Q8WWU5 (TCP11_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
T-complex protein 11 homolog

Gene names

Name:

TCP11

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	503 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May play an important role in sperm function and fertility. Ref.1
Subcellular location	Membrane; Single-pass membrane protein Potential.
Tissue specificity	Expressed only in fertile adult testis. Ref.1
Sequence similarities	Belongs to the TCP11 family.

Ontologies

Keywords
Biological process	Differentiation Spermatogenesis
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW multicellular organismal development Traceable author statement PubMed 1893875. Source: UniProtKB spermatogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8WWU5-1)

Also known as: TCP11b;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8WWU5-2)

Also known as: TCP11d;

The sequence of this isoform differs from the canonical sequence as follows:
     1-78: MPDVKESVPP...YMEEKVLPPS → MAPKGILGSFPTAMNL

Isoform 3 (identifier: Q8WWU5-3)

Also known as: TCP11c;

The sequence of this isoform differs from the canonical sequence as follows:
     1-63: Missing.

Isoform 4 (identifier: Q8WWU5-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-42: MPDVKESVPPKYPGDSEGRSCKPETSGPPQEDKSGSEDPPPF → MTRGGGGGV

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 503	503	T-complex protein 11 homolog		PRO_0000324298
Regions
	Transmembrane	330 – 349	20	Helical; Potential
Natural variations
	Alternative sequence	1 – 78	78	MPDVK…VLPPS → MAPKGILGSFPTAMNL in isoform 2.		VSP_032186
	Alternative sequence	1 – 63	63	Missing in isoform 3.		VSP_032185
	Alternative sequence	1 – 42	42	MPDVK…DPPPF → MTRGGGGGV in isoform 4.		VSP_045217
	Natural variant	253	1	G → A. Corresponds to variant rs2234045 [ dbSNP | Ensembl ].		VAR_039692
	Natural variant	429	1	R → Q. Corresponds to variant rs2234051 [ dbSNP | Ensembl ].		VAR_039693

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (TCP11b) [UniParc]. Last modified March 1, 2002. Version 1. Checksum: F567492970A3F68B	FASTA	503	56,141
	10 20 30 40 50 60 MPDVKESVPP KYPGDSEGRS CKPETSGPPQ EDKSGSEDPP PFLSVTGLTE TVNEVSKLSN 70 80 90 100 110 120 KIGMNCDYYM EEKVLPPSSL EGKVKETVHN AFWDHLKEQL SATPPDFSCA LELLKEIKEI 130 140 150 160 170 180 LLSLLLPRQN RLRIEIEEAL DMDLLKQEAE HGALKVLYLS KYVLNMMALL CAPVRDEAVQ 190 200 210 220 230 240 KLENITDPVW LLRGIFQVLG RMKMDMVNYT IQSLQPHLQE HSIQYERAKF QELLNKQPSL 250 260 270 280 290 300 LNHTTKWLTQ AAGDLTMSPP TCPDTSDSSS VAGPSPNEAA NNPEPLSPTM VLCQGFLNLL 310 320 330 340 350 360 LWDLENEEFP ETLLMDRTRL QELKSQLHQL TVMASVLLVA SSFSGSVLFG SPQFVDKLKR 370 380 390 400 410 420 ITKSLLEDFH SRPEEAILTV SEQVSQEIHQ SLKNMGLVAL SSDNTASLMG QLQNIAKKEN 430 440 450 460 470 480 CVCSVIDQRI HLFLKCCLVL GVQRSLLDLP GGLTLIEAEL AELGQKFVNL THHNQQVFGP 490 500 YYTEILKTLI SPAQALETKV ESV
	Isoform 2 (TCP11d) [UniParc]. Checksum: 8775470FD36B5FD1	FASTA	441	49,329
	10 20 30 40 50 60 MAPKGILGSF PTAMNLSLEG KVKETVHNAF WDHLKEQLSA TPPDFSCALE LLKEIKEILL 70 80 90 100 110 120 SLLLPRQNRL RIEIEEALDM DLLKQEAEHG ALKVLYLSKY VLNMMALLCA PVRDEAVQKL 130 140 150 160 170 180 ENITDPVWLL RGIFQVLGRM KMDMVNYTIQ SLQPHLQEHS IQYERAKFQE LLNKQPSLLN 190 200 210 220 230 240 HTTKWLTQAA GDLTMSPPTC PDTSDSSSVA GPSPNEAANN PEPLSPTMVL CQGFLNLLLW 250 260 270 280 290 300 DLENEEFPET LLMDRTRLQE LKSQLHQLTV MASVLLVASS FSGSVLFGSP QFVDKLKRIT 310 320 330 340 350 360 KSLLEDFHSR PEEAILTVSE QVSQEIHQSL KNMGLVALSS DNTASLMGQL QNIAKKENCV 370 380 390 400 410 420 CSVIDQRIHL FLKCCLVLGV QRSLLDLPGG LTLIEAELAE LGQKFVNLTH HNQQVFGPYY 430 440 TEILKTLISP AQALETKVES V
	Isoform 3 (TCP11c) [UniParc]. Checksum: C7D8BBBB6F1922A7	FASTA	440	49,500
	10 20 30 40 50 60 MNCDYYMEEK VLPPSSLEGK VKETVHNAFW DHLKEQLSAT PPDFSCALEL LKEIKEILLS 70 80 90 100 110 120 LLLPRQNRLR IEIEEALDMD LLKQEAEHGA LKVLYLSKYV LNMMALLCAP VRDEAVQKLE 130 140 150 160 170 180 NITDPVWLLR GIFQVLGRMK MDMVNYTIQS LQPHLQEHSI QYERAKFQEL LNKQPSLLNH 190 200 210 220 230 240 TTKWLTQAAG DLTMSPPTCP DTSDSSSVAG PSPNEAANNP EPLSPTMVLC QGFLNLLLWD 250 260 270 280 290 300 LENEEFPETL LMDRTRLQEL KSQLHQLTVM ASVLLVASSF SGSVLFGSPQ FVDKLKRITK 310 320 330 340 350 360 SLLEDFHSRP EEAILTVSEQ VSQEIHQSLK NMGLVALSSD NTASLMGQLQ NIAKKENCVC 370 380 390 400 410 420 SVIDQRIHLF LKCCLVLGVQ RSLLDLPGGL TLIEAELAEL GQKFVNLTHH NQQVFGPYYT 430 440 EILKTLISPA QALETKVESV
	Isoform 4 [UniParc]. Checksum: 2460B5E00F13D0BE	FASTA	470	52,445
	10 20 30 40 50 60 MTRGGGGGVL SVTGLTETVN EVSKLSNKIG MNCDYYMEEK VLPPSSLEGK VKETVHNAFW 70 80 90 100 110 120 DHLKEQLSAT PPDFSCALEL LKEIKEILLS LLLPRQNRLR IEIEEALDMD LLKQEAEHGA 130 140 150 160 170 180 LKVLYLSKYV LNMMALLCAP VRDEAVQKLE NITDPVWLLR GIFQVLGRMK MDMVNYTIQS 190 200 210 220 230 240 LQPHLQEHSI QYERAKFQEL LNKQPSLLNH TTKWLTQAAG DLTMSPPTCP DTSDSSSVAG 250 260 270 280 290 300 PSPNEAANNP EPLSPTMVLC QGFLNLLLWD LENEEFPETL LMDRTRLQEL KSQLHQLTVM 310 320 330 340 350 360 ASVLLVASSF SGSVLFGSPQ FVDKLKRITK SLLEDFHSRP EEAILTVSEQ VSQEIHQSLK 370 380 390 400 410 420 NMGLVALSSD NTASLMGQLQ NIAKKENCVC SVIDQRIHLF LKCCLVLGVQ RSLLDLPGGL 430 440 450 460 470 TLIEAELAEL GQKFVNLTHH NQQVFGPYYT EILKTLISPA QALETKVESV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular characterization of the TCP11 gene which is the human homologue of the mouse gene encoding the receptor of fertilization promoting peptide." Ma Y., Zhang S., Xia Q., Zhang G., Huang X., Huang M., Xiao C., Pan A., Sun Y., Lebo R., Milunsky A. Mol. Hum. Reprod. 8:24-31(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, TISSUE SPECIFICITY. Tissue: Testis.
[2]	"Cloning, expression and alternative splicing of a novel isoform of human TCP11b gene." Ma Y.X., Zhang S.Z., Wu Q.Q., Sun Y. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 35:182-188(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]	"Cloning, expression, and alternative splicing of the novel isoform of hTCP11 gene." Ma Y.X., Zhang S.Z., Wu Q.Q., Sun Y., Qiu W.M., Xu W.M. Zhongguo Yi Xue Ke Xue Yuan Xue Bao 25:122-128(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 4). Tissue: Testis.
[5]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3). Tissue: Brain and Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF269223 mRNA. Translation: AAF75551.1. AY069943 mRNA. Translation: AAL58042.1. AF260330 mRNA. Translation: AAF91370.1. AF536532 mRNA. Translation: AAN04044.1. AF536533 mRNA. Translation: AAN04045.1. AK057234 mRNA. Translation: BAG51889.1. AK301975 mRNA. Translation: BAH13597.1. AK315078 mRNA. Translation: BAG37546.1. AL138721 Genomic DNA. Translation: CAI12438.1. CH471081 Genomic DNA. Translation: EAX03809.1. BC033729 mRNA. Translation: AAH33729.1. BC040003 mRNA. Translation: AAH40003.1. BC048418 mRNA. Translation: AAH48418.1. BC090050 mRNA. Translation: AAH90050.1.
IPI	IPI00103433. IPI00396136. IPI00888582.
RefSeq	NP_001087197.1. NM_001093728.2. NP_001248746.1. NM_001261817.1. NP_001248747.1. NM_001261818.1. NP_001248748.1. NM_001261819.1. NP_001248749.1. NM_001261820.1. NP_001248750.1. NM_001261821.1. NP_061149.1. NM_018679.5.
UniGene	Hs.435371.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8WWU5. 2 interactions.
STRING	9606.ENSP00000308708.
PTM databases
PhosphoSite	Q8WWU5.
Polymorphism databases
DMDM	74716246.
Proteomic databases
PaxDb	Q8WWU5.
PRIDE	Q8WWU5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000244645; ENSP00000244645; ENSG00000124678. ENST00000373974; ENSP00000363085; ENSG00000124678. ENST00000373979; ENSP00000363091; ENSG00000124678. ENST00000418521; ENSP00000415320; ENSG00000124678. ENST00000512012; ENSP00000425995; ENSG00000124678.
GeneID	6954.
KEGG	hsa:6954.
UCSC	uc003ojz.1. human. uc003okb.2. human.
Organism-specific databases
CTD	6954.
GeneCards	GC06M035132.
HGNC	HGNC:11658. TCP11.
MIM	186982. gene.
neXtProt	NX_Q8WWU5.
PharmGKB	PA36409.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG257003.
HOVERGEN	HBG008348.
InParanoid	Q8WWU5.
PhylomeDB	Q8WWU5.
Gene expression databases
ArrayExpress	Q8WWU5.
Bgee	Q8WWU5.
CleanEx	HS_TCP11.
Genevestigator	Q8WWU5.
Family and domain databases
InterPro	IPR008862. Tcp11. [Graphical view]
PANTHER	PTHR12832. PTHR12832. 1 hit.
Pfam	PF05794. Tcp11. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	6954.
NextBio	27231.
SOURCE	Search...

Entry information

Entry name

TCP11_HUMAN

Accession

Primary (citable) accession number: Q8WWU5
Secondary accession number(s): B2RCE9 , B3KQ27, B7Z7G1, Q8NF85, Q9NQZ9, Q9NR39

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	March 1, 2002
Last modified:	April 3, 2013
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.