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Protein

Intelectin-2

Gene

ITLN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a role in the defense system against pathogens.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi98Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi99Calcium 2By similarity1
Metal bindingi101Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi104Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi109Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi110Calcium 2By similarity1
Metal bindingi145Calcium 1By similarity1
Metal bindingi272Calcium 3By similarity1
Metal bindingi274Calcium 3By similarity1
Metal bindingi294Calcium 1By similarity1

GO - Molecular functioni

Keywordsi

LigandCalcium, Lectin, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Intelectin-2
Alternative name(s):
Endothelial lectin HL-2
Gene namesi
Name:ITLN2
ORF Names:UNQ2789/PRO7179
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000158764.6
HGNCiHGNC:20599 ITLN2
MIMi609874 gene
neXtProtiNX_Q8WWU7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi142683
OpenTargetsiENSG00000158764
PharmGKBiPA134879128

Polymorphism and mutation databases

BioMutaiITLN2
DMDMi55976554

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000000914927 – 325Intelectin-2Add BLAST299

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi53 ↔ 82By similarity
Disulfide bondi106 ↔ 292By similarity
Disulfide bondi211 ↔ 271By similarity
Disulfide bondi263 ↔ 277By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ8WWU7
PeptideAtlasiQ8WWU7
PRIDEiQ8WWU7

PTM databases

iPTMnetiQ8WWU7
PhosphoSitePlusiQ8WWU7

Expressioni

Tissue specificityi

Expressed only in the small intestine.1 Publication

Gene expression databases

BgeeiENSG00000158764
CleanExiHS_ITLN2

Organism-specific databases

HPAiHPA006683

Interactioni

Protein-protein interaction databases

BioGridi126772, 3 interactors
STRINGi9606.ENSP00000357008

Structurei

3D structure databases

ProteinModelPortaliQ8WWU7
SMRiQ8WWU7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 267Fibrinogen C-terminalPROSITE-ProRule annotationAdd BLAST224

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni274 – 275Carbohydrate bindingBy similarity2

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IGEB Eukaryota
ENOG4110R6N LUCA
GeneTreeiENSGT00390000008567
HOGENOMiHOG000026788
HOVERGENiHBG052157
InParanoidiQ8WWU7
KOiK17527
OMAiTHVKSSC
OrthoDBiEOG091G0QYK
PhylomeDBiQ8WWU7
TreeFamiTF328530

Family and domain databases

Gene3Di3.90.215.10, 1 hit
InterProiView protein in InterPro
IPR036056 Fibrinogen-like_C
IPR014716 Fibrinogen_a/b/g_C_1
IPR002181 Fibrinogen_a/b/g_C_dom
SUPFAMiSSF56496 SSF56496, 1 hit
PROSITEiView protein in PROSITE
PS51406 FIBRINOGEN_C_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WWU7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLSMLRTMTR LCFLLFFSVA TSGCSAAAAS SLEMLSREFE TCAFSFSSLP
60 70 80 90 100
RSCKEIKERC HSAGDGLYFL RTKNGVVYQT FCDMTSGGGG WTLVASVHEN
110 120 130 140 150
DMRGKCTVGD RWSSQQGNKA DYPEGDGNWA NYNTFGSAEA ATSDDYKNPG
160 170 180 190 200
YYDIQAKDLG IWHVPNKSPM QHWRNSALLR YRTNTGFLQR LGHNLFGIYQ
210 220 230 240 250
KYPVKYRSGK CWNDNGPAIP VVYDFGDAKK TASYYSPYGQ REFVAGFVQF
260 270 280 290 300
RVFNNERAAN ALCAGIKVTG CNTEHHCIGG GGFFPQGKPR QCGDFSAFDW
310 320
DGYGTHVKSS CSREITEAAV LLFYR
Length:325
Mass (Da):36,212
Last modified:March 1, 2002 - v1
Checksum:i283C9A12AED2EBFC
GO
Isoform 2 (identifier: Q8WWU7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     26-26: Missing.

Note: No experimental confirmation available.
Show »
Length:324
Mass (Da):36,141
Checksum:iFB914096EFB771AD
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_019926103R → H1 PublicationCorresponds to variant dbSNP:rs6680969Ensembl.1
Natural variantiVAR_049076171Q → R. Corresponds to variant dbSNP:rs12090411Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05509326Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY065973 mRNA Translation: AAL58074.1
AY358905 mRNA Translation: AAQ89264.1
AL354714 Genomic DNA No translation available.
AL591806 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW52685.1
BC117225 mRNA Translation: AAI17226.1
BC143341 mRNA Translation: AAI43342.1
CCDSiCCDS1212.1 [Q8WWU7-1]
RefSeqiNP_543154.1, NM_080878.2 [Q8WWU7-1]
XP_011507512.1, XM_011509210.1 [Q8WWU7-1]
XP_011507513.1, XM_011509211.1 [Q8WWU7-2]
UniGeneiHs.385631

Genome annotation databases

EnsembliENST00000368029; ENSP00000357008; ENSG00000158764 [Q8WWU7-1]
GeneIDi142683
KEGGihsa:142683
UCSCiuc001fxd.4 human [Q8WWU7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiITLN2_HUMAN
AccessioniPrimary (citable) accession number: Q8WWU7
Secondary accession number(s): Q17RR2, Q5VYI0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: March 1, 2002
Last modified: May 23, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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