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Q8WWU7

- ITLN2_HUMAN

UniProt

Q8WWU7 - ITLN2_HUMAN

Protein

Intelectin-2

Gene

ITLN2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    May play a role in the defense system against pathogens.By similarity

    Keywords - Ligandi

    Lectin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Intelectin-2
    Alternative name(s):
    Endothelial lectin HL-2
    Gene namesi
    Name:ITLN2
    ORF Names:UNQ2789/PRO7179
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:20599. ITLN2.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134879128.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Sequence AnalysisAdd
    BLAST
    Chaini27 – 325299Intelectin-2PRO_0000009149Add
    BLAST

    Proteomic databases

    PaxDbiQ8WWU7.
    PRIDEiQ8WWU7.

    PTM databases

    PhosphoSiteiQ8WWU7.

    Expressioni

    Tissue specificityi

    Expressed only in the small intestine.1 Publication

    Gene expression databases

    BgeeiQ8WWU7.
    CleanExiHS_ITLN2.
    GenevestigatoriQ8WWU7.

    Organism-specific databases

    HPAiHPA006683.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000357008.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8WWU7.
    SMRiQ8WWU7. Positions 48-173.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini44 – 267224Fibrinogen C-terminalPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 fibrinogen C-terminal domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG25076.
    HOGENOMiHOG000026788.
    HOVERGENiHBG052157.
    InParanoidiQ8WWU7.
    KOiK17527.
    OMAiTHVKSSC.
    OrthoDBiEOG76739X.
    PhylomeDBiQ8WWU7.
    TreeFamiTF328530.

    Family and domain databases

    Gene3Di3.90.215.10. 1 hit.
    InterProiIPR014716. Fibrinogen_a/b/g_C_1.
    IPR002181. Fibrinogen_a/b/g_C_dom.
    [Graphical view]
    PfamiPF00147. Fibrinogen_C. 1 hit.
    [Graphical view]
    SMARTiSM00186. FBG. 1 hit.
    [Graphical view]
    SUPFAMiSSF56496. SSF56496. 1 hit.
    PROSITEiPS51406. FIBRINOGEN_C_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8WWU7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLSMLRTMTR LCFLLFFSVA TSGCSAAAAS SLEMLSREFE TCAFSFSSLP    50
    RSCKEIKERC HSAGDGLYFL RTKNGVVYQT FCDMTSGGGG WTLVASVHEN 100
    DMRGKCTVGD RWSSQQGNKA DYPEGDGNWA NYNTFGSAEA ATSDDYKNPG 150
    YYDIQAKDLG IWHVPNKSPM QHWRNSALLR YRTNTGFLQR LGHNLFGIYQ 200
    KYPVKYRSGK CWNDNGPAIP VVYDFGDAKK TASYYSPYGQ REFVAGFVQF 250
    RVFNNERAAN ALCAGIKVTG CNTEHHCIGG GGFFPQGKPR QCGDFSAFDW 300
    DGYGTHVKSS CSREITEAAV LLFYR 325
    Length:325
    Mass (Da):36,212
    Last modified:March 1, 2002 - v1
    Checksum:i283C9A12AED2EBFC
    GO
    Isoform 2 (identifier: Q8WWU7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         26-26: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:324
    Mass (Da):36,141
    Checksum:iFB914096EFB771AD
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti103 – 1031R → H.1 Publication
    Corresponds to variant rs6680969 [ dbSNP | Ensembl ].
    VAR_019926
    Natural varianti171 – 1711Q → R.
    Corresponds to variant rs12090411 [ dbSNP | Ensembl ].
    VAR_049076

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei26 – 261Missing in isoform 2. 1 PublicationVSP_055093

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY065973 mRNA. Translation: AAL58074.1.
    AY358905 mRNA. Translation: AAQ89264.1.
    AL354714, AL591806 Genomic DNA. Translation: CAH72351.1.
    AL591806, AL354714 Genomic DNA. Translation: CAI15364.1.
    CH471121 Genomic DNA. Translation: EAW52685.1.
    BC117225 mRNA. Translation: AAI17226.1.
    BC143341 mRNA. Translation: AAI43342.1.
    CCDSiCCDS1212.1. [Q8WWU7-1]
    RefSeqiNP_543154.1. NM_080878.2.
    UniGeneiHs.385631.

    Genome annotation databases

    EnsembliENST00000368029; ENSP00000357008; ENSG00000158764. [Q8WWU7-1]
    GeneIDi142683.
    KEGGihsa:142683.
    UCSCiuc001fxd.3. human. [Q8WWU7-1]

    Polymorphism databases

    DMDMi55976554.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY065973 mRNA. Translation: AAL58074.1 .
    AY358905 mRNA. Translation: AAQ89264.1 .
    AL354714 , AL591806 Genomic DNA. Translation: CAH72351.1 .
    AL591806 , AL354714 Genomic DNA. Translation: CAI15364.1 .
    CH471121 Genomic DNA. Translation: EAW52685.1 .
    BC117225 mRNA. Translation: AAI17226.1 .
    BC143341 mRNA. Translation: AAI43342.1 .
    CCDSi CCDS1212.1. [Q8WWU7-1 ]
    RefSeqi NP_543154.1. NM_080878.2.
    UniGenei Hs.385631.

    3D structure databases

    ProteinModelPortali Q8WWU7.
    SMRi Q8WWU7. Positions 48-173.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000357008.

    PTM databases

    PhosphoSitei Q8WWU7.

    Polymorphism databases

    DMDMi 55976554.

    Proteomic databases

    PaxDbi Q8WWU7.
    PRIDEi Q8WWU7.

    Protocols and materials databases

    DNASUi 142683.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000368029 ; ENSP00000357008 ; ENSG00000158764 . [Q8WWU7-1 ]
    GeneIDi 142683.
    KEGGi hsa:142683.
    UCSCi uc001fxd.3. human. [Q8WWU7-1 ]

    Organism-specific databases

    CTDi 142683.
    GeneCardsi GC01M160914.
    HGNCi HGNC:20599. ITLN2.
    HPAi HPA006683.
    MIMi 609874. gene.
    neXtProti NX_Q8WWU7.
    PharmGKBi PA134879128.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG25076.
    HOGENOMi HOG000026788.
    HOVERGENi HBG052157.
    InParanoidi Q8WWU7.
    KOi K17527.
    OMAi THVKSSC.
    OrthoDBi EOG76739X.
    PhylomeDBi Q8WWU7.
    TreeFami TF328530.

    Miscellaneous databases

    GenomeRNAii 142683.
    NextBioi 84605.
    PROi Q8WWU7.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8WWU7.
    CleanExi HS_ITLN2.
    Genevestigatori Q8WWU7.

    Family and domain databases

    Gene3Di 3.90.215.10. 1 hit.
    InterProi IPR014716. Fibrinogen_a/b/g_C_1.
    IPR002181. Fibrinogen_a/b/g_C_dom.
    [Graphical view ]
    Pfami PF00147. Fibrinogen_C. 1 hit.
    [Graphical view ]
    SMARTi SM00186. FBG. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56496. SSF56496. 1 hit.
    PROSITEi PS51406. FIBRINOGEN_C_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human homologs of the Xenopus oocyte cortical granule lectin XL35."
      Lee J.K., Schnee J., Pang M., Wolfert M., Baum L.G., Moremen K.W., Pierce M.
      Glycobiology 11:65-73(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
      Tissue: Small intestine.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    3. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT HIS-103.
      Tissue: Brain.

    Entry informationi

    Entry nameiITLN2_HUMAN
    AccessioniPrimary (citable) accession number: Q8WWU7
    Secondary accession number(s): Q17RR2, Q5VYI0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 23, 2004
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3