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Protein

Intelectin-2

Gene

ITLN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in the defense system against pathogens.By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Intelectin-2
Alternative name(s):
Endothelial lectin HL-2
Gene namesi
Name:ITLN2
ORF Names:UNQ2789/PRO7179
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:20599. ITLN2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134879128.

Polymorphism and mutation databases

BioMutaiITLN2.
DMDMi55976554.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence AnalysisAdd
BLAST
Chaini27 – 325299Intelectin-2PRO_0000009149Add
BLAST

Proteomic databases

PaxDbiQ8WWU7.
PRIDEiQ8WWU7.

PTM databases

PhosphoSiteiQ8WWU7.

Expressioni

Tissue specificityi

Expressed only in the small intestine.1 Publication

Gene expression databases

BgeeiQ8WWU7.
CleanExiHS_ITLN2.

Organism-specific databases

HPAiHPA006683.

Interactioni

Protein-protein interaction databases

BioGridi126772. 2 interactions.
STRINGi9606.ENSP00000357008.

Structurei

3D structure databases

ProteinModelPortaliQ8WWU7.
SMRiQ8WWU7. Positions 48-173.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini44 – 267224Fibrinogen C-terminalPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 fibrinogen C-terminal domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG25076.
GeneTreeiENSGT00390000008567.
HOGENOMiHOG000026788.
HOVERGENiHBG052157.
InParanoidiQ8WWU7.
KOiK17527.
OMAiYYLTTAN.
OrthoDBiEOG76739X.
PhylomeDBiQ8WWU7.
TreeFamiTF328530.

Family and domain databases

Gene3Di3.90.215.10. 1 hit.
InterProiIPR014716. Fibrinogen_a/b/g_C_1.
IPR002181. Fibrinogen_a/b/g_C_dom.
[Graphical view]
PfamiPF00147. Fibrinogen_C. 1 hit.
[Graphical view]
SMARTiSM00186. FBG. 1 hit.
[Graphical view]
SUPFAMiSSF56496. SSF56496. 1 hit.
PROSITEiPS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WWU7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLSMLRTMTR LCFLLFFSVA TSGCSAAAAS SLEMLSREFE TCAFSFSSLP
60 70 80 90 100
RSCKEIKERC HSAGDGLYFL RTKNGVVYQT FCDMTSGGGG WTLVASVHEN
110 120 130 140 150
DMRGKCTVGD RWSSQQGNKA DYPEGDGNWA NYNTFGSAEA ATSDDYKNPG
160 170 180 190 200
YYDIQAKDLG IWHVPNKSPM QHWRNSALLR YRTNTGFLQR LGHNLFGIYQ
210 220 230 240 250
KYPVKYRSGK CWNDNGPAIP VVYDFGDAKK TASYYSPYGQ REFVAGFVQF
260 270 280 290 300
RVFNNERAAN ALCAGIKVTG CNTEHHCIGG GGFFPQGKPR QCGDFSAFDW
310 320
DGYGTHVKSS CSREITEAAV LLFYR
Length:325
Mass (Da):36,212
Last modified:March 1, 2002 - v1
Checksum:i283C9A12AED2EBFC
GO
Isoform 2 (identifier: Q8WWU7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     26-26: Missing.

Note: No experimental confirmation available.
Show »
Length:324
Mass (Da):36,141
Checksum:iFB914096EFB771AD
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti103 – 1031R → H.1 Publication
Corresponds to variant rs6680969 [ dbSNP | Ensembl ].
VAR_019926
Natural varianti171 – 1711Q → R.
Corresponds to variant rs12090411 [ dbSNP | Ensembl ].
VAR_049076

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei26 – 261Missing in isoform 2. 1 PublicationVSP_055093

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY065973 mRNA. Translation: AAL58074.1.
AY358905 mRNA. Translation: AAQ89264.1.
AL354714, AL591806 Genomic DNA. Translation: CAH72351.1.
AL591806, AL354714 Genomic DNA. Translation: CAI15364.1.
CH471121 Genomic DNA. Translation: EAW52685.1.
BC117225 mRNA. Translation: AAI17226.1.
BC143341 mRNA. Translation: AAI43342.1.
CCDSiCCDS1212.1. [Q8WWU7-1]
RefSeqiNP_543154.1. NM_080878.2. [Q8WWU7-1]
XP_011507512.1. XM_011509210.1. [Q8WWU7-1]
XP_011507513.1. XM_011509211.1. [Q8WWU7-2]
UniGeneiHs.385631.

Genome annotation databases

EnsembliENST00000368029; ENSP00000357008; ENSG00000158764.
GeneIDi142683.
KEGGihsa:142683.
UCSCiuc001fxd.3. human. [Q8WWU7-1]
uc009wts.3. human.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY065973 mRNA. Translation: AAL58074.1.
AY358905 mRNA. Translation: AAQ89264.1.
AL354714, AL591806 Genomic DNA. Translation: CAH72351.1.
AL591806, AL354714 Genomic DNA. Translation: CAI15364.1.
CH471121 Genomic DNA. Translation: EAW52685.1.
BC117225 mRNA. Translation: AAI17226.1.
BC143341 mRNA. Translation: AAI43342.1.
CCDSiCCDS1212.1. [Q8WWU7-1]
RefSeqiNP_543154.1. NM_080878.2. [Q8WWU7-1]
XP_011507512.1. XM_011509210.1. [Q8WWU7-1]
XP_011507513.1. XM_011509211.1. [Q8WWU7-2]
UniGeneiHs.385631.

3D structure databases

ProteinModelPortaliQ8WWU7.
SMRiQ8WWU7. Positions 48-173.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126772. 2 interactions.
STRINGi9606.ENSP00000357008.

PTM databases

PhosphoSiteiQ8WWU7.

Polymorphism and mutation databases

BioMutaiITLN2.
DMDMi55976554.

Proteomic databases

PaxDbiQ8WWU7.
PRIDEiQ8WWU7.

Protocols and materials databases

DNASUi142683.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368029; ENSP00000357008; ENSG00000158764.
GeneIDi142683.
KEGGihsa:142683.
UCSCiuc001fxd.3. human. [Q8WWU7-1]
uc009wts.3. human.

Organism-specific databases

CTDi142683.
GeneCardsiGC01M160914.
HGNCiHGNC:20599. ITLN2.
HPAiHPA006683.
MIMi609874. gene.
neXtProtiNX_Q8WWU7.
PharmGKBiPA134879128.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG25076.
GeneTreeiENSGT00390000008567.
HOGENOMiHOG000026788.
HOVERGENiHBG052157.
InParanoidiQ8WWU7.
KOiK17527.
OMAiYYLTTAN.
OrthoDBiEOG76739X.
PhylomeDBiQ8WWU7.
TreeFamiTF328530.

Miscellaneous databases

GenomeRNAii142683.
NextBioi84605.
PROiQ8WWU7.
SOURCEiSearch...

Gene expression databases

BgeeiQ8WWU7.
CleanExiHS_ITLN2.

Family and domain databases

Gene3Di3.90.215.10. 1 hit.
InterProiIPR014716. Fibrinogen_a/b/g_C_1.
IPR002181. Fibrinogen_a/b/g_C_dom.
[Graphical view]
PfamiPF00147. Fibrinogen_C. 1 hit.
[Graphical view]
SMARTiSM00186. FBG. 1 hit.
[Graphical view]
SUPFAMiSSF56496. SSF56496. 1 hit.
PROSITEiPS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Human homologs of the Xenopus oocyte cortical granule lectin XL35."
    Lee J.K., Schnee J., Pang M., Wolfert M., Baum L.G., Moremen K.W., Pierce M.
    Glycobiology 11:65-73(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    Tissue: Small intestine.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT HIS-103.
    Tissue: Brain.

Entry informationi

Entry nameiITLN2_HUMAN
AccessioniPrimary (citable) accession number: Q8WWU7
Secondary accession number(s): Q17RR2, Q5VYI0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: March 1, 2002
Last modified: July 22, 2015
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.