Q8WWW8 (GAB3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
GRB2-associated-binding protein 3

Alternative name(s):
GRB2-associated binder 3
Growth factor receptor bound protein 2-associated protein 3

Gene names

Name:

GAB3

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	586 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subunit structure	Interacts with PIK3R/p85, SHP2 and GRAP2/MONA By similarity. May interact with Grb2.
Post-translational modification	Phosphorylated on tyrosine residue(s) after macrophage colony-stimulating factor (M-CSF) receptor stimulation By similarity.
Sequence similarities	Belongs to the GAB family. Contains 1 PH domain.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 586	586	GRB2-associated-binding protein 3		PRO_0000318939
Regions
	Domain	5 – 117	113	PH
Natural variations
	Natural variant	237	1	P → S. Corresponds to variant rs17281349 [ dbSNP | Ensembl ].		VAR_038917

Sequences

	Sequence		Length	Mass (Da)
	Q8WWW8 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 9DE0223C34AD8FFE	FASTA	586	65,589
	10 20 30 40 50 60 MSAGDAVCTG WLVKSPPERK LQRYAWRKRW FVLRRGRMSG NPDVLEYYRN KHSSKPIRVI 70 80 90 100 110 120 DLSECAVWKH VGPSFVRKEF QNNFVFIVKT TSRTFYLVAK TEQEMQVWVH SISQVCNLGH 130 140 150 160 170 180 LEDGADSMES LSYTPSSLQP SSASSLLTAH AASSSLPRDD PNTNAVATEE TRSESELLFL 190 200 210 220 230 240 PDYLVLSNCE TGRLHHTSLP TRCDSWSNSD RSLEQASFDD VFVDCLQPLP SSHLVHPSCH 250 260 270 280 290 300 GSGAQEVPSS RPQAALIWSR EINGPPRDHL SSSPLLESSL SSTIQVDKNQ GSLPCGAKEL 310 320 330 340 350 360 DIMSNTPPPR PPKPSHLSER RQEEWSTHSG SKKPECTLVP RRISLSGLDN MRTWKADVEG 370 380 390 400 410 420 QSLRHRDKRL SLNLPCRFSP MYPTASASIE DSYVPMSPQA GASGLGPHCS PDDYIPMNSG 430 440 450 460 470 480 SISSPLPELP ANLEPPPVNR DLKPQRKSRP PPLDLRNLSI IREHASLTRT RTVPCSRTSF 490 500 510 520 530 540 LSPERNGINS ARFFANPVSR EDEESYIEME EHRTASSLSS GALTWTKKFS LDYLALDFNS 550 560 570 580 ASPAPMQQKL LLSEEQRVDY VQVDEQKTQA LQSTKQEWTD ERQSKV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Gab3, a new DOS/Gab family member, facilitates macrophage differentiation." Wolf I., Jenkins B.J., Liu Y., Seiffert M., Custodio J.M., Young P., Rohrschneider L.R. Mol. Cell. Biol. 22:231-244(2002) [PubMed: 11739737] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Dendritic cell and Eosinophil.
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY057989 mRNA. Translation: AAL25825.1. CH471172 Genomic DNA. Translation: EAW72667.1.
IPI	IPI00103456.
RefSeq	NP_001075042.1. NM_001081573.1. NP_542179.1. NM_080612.2.
UniGene	Hs.496982.
3D structure databases
HSSP	HSSP built from PDB template 1FAO based on UniProtKB Q9UN19.
ProteinModelPortal	Q8WWW8.
SMR	Q8WWW8. Positions 4-121.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-1594309.
STRING	Q8WWW8.
PTM databases
PhosphoSite	Q8WWW8.
Polymorphism databases
DMDM	74716251.
Proteomic databases
PRIDE	Q8WWW8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000369575; ENSP00000358588; ENSG00000160219.
GeneID	139716.
KEGG	hsa:139716.
UCSC	uc004fmj.1. human.
Organism-specific databases
CTD	139716.
GeneCards	GC0XM153903.
H-InvDB	HIX0019567.
HGNC	HGNC:17515. GAB3.
HPA	HPA010090.
MIM	300482. gene.
neXtProt	NX_Q8WWW8.
PharmGKB	PA28479.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG19472.
GeneTree	ENSGT00510000046662.
HOVERGEN	HBG107126.
InParanoid	Q8WWW8.
OrthoDB	EOG49S66K.
PhylomeDB	Q8WWW8.
Gene expression databases
ArrayExpress	Q8WWW8.
Bgee	Q8WWW8.
CleanEx	HS_GAB3.
Genevestigator	Q8WWW8.
Family and domain databases
InterPro	IPR011993. PH_type. IPR001849. Pleckstrin_homology. [Graphical view]
Gene3D	G3DSA:2.30.29.30. PH_type. 1 hit.
Pfam	PF00169. PH. 1 hit. [Graphical view]
SMART	SM00233. PH. 1 hit. [Graphical view]
PROSITE	PS50003. PH_DOMAIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	84016.
SOURCE	Search...

Entry information

Entry name

GAB3_HUMAN

Accession

Primary (citable) accession number: Q8WWW8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	March 1, 2002
Last modified:	January 25, 2012
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.