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Protein

Solute carrier family 13 member 3

Gene

SLC13A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

High-affinity sodium-dicarboxylate cotransporter that accepts a range of substrates with 4-5 carbon atoms. The stoichiometry is probably 3 Na+ for 1 divalent succinate.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

BioCyciZFISH:ENSG00000158296-MONOMER.
ReactomeiR-HSA-433137. Sodium-coupled sulphate, di- and tri-carboxylate transporters.

Protein family/group databases

TCDBi2.A.47.1.15. the divalent anion:na(+) symporter (dass) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 13 member 3
Alternative name(s):
Na(+)/dicarboxylate cotransporter 3
Short name:
NaDC-3
Short name:
hNaDC3
Sodium-dependent high-affinity dicarboxylate transporter 2
Gene namesi
Name:SLC13A3
Synonyms:NADC3, SDCT2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:14430. SLC13A3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 16CytoplasmicSequence analysisAdd BLAST16
Transmembranei17 – 37HelicalSequence analysisAdd BLAST21
Topological domaini38 – 55ExtracellularSequence analysisAdd BLAST18
Transmembranei56 – 76HelicalSequence analysisAdd BLAST21
Topological domaini77 – 82CytoplasmicSequence analysis6
Transmembranei83 – 103HelicalSequence analysisAdd BLAST21
Topological domaini104 – 137ExtracellularSequence analysisAdd BLAST34
Transmembranei138 – 158HelicalSequence analysisAdd BLAST21
Topological domaini159 – 229CytoplasmicSequence analysisAdd BLAST71
Transmembranei230 – 250HelicalSequence analysisAdd BLAST21
Topological domaini251 – 278ExtracellularSequence analysisAdd BLAST28
Transmembranei279 – 299HelicalSequence analysisAdd BLAST21
Topological domaini300 – 336CytoplasmicSequence analysisAdd BLAST37
Transmembranei337 – 357HelicalSequence analysisAdd BLAST21
Topological domaini358 – 372ExtracellularSequence analysisAdd BLAST15
Transmembranei373 – 393HelicalSequence analysisAdd BLAST21
Topological domaini394 – 422CytoplasmicSequence analysisAdd BLAST29
Intramembranei423 – 443HelicalSequence analysisAdd BLAST21
Topological domaini444 – 461CytoplasmicSequence analysisAdd BLAST18
Transmembranei462 – 482HelicalSequence analysisAdd BLAST21
Topological domaini483 – 505ExtracellularSequence analysisAdd BLAST23
Transmembranei506 – 526HelicalSequence analysisAdd BLAST21
Topological domaini527 – 546CytoplasmicSequence analysisAdd BLAST20
Transmembranei547 – 567HelicalSequence analysisAdd BLAST21
Topological domaini568 – 602ExtracellularSequence analysisAdd BLAST35

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi64849.
OpenTargetsiENSG00000158296.
PharmGKBiPA37881.

Chemistry databases

DrugBankiDB00139. Succinic acid.

Polymorphism and mutation databases

BioMutaiSLC13A3.
DMDMi23396845.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001724921 – 602Solute carrier family 13 member 3Add BLAST602

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi586N-linked (GlcNAc...)Sequence analysis1
Glycosylationi596N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8WWT9.
PaxDbiQ8WWT9.
PeptideAtlasiQ8WWT9.
PRIDEiQ8WWT9.

PTM databases

iPTMnetiQ8WWT9.
PhosphoSitePlusiQ8WWT9.

Expressioni

Tissue specificityi

Expression is highest in kidney. Detected in placenta, brain, liver and pancreas.

Gene expression databases

BgeeiENSG00000158296.
ExpressionAtlasiQ8WWT9. baseline and differential.
GenevisibleiQ8WWT9. HS.

Organism-specific databases

HPAiHPA014353.
HPA014736.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000279027.

Structurei

3D structure databases

ProteinModelPortaliQ8WWT9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1281. Eukaryota.
COG0471. LUCA.
GeneTreeiENSGT00550000074480.
HOGENOMiHOG000278432.
HOVERGENiHBG055339.
InParanoidiQ8WWT9.
KOiK14445.
OMAiVKPAWLI.
OrthoDBiEOG091G092X.
PhylomeDBiQ8WWT9.
TreeFamiTF312913.

Family and domain databases

InterProiIPR001898. Na/sul_symport.
[Graphical view]
PfamiPF00939. Na_sulph_symp. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WWT9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAALAAAAKK VWSARRLLVL LFTPLALLPV VFALPPKEGR CLFVILLMAV
60 70 80 90 100
YWCTEALPLS VTALLPIVLF PFMGILPSNK VCPQYFLDTN FLFLSGLIMA
110 120 130 140 150
SAIEEWNLHR RIALKILMLV GVQPARLILG MMVTTSFLSM WLSNTASTAM
160 170 180 190 200
MLPIANAILK SLFGQKEVRK DPSQESEENT AAVRRNGLHT VPTEMQFLAS
210 220 230 240 250
TEAKDHPGET EVPLDLPADS RKEDEYRRNI WKGFLISIPY SASIGGTATL
260 270 280 290 300
TGTAPNLILL GQLKSFFPQC DVVNFGSWFI FAFPLMLLFL LAGWLWISFL
310 320 330 340 350
YGGLSFRGWR KNKSEIRTNA EDRARAVIRE EYQNLGPIKF AEQAVFILFC
360 370 380 390 400
MFAILLFTRD PKFIPGWASL FNPGFLSDAV TGVAIVTILF FFPSQRPSLK
410 420 430 440 450
WWFDFKAPNT ETEPLLTWKK AQETVPWNII LLLGGGFAMA KGCEESGLSV
460 470 480 490 500
WIGGQLHPLE NVPPALAVLL ITVVIAFFTE FASNTATIII FLPVLAELAI
510 520 530 540 550
RLRVHPLYLM IPGTVGCSFA FMLPVSTPPN SIAFASGHLL VKDMVRTGLL
560 570 580 590 600
MNLMGVLLLS LAMNTWAQTI FQLGTFPDWA DMYSVNVTAL PPTLANDTFR

TL
Length:602
Mass (Da):66,841
Last modified:March 1, 2002 - v1
Checksum:i611A50994BA37687
GO
Isoform 2 (identifier: Q8WWT9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     181-297: AAVRRNGLHT...LFLLAGWLWI → GIEPNTFLSE...RVLSFLPGGM
     298-602: Missing.

Note: Gene prediction based on EST data.
Show »
Length:232
Mass (Da):25,684
Checksum:i7EEDA215B050ABEB
GO
Isoform 3 (identifier: Q8WWT9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-47: Missing.
     340-374: Missing.

Note: No experimental confirmation available.
Show »
Length:520
Mass (Da):57,766
Checksum:iD9CB6E6BE1A5C936
GO
Isoform 4 (identifier: Q8WWT9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     182-292: AVRRNGLHTV...FPLMLLFLLA → KTTLGRQRFH...LTSSCLASSR
     375-388: FLSDAVTGVAIVTI → CKMGIISISTIQKM
     389-602: Missing.

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:338
Mass (Da):37,669
Checksum:i022516BECC8D3961
GO
Isoform 5 (identifier: Q8WWT9-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     182-292: AVRRNGLHTV...FPLMLLFLLA → KTTLGRQRFH...LTSSCLASSR

Note: No experimental confirmation available.
Show »
Length:552
Mass (Da):61,099
Checksum:iEF5734E90BBE2167
GO
Isoform 6 (identifier: Q8WWT9-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-47: Missing.

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:555
Mass (Da):61,757
Checksum:iE433B6A826BA4D77
GO

Sequence cautioni

The sequence AAF73251 differs from that shown. Reason: Frameshift at positions 188 and 199.Curated
The sequence CAC09447 differs from that shown. erroneous CDS prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti94L → P in BAC04834 (PubMed:14702039).Curated1
Sequence conflicti364I → V in AAH35966 (PubMed:15489334).Curated1
Sequence conflicti572Q → P in BAB71262 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0152911 – 47Missing in isoform 3 and isoform 6. 1 PublicationAdd BLAST47
Alternative sequenceiVSP_006123181 – 297AAVRR…GWLWI → GIEPNTFLSEERLKLQAPLV IRLGQITESGQWNMSGNDVC NFRVLSFLPGGM in isoform 2. CuratedAdd BLAST117
Alternative sequenceiVSP_015292182 – 292AVRRN…LFLLA → KTTLGRQRFHWICRLTPGRR MNIVGTSGRASSSPSPTQPV LGAQPHSRAQPLTSSCLASS R in isoform 4 and isoform 5. 1 PublicationAdd BLAST111
Alternative sequenceiVSP_006124298 – 602Missing in isoform 2. CuratedAdd BLAST305
Alternative sequenceiVSP_015293340 – 374Missing in isoform 3. 1 PublicationAdd BLAST35
Alternative sequenceiVSP_015294375 – 388FLSDA…AIVTI → CKMGIISISTIQKM in isoform 4. CuratedAdd BLAST14
Alternative sequenceiVSP_015295389 – 602Missing in isoform 4. CuratedAdd BLAST214

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF154121 mRNA. Translation: AAF73251.1. Frameshift.
AY072810 mRNA. Translation: AAL66762.1.
AK056713 mRNA. Translation: BAB71262.1.
AK096658 mRNA. Translation: BAC04834.1.
AK295748 mRNA. Translation: BAG58580.1.
AL133520 Genomic DNA. No translation available.
AL034424 Genomic DNA. No translation available.
CH471077 Genomic DNA. Translation: EAW75725.1.
CH471077 Genomic DNA. Translation: EAW75726.1.
BC035966 mRNA. Translation: AAH35966.1.
AL442082 mRNA. Translation: CAC09447.2. Sequence problems.
CCDSiCCDS13400.1. [Q8WWT9-1]
CCDS42886.1. [Q8WWT9-6]
CCDS54469.1. [Q8WWT9-3]
CCDS54470.1. [Q8WWT9-5]
RefSeqiNP_001011554.1. NM_001011554.2. [Q8WWT9-6]
NP_001180268.1. NM_001193339.1. [Q8WWT9-5]
NP_001180269.1. NM_001193340.1. [Q8WWT9-3]
NP_073740.2. NM_022829.5. [Q8WWT9-1]
UniGeneiHs.655498.
Hs.670365.

Genome annotation databases

EnsembliENST00000279027; ENSP00000279027; ENSG00000158296. [Q8WWT9-1]
ENST00000290317; ENSP00000290317; ENSG00000158296. [Q8WWT9-6]
ENST00000413164; ENSP00000415852; ENSG00000158296. [Q8WWT9-5]
ENST00000472148; ENSP00000420177; ENSG00000158296. [Q8WWT9-3]
ENST00000495082; ENSP00000419621; ENSG00000158296. [Q8WWT9-6]
GeneIDi64849.
KEGGihsa:64849.
UCSCiuc002xsf.3. human. [Q8WWT9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF154121 mRNA. Translation: AAF73251.1. Frameshift.
AY072810 mRNA. Translation: AAL66762.1.
AK056713 mRNA. Translation: BAB71262.1.
AK096658 mRNA. Translation: BAC04834.1.
AK295748 mRNA. Translation: BAG58580.1.
AL133520 Genomic DNA. No translation available.
AL034424 Genomic DNA. No translation available.
CH471077 Genomic DNA. Translation: EAW75725.1.
CH471077 Genomic DNA. Translation: EAW75726.1.
BC035966 mRNA. Translation: AAH35966.1.
AL442082 mRNA. Translation: CAC09447.2. Sequence problems.
CCDSiCCDS13400.1. [Q8WWT9-1]
CCDS42886.1. [Q8WWT9-6]
CCDS54469.1. [Q8WWT9-3]
CCDS54470.1. [Q8WWT9-5]
RefSeqiNP_001011554.1. NM_001011554.2. [Q8WWT9-6]
NP_001180268.1. NM_001193339.1. [Q8WWT9-5]
NP_001180269.1. NM_001193340.1. [Q8WWT9-3]
NP_073740.2. NM_022829.5. [Q8WWT9-1]
UniGeneiHs.655498.
Hs.670365.

3D structure databases

ProteinModelPortaliQ8WWT9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000279027.

Chemistry databases

DrugBankiDB00139. Succinic acid.

Protein family/group databases

TCDBi2.A.47.1.15. the divalent anion:na(+) symporter (dass) family.

PTM databases

iPTMnetiQ8WWT9.
PhosphoSitePlusiQ8WWT9.

Polymorphism and mutation databases

BioMutaiSLC13A3.
DMDMi23396845.

Proteomic databases

MaxQBiQ8WWT9.
PaxDbiQ8WWT9.
PeptideAtlasiQ8WWT9.
PRIDEiQ8WWT9.

Protocols and materials databases

DNASUi64849.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000279027; ENSP00000279027; ENSG00000158296. [Q8WWT9-1]
ENST00000290317; ENSP00000290317; ENSG00000158296. [Q8WWT9-6]
ENST00000413164; ENSP00000415852; ENSG00000158296. [Q8WWT9-5]
ENST00000472148; ENSP00000420177; ENSG00000158296. [Q8WWT9-3]
ENST00000495082; ENSP00000419621; ENSG00000158296. [Q8WWT9-6]
GeneIDi64849.
KEGGihsa:64849.
UCSCiuc002xsf.3. human. [Q8WWT9-1]

Organism-specific databases

CTDi64849.
DisGeNETi64849.
GeneCardsiSLC13A3.
HGNCiHGNC:14430. SLC13A3.
HPAiHPA014353.
HPA014736.
MIMi606411. gene.
neXtProtiNX_Q8WWT9.
OpenTargetsiENSG00000158296.
PharmGKBiPA37881.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1281. Eukaryota.
COG0471. LUCA.
GeneTreeiENSGT00550000074480.
HOGENOMiHOG000278432.
HOVERGENiHBG055339.
InParanoidiQ8WWT9.
KOiK14445.
OMAiVKPAWLI.
OrthoDBiEOG091G092X.
PhylomeDBiQ8WWT9.
TreeFamiTF312913.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000158296-MONOMER.
ReactomeiR-HSA-433137. Sodium-coupled sulphate, di- and tri-carboxylate transporters.

Miscellaneous databases

ChiTaRSiSLC13A3. human.
GeneWikiiSLC13A3.
GenomeRNAii64849.
PROiQ8WWT9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000158296.
ExpressionAtlasiQ8WWT9. baseline and differential.
GenevisibleiQ8WWT9. HS.

Family and domain databases

InterProiIPR001898. Na/sul_symport.
[Graphical view]
PfamiPF00939. Na_sulph_symp. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS13A3_HUMAN
AccessioniPrimary (citable) accession number: Q8WWT9
Secondary accession number(s): B4DIR8
, E1P5U4, F6WI18, Q5JYC9, Q5JYD0, Q5JYD1, Q5TCQ2, Q8IVB1, Q8N8K4, Q96MM5, Q9BR25, Q9H1G1, Q9H3W4, Q9NQN5, Q9NS04
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: March 1, 2002
Last modified: November 2, 2016
This is version 144 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.