GAB3

Functionⁱ

GO - Biological processⁱ

macrophage differentiation Source: Ensembl

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: GRB2-associated-binding protein 3 Alternative name(s): GRB2-associated binder 3 Growth factor receptor bound protein 2-associated protein 3
Gene namesⁱ	Name:GAB3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:17515. GAB3.

HGNCⁱ

HGNC:17515. GAB3.

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	139716.
Open Targets More...OpenTargetsⁱ	ENSG00000160219.
PharmGKBⁱ	PA28479.

Polymorphism and mutation databases

BioMutaⁱ	GAB3.
DMDMⁱ	74716251.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000318939	1 – 586	GRB2-associated-binding protein 3Add BLAST		586

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	344	PhosphoserineCombined sources		1
Modified residueⁱ	482	PhosphoserineCombined sources		1

Post-translational modificationⁱ

Phosphorylated on tyrosine residue(s) after macrophage colony-stimulating factor (M-CSF) receptor stimulation.By similarity

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

PaxDbⁱ	Q8WWW8.
PeptideAtlas More...PeptideAtlasⁱ	Q8WWW8.
PRIDEⁱ	Q8WWW8.

PTM databases

iPTMnetⁱ	Q8WWW8.
PhosphoSitePlusⁱ	Q8WWW8.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000160219.
CleanExⁱ	HS_GAB3.
ExpressionAtlasⁱ	Q8WWW8. baseline and differential.
Genevisibleⁱ	Q8WWW8. HS.

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA010090.

HPAⁱ

HPA010090.

Interactionⁱ

Subunit structureⁱ

Interacts with PIK3R/p85, SHP2 and GRAP2/MONA (By similarity). May interact with Grb2.By similarity

Protein-protein interaction databases

BioGridⁱ	126581. 6 interactors.
IntActⁱ	Q8WWW8. 1 interactor.
Molecular INTeraction database More...MINTⁱ	MINT-1594309.
STRINGⁱ	9606.ENSP00000399588.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8WWW8.
SMRⁱ	Q8WWW8.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	5 – 117	PHPROSITE-ProRule annotationAdd BLAST		113

Sequence similaritiesⁱ

Belongs to the GAB family.Curated

Phylogenomic databases

eggNOGⁱ	ENOG410IEG0. Eukaryota. ENOG4111RDE. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000046662.
HOGENOMⁱ	HOG000236270.
HOVERGENⁱ	HBG107126.
InParanoidⁱ	Q8WWW8.
OMAⁱ	EFQNNFV.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G03BY.
PhylomeDBⁱ	Q8WWW8.
TreeFamⁱ	TF329487.

Family and domain databases

Gene3Dⁱ	2.30.29.30. 1 hit.
InterProⁱ	View protein in InterPro IPR011993. PH_dom-like. IPR001849. PH_domain.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00169. PH. 1 hit.
SMARTⁱ	View protein in SMART SM00233. PH. 1 hit.
SUPFAMⁱ	SSF50729. SSF50729. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50003. PH_DOMAIN. 1 hit.

Sequences (3)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: Q8WWW8-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSAGDAVCTG WLVKSPPERK LQRYAWRKRW FVLRRGRMSG NPDVLEYYRN 
        60         70         80         90        100
KHSSKPIRVI DLSECAVWKH VGPSFVRKEF QNNFVFIVKT TSRTFYLVAK 
       110        120        130        140        150
TEQEMQVWVH SISQVCNLGH LEDGADSMES LSYTPSSLQP SSASSLLTAH 
       160        170        180        190        200
AASSSLPRDD PNTNAVATEE TRSESELLFL PDYLVLSNCE TGRLHHTSLP 
       210        220        230        240        250
TRCDSWSNSD RSLEQASFDD VFVDCLQPLP SSHLVHPSCH GSGAQEVPSS 
       260        270        280        290        300
RPQAALIWSR EINGPPRDHL SSSPLLESSL SSTIQVDKNQ GSLPCGAKEL 
       310        320        330        340        350
DIMSNTPPPR PPKPSHLSER RQEEWSTHSG SKKPECTLVP RRISLSGLDN 
       360        370        380        390        400
MRTWKADVEG QSLRHRDKRL SLNLPCRFSP MYPTASASIE DSYVPMSPQA 
       410        420        430        440        450
GASGLGPHCS PDDYIPMNSG SISSPLPELP ANLEPPPVNR DLKPQRKSRP 
       460        470        480        490        500
PPLDLRNLSI IREHASLTRT RTVPCSRTSF LSPERNGINS ARFFANPVSR 
       510        520        530        540        550
EDEESYIEME EHRTASSLSS GALTWTKKFS LDYLALDFNS ASPAPMQQKL 
       560        570        580 
LLSEEQRVDY VQVDEQKTQA LQSTKQEWTD ERQSKV

Length:586

Mass (Da):65,589

Last modified:March 1, 2002 - v1

Checksum:ⁱ9DE0223C34AD8FFE

GO

Isoform 2 (identifier: Q8WWW8-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
125-125: A → AA

« Hide

        10         20         30         40         50
MSAGDAVCTG WLVKSPPERK LQRYAWRKRW FVLRRGRMSG NPDVLEYYRN 
        60         70         80         90        100
KHSSKPIRVI DLSECAVWKH VGPSFVRKEF QNNFVFIVKT TSRTFYLVAK 
       110        120        130        140        150
TEQEMQVWVH SISQVCNLGH LEDGAADSME SLSYTPSSLQ PSSASSLLTA 
       160        170        180        190        200
HAASSSLPRD DPNTNAVATE ETRSESELLF LPDYLVLSNC ETGRLHHTSL 
       210        220        230        240        250
PTRCDSWSNS DRSLEQASFD DVFVDCLQPL PSSHLVHPSC HGSGAQEVPS 
       260        270        280        290        300
SRPQAALIWS REINGPPRDH LSSSPLLESS LSSTIQVDKN QGSLPCGAKE 
       310        320        330        340        350
LDIMSNTPPP RPPKPSHLSE RRQEEWSTHS GSKKPECTLV PRRISLSGLD 
       360        370        380        390        400
NMRTWKADVE GQSLRHRDKR LSLNLPCRFS PMYPTASASI EDSYVPMSPQ 
       410        420        430        440        450
AGASGLGPHC SPDDYIPMNS GSISSPLPEL PANLEPPPVN RDLKPQRKSR 
       460        470        480        490        500
PPPLDLRNLS IIREHASLTR TRTVPCSRTS FLSPERNGIN SARFFANPVS 
       510        520        530        540        550
REDEESYIEM EEHRTASSLS SGALTWTKKF SLDYLALDFN SASPAPMQQK 
       560        570        580 
LLLSEEQRVD YVQVDEQKTQ ALQSTKQEWT DERQSKV

Note: No experimental confirmation available.

Show »

Length:587

Mass (Da):65,660

Checksum:ⁱ1CB708E1FAD65972

GO

Isoform 3 (identifier: Q8WWW8-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
125-125: A → AA
510-548: Missing.

« Hide

        10         20         30         40         50
MSAGDAVCTG WLVKSPPERK LQRYAWRKRW FVLRRGRMSG NPDVLEYYRN 
        60         70         80         90        100
KHSSKPIRVI DLSECAVWKH VGPSFVRKEF QNNFVFIVKT TSRTFYLVAK 
       110        120        130        140        150
TEQEMQVWVH SISQVCNLGH LEDGAADSME SLSYTPSSLQ PSSASSLLTA 
       160        170        180        190        200
HAASSSLPRD DPNTNAVATE ETRSESELLF LPDYLVLSNC ETGRLHHTSL 
       210        220        230        240        250
PTRCDSWSNS DRSLEQASFD DVFVDCLQPL PSSHLVHPSC HGSGAQEVPS 
       260        270        280        290        300
SRPQAALIWS REINGPPRDH LSSSPLLESS LSSTIQVDKN QGSLPCGAKE 
       310        320        330        340        350
LDIMSNTPPP RPPKPSHLSE RRQEEWSTHS GSKKPECTLV PRRISLSGLD 
       360        370        380        390        400
NMRTWKADVE GQSLRHRDKR LSLNLPCRFS PMYPTASASI EDSYVPMSPQ 
       410        420        430        440        450
AGASGLGPHC SPDDYIPMNS GSISSPLPEL PANLEPPPVN RDLKPQRKSR 
       460        470        480        490        500
PPPLDLRNLS IIREHASLTR TRTVPCSRTS FLSPERNGIN SARFFANPVS 
       510        520        530        540 
REDEESYIEM KLLLSEEQRV DYVQVDEQKT QALQSTKQEW TDERQSKV

Note: No experimental confirmation available.

Show »

Length:548

Mass (Da):61,391

Checksum:ⁱED87E53B2123B2D9

GO

Sequence cautionⁱ

The sequence AK307927 differs from that shown. Reason: Erroneous termination at position 587. Translated as stop.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_038917	237	P → S. Corresponds to variant dbSNP:rs17281349Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_045033	125	A → AA in isoform 2 and isoform 3. 1 Publication		1
Alternative sequenceⁱVSP_055259	510 – 548	Missing in isoform 3. 1 PublicationAdd BLAST		39

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY057989 mRNA. Translation: AAL25825.1. AK126283 mRNA. Translation: BAG54302.1. AK307927 mRNA. No translation available. AC107450 Genomic DNA. No translation available. AC109993 Genomic DNA. No translation available. CH471172 Genomic DNA. Translation: EAW72665.1. CH471172 Genomic DNA. Translation: EAW72667.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS14760.1. [Q8WWW8-1] CCDS48198.1. [Q8WWW8-2] CCDS65357.1. [Q8WWW8-3]
NCBI Reference Sequences More...RefSeqⁱ	NP_001075042.1. NM_001081573.2. [Q8WWW8-2] NP_001269212.1. NM_001282283.1. [Q8WWW8-3] NP_542179.1. NM_080612.3. [Q8WWW8-1] XP_005274705.1. XM_005274648.1. [Q8WWW8-2] XP_006724867.1. XM_006724804.1. [Q8WWW8-2]
UniGeneⁱ	Hs.496982.

Genome annotation databases

Ensemblⁱ	ENST00000369568; ENSP00000358581; ENSG00000160219. [Q8WWW8-3] ENST00000369575; ENSP00000358588; ENSG00000160219. [Q8WWW8-1] ENST00000424127; ENSP00000399588; ENSG00000160219. [Q8WWW8-2]
GeneIDⁱ	139716.
KEGGⁱ	hsa:139716.
UCSC genome browser More...UCSCⁱ	uc004fmj.3. human. [Q8WWW8-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY057989 mRNA. Translation: AAL25825.1. AK126283 mRNA. Translation: BAG54302.1. AK307927 mRNA. No translation available. AC107450 Genomic DNA. No translation available. AC109993 Genomic DNA. No translation available. CH471172 Genomic DNA. Translation: EAW72665.1. CH471172 Genomic DNA. Translation: EAW72667.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS14760.1. [Q8WWW8-1] CCDS48198.1. [Q8WWW8-2] CCDS65357.1. [Q8WWW8-3]
NCBI Reference Sequences More...RefSeqⁱ	NP_001075042.1. NM_001081573.2. [Q8WWW8-2] NP_001269212.1. NM_001282283.1. [Q8WWW8-3] NP_542179.1. NM_080612.3. [Q8WWW8-1] XP_005274705.1. XM_005274648.1. [Q8WWW8-2] XP_006724867.1. XM_006724804.1. [Q8WWW8-2]
UniGeneⁱ	Hs.496982.

3D structure databases

ProteinModelPortalⁱ	Q8WWW8.
SMRⁱ	Q8WWW8.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	126581. 6 interactors.
IntActⁱ	Q8WWW8. 1 interactor.
Molecular INTeraction database More...MINTⁱ	MINT-1594309.
STRINGⁱ	9606.ENSP00000399588.

PTM databases

iPTMnetⁱ	Q8WWW8.
PhosphoSitePlusⁱ	Q8WWW8.

Polymorphism and mutation databases

BioMutaⁱ	GAB3.
DMDMⁱ	74716251.

Proteomic databases

PaxDbⁱ	Q8WWW8.
PeptideAtlas More...PeptideAtlasⁱ	Q8WWW8.
PRIDEⁱ	Q8WWW8.

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	139716.
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000369568; ENSP00000358581; ENSG00000160219. [Q8WWW8-3] ENST00000369575; ENSP00000358588; ENSG00000160219. [Q8WWW8-1] ENST00000424127; ENSP00000399588; ENSG00000160219. [Q8WWW8-2]
GeneIDⁱ	139716.
KEGGⁱ	hsa:139716.
UCSC genome browser More...UCSCⁱ	uc004fmj.3. human. [Q8WWW8-1]

Organism-specific databases

CTDⁱ	139716.
DisGeNET More...DisGeNETⁱ	139716.
GeneCardsⁱ	GAB3.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:17515. GAB3.
Human Protein Atlas More...HPAⁱ	HPA010090.
MIMⁱ	300482. gene.
neXtProtⁱ	NX_Q8WWW8.
Open Targets More...OpenTargetsⁱ	ENSG00000160219.
PharmGKBⁱ	PA28479.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IEG0. Eukaryota. ENOG4111RDE. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000046662.
HOGENOMⁱ	HOG000236270.
HOVERGENⁱ	HBG107126.
InParanoidⁱ	Q8WWW8.
OMAⁱ	EFQNNFV.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G03BY.
PhylomeDBⁱ	Q8WWW8.
TreeFamⁱ	TF329487.

Miscellaneous databases

ChiTaRSⁱ	GAB3. human.
GenomeRNAiⁱ	139716.
Protein Ontology More...PROⁱ	PR:Q8WWW8.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000160219.
CleanExⁱ	HS_GAB3.
ExpressionAtlasⁱ	Q8WWW8. baseline and differential.
Genevisibleⁱ	Q8WWW8. HS.

Family and domain databases

Gene3Dⁱ	2.30.29.30. 1 hit.
InterProⁱ	View protein in InterPro IPR011993. PH_dom-like. IPR001849. PH_domain.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00169. PH. 1 hit.
SMARTⁱ	View protein in SMART SM00233. PH. 1 hit.
SUPFAMⁱ	SSF50729. SSF50729. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50003. PH_DOMAIN. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	GAB3_HUMAN
Accessionⁱ	Q8WWW8Primary (citable) accession number: Q8WWW8 Secondary accession number(s): A6NHF8, E9PB44
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
	Last sequence update:	March 1, 2002
	Last modified:	March 15, 2017
	This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8WWW8 (GAB3_HUMAN)

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GRB2-associated-binding protein 3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequences (3)ⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ