Q8WWT9 (S13A3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Solute carrier family 13 member 3

Alternative name(s):
Na(+)/dicarboxylate cotransporter 3
Short name=NaDC-3
Short name=hNaDC3
Sodium-dependent high-affinity dicarboxylate transporter 2

Gene names

Name:	SLC13A3
Synonyms:	NADC3, SDCT2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	602 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	High-affinity sodium-dicarboxylate cotransporter that accepts a range of substrates with 4-5 carbon atoms. The stoichiometry is probably 3 Na+ for 1 divalent succinate.
Subcellular location	Cell membrane; Multi-pass membrane protein Ref.8.
Tissue specificity	Expression is highest in kidney. Detected in placenta, brain, liver and pancreas.
Sequence similarities	Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily. [View classification]
Sequence caution	The sequence AAF73251.1 differs from that shown. Reason: Frameshift at positions 188 and 199. The sequence CAC09447.2 differs from that shown. Reason: Erroneous initiation. The sequence CAI42505.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI42506.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI42507.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Ion transport Sodium transport Symport Transport
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing
Domain	Transmembrane Transmembrane helix
Ligand	Sodium
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	transmembrane transport Traceable author statement. Source: Reactome
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome
Molecular_function	high affinity sodium:dicarboxylate symporter activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8WWT9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8WWT9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     181-297: AAVRRNGLHT...LFLLAGWLWI → GIEPNTFLSE...RVLSFLPGGM
     298-602: Missing.

Note: Gene prediction based on EST data.

Isoform 3 (identifier: Q8WWT9-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-47: Missing.
     340-374: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q8WWT9-4)

The sequence of this isoform differs from the canonical sequence as follows:
     182-292: AVRRNGLHTV...FPLMLLFLLA → KTTLGRQRFH...LTSSCLASSR
     375-388: FLSDAVTGVAIVTI → CKMGIISISTIQKM
     389-602: Missing.

Note: Gene prediction based on EST data. No experimental confirmation available.

Isoform 5 (identifier: Q8WWT9-5)

The sequence of this isoform differs from the canonical sequence as follows:
     182-292: AVRRNGLHTV...FPLMLLFLLA → KTTLGRQRFH...LTSSCLASSR

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 602	602	Solute carrier family 13 member 3		PRO_0000172492
Regions
	Topological domain	1 – 16	16	Cytoplasmic Potential
	Transmembrane	17 – 37	21	Helical; Potential
	Topological domain	38 – 55	18	Extracellular Potential
	Transmembrane	56 – 76	21	Helical; Potential
	Topological domain	77 – 82	6	Cytoplasmic Potential
	Transmembrane	83 – 103	21	Helical; Potential
	Topological domain	104 – 137	34	Extracellular Potential
	Transmembrane	138 – 158	21	Helical; Potential
	Topological domain	159 – 229	71	Cytoplasmic Potential
	Transmembrane	230 – 250	21	Helical; Potential
	Topological domain	251 – 278	28	Extracellular Potential
	Transmembrane	279 – 299	21	Helical; Potential
	Topological domain	300 – 336	37	Cytoplasmic Potential
	Transmembrane	337 – 357	21	Helical; Potential
	Topological domain	358 – 372	15	Extracellular Potential
	Transmembrane	373 – 393	21	Helical; Potential
	Topological domain	394 – 422	29	Cytoplasmic Potential
	Intramembrane	423 – 443	21	Helical; Potential
	Topological domain	444 – 461	18	Cytoplasmic Potential
	Transmembrane	462 – 482	21	Helical; Potential
	Topological domain	483 – 505	23	Extracellular Potential
	Transmembrane	506 – 526	21	Helical; Potential
	Topological domain	527 – 546	20	Cytoplasmic Potential
	Transmembrane	547 – 567	21	Helical; Potential
	Topological domain	568 – 602	35	Extracellular Potential
Amino acid modifications
	Glycosylation	586	1	N-linked (GlcNAc...) Potential
	Glycosylation	596	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	1 – 47	47	Missing in isoform 3.		VSP_015291
	Alternative sequence	181 – 297	117	AAVRR…GWLWI → GIEPNTFLSEERLKLQAPLV IRLGQITESGQWNMSGNDVC NFRVLSFLPGGM in isoform 2.		VSP_006123
	Alternative sequence	182 – 292	111	AVRRN…LFLLA → KTTLGRQRFHWICRLTPGRR MNIVGTSGRASSSPSPTQPV LGAQPHSRAQPLTSSCLASS R in isoform 4 and isoform 5.		VSP_015292
	Alternative sequence	298 – 602	305	Missing in isoform 2.		VSP_006124
	Alternative sequence	340 – 374	35	Missing in isoform 3.		VSP_015293
	Alternative sequence	375 – 388	14	FLSDA…AIVTI → CKMGIISISTIQKM in isoform 4.		VSP_015294
	Alternative sequence	389 – 602	214	Missing in isoform 4.		VSP_015295
Experimental info
	Sequence conflict	94	1	L → P in BAC04834. Ref.3
	Sequence conflict	364	1	I → V in AAH35966. Ref.6
	Sequence conflict	572	1	Q → P in BAB71262. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 611A50994BA37687	FASTA	602	66,841
	10 20 30 40 50 60 MAALAAAAKK VWSARRLLVL LFTPLALLPV VFALPPKEGR CLFVILLMAV YWCTEALPLS 70 80 90 100 110 120 VTALLPIVLF PFMGILPSNK VCPQYFLDTN FLFLSGLIMA SAIEEWNLHR RIALKILMLV 130 140 150 160 170 180 GVQPARLILG MMVTTSFLSM WLSNTASTAM MLPIANAILK SLFGQKEVRK DPSQESEENT 190 200 210 220 230 240 AAVRRNGLHT VPTEMQFLAS TEAKDHPGET EVPLDLPADS RKEDEYRRNI WKGFLISIPY 250 260 270 280 290 300 SASIGGTATL TGTAPNLILL GQLKSFFPQC DVVNFGSWFI FAFPLMLLFL LAGWLWISFL 310 320 330 340 350 360 YGGLSFRGWR KNKSEIRTNA EDRARAVIRE EYQNLGPIKF AEQAVFILFC MFAILLFTRD 370 380 390 400 410 420 PKFIPGWASL FNPGFLSDAV TGVAIVTILF FFPSQRPSLK WWFDFKAPNT ETEPLLTWKK 430 440 450 460 470 480 AQETVPWNII LLLGGGFAMA KGCEESGLSV WIGGQLHPLE NVPPALAVLL ITVVIAFFTE 490 500 510 520 530 540 FASNTATIII FLPVLAELAI RLRVHPLYLM IPGTVGCSFA FMLPVSTPPN SIAFASGHLL 550 560 570 580 590 600 VKDMVRTGLL MNLMGVLLLS LAMNTWAQTI FQLGTFPDWA DMYSVNVTAL PPTLANDTFR TL
	Isoform 2 [UniParc]. Checksum: 7EEDA215B050ABEB	FASTA	232	25,684
	10 20 30 40 50 60 MAALAAAAKK VWSARRLLVL LFTPLALLPV VFALPPKEGR CLFVILLMAV YWCTEALPLS 70 80 90 100 110 120 VTALLPIVLF PFMGILPSNK VCPQYFLDTN FLFLSGLIMA SAIEEWNLHR RIALKILMLV 130 140 150 160 170 180 GVQPARLILG MMVTTSFLSM WLSNTASTAM MLPIANAILK SLFGQKEVRK DPSQESEENT 190 200 210 220 230 GIEPNTFLSE ERLKLQAPLV IRLGQITESG QWNMSGNDVC NFRVLSFLPG GM
	Isoform 3 [UniParc]. Checksum: D9CB6E6BE1A5C936	FASTA	520	57,766
	10 20 30 40 50 60 MAVYWCTEAL PLSVTALLPI VLFPFMGILP SNKVCPQYFL DTNFLFLSGL IMASAIEEWN 70 80 90 100 110 120 LHRRIALKIL MLVGVQPARL ILGMMVTTSF LSMWLSNTAS TAMMLPIANA ILKSLFGQKE 130 140 150 160 170 180 VRKDPSQESE ENTAAVRRNG LHTVPTEMQF LASTEAKDHP GETEVPLDLP ADSRKEDEYR 190 200 210 220 230 240 RNIWKGFLIS IPYSASIGGT ATLTGTAPNL ILLGQLKSFF PQCDVVNFGS WFIFAFPLML 250 260 270 280 290 300 LFLLAGWLWI SFLYGGLSFR GWRKNKSEIR TNAEDRARAV IREEYQNLGP IKFLSDAVTG 310 320 330 340 350 360 VAIVTILFFF PSQRPSLKWW FDFKAPNTET EPLLTWKKAQ ETVPWNIILL LGGGFAMAKG 370 380 390 400 410 420 CEESGLSVWI GGQLHPLENV PPALAVLLIT VVIAFFTEFA SNTATIIIFL PVLAELAIRL 430 440 450 460 470 480 RVHPLYLMIP GTVGCSFAFM LPVSTPPNSI AFASGHLLVK DMVRTGLLMN LMGVLLLSLA 490 500 510 520 MNTWAQTIFQ LGTFPDWADM YSVNVTALPP TLANDTFRTL
	Isoform 4 [UniParc]. Checksum: 022516BECC8D3961	FASTA	338	37,669
	10 20 30 40 50 60 MAALAAAAKK VWSARRLLVL LFTPLALLPV VFALPPKEGR CLFVILLMAV YWCTEALPLS 70 80 90 100 110 120 VTALLPIVLF PFMGILPSNK VCPQYFLDTN FLFLSGLIMA SAIEEWNLHR RIALKILMLV 130 140 150 160 170 180 GVQPARLILG MMVTTSFLSM WLSNTASTAM MLPIANAILK SLFGQKEVRK DPSQESEENT 190 200 210 220 230 240 AKTTLGRQRF HWICRLTPGR RMNIVGTSGR ASSSPSPTQP VLGAQPHSRA QPLTSSCLAS 250 260 270 280 290 300 SRGWLWISFL YGGLSFRGWR KNKSEIRTNA EDRARAVIRE EYQNLGPIKF AEQAVFILFC 310 320 330 MFAILLFTRD PKFIPGWASL FNPGCKMGII SISTIQKM
	Isoform 5 [UniParc]. Checksum: EF5734E90BBE2167	FASTA	552	61,099
	10 20 30 40 50 60 MAALAAAAKK VWSARRLLVL LFTPLALLPV VFALPPKEGR CLFVILLMAV YWCTEALPLS 70 80 90 100 110 120 VTALLPIVLF PFMGILPSNK VCPQYFLDTN FLFLSGLIMA SAIEEWNLHR RIALKILMLV 130 140 150 160 170 180 GVQPARLILG MMVTTSFLSM WLSNTASTAM MLPIANAILK SLFGQKEVRK DPSQESEENT 190 200 210 220 230 240 AKTTLGRQRF HWICRLTPGR RMNIVGTSGR ASSSPSPTQP VLGAQPHSRA QPLTSSCLAS 250 260 270 280 290 300 SRGWLWISFL YGGLSFRGWR KNKSEIRTNA EDRARAVIRE EYQNLGPIKF AEQAVFILFC 310 320 330 340 350 360 MFAILLFTRD PKFIPGWASL FNPGFLSDAV TGVAIVTILF FFPSQRPSLK WWFDFKAPNT 370 380 390 400 410 420 ETEPLLTWKK AQETVPWNII LLLGGGFAMA KGCEESGLSV WIGGQLHPLE NVPPALAVLL 430 440 450 460 470 480 ITVVIAFFTE FASNTATIII FLPVLAELAI RLRVHPLYLM IPGTVGCSFA FMLPVSTPPN 490 500 510 520 530 540 SIAFASGHLL VKDMVRTGLL MNLMGVLLLS LAMNTWAQTI FQLGTFPDWA DMYSVNVTAL 550 PPTLANDTFR TL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Structure, function, and genomic organization of human Na(+)-dependent high-affinity dicarboxylate transporter." Wang H., Fei Y.-J., Kekuda R., Yang-Feng T.L., Devoe L.D., Leibach F.H., Prasad P.D., Ganapathy V. Am. J. Physiol. 278:C1019-C1030(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Placenta.
[2]	"Cloning and characterization of energy metabolism-related sodium-dependent high-affinity dicarboxylate transporter gene from human kidney." Bai X.-Y., Chen X.-M., Qiu Q. Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Kidney.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 5). Tissue: Brain, Hippocampus and Placenta.
[4]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Kidney.
[7]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 433-602 (ISOFORM 1). Tissue: Brain.
[8]	"Membrane topology structure of human high-affinity, sodium-dependent dicarboxylate transporter." Bai X.Y., Chen X., Sun A.Q., Feng Z., Hou K., Fu B. FASEB J. 21:2409-2417(2007) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, MEMBRANE TOPOLOGY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF154121 mRNA. Translation: AAF73251.1. Frameshift. AY072810 mRNA. Translation: AAL66762.1. AK056713 mRNA. Translation: BAB71262.1. AK096658 mRNA. Translation: BAC04834.1. AK295748 mRNA. Translation: BAG58580.1. AL133520, AL034424 Genomic DNA. Translation: CAI18891.1. AL034424, AL133520 Genomic DNA. Translation: CAI42503.1. AL034424 Genomic DNA. Translation: CAI42505.1. Sequence problems. AL034424 Genomic DNA. Translation: CAI42506.1. Sequence problems. AL034424 Genomic DNA. Translation: CAI42507.1. Sequence problems. CH471077 Genomic DNA. Translation: EAW75725.1. CH471077 Genomic DNA. Translation: EAW75726.1. BC035966 mRNA. Translation: AAH35966.1. AL442082 mRNA. Translation: CAC09447.2. Different initiation.
IPI	IPI00103426. IPI00219247. IPI00552487. IPI00747380. IPI00940566.
RefSeq	NP_001011554.1. NM_001011554.2. NP_001180268.1. NM_001193339.1. NP_001180269.1. NM_001193340.1. NP_073740.2. NM_022829.5.
UniGene	Hs.655498.
3D structure databases
ProteinModelPortal	Q8WWT9.
ModBase	Search...
PTM databases
PhosphoSite	Q8WWT9.
Polymorphism databases
DMDM	23396845.
Proteomic databases
PaxDb	Q8WWT9.
PRIDE	Q8WWT9.
Protocols and materials databases
DNASU	64849.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000279027; ENSP00000279027; ENSG00000158296. ENST00000339636; ENSP00000344912; ENSG00000158296. ENST00000372121; ENSP00000361193; ENSG00000158296. ENST00000396360; ENSP00000379648; ENSG00000158296. ENST00000413164; ENSP00000415852; ENSG00000158296. ENST00000420568; ENSP00000395095; ENSG00000158296. ENST00000472148; ENSP00000420177; ENSG00000158296.
GeneID	64849.
KEGG	hsa:64849.
UCSC	uc002xsf.2. human. uc010gho.2. human.
Organism-specific databases
CTD	64849.
GeneCards	GC20M045186.
HGNC	HGNC:14430. SLC13A3.
HPA	HPA014353. HPA014736.
MIM	606411. gene.
neXtProt	NX_Q8WWT9.
PharmGKB	PA37881.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0471.
HOVERGEN	HBG055339.
InParanoid	Q8WWT9.
KO	K14445.
OMA	RKTYVFV.
OrthoDB	EOG45756D.
PhylomeDB	Q8WWT9.
Enzyme and pathway databases
Reactome	REACT_15518. Transmembrane transport of small molecules. REACT_20633. Bile salt and organic anion SLC transporters.
Gene expression databases
ArrayExpress	Q8WWT9.
Bgee	Q8WWT9.
Genevestigator	Q8WWT9.
GermOnline	ENSG00000158296. Homo sapiens.
Family and domain databases
InterPro	IPR001898. Na/sul_symport. [Graphical view]
Pfam	PF00939. Na_sulph_symp. 1 hit. [Graphical view]
ProtoNet	Search...
Other
DrugBank	DB00139. Succinic acid.
GenomeRNAi	64849.
NextBio	66966.
SOURCE	Search...

Entry information

Entry name

S13A3_HUMAN

Accession

Primary (citable) accession number: Q8WWT9
Secondary accession number(s): B4DIR8 , E1P5U4, Q5JYC9, Q5JYD0, Q5JYD1, Q5TCQ2, Q8IVB1, Q8N8K4, Q96MM5, Q9BR25, Q9H1G1, Q9H3W4, Q9NQN5, Q9NS04

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 19, 2002
Last sequence update:	March 1, 2002
Last modified:	April 3, 2013
This is version 109 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.