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Protein

Ankyrin repeat and SOCS box protein 5

Gene

ASB5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. May play a role in the initiation of arteriogenesis (By similarity).By similarity

Pathwayi

GO - Biological processi

  1. intracellular signal transduction Source: InterPro
  2. protein ubiquitination Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiREACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat and SOCS box protein 5
Short name:
ASB-5
Gene namesi
Name:ASB5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:17180. ASB5.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25033.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 329329Ankyrin repeat and SOCS box protein 5PRO_0000066930Add
BLAST

Proteomic databases

PaxDbiQ8WWX0.
PRIDEiQ8WWX0.

Expressioni

Gene expression databases

BgeeiQ8WWX0.
CleanExiHS_ASB5.
ExpressionAtlasiQ8WWX0. baseline and differential.
GenevestigatoriQ8WWX0.

Organism-specific databases

HPAiHPA028870.

Interactioni

Protein-protein interaction databases

BioGridi126611. 22 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ8WWX0.
SMRiQ8WWX0. Positions 36-326.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati69 – 9830ANK 1Add
BLAST
Repeati102 – 13130ANK 2Add
BLAST
Repeati135 – 16430ANK 3Add
BLAST
Repeati167 – 19630ANK 4Add
BLAST
Repeati200 – 22930ANK 5Add
BLAST
Repeati232 – 26130ANK 6Add
BLAST
Domaini278 – 32952SOCS boxPROSITE-ProRule annotationAdd
BLAST

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.By similarity

Sequence similaritiesi

Contains 6 ANK repeats.PROSITE-ProRule annotation
Contains 1 SOCS box domain.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiCOG0666.
GeneTreeiENSGT00730000110500.
HOGENOMiHOG000231513.
HOVERGENiHBG001376.
InParanoidiQ8WWX0.
KOiK10327.
OMAiNYIGRPR.
OrthoDBiEOG7J447G.
PhylomeDBiQ8WWX0.
TreeFamiTF331945.

Family and domain databases

Gene3Di1.25.40.20. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001496. SOCS_C.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
PF07525. SOCS_box. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 6 hits.
SM00969. SOCS_box. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
PS50225. SOCS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8WWX0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSVLEENRPF AQQLSNVYFT ILSLFCFKLF VKISLAILSH FYIVKGNRKE
60 70 80 90 100
AARIAAEFYG VTQGQGSWAD RSPLHEAASQ GRLLALRTLL SQGYNVNAVT
110 120 130 140 150
LDHVTPLHEA CLGDHVACAR TLLEAGANVN AITIDGVTPL FNACSQGSPS
160 170 180 190 200
CAELLLEYGA KAQLESCLPS PTHEAASKGH HECLDILISW GIDVDQEIPH
210 220 230 240 250
LGTPLYVACM SQQFHCIWKL LYAGADVQKG KYWDTPLHAA AQQSSTEIVN
260 270 280 290 300
LLLEFGADIN AKNTELLRPI DVATSSSMVE RILLQHEATP SSLYQLCRLC
310 320
IRSYIGKPRL HLIPQLQLPT LLKNFLQYR
Length:329
Mass (Da):36,341
Last modified:March 1, 2002 - v1
Checksum:i966B823CED8A8B71
GO
Isoform 2 (identifier: Q8WWX0-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-65: MSVLEENRPF...AEFYGVTQGQ → MPLCNGGNLAVT

Note: No experimental confirmation available.

Show »
Length:276
Mass (Da):30,083
Checksum:i1AC765F7DCBAD03F
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 6565MSVLE…VTQGQ → MPLCNGGNLAVT in isoform 2. 1 PublicationVSP_054425Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY057053 mRNA. Translation: AAL18248.1.
AK098693 mRNA. Translation: BAC05382.1.
AC019163 Genomic DNA. No translation available.
AC093605 Genomic DNA. No translation available.
BC065710 mRNA. Translation: AAH65710.1.
CCDSiCCDS3827.1. [Q8WWX0-1]
RefSeqiNP_543150.1. NM_080874.3. [Q8WWX0-1]
XP_005262816.1. XM_005262759.1. [Q8WWX0-1]
UniGeneiHs.591712.

Genome annotation databases

EnsembliENST00000296525; ENSP00000296525; ENSG00000164122. [Q8WWX0-1]
ENST00000512254; ENSP00000422877; ENSG00000164122. [Q8WWX0-2]
GeneIDi140458.
KEGGihsa:140458.
UCSCiuc003iuq.2. human. [Q8WWX0-1]

Polymorphism databases

DMDMi20531989.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY057053 mRNA. Translation: AAL18248.1.
AK098693 mRNA. Translation: BAC05382.1.
AC019163 Genomic DNA. No translation available.
AC093605 Genomic DNA. No translation available.
BC065710 mRNA. Translation: AAH65710.1.
CCDSiCCDS3827.1. [Q8WWX0-1]
RefSeqiNP_543150.1. NM_080874.3. [Q8WWX0-1]
XP_005262816.1. XM_005262759.1. [Q8WWX0-1]
UniGeneiHs.591712.

3D structure databases

ProteinModelPortaliQ8WWX0.
SMRiQ8WWX0. Positions 36-326.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126611. 22 interactions.

Polymorphism databases

DMDMi20531989.

Proteomic databases

PaxDbiQ8WWX0.
PRIDEiQ8WWX0.

Protocols and materials databases

DNASUi140458.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296525; ENSP00000296525; ENSG00000164122. [Q8WWX0-1]
ENST00000512254; ENSP00000422877; ENSG00000164122. [Q8WWX0-2]
GeneIDi140458.
KEGGihsa:140458.
UCSCiuc003iuq.2. human. [Q8WWX0-1]

Organism-specific databases

CTDi140458.
GeneCardsiGC04M177134.
HGNCiHGNC:17180. ASB5.
HPAiHPA028870.
MIMi615050. gene.
neXtProtiNX_Q8WWX0.
PharmGKBiPA25033.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0666.
GeneTreeiENSGT00730000110500.
HOGENOMiHOG000231513.
HOVERGENiHBG001376.
InParanoidiQ8WWX0.
KOiK10327.
OMAiNYIGRPR.
OrthoDBiEOG7J447G.
PhylomeDBiQ8WWX0.
TreeFamiTF331945.

Enzyme and pathway databases

UniPathwayiUPA00143.
ReactomeiREACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

ChiTaRSiASB5. human.
GenomeRNAii140458.
NextBioi84105.
PROiQ8WWX0.
SOURCEiSearch...

Gene expression databases

BgeeiQ8WWX0.
CleanExiHS_ASB5.
ExpressionAtlasiQ8WWX0. baseline and differential.
GenevestigatoriQ8WWX0.

Family and domain databases

Gene3Di1.25.40.20. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001496. SOCS_C.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
PF07525. SOCS_box. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 6 hits.
SM00969. SOCS_box. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
PS50225. SOCS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Kile B.T., Hilton D.J., Nicola N.A.
    Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Skeletal muscle.

Entry informationi

Entry nameiASB5_HUMAN
AccessioniPrimary (citable) accession number: Q8WWX0
Secondary accession number(s): Q8N7B5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: March 1, 2002
Last modified: January 7, 2015
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.