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Q8WWT9

- S13A3_HUMAN

UniProt

Q8WWT9 - S13A3_HUMAN

Protein

Solute carrier family 13 member 3

Gene

SLC13A3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 125 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    High-affinity sodium-dicarboxylate cotransporter that accepts a range of substrates with 4-5 carbon atoms. The stoichiometry is probably 3 Na+ for 1 divalent succinate.

    GO - Molecular functioni

    1. high-affinity sodium:dicarboxylate symporter activity Source: Ensembl

    GO - Biological processi

    1. transmembrane transport Source: Reactome

    Keywords - Biological processi

    Ion transport, Sodium transport, Symport, Transport

    Keywords - Ligandi

    Sodium

    Enzyme and pathway databases

    ReactomeiREACT_20646. Sodium-coupled sulphate, di- and tri-carboxylate transporters.

    Protein family/group databases

    TCDBi2.A.47.1.15. the divalent anion:na(+) symporter (dass) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier family 13 member 3
    Alternative name(s):
    Na(+)/dicarboxylate cotransporter 3
    Short name:
    NaDC-3
    Short name:
    hNaDC3
    Sodium-dependent high-affinity dicarboxylate transporter 2
    Gene namesi
    Name:SLC13A3
    Synonyms:NADC3, SDCT2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:14430. SLC13A3.

    Subcellular locationi

    Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37881.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 602602Solute carrier family 13 member 3PRO_0000172492Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi586 – 5861N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi596 – 5961N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ8WWT9.
    PaxDbiQ8WWT9.
    PRIDEiQ8WWT9.

    PTM databases

    PhosphoSiteiQ8WWT9.

    Expressioni

    Tissue specificityi

    Expression is highest in kidney. Detected in placenta, brain, liver and pancreas.

    Gene expression databases

    ArrayExpressiQ8WWT9.
    BgeeiQ8WWT9.
    GenevestigatoriQ8WWT9.

    Organism-specific databases

    HPAiHPA014353.
    HPA014736.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8WWT9.
    SMRiQ8WWT9. Positions 15-162, 418-566.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1616CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini38 – 5518ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini77 – 826CytoplasmicSequence Analysis
    Topological domaini104 – 13734ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini159 – 22971CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini251 – 27828ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini300 – 33637CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini358 – 37215ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini394 – 42229CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini444 – 46118CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini483 – 50523ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini527 – 54620CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini568 – 60235ExtracellularSequence AnalysisAdd
    BLAST

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei423 – 44321HelicalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei17 – 3721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei56 – 7621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei83 – 10321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei138 – 15821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei230 – 25021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei279 – 29921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei337 – 35721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei373 – 39321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei462 – 48221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei506 – 52621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei547 – 56721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0471.
    HOVERGENiHBG055339.
    InParanoidiQ8WWT9.
    KOiK14445.
    OMAiWWVTEAI.
    OrthoDBiEOG7G1V5S.
    PhylomeDBiQ8WWT9.
    TreeFamiTF312913.

    Family and domain databases

    InterProiIPR001898. Na/sul_symport.
    [Graphical view]
    PfamiPF00939. Na_sulph_symp. 1 hit.
    [Graphical view]

    Sequences (6)i

    Sequence statusi: Complete.

    This entry describes 6 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8WWT9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAALAAAAKK VWSARRLLVL LFTPLALLPV VFALPPKEGR CLFVILLMAV    50
    YWCTEALPLS VTALLPIVLF PFMGILPSNK VCPQYFLDTN FLFLSGLIMA 100
    SAIEEWNLHR RIALKILMLV GVQPARLILG MMVTTSFLSM WLSNTASTAM 150
    MLPIANAILK SLFGQKEVRK DPSQESEENT AAVRRNGLHT VPTEMQFLAS 200
    TEAKDHPGET EVPLDLPADS RKEDEYRRNI WKGFLISIPY SASIGGTATL 250
    TGTAPNLILL GQLKSFFPQC DVVNFGSWFI FAFPLMLLFL LAGWLWISFL 300
    YGGLSFRGWR KNKSEIRTNA EDRARAVIRE EYQNLGPIKF AEQAVFILFC 350
    MFAILLFTRD PKFIPGWASL FNPGFLSDAV TGVAIVTILF FFPSQRPSLK 400
    WWFDFKAPNT ETEPLLTWKK AQETVPWNII LLLGGGFAMA KGCEESGLSV 450
    WIGGQLHPLE NVPPALAVLL ITVVIAFFTE FASNTATIII FLPVLAELAI 500
    RLRVHPLYLM IPGTVGCSFA FMLPVSTPPN SIAFASGHLL VKDMVRTGLL 550
    MNLMGVLLLS LAMNTWAQTI FQLGTFPDWA DMYSVNVTAL PPTLANDTFR 600
    TL 602
    Length:602
    Mass (Da):66,841
    Last modified:March 1, 2002 - v1
    Checksum:i611A50994BA37687
    GO
    Isoform 2 (identifier: Q8WWT9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         181-297: AAVRRNGLHT...LFLLAGWLWI → GIEPNTFLSE...RVLSFLPGGM
         298-602: Missing.

    Note: Gene prediction based on EST data.

    Show »
    Length:232
    Mass (Da):25,684
    Checksum:i7EEDA215B050ABEB
    GO
    Isoform 3 (identifier: Q8WWT9-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-47: Missing.
         340-374: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:520
    Mass (Da):57,766
    Checksum:iD9CB6E6BE1A5C936
    GO
    Isoform 4 (identifier: Q8WWT9-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         182-292: AVRRNGLHTV...FPLMLLFLLA → KTTLGRQRFH...LTSSCLASSR
         375-388: FLSDAVTGVAIVTI → CKMGIISISTIQKM
         389-602: Missing.

    Note: No experimental confirmation available. Gene prediction based on EST data.

    Show »
    Length:338
    Mass (Da):37,669
    Checksum:i022516BECC8D3961
    GO
    Isoform 5 (identifier: Q8WWT9-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         182-292: AVRRNGLHTV...FPLMLLFLLA → KTTLGRQRFH...LTSSCLASSR

    Note: No experimental confirmation available.

    Show »
    Length:552
    Mass (Da):61,099
    Checksum:iEF5734E90BBE2167
    GO
    Isoform 6 (identifier: Q8WWT9-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-47: Missing.

    Note: No experimental confirmation available. Gene prediction based on EST data.

    Show »
    Length:555
    Mass (Da):61,757
    Checksum:iE433B6A826BA4D77
    GO

    Sequence cautioni

    The sequence CAC09447.2 differs from that shown. Reason: erroneous CDS prediction.
    The sequence AAF73251.1 differs from that shown. Reason: Frameshift at positions 188 and 199.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti94 – 941L → P in BAC04834. (PubMed:14702039)Curated
    Sequence conflicti364 – 3641I → V in AAH35966. (PubMed:15489334)Curated
    Sequence conflicti572 – 5721Q → P in BAB71262. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 4747Missing in isoform 3 and isoform 6. 1 PublicationVSP_015291Add
    BLAST
    Alternative sequencei181 – 297117AAVRR…GWLWI → GIEPNTFLSEERLKLQAPLV IRLGQITESGQWNMSGNDVC NFRVLSFLPGGM in isoform 2. CuratedVSP_006123Add
    BLAST
    Alternative sequencei182 – 292111AVRRN…LFLLA → KTTLGRQRFHWICRLTPGRR MNIVGTSGRASSSPSPTQPV LGAQPHSRAQPLTSSCLASS R in isoform 4 and isoform 5. 1 PublicationVSP_015292Add
    BLAST
    Alternative sequencei298 – 602305Missing in isoform 2. CuratedVSP_006124Add
    BLAST
    Alternative sequencei340 – 37435Missing in isoform 3. 1 PublicationVSP_015293Add
    BLAST
    Alternative sequencei375 – 38814FLSDA…AIVTI → CKMGIISISTIQKM in isoform 4. CuratedVSP_015294Add
    BLAST
    Alternative sequencei389 – 602214Missing in isoform 4. CuratedVSP_015295Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF154121 mRNA. Translation: AAF73251.1. Frameshift.
    AY072810 mRNA. Translation: AAL66762.1.
    AK056713 mRNA. Translation: BAB71262.1.
    AK096658 mRNA. Translation: BAC04834.1.
    AK295748 mRNA. Translation: BAG58580.1.
    AL133520 Genomic DNA. No translation available.
    AL034424 Genomic DNA. No translation available.
    CH471077 Genomic DNA. Translation: EAW75725.1.
    CH471077 Genomic DNA. Translation: EAW75726.1.
    BC035966 mRNA. Translation: AAH35966.1.
    AL442082 mRNA. Translation: CAC09447.2. Sequence problems.
    CCDSiCCDS13400.1. [Q8WWT9-1]
    CCDS42886.1. [Q8WWT9-6]
    CCDS54469.1. [Q8WWT9-3]
    CCDS54470.1. [Q8WWT9-5]
    RefSeqiNP_001011554.1. NM_001011554.2. [Q8WWT9-6]
    NP_001180268.1. NM_001193339.1. [Q8WWT9-5]
    NP_001180269.1. NM_001193340.1. [Q8WWT9-3]
    NP_073740.2. NM_022829.5. [Q8WWT9-1]
    UniGeneiHs.655498.
    Hs.670365.

    Genome annotation databases

    EnsembliENST00000279027; ENSP00000279027; ENSG00000158296. [Q8WWT9-1]
    ENST00000290317; ENSP00000290317; ENSG00000158296. [Q8WWT9-6]
    ENST00000372121; ENSP00000361193; ENSG00000158296. [Q8WWT9-4]
    ENST00000413164; ENSP00000415852; ENSG00000158296. [Q8WWT9-5]
    ENST00000472148; ENSP00000420177; ENSG00000158296. [Q8WWT9-3]
    ENST00000495082; ENSP00000419621; ENSG00000158296. [Q8WWT9-6]
    GeneIDi64849.
    KEGGihsa:64849.
    UCSCiuc002xsf.2. human. [Q8WWT9-1]
    uc010gho.2. human. [Q8WWT9-3]
    uc010zxw.2. human. [Q8WWT9-5]

    Polymorphism databases

    DMDMi23396845.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF154121 mRNA. Translation: AAF73251.1 . Frameshift.
    AY072810 mRNA. Translation: AAL66762.1 .
    AK056713 mRNA. Translation: BAB71262.1 .
    AK096658 mRNA. Translation: BAC04834.1 .
    AK295748 mRNA. Translation: BAG58580.1 .
    AL133520 Genomic DNA. No translation available.
    AL034424 Genomic DNA. No translation available.
    CH471077 Genomic DNA. Translation: EAW75725.1 .
    CH471077 Genomic DNA. Translation: EAW75726.1 .
    BC035966 mRNA. Translation: AAH35966.1 .
    AL442082 mRNA. Translation: CAC09447.2 . Sequence problems.
    CCDSi CCDS13400.1. [Q8WWT9-1 ]
    CCDS42886.1. [Q8WWT9-6 ]
    CCDS54469.1. [Q8WWT9-3 ]
    CCDS54470.1. [Q8WWT9-5 ]
    RefSeqi NP_001011554.1. NM_001011554.2. [Q8WWT9-6 ]
    NP_001180268.1. NM_001193339.1. [Q8WWT9-5 ]
    NP_001180269.1. NM_001193340.1. [Q8WWT9-3 ]
    NP_073740.2. NM_022829.5. [Q8WWT9-1 ]
    UniGenei Hs.655498.
    Hs.670365.

    3D structure databases

    ProteinModelPortali Q8WWT9.
    SMRi Q8WWT9. Positions 15-162, 418-566.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    DrugBanki DB00139. Succinic acid.

    Protein family/group databases

    TCDBi 2.A.47.1.15. the divalent anion:na(+) symporter (dass) family.

    PTM databases

    PhosphoSitei Q8WWT9.

    Polymorphism databases

    DMDMi 23396845.

    Proteomic databases

    MaxQBi Q8WWT9.
    PaxDbi Q8WWT9.
    PRIDEi Q8WWT9.

    Protocols and materials databases

    DNASUi 64849.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000279027 ; ENSP00000279027 ; ENSG00000158296 . [Q8WWT9-1 ]
    ENST00000290317 ; ENSP00000290317 ; ENSG00000158296 . [Q8WWT9-6 ]
    ENST00000372121 ; ENSP00000361193 ; ENSG00000158296 . [Q8WWT9-4 ]
    ENST00000413164 ; ENSP00000415852 ; ENSG00000158296 . [Q8WWT9-5 ]
    ENST00000472148 ; ENSP00000420177 ; ENSG00000158296 . [Q8WWT9-3 ]
    ENST00000495082 ; ENSP00000419621 ; ENSG00000158296 . [Q8WWT9-6 ]
    GeneIDi 64849.
    KEGGi hsa:64849.
    UCSCi uc002xsf.2. human. [Q8WWT9-1 ]
    uc010gho.2. human. [Q8WWT9-3 ]
    uc010zxw.2. human. [Q8WWT9-5 ]

    Organism-specific databases

    CTDi 64849.
    GeneCardsi GC20M045186.
    HGNCi HGNC:14430. SLC13A3.
    HPAi HPA014353.
    HPA014736.
    MIMi 606411. gene.
    neXtProti NX_Q8WWT9.
    PharmGKBi PA37881.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0471.
    HOVERGENi HBG055339.
    InParanoidi Q8WWT9.
    KOi K14445.
    OMAi WWVTEAI.
    OrthoDBi EOG7G1V5S.
    PhylomeDBi Q8WWT9.
    TreeFami TF312913.

    Enzyme and pathway databases

    Reactomei REACT_20646. Sodium-coupled sulphate, di- and tri-carboxylate transporters.

    Miscellaneous databases

    GeneWikii SLC13A3.
    GenomeRNAii 64849.
    NextBioi 66966.
    PROi Q8WWT9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8WWT9.
    Bgeei Q8WWT9.
    Genevestigatori Q8WWT9.

    Family and domain databases

    InterProi IPR001898. Na/sul_symport.
    [Graphical view ]
    Pfami PF00939. Na_sulph_symp. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure, function, and genomic organization of human Na(+)-dependent high-affinity dicarboxylate transporter."
      Wang H., Fei Y.-J., Kekuda R., Yang-Feng T.L., Devoe L.D., Leibach F.H., Prasad P.D., Ganapathy V.
      Am. J. Physiol. 278:C1019-C1030(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Placenta.
    2. "Cloning and characterization of energy metabolism-related sodium-dependent high-affinity dicarboxylate transporter gene from human kidney."
      Bai X.-Y., Chen X.-M., Qiu Q.
      Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Kidney.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 5).
      Tissue: Brain, Hippocampus and Placenta.
    4. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Kidney.
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 433-602 (ISOFORM 1).
      Tissue: Brain.
    8. "Membrane topology structure of human high-affinity, sodium-dependent dicarboxylate transporter."
      Bai X.Y., Chen X., Sun A.Q., Feng Z., Hou K., Fu B.
      FASEB J. 21:2409-2417(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, MEMBRANE TOPOLOGY.

    Entry informationi

    Entry nameiS13A3_HUMAN
    AccessioniPrimary (citable) accession number: Q8WWT9
    Secondary accession number(s): B4DIR8
    , E1P5U4, F6WI18, Q5JYC9, Q5JYD0, Q5JYD1, Q5TCQ2, Q8IVB1, Q8N8K4, Q96MM5, Q9BR25, Q9H1G1, Q9H3W4, Q9NQN5, Q9NS04
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2002
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 125 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3