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Protein

GRB2-associated-binding protein 3

Gene

GAB3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
GRB2-associated-binding protein 3
Alternative name(s):
GRB2-associated binder 3
Growth factor receptor bound protein 2-associated protein 3
Gene namesi
Name:GAB3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000160219.11
HGNCiHGNC:17515 GAB3
MIMi300482 gene
neXtProtiNX_Q8WWW8

Pathology & Biotechi

Organism-specific databases

DisGeNETi139716
OpenTargetsiENSG00000160219
PharmGKBiPA28479

Polymorphism and mutation databases

BioMutaiGAB3
DMDMi74716251

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003189391 – 586GRB2-associated-binding protein 3Add BLAST586

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei344PhosphoserineCombined sources1
Modified residuei482PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated on tyrosine residue(s) after macrophage colony-stimulating factor (M-CSF) receptor stimulation.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8WWW8
PeptideAtlasiQ8WWW8
PRIDEiQ8WWW8

PTM databases

iPTMnetiQ8WWW8
PhosphoSitePlusiQ8WWW8

Expressioni

Gene expression databases

BgeeiENSG00000160219
CleanExiHS_GAB3
ExpressionAtlasiQ8WWW8 baseline and differential
GenevisibleiQ8WWW8 HS

Organism-specific databases

HPAiHPA010090

Interactioni

Subunit structurei

Interacts with PIK3R/p85, SHP2 and GRAP2/MONA (By similarity). May interact with Grb2.By similarity

Protein-protein interaction databases

BioGridi126581, 6 interactors
ELMiQ8WWW8
IntActiQ8WWW8, 1 interactor
MINTiQ8WWW8
STRINGi9606.ENSP00000399588

Structurei

3D structure databases

ProteinModelPortaliQ8WWW8
SMRiQ8WWW8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 117PHPROSITE-ProRule annotationAdd BLAST113

Sequence similaritiesi

Belongs to the GAB family.Curated

Phylogenomic databases

eggNOGiENOG410IEG0 Eukaryota
ENOG4111RDE LUCA
GeneTreeiENSGT00510000046662
HOGENOMiHOG000236270
HOVERGENiHBG107126
InParanoidiQ8WWW8
OMAiEFQNNFV
OrthoDBiEOG091G03BY
PhylomeDBiQ8WWW8
TreeFamiTF329487

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PfamiView protein in Pfam
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WWW8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSAGDAVCTG WLVKSPPERK LQRYAWRKRW FVLRRGRMSG NPDVLEYYRN
60 70 80 90 100
KHSSKPIRVI DLSECAVWKH VGPSFVRKEF QNNFVFIVKT TSRTFYLVAK
110 120 130 140 150
TEQEMQVWVH SISQVCNLGH LEDGADSMES LSYTPSSLQP SSASSLLTAH
160 170 180 190 200
AASSSLPRDD PNTNAVATEE TRSESELLFL PDYLVLSNCE TGRLHHTSLP
210 220 230 240 250
TRCDSWSNSD RSLEQASFDD VFVDCLQPLP SSHLVHPSCH GSGAQEVPSS
260 270 280 290 300
RPQAALIWSR EINGPPRDHL SSSPLLESSL SSTIQVDKNQ GSLPCGAKEL
310 320 330 340 350
DIMSNTPPPR PPKPSHLSER RQEEWSTHSG SKKPECTLVP RRISLSGLDN
360 370 380 390 400
MRTWKADVEG QSLRHRDKRL SLNLPCRFSP MYPTASASIE DSYVPMSPQA
410 420 430 440 450
GASGLGPHCS PDDYIPMNSG SISSPLPELP ANLEPPPVNR DLKPQRKSRP
460 470 480 490 500
PPLDLRNLSI IREHASLTRT RTVPCSRTSF LSPERNGINS ARFFANPVSR
510 520 530 540 550
EDEESYIEME EHRTASSLSS GALTWTKKFS LDYLALDFNS ASPAPMQQKL
560 570 580
LLSEEQRVDY VQVDEQKTQA LQSTKQEWTD ERQSKV
Length:586
Mass (Da):65,589
Last modified:March 1, 2002 - v1
Checksum:i9DE0223C34AD8FFE
GO
Isoform 2 (identifier: Q8WWW8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     125-125: A → AA

Note: No experimental confirmation available.
Show »
Length:587
Mass (Da):65,660
Checksum:i1CB708E1FAD65972
GO
Isoform 3 (identifier: Q8WWW8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     125-125: A → AA
     510-548: Missing.

Note: No experimental confirmation available.
Show »
Length:548
Mass (Da):61,391
Checksum:iED87E53B2123B2D9
GO

Sequence cautioni

The sequence AK307927 differs from that shown. Reason: Erroneous termination at position 587. Translated as stop.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_038917237P → S. Corresponds to variant dbSNP:rs17281349Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_045033125A → AA in isoform 2 and isoform 3. 1 Publication1
Alternative sequenceiVSP_055259510 – 548Missing in isoform 3. 1 PublicationAdd BLAST39

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY057989 mRNA Translation: AAL25825.1
AK126283 mRNA Translation: BAG54302.1
AK307927 mRNA No translation available.
AC107450 Genomic DNA No translation available.
AC109993 Genomic DNA No translation available.
CH471172 Genomic DNA Translation: EAW72665.1
CH471172 Genomic DNA Translation: EAW72667.1
CCDSiCCDS14760.1 [Q8WWW8-1]
CCDS48198.1 [Q8WWW8-2]
CCDS65357.1 [Q8WWW8-3]
RefSeqiNP_001075042.1, NM_001081573.2 [Q8WWW8-2]
NP_001269212.1, NM_001282283.1 [Q8WWW8-3]
NP_542179.1, NM_080612.3 [Q8WWW8-1]
XP_005274705.1, XM_005274648.1 [Q8WWW8-2]
XP_006724867.1, XM_006724804.1 [Q8WWW8-2]
UniGeneiHs.496982

Genome annotation databases

EnsembliENST00000369568; ENSP00000358581; ENSG00000160219 [Q8WWW8-3]
ENST00000369575; ENSP00000358588; ENSG00000160219 [Q8WWW8-1]
ENST00000424127; ENSP00000399588; ENSG00000160219 [Q8WWW8-2]
GeneIDi139716
KEGGihsa:139716
UCSCiuc004fmj.3 human [Q8WWW8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiGAB3_HUMAN
AccessioniPrimary (citable) accession number: Q8WWW8
Secondary accession number(s): A6NHF8, E9PB44
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: March 1, 2002
Last modified: May 23, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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