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Q8WWR8

- NEUR4_HUMAN

UniProt

Q8WWR8 - NEUR4_HUMAN

Protein

Sialidase-4

Gene

NEU4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 3 (07 Mar 2006)
      Previous versions | rss
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    Functioni

    May function in lysosomal catabolism of sialylated glycoconjugates. Has sialidase activity towards synthetic substrates, such as 2'-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid (4-MU-NANA or 4MU-NeuAc). Has a broad substrate specificity being active on glycoproteins, oligosaccharides and sialylated glycolipids.2 Publications

    Catalytic activityi

    Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.1 Publication

    pH dependencei

    Optimum pH is 3.2.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei23 – 231SubstrateBy similarity
    Binding sitei43 – 431SubstrateBy similarity
    Active sitei47 – 471Proton acceptorBy similarity
    Active sitei48 – 481Proton acceptorBy similarity
    Binding sitei177 – 1771SubstrateBy similarity
    Binding sitei179 – 1791SubstrateBy similarity
    Binding sitei222 – 2221SubstrateBy similarity
    Binding sitei242 – 2421SubstrateBy similarity
    Binding sitei389 – 3891SubstrateBy similarity
    Active sitei419 – 4191NucleophileBy similarity
    Active sitei440 – 4401Sequence Analysis

    GO - Molecular functioni

    1. exo-alpha-(2->3)-sialidase activity Source: UniProtKB-EC
    2. exo-alpha-(2->6)-sialidase activity Source: UniProtKB-EC
    3. exo-alpha-(2->8)-sialidase activity Source: UniProtKB-EC
    4. exo-alpha-sialidase activity Source: UniProtKB
    5. protein binding Source: IntAct

    GO - Biological processi

    1. ganglioside catabolic process Source: UniProtKB
    2. glycoprotein catabolic process Source: UniProtKB
    3. glycosphingolipid metabolic process Source: Reactome
    4. oligosaccharide catabolic process Source: UniProtKB
    5. small molecule metabolic process Source: Reactome
    6. sphingolipid metabolic process Source: Reactome

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    Carbohydrate metabolism, Lipid degradation, Lipid metabolism

    Enzyme and pathway databases

    BRENDAi3.2.1.18. 2681.
    ReactomeiREACT_116105. Glycosphingolipid metabolism.
    REACT_200874. Sialic acid metabolism.
    SABIO-RKQ8WWR8.

    Protein family/group databases

    CAZyiGH33. Glycoside Hydrolase Family 33.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sialidase-4 (EC:3.2.1.18)
    Alternative name(s):
    N-acetyl-alpha-neuraminidase 4
    Gene namesi
    Name:NEU4
    ORF Names:LP5125
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:21328. NEU4.

    Subcellular locationi

    Isoform 2 : Lysosome lumen
    Note: According to PubMed:15213228, isoform 2 is soluble, N-glycosylated and found in the lumen of lysosomes. However, no signal sequence nor N-glycosylation site is predicted from the sequence.

    GO - Cellular componenti

    1. lysosomal lumen Source: Reactome
    2. lysosome Source: UniProtKB
    3. mitochondrion Source: Ensembl
    4. organelle inner membrane Source: UniProtKB

    Keywords - Cellular componenti

    Lysosome, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134917116.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 484484Sialidase-4PRO_0000208906Add
    BLAST

    Post-translational modificationi

    According to PubMed:15213228, phosphorylation of mannose residues may ensure efficient transport of isoform 2 to the lysosomes via the mannose 6-phosphate receptor.
    Isoform 2 is glycosylated.1 Publication

    Proteomic databases

    PaxDbiQ8WWR8.
    PRIDEiQ8WWR8.

    PTM databases

    PhosphoSiteiQ8WWR8.

    Expressioni

    Tissue specificityi

    Ubiquitous with higher expression in heart, skeletal muscle, liver and placenta.1 Publication

    Inductioni

    Down-regulated during monocyte to macrophage differentiation.1 Publication

    Gene expression databases

    ArrayExpressiQ8WWR8.
    BgeeiQ8WWR8.
    CleanExiHS_NEU4.
    GenevestigatoriQ8WWR8.

    Organism-specific databases

    HPAiHPA037394.
    HPA037395.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    MDFIQ997504EBI-746964,EBI-724076
    PLSCR1O151622EBI-746964,EBI-740019

    Protein-protein interaction databases

    BioGridi126209. 5 interactions.
    IntActiQ8WWR8. 5 interactions.
    MINTiMINT-1447950.
    STRINGi9606.ENSP00000385149.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8WWR8.
    SMRiQ8WWR8. Positions 22-344, 371-461.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati127 – 13812BNR 1Add
    BLAST
    Repeati200 – 21112BNR 2Add
    BLAST
    Repeati251 – 26212BNR 3Add
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi22 – 254FRIP motif

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi284 – 37592Pro-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 33 family.Curated
    Contains 3 BNR repeats.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG84455.
    HOGENOMiHOG000233778.
    HOVERGENiHBG052608.
    InParanoidiQ8WWR8.
    KOiK12357.
    OMAiMNPCPVL.
    OrthoDBiEOG7MSMNP.
    PhylomeDBiQ8WWR8.
    TreeFamiTF331063.

    Family and domain databases

    Gene3Di2.120.10.10. 2 hits.
    InterProiIPR026946. Sialidase-4.
    IPR026856. Sialidase_fam.
    IPR011040. Sialidases.
    [Graphical view]
    PANTHERiPTHR10628. PTHR10628. 1 hit.
    PTHR10628:SF8. PTHR10628:SF8. 1 hit.
    SUPFAMiSSF50939. SSF50939. 2 hits.

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8WWR8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGVPRTPSRT VLFERERTGL TYRVPSLLPV PPGPTLLAFV EQRLSPDDSH    50
    AHRLVLRRGT LAGGSVRWGA LHVLGTAALA EHRSMNPCPV HDAGTGTVFL 100
    FFIAVLGHTP EAVQIATGRN AARLCCVASR DAGLSWGSAR DLTEEAIGGA 150
    VQDWATFAVG PGHGVQLPSG RLLVPAYTYR VDRRECFGKI CRTSPHSFAF 200
    YSDDHGRTWR CGGLVPNLRS GECQLAAVDG GQAGSFLYCN ARSPLGSRVQ 250
    ALSTDEGTSF LPAERVASLP ETAWGCQGSI VGFPAPAPNR PRDDSWSVGP 300
    GSPLQPPLLG PGVHEPPEEA AVDPRGGQVP GGPFSRLQPR GDGPRQPGPR 350
    PGVSGDVGSW TLALPMPFAA PPQSPTWLLY SHPVGRRARL HMGIRLSQSP 400
    LDPRSWTEPW VIYEGPSGYS DLASIGPAPE GGLVFACLYE SGARTSYDEI 450
    SFCTFSLREV LENVPASPKP PNLGDKPRGC CWPS 484
    Length:484
    Mass (Da):51,572
    Last modified:March 7, 2006 - v3
    Checksum:i14A878C2A9F18863
    GO
    Isoform 2 (identifier: Q8WWR8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MMSSAAFPRWLSM

    Show »
    Length:496
    Mass (Da):52,938
    Checksum:i1DE1395862011A36
    GO
    Isoform 3 (identifier: Q8WWR8-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MMSSAAFPRWLQSM

    Note: Gene prediction based on EST data.

    Show »
    Length:497
    Mass (Da):53,066
    Checksum:iC933EFAEC7383F69
    GO

    Sequence cautioni

    The sequence AAP34475.1 differs from that shown. Reason: Frameshift at position 291.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti184 – 1841R → L in CAC81904. (PubMed:14962670)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti301 – 3011G → R.3 Publications
    Corresponds to variant rs11545301 [ dbSNP | Ensembl ].
    VAR_067458

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 11M → MMSSAAFPRWLSM in isoform 2. 1 PublicationVSP_037491
    Alternative sequencei1 – 11M → MMSSAAFPRWLQSM in isoform 3. CuratedVSP_047123

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ277883 mRNA. Translation: CAC81904.1.
    AK289421 mRNA. Translation: BAF82110.1.
    AY203952 mRNA. Translation: AAP34475.1. Frameshift.
    AC114730 Genomic DNA. Translation: AAX82022.1.
    CH471063 Genomic DNA. Translation: EAW71296.1.
    BC012899 mRNA. Translation: AAH12899.2.
    CCDSiCCDS2553.1. [Q8WWR8-2]
    CCDS54441.1. [Q8WWR8-3]
    CCDS54442.1. [Q8WWR8-1]
    RefSeqiNP_001161071.1. NM_001167599.2. [Q8WWR8-3]
    NP_001161072.1. NM_001167600.2. [Q8WWR8-1]
    NP_001161073.1. NM_001167601.2. [Q8WWR8-1]
    NP_001161074.1. NM_001167602.2. [Q8WWR8-1]
    NP_542779.2. NM_080741.3. [Q8WWR8-2]
    UniGeneiHs.551747.

    Genome annotation databases

    EnsembliENST00000325935; ENSP00000320318; ENSG00000204099. [Q8WWR8-3]
    ENST00000391969; ENSP00000375830; ENSG00000204099. [Q8WWR8-1]
    ENST00000404257; ENSP00000385149; ENSG00000204099. [Q8WWR8-2]
    ENST00000405370; ENSP00000384804; ENSG00000204099. [Q8WWR8-1]
    ENST00000407683; ENSP00000385402; ENSG00000204099. [Q8WWR8-1]
    GeneIDi129807.
    KEGGihsa:129807.
    UCSCiuc002wcm.3. human. [Q8WWR8-1]
    uc002wcn.2. human. [Q8WWR8-2]
    uc002wcp.2. human.

    Polymorphism databases

    DMDMi90110434.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ277883 mRNA. Translation: CAC81904.1 .
    AK289421 mRNA. Translation: BAF82110.1 .
    AY203952 mRNA. Translation: AAP34475.1 . Frameshift.
    AC114730 Genomic DNA. Translation: AAX82022.1 .
    CH471063 Genomic DNA. Translation: EAW71296.1 .
    BC012899 mRNA. Translation: AAH12899.2 .
    CCDSi CCDS2553.1. [Q8WWR8-2 ]
    CCDS54441.1. [Q8WWR8-3 ]
    CCDS54442.1. [Q8WWR8-1 ]
    RefSeqi NP_001161071.1. NM_001167599.2. [Q8WWR8-3 ]
    NP_001161072.1. NM_001167600.2. [Q8WWR8-1 ]
    NP_001161073.1. NM_001167601.2. [Q8WWR8-1 ]
    NP_001161074.1. NM_001167602.2. [Q8WWR8-1 ]
    NP_542779.2. NM_080741.3. [Q8WWR8-2 ]
    UniGenei Hs.551747.

    3D structure databases

    ProteinModelPortali Q8WWR8.
    SMRi Q8WWR8. Positions 22-344, 371-461.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 126209. 5 interactions.
    IntActi Q8WWR8. 5 interactions.
    MINTi MINT-1447950.
    STRINGi 9606.ENSP00000385149.

    Chemistry

    BindingDBi Q8WWR8.
    ChEMBLi CHEMBL4174.

    Protein family/group databases

    CAZyi GH33. Glycoside Hydrolase Family 33.

    PTM databases

    PhosphoSitei Q8WWR8.

    Polymorphism databases

    DMDMi 90110434.

    Proteomic databases

    PaxDbi Q8WWR8.
    PRIDEi Q8WWR8.

    Protocols and materials databases

    DNASUi 129807.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000325935 ; ENSP00000320318 ; ENSG00000204099 . [Q8WWR8-3 ]
    ENST00000391969 ; ENSP00000375830 ; ENSG00000204099 . [Q8WWR8-1 ]
    ENST00000404257 ; ENSP00000385149 ; ENSG00000204099 . [Q8WWR8-2 ]
    ENST00000405370 ; ENSP00000384804 ; ENSG00000204099 . [Q8WWR8-1 ]
    ENST00000407683 ; ENSP00000385402 ; ENSG00000204099 . [Q8WWR8-1 ]
    GeneIDi 129807.
    KEGGi hsa:129807.
    UCSCi uc002wcm.3. human. [Q8WWR8-1 ]
    uc002wcn.2. human. [Q8WWR8-2 ]
    uc002wcp.2. human.

    Organism-specific databases

    CTDi 129807.
    GeneCardsi GC02P242770.
    HGNCi HGNC:21328. NEU4.
    HPAi HPA037394.
    HPA037395.
    MIMi 608527. gene.
    neXtProti NX_Q8WWR8.
    PharmGKBi PA134917116.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG84455.
    HOGENOMi HOG000233778.
    HOVERGENi HBG052608.
    InParanoidi Q8WWR8.
    KOi K12357.
    OMAi MNPCPVL.
    OrthoDBi EOG7MSMNP.
    PhylomeDBi Q8WWR8.
    TreeFami TF331063.

    Enzyme and pathway databases

    BRENDAi 3.2.1.18. 2681.
    Reactomei REACT_116105. Glycosphingolipid metabolism.
    REACT_200874. Sialic acid metabolism.
    SABIO-RK Q8WWR8.

    Miscellaneous databases

    GeneWikii NEU4.
    GenomeRNAii 129807.
    NextBioi 35534929.
    PROi Q8WWR8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8WWR8.
    Bgeei Q8WWR8.
    CleanExi HS_NEU4.
    Genevestigatori Q8WWR8.

    Family and domain databases

    Gene3Di 2.120.10.10. 2 hits.
    InterProi IPR026946. Sialidase-4.
    IPR026856. Sialidase_fam.
    IPR011040. Sialidases.
    [Graphical view ]
    PANTHERi PTHR10628. PTHR10628. 1 hit.
    PTHR10628:SF8. PTHR10628:SF8. 1 hit.
    SUPFAMi SSF50939. SSF50939. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of NEU4, the fourth member of the human sialidase gene family."
      Monti E., Bassi M.T., Bresciani R., Civini S., Croci G.L., Papini N., Riboni M., Zanchetti G., Ballabio A., Preti A., Tettamanti G., Venerando B., Borsani G.
      Genomics 83:445-453(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, VARIANT ARG-301.
      Tissue: Fibroblast.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-301.
      Tissue: Mammary gland.
    3. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
      Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
      , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
      Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-301.
    4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Oligodendroglioma.
    7. "Neu4, a novel human lysosomal lumen sialidase, confers normal phenotype to sialidosis and galactosialidosis cells."
      Seyrantepe V., Landry K., Trudel S., Hassan J.A., Morales C.R., Pshezhetsky A.V.
      J. Biol. Chem. 279:37021-37029(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, IDENTIFICATION BY MASS SPECTROMETRY, ALTERNATIVE SPLICING (ISOFORM 2), CATALYTIC ACTIVITY, SUBCELLULAR LOCATION, GLYCOSYLATION.
    8. "Differential expression of endogenous sialidases of human monocytes during cellular differentiation into macrophages."
      Stamatos N.M., Liang F., Nan X., Landry K., Cross A.S., Wang L.X., Pshezhetsky A.V.
      FEBS J. 272:2545-2556(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.

    Entry informationi

    Entry nameiNEUR4_HUMAN
    AccessioniPrimary (citable) accession number: Q8WWR8
    Secondary accession number(s): A8K056, J3KNJ5, Q96D64
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2004
    Last sequence update: March 7, 2006
    Last modified: October 1, 2014
    This is version 110 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3