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Protein

GRB2-associated-binding protein 3

Gene

GAB3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
GRB2-associated-binding protein 3
Alternative name(s):
GRB2-associated binder 3
Growth factor receptor bound protein 2-associated protein 3
Gene namesi
Name:GAB3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:17515. GAB3.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28479.

Polymorphism and mutation databases

BioMutaiGAB3.
DMDMi74716251.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 586586GRB2-associated-binding protein 3PRO_0000318939Add
BLAST

Post-translational modificationi

Phosphorylated on tyrosine residue(s) after macrophage colony-stimulating factor (M-CSF) receptor stimulation.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8WWW8.
PaxDbiQ8WWW8.
PRIDEiQ8WWW8.

PTM databases

PhosphoSiteiQ8WWW8.

Expressioni

Gene expression databases

BgeeiQ8WWW8.
CleanExiHS_GAB3.
ExpressionAtlasiQ8WWW8. baseline and differential.
GenevisibleiQ8WWW8. HS.

Organism-specific databases

HPAiHPA010090.

Interactioni

Subunit structurei

Interacts with PIK3R/p85, SHP2 and GRAP2/MONA (By similarity). May interact with Grb2.By similarity

Protein-protein interaction databases

BioGridi126581. 7 interactions.
IntActiQ8WWW8. 1 interaction.
MINTiMINT-1594309.
STRINGi9606.ENSP00000399588.

Structurei

3D structure databases

ProteinModelPortaliQ8WWW8.
SMRiQ8WWW8. Positions 26-109.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 117113PHPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the GAB family.Curated
Contains 1 PH domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IEG0. Eukaryota.
ENOG4111RDE. LUCA.
GeneTreeiENSGT00510000046662.
HOGENOMiHOG000236270.
HOVERGENiHBG107126.
InParanoidiQ8WWW8.
OMAiEFQNNFV.
OrthoDBiEOG7T4MJJ.
PhylomeDBiQ8WWW8.
TreeFamiTF329487.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WWW8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSAGDAVCTG WLVKSPPERK LQRYAWRKRW FVLRRGRMSG NPDVLEYYRN
60 70 80 90 100
KHSSKPIRVI DLSECAVWKH VGPSFVRKEF QNNFVFIVKT TSRTFYLVAK
110 120 130 140 150
TEQEMQVWVH SISQVCNLGH LEDGADSMES LSYTPSSLQP SSASSLLTAH
160 170 180 190 200
AASSSLPRDD PNTNAVATEE TRSESELLFL PDYLVLSNCE TGRLHHTSLP
210 220 230 240 250
TRCDSWSNSD RSLEQASFDD VFVDCLQPLP SSHLVHPSCH GSGAQEVPSS
260 270 280 290 300
RPQAALIWSR EINGPPRDHL SSSPLLESSL SSTIQVDKNQ GSLPCGAKEL
310 320 330 340 350
DIMSNTPPPR PPKPSHLSER RQEEWSTHSG SKKPECTLVP RRISLSGLDN
360 370 380 390 400
MRTWKADVEG QSLRHRDKRL SLNLPCRFSP MYPTASASIE DSYVPMSPQA
410 420 430 440 450
GASGLGPHCS PDDYIPMNSG SISSPLPELP ANLEPPPVNR DLKPQRKSRP
460 470 480 490 500
PPLDLRNLSI IREHASLTRT RTVPCSRTSF LSPERNGINS ARFFANPVSR
510 520 530 540 550
EDEESYIEME EHRTASSLSS GALTWTKKFS LDYLALDFNS ASPAPMQQKL
560 570 580
LLSEEQRVDY VQVDEQKTQA LQSTKQEWTD ERQSKV
Length:586
Mass (Da):65,589
Last modified:March 1, 2002 - v1
Checksum:i9DE0223C34AD8FFE
GO
Isoform 2 (identifier: Q8WWW8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     125-125: A → AA

Note: No experimental confirmation available.
Show »
Length:587
Mass (Da):65,660
Checksum:i1CB708E1FAD65972
GO
Isoform 3 (identifier: Q8WWW8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     125-125: A → AA
     510-548: Missing.

Note: No experimental confirmation available.
Show »
Length:548
Mass (Da):61,391
Checksum:iED87E53B2123B2D9
GO

Sequence cautioni

The sequence AK307927 differs from that shown. Reason: Erroneous termination at position 587. Translated as stop.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti237 – 2371P → S.
Corresponds to variant rs17281349 [ dbSNP | Ensembl ].
VAR_038917

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei125 – 1251A → AA in isoform 2 and isoform 3. 1 PublicationVSP_045033
Alternative sequencei510 – 54839Missing in isoform 3. 1 PublicationVSP_055259Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY057989 mRNA. Translation: AAL25825.1.
AK126283 mRNA. Translation: BAG54302.1.
AK307927 mRNA. No translation available.
AC107450 Genomic DNA. No translation available.
AC109993 Genomic DNA. No translation available.
CH471172 Genomic DNA. Translation: EAW72665.1.
CH471172 Genomic DNA. Translation: EAW72667.1.
CCDSiCCDS14760.1. [Q8WWW8-1]
CCDS48198.1. [Q8WWW8-2]
CCDS65357.1. [Q8WWW8-3]
RefSeqiNP_001075042.1. NM_001081573.2. [Q8WWW8-2]
NP_001269212.1. NM_001282283.1. [Q8WWW8-3]
NP_542179.1. NM_080612.3. [Q8WWW8-1]
XP_005274705.1. XM_005274648.1. [Q8WWW8-2]
XP_006724867.1. XM_006724804.1. [Q8WWW8-2]
XP_011529406.1. XM_011531104.1. [Q8WWW8-2]
UniGeneiHs.496982.

Genome annotation databases

EnsembliENST00000369568; ENSP00000358581; ENSG00000160219. [Q8WWW8-3]
ENST00000369575; ENSP00000358588; ENSG00000160219. [Q8WWW8-1]
ENST00000424127; ENSP00000399588; ENSG00000160219. [Q8WWW8-2]
GeneIDi139716.
KEGGihsa:139716.
UCSCiuc004fmj.3. human. [Q8WWW8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY057989 mRNA. Translation: AAL25825.1.
AK126283 mRNA. Translation: BAG54302.1.
AK307927 mRNA. No translation available.
AC107450 Genomic DNA. No translation available.
AC109993 Genomic DNA. No translation available.
CH471172 Genomic DNA. Translation: EAW72665.1.
CH471172 Genomic DNA. Translation: EAW72667.1.
CCDSiCCDS14760.1. [Q8WWW8-1]
CCDS48198.1. [Q8WWW8-2]
CCDS65357.1. [Q8WWW8-3]
RefSeqiNP_001075042.1. NM_001081573.2. [Q8WWW8-2]
NP_001269212.1. NM_001282283.1. [Q8WWW8-3]
NP_542179.1. NM_080612.3. [Q8WWW8-1]
XP_005274705.1. XM_005274648.1. [Q8WWW8-2]
XP_006724867.1. XM_006724804.1. [Q8WWW8-2]
XP_011529406.1. XM_011531104.1. [Q8WWW8-2]
UniGeneiHs.496982.

3D structure databases

ProteinModelPortaliQ8WWW8.
SMRiQ8WWW8. Positions 26-109.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126581. 7 interactions.
IntActiQ8WWW8. 1 interaction.
MINTiMINT-1594309.
STRINGi9606.ENSP00000399588.

PTM databases

PhosphoSiteiQ8WWW8.

Polymorphism and mutation databases

BioMutaiGAB3.
DMDMi74716251.

Proteomic databases

MaxQBiQ8WWW8.
PaxDbiQ8WWW8.
PRIDEiQ8WWW8.

Protocols and materials databases

DNASUi139716.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369568; ENSP00000358581; ENSG00000160219. [Q8WWW8-3]
ENST00000369575; ENSP00000358588; ENSG00000160219. [Q8WWW8-1]
ENST00000424127; ENSP00000399588; ENSG00000160219. [Q8WWW8-2]
GeneIDi139716.
KEGGihsa:139716.
UCSCiuc004fmj.3. human. [Q8WWW8-1]

Organism-specific databases

CTDi139716.
GeneCardsiGAB3.
HGNCiHGNC:17515. GAB3.
HPAiHPA010090.
MIMi300482. gene.
neXtProtiNX_Q8WWW8.
PharmGKBiPA28479.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEG0. Eukaryota.
ENOG4111RDE. LUCA.
GeneTreeiENSGT00510000046662.
HOGENOMiHOG000236270.
HOVERGENiHBG107126.
InParanoidiQ8WWW8.
OMAiEFQNNFV.
OrthoDBiEOG7T4MJJ.
PhylomeDBiQ8WWW8.
TreeFamiTF329487.

Miscellaneous databases

ChiTaRSiGAB3. human.
GenomeRNAii139716.
NextBioi35462577.
PROiQ8WWW8.
SOURCEiSearch...

Gene expression databases

BgeeiQ8WWW8.
CleanExiHS_GAB3.
ExpressionAtlasiQ8WWW8. baseline and differential.
GenevisibleiQ8WWW8. HS.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Gab3, a new DOS/Gab family member, facilitates macrophage differentiation."
    Wolf I., Jenkins B.J., Liu Y., Seiffert M., Custodio J.M., Young P., Rohrschneider L.R.
    Mol. Cell. Biol. 22:231-244(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Dendritic cell and Eosinophil.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Tissue: Thalamus and Trachea.
  3. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiGAB3_HUMAN
AccessioniPrimary (citable) accession number: Q8WWW8
Secondary accession number(s): A6NHF8, E9PB44
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: March 1, 2002
Last modified: May 11, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.