: InterPro
    2. protein ubiquitination Source: UniProtKB-UniPathway

    Keywords - Biological processi

    Ubl conjugation pathway

    Enzyme and pathway databases

    ReactomeiREACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.
    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ankyrin repeat and SOCS box protein 5
    Short name:
    ASB-5
    Gene namesi
    Name:ASB5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:17180. ASB5.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25033.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 329329Ankyrin repeat and SOCS box protein 5PRO_0000066930Add
    BLAST

    Proteomic databases

    PaxDbiQ8WWX0.
    PRIDEiQ8WWX0.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8WWX0.
    BgeeiQ8WWX0.
    CleanExiHS_ASB5.
    GenevestigatoriQ8WWX0.

    Organism-specific databases

    HPAiHPA028870.

    Interactioni

    Protein-protein interaction databases

    BioGridi126611. 22 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8WWX0.
    SMRiQ8WWX0. Positions 36-328.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati69 – 9830ANK 1Add
    BLAST
    Repeati102 – 13130ANK 2Add
    BLAST
    Repeati135 – 16430ANK 3Add
    BLAST
    Repeati167 – 19630ANK 4Add
    BLAST
    Repeati200 – 22930ANK 5Add
    BLAST
    Repeati232 – 26130ANK 6Add
    BLAST
    Domaini278 – 32952SOCS boxPROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.By similarity

    Sequence similaritiesi

    Contains 6 ANK repeats.PROSITE-ProRule annotation
    Contains 1 SOCS box domain.PROSITE-ProRule annotation

    Keywords - Domaini

    ANK repeat, Repeat

    Phylogenomic databases

    eggNOGiCOG0666.
    HOGENOMiHOG000231513.
    HOVERGENiHBG001376.
    InParanoidiQ8WWX0.
    KOiK10327.
    OMAiQGSTSCT.
    OrthoDBiEOG7J447G.
    PhylomeDBiQ8WWX0.
    TreeFamiTF331945.

    Family and domain databases

    Gene3Di1.25.40.20. 2 hits.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR001496. SOCS_C.
    [Graphical view]
    PfamiPF12796. Ank_2. 2 hits.
    PF07525. SOCS_box. 1 hit.
    [Graphical view]
    PRINTSiPR01415. ANKYRIN.
    SMARTiSM00248. ANK. 6 hits.
    SM00969. SOCS_box. 1 hit.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 1 hit.
    PROSITEiPS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 4 hits.
    PS50225. SOCS. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8WWX0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSVLEENRPF AQQLSNVYFT ILSLFCFKLF VKISLAILSH FYIVKGNRKE    50
    AARIAAEFYG VTQGQGSWAD RSPLHEAASQ GRLLALRTLL SQGYNVNAVT 100
    LDHVTPLHEA CLGDHVACAR TLLEAGANVN AITIDGVTPL FNACSQGSPS 150
    CAELLLEYGA KAQLESCLPS PTHEAASKGH HECLDILISW GIDVDQEIPH 200
    LGTPLYVACM SQQFHCIWKL LYAGADVQKG KYWDTPLHAA AQQSSTEIVN 250
    LLLEFGADIN AKNTELLRPI DVATSSSMVE RILLQHEATP SSLYQLCRLC 300
    IRSYIGKPRL HLIPQLQLPT LLKNFLQYR 329
    Length:329
    Mass (Da):36,341
    Last modified:March 1, 2002 - v1
    Checksum:i966B823CED8A8B71
    GO
    Isoform 2 (identifier: Q8WWX0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-65: MSVLEENRPF...AEFYGVTQGQ → MPLCNGGNLAVT

    Note: No experimental confirmation available.

    Show »
    Length:276
    Mass (Da):30,083
    Checksum:i1AC765F7DCBAD03F
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 6565MSVLE…VTQGQ → MPLCNGGNLAVT in isoform 2. 1 PublicationVSP_054425Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY057053 mRNA. Translation: AAL18248.1.
    AK098693 mRNA. Translation: BAC05382.1.
    AC019163 Genomic DNA. No translation available.
    AC093605 Genomic DNA. No translation available.
    BC065710 mRNA. Translation: AAH65710.1.
    CCDSiCCDS3827.1. [Q8WWX0-1]
    RefSeqiNP_543150.1. NM_080874.3. [Q8WWX0-1]
    XP_005262816.1. XM_005262759.1. [Q8WWX0-1]
    UniGeneiHs.591712.

    Genome annotation databases

    EnsembliENST00000296525; ENSP00000296525; ENSG00000164122. [Q8WWX0-1]
    ENST00000512254; ENSP00000422877; ENSG00000164122. [Q8WWX0-2]
    GeneIDi140458.
    KEGGihsa:140458.
    UCSCiuc003iuq.2. human. [Q8WWX0-1]

    Polymorphism databases

    DMDMi20531989.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY057053 mRNA. Translation: AAL18248.1 .
    AK098693 mRNA. Translation: BAC05382.1 .
    AC019163 Genomic DNA. No translation available.
    AC093605 Genomic DNA. No translation available.
    BC065710 mRNA. Translation: AAH65710.1 .
    CCDSi CCDS3827.1. [Q8WWX0-1 ]
    RefSeqi NP_543150.1. NM_080874.3. [Q8WWX0-1 ]
    XP_005262816.1. XM_005262759.1. [Q8WWX0-1 ]
    UniGenei Hs.591712.

    3D structure databases

    ProteinModelPortali Q8WWX0.
    SMRi Q8WWX0. Positions 36-328.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 126611. 22 interactions.

    Polymorphism databases

    DMDMi 20531989.

    Proteomic databases

    PaxDbi Q8WWX0.
    PRIDEi Q8WWX0.

    Protocols and materials databases

    DNASUi 140458.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000296525 ; ENSP00000296525 ; ENSG00000164122 . [Q8WWX0-1 ]
    ENST00000512254 ; ENSP00000422877 ; ENSG00000164122 . [Q8WWX0-2 ]
    GeneIDi 140458.
    KEGGi hsa:140458.
    UCSCi uc003iuq.2. human. [Q8WWX0-1 ]

    Organism-specific databases

    CTDi 140458.
    GeneCardsi GC04M177134.
    HGNCi HGNC:17180. ASB5.
    HPAi HPA028870.
    MIMi 615050. gene.
    neXtProti NX_Q8WWX0.
    PharmGKBi PA25033.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0666.
    HOGENOMi HOG000231513.
    HOVERGENi HBG001376.
    InParanoidi Q8WWX0.
    KOi K10327.
    OMAi QGSTSCT.
    OrthoDBi EOG7J447G.
    PhylomeDBi Q8WWX0.
    TreeFami TF331945.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .
    Reactomei REACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.

    Miscellaneous databases

    ChiTaRSi ASB5. human.
    GenomeRNAii 140458.
    NextBioi 84105.
    PROi Q8WWX0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8WWX0.
    Bgeei Q8WWX0.
    CleanExi HS_ASB5.
    Genevestigatori Q8WWX0.

    Family and domain databases

    Gene3Di 1.25.40.20. 2 hits.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR001496. SOCS_C.
    [Graphical view ]
    Pfami PF12796. Ank_2. 2 hits.
    PF07525. SOCS_box. 1 hit.
    [Graphical view ]
    PRINTSi PR01415. ANKYRIN.
    SMARTi SM00248. ANK. 6 hits.
    SM00969. SOCS_box. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48403. SSF48403. 1 hit.
    PROSITEi PS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 4 hits.
    PS50225. SOCS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Kile B.T., Hilton D.J., Nicola N.A.
      Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Testis.
    3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Skeletal muscle.

    Entry informationi

    Entry nameiASB5_HUMAN
    AccessioniPrimary (citable) accession number: Q8WWX0
    Secondary accession number(s): Q8N7B5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2002
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3