Reviewed, UniProtKB/Swiss-Prot Q8WWR9 (PDPFL_HUMAN)

Names and origin

Protein names

Recommended name:
    Pancreatic progenitor cell differentiation and proliferation factor-like protein
Alternative name(s):
    Exocrine differentiation and proliferation factor-like protein

Gene names

Name:

C8orf22

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	84 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Sequence similarities

Belongs to the PPDPF family.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Technical term	Complete proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8WWR9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: No experimental confirmation available.

Isoform 2 (identifier: Q8WWR9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     79-84: SLSGRS → MNS

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 84	84	Pancreatic progenitor cell differentiation and proliferation factor-like protein		PRO_0000228102
Natural variations
	Alternative sequence	79 – 84	6	SLSGRS → MNS in isoform 2.		VSP_017651

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 9D325334C3C3FC69	FASTA	84	9,188
	10 20 30 40 50 60 MASVPSIGCL LARNQYYRKS SVSSVSSLTS SDSVNFIDDD KPQQGLPEVA ESTWWFKSFF 70 80 HSEPVLSNVR IKDLSATGSL SGRS
	Isoform 2. Checksum: 54C0B0DC69A46945	FASTA	81	8,933
	10 20 30 40 50 60 MASVPSIGCL LARNQYYRKS SVSSVSSLTS SDSVNFIDDD KPQQGLPEVA ESTWWFKSFF 70 80 HSEPVLSNVR IKDLSATGMN S

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Full-length sequencing of 100 cDNA clones from human adult skeletal muscle." Stanchi F., Lanfranchi G. Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Skeletal muscle.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Skeletal muscle.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ276240 mRNA. Translation: CAC81690.1. BC017981 mRNA. Translation: AAH17981.1.
IPI	IPI00383113. IPI00740107.
RefSeq	NP_001007177.1.
UniGene	Hs.49890
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENST00000303202; ENSP00000304926; ENSG00000168333; Homo sapiens. [Genome view]
GeneID	492307.
KEGG	hsa:492307.
UCSC	uc003xqq.2. human.
Organism-specific databases
CTD	492307.
GeneCards	GC08P050148.
HGNC	HGNC:31745. C8orf22.
PharmGKB	PA134881233.
GenAtlas	Search...
Phylogenomic databases
OMA	YRKASIS
Gene expression databases
ArrayExpress	Q8WWR9.
Bgee	Q8WWR9.
CleanEx	HS_C8orf22.
Genevestigator	Q8WWR9.
GermOnline	ENSG00000168333. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other Resources
NextBio	111726.

Entry information

Entry name

PDPFL_HUMAN

Accession

Primary (citable) accession number: Q8WWR9
Secondary accession number(s): Q8WVI1

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 21, 2006
Last sequence update:	March 1, 2002
Last modified:	November 24, 2009
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.