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Q8WWQ8

- STAB2_HUMAN

UniProt

Q8WWQ8 - STAB2_HUMAN

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Protein

Stabilin-2

Gene
STAB2, FEEL2, FELL, FEX2, HARE
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Hyaluronan receptor that binds to and mediates endocytosis of hyaluronic acid (HA). Acts also, in different species, as a primary systemic scavenger receptor for heparin (Hep), chondroitin sulfate (CS), dermatan sulfate (DS), nonglycosaminoglycan (GAG), acetylated low-density lipoprotein (AcLDL), pro-collagen propeptides and advanced glycation end products (AGE). May serve to maintain tissue integrity by supporting extracellular matrix turnover or it may contribute to maintaining fluidity of bodily liquids by resorption of hyaluronan. Counter receptor which plays an important role in lymphocyte recruitment in the hepatic vasculature. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. The proteolytically processed 190 kDa form also functions as an endocytosis receptor for heparin internalisation as well as HA and CS.11 Publications

GO - Molecular functioni

  1. hyaluronic acid binding Source: UniProtKB
  2. low-density lipoprotein particle binding Source: UniProtKB
  3. low-density lipoprotein receptor activity Source: UniProtKB
  4. protein binding Source: IntAct
  5. protein disulfide oxidoreductase activity Source: UniProtKB
  6. scavenger receptor activity Source: UniProtKB

GO - Biological processi

  1. angiogenesis Source: UniProtKB
  2. carbohydrate metabolic process Source: Reactome
  3. cell adhesion Source: UniProtKB
  4. defense response to bacterium Source: UniProtKB
  5. endocytosis Source: UniProtKB
  6. glycosaminoglycan metabolic process Source: Reactome
  7. hyaluronan catabolic process Source: Reactome
  8. hyaluronan metabolic process Source: Reactome
  9. oxidation-reduction process Source: GOC
  10. receptor-mediated endocytosis Source: UniProtKB
  11. regulation of blood coagulation Source: UniProt
  12. regulation of gene expression Source: UniProt
  13. small molecule metabolic process Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Endocytosis

Keywords - Ligandi

Hyaluronic acid

Enzyme and pathway databases

ReactomeiREACT_120996. Hyaluronan uptake and degradation.
REACT_164002. Scavenging by Class H Receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Stabilin-2
Alternative name(s):
FAS1 EGF-like and X-link domain-containing adhesion molecule 2
Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 2
Short name:
FEEL-2
Hyaluronan receptor for endocytosis
Cleaved into the following chain:
Alternative name(s):
190 kDa hyaluronan receptor for endocytosis
Gene namesi
Name:STAB2
Synonyms:FEEL2, FELL, FEX2, HARE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:18629. STAB2.

Subcellular locationi

Cell membrane; Single-pass type I membrane protein. Cytoplasm
Note: Only a small amount appears to be present at the cell surface.2 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 24582439Extracellular Reviewed predictionAdd
BLAST
Transmembranei2459 – 247921Helical; Reviewed predictionAdd
BLAST
Topological domaini2480 – 255172Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. endocytic vesicle membrane Source: Reactome
  3. external side of plasma membrane Source: UniProtKB
  4. integral component of plasma membrane Source: UniProtKB
  5. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38611.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed predictionAdd
BLAST
Chaini20 – 25512532Stabilin-2PRO_0000007712Add
BLAST
Chaini1136 – 25511416190 kDa form stabilin-21 PublicationPRO_0000007713Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi112 ↔ 126 By similarity
Disulfide bondi120 ↔ 136 By similarity
Glycosylationi133 – 1331N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi138 ↔ 147 By similarity
Disulfide bondi160 ↔ 171 By similarity
Disulfide bondi164 ↔ 181 By similarity
Disulfide bondi183 ↔ 192 By similarity
Disulfide bondi199 ↔ 210 By similarity
Disulfide bondi204 ↔ 222 By similarity
Disulfide bondi224 ↔ 235 By similarity
Disulfide bondi241 ↔ 252 By similarity
Disulfide bondi246 ↔ 262 By similarity
Disulfide bondi264 ↔ 275 By similarity
Disulfide bondi326 ↔ 338 By similarity
Disulfide bondi332 ↔ 348 By similarity
Glycosylationi337 – 3371N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi350 ↔ 361 By similarity
Glycosylationi449 – 4491N-linked (GlcNAc...) Reviewed prediction
Glycosylationi619 – 6191N-linked (GlcNAc...) Reviewed prediction
Glycosylationi720 – 7201N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi740 ↔ 754 By similarity
Disulfide bondi748 ↔ 764 By similarity
Glycosylationi761 – 7611N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi766 ↔ 775 By similarity
Disulfide bondi830 ↔ 843 By similarity
Disulfide bondi837 ↔ 852 By similarity
Glycosylationi847 – 8471N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi854 ↔ 865 By similarity
Disulfide bondi871 ↔ 885 By similarity
Disulfide bondi879 ↔ 895 By similarity
Disulfide bondi897 ↔ 908 By similarity
Disulfide bondi914 ↔ 928 By similarity
Disulfide bondi922 ↔ 938 By similarity
Glycosylationi925 – 9251N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi940 ↔ 951 By similarity
Disulfide bondi957 ↔ 970 By similarity
Disulfide bondi964 ↔ 980 By similarity
Glycosylationi1016 – 10161N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1028 – 10281N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1100 – 11001N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1247 – 12471N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1275 – 12751N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1348 ↔ 1362 By similarity
Disulfide bondi1356 ↔ 1372 By similarity
Glycosylationi1367 – 13671N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1374 ↔ 1383 By similarity
Disulfide bondi1395 ↔ 1406 By similarity
Disulfide bondi1399 ↔ 1416 By similarity
Disulfide bondi1418 ↔ 1427 By similarity
Glycosylationi1429 – 14291N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1436 ↔ 1446 By similarity
Glycosylationi1437 – 14371N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1440 ↔ 1456 By similarity
Disulfide bondi1458 ↔ 1469 By similarity
Glycosylationi1465 – 14651N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1475 ↔ 1488 By similarity
Disulfide bondi1482 ↔ 1498 By similarity
Disulfide bondi1500 ↔ 1511 By similarity
Disulfide bondi1517 ↔ 1530 By similarity
Disulfide bondi1524 ↔ 1540 By similarity
Disulfide bondi1542 ↔ 1553 By similarity
Disulfide bondi1559 ↔ 1572 By similarity
Disulfide bondi1566 ↔ 1582 By similarity
Glycosylationi1573 – 15731N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1679 – 16791N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1743 – 17431N-linked (GlcNAc...)1 Publication
Disulfide bondi1962 ↔ 1976 By similarity
Disulfide bondi1970 ↔ 1986 By similarity
Disulfide bondi1988 ↔ 1997 By similarity
Glycosylationi1993 – 19931N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi2009 ↔ 2020 By similarity
Disulfide bondi2014 ↔ 2030 By similarity
Disulfide bondi2032 ↔ 2041 By similarity
Disulfide bondi2051 ↔ 2061 By similarity
Disulfide bondi2055 ↔ 2067 By similarity
Glycosylationi2064 – 20641N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi2069 ↔ 2080 By similarity
Disulfide bondi2086 ↔ 2099 By similarity
Disulfide bondi2093 ↔ 2108 By similarity
Disulfide bondi2110 ↔ 2121 By similarity
Disulfide bondi2127 ↔ 2141 By similarity
Disulfide bondi2135 ↔ 2151 By similarity
Disulfide bondi2153 ↔ 2164 By similarity
Disulfide bondi2220 ↔ 2289 By similarity
Disulfide bondi2244 ↔ 2265 By similarity
Glycosylationi2280 – 22801N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2296 – 22961N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2336 – 23361N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2368 – 23681N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2382 – 23821N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2393 – 23931N-linked (GlcNAc...) Reviewed prediction
Modified residuei2497 – 24971Phosphoserine By similarity

Post-translational modificationi

Glycosylated.1 Publication
Proteolytically processed to yield a 190 kDa protein.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ8WWQ8.
PaxDbiQ8WWQ8.
PRIDEiQ8WWQ8.

PTM databases

PhosphoSiteiQ8WWQ8.

Expressioni

Tissue specificityi

Highly expressed in sinusoidal endothelial cells of liver, spleen and lymph nodes. Also expressed in non SEC-cells such as HMDMs (monocyte-derivedmacrophages), HAMs (T-cell leukemia virus type 1-associated myelopathy), and several macrophage cell line.6 Publications

Gene expression databases

ArrayExpressiQ8WWQ8.
BgeeiQ8WWQ8.
CleanExiHS_STAB2.
GenevestigatoriQ8WWQ8.

Organism-specific databases

HPAiHPA026871.

Interactioni

Subunit structurei

Interacts with GULP1 and heparin. Also interacts with alpha-M/beta-2 integrin (ITGAM and ITGB2) and thymosin beta 4 (TMSB4X and/or TMSB4Y).3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Tmsb4xP200653EBI-7945957,EBI-7946048From a different organism.

Protein-protein interaction databases

BioGridi120727. 7 interactions.
IntActiQ8WWQ8. 2 interactions.
MINTiMINT-6542238.
STRINGi9606.ENSP00000373539.

Structurei

3D structure databases

ProteinModelPortaliQ8WWQ8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini108 – 14841EGF-like 1Add
BLAST
Domaini156 – 19338EGF-like 2Add
BLAST
Domaini195 – 23642EGF-like 3Add
BLAST
Domaini237 – 27640EGF-like 4Add
BLAST
Domaini322 – 36241EGF-like 5Add
BLAST
Domaini371 – 505135FAS1 1Add
BLAST
Domaini515 – 652138FAS1 2Add
BLAST
Domaini736 – 77641EGF-like 6Add
BLAST
Domaini826 – 86641EGF-like 7Add
BLAST
Domaini867 – 90943EGF-like 8Add
BLAST
Domaini910 – 95243EGF-like 9Add
BLAST
Domaini953 – 99240EGF-like 10Add
BLAST
Domaini994 – 1127134FAS1 3Add
BLAST
Domaini1137 – 1265129FAS1 4Add
BLAST
Domaini1343 – 140866Laminin EGF-like 1Add
BLAST
Domaini1432 – 147039EGF-like 11Add
BLAST
Domaini1471 – 151242EGF-like 12Add
BLAST
Domaini1513 – 155442EGF-like 13Add
BLAST
Domaini1555 – 159440EGF-like 14Add
BLAST
Domaini1596 – 1724129FAS1 5Add
BLAST
Domaini1740 – 1881142FAS1 6Add
BLAST
Domaini1957 – 202266Laminin EGF-like 2Add
BLAST
Domaini2047 – 208135EGF-like 15Add
BLAST
Domaini2082 – 212241EGF-like 16Add
BLAST
Domaini2123 – 216543EGF-like 17Add
BLAST
Domaini2198 – 229194LinkAdd
BLAST
Domaini2311 – 2446136FAS1 7Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2504 – 251411Interaction with TMSB4XAdd
BLAST

Domaini

Recognizes phosphatidyl serine via its epidermal growth factor-like domains.

Sequence similaritiesi

Contains 17 EGF-like domains.
Contains 7 FAS1 domains.
Contains 1 Link domain.

Keywords - Domaini

EGF-like domain, Laminin EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2335.
HOVERGENiHBG079218.
InParanoidiQ8WWQ8.
OMAiIPKCCKG.
OrthoDBiEOG7PS1DH.
PhylomeDBiQ8WWQ8.
TreeFamiTF331489.

Family and domain databases

Gene3Di2.30.180.10. 7 hits.
2.40.155.10. 8 hits.
3.10.100.10. 1 hit.
InterProiIPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR024731. EGF_dom_MSP1-like.
IPR002049. EGF_laminin.
IPR000782. FAS1_domain.
IPR023413. GFP_like.
IPR000538. Link.
[Graphical view]
PfamiPF12947. EGF_3. 7 hits.
PF02469. Fasciclin. 7 hits.
PF00193. Xlink. 1 hit.
[Graphical view]
SMARTiSM00181. EGF. 20 hits.
SM00554. FAS1. 7 hits.
SM00445. LINK. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
SSF82153. SSF82153. 7 hits.
PROSITEiPS00022. EGF_1. 7 hits.
PS01186. EGF_2. 16 hits.
PS50026. EGF_3. 21 hits.
PS01248. EGF_LAM_1. 2 hits.
PS50213. FAS1. 7 hits.
PS01241. LINK_1. 1 hit.
PS50963. LINK_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8WWQ8-1 [UniParc]FASTAAdd to Basket

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MMLQHLVIFC LGLVVQNFCS PAETTGQARR CDRKSLLTIR TECRSCALNL     50
GVKCPDGYTM ITSGSVGVRD CRYTFEVRTY SLSLPGCRHI CRKDYLQPRC 100
CPGRWGPDCI ECPGGAGSPC NGRGSCAEGM EGNGTCSCQE GFGGTACETC 150
ADDNLFGPSC SSVCNCVHGV CNSGLDGDGT CECYSAYTGP KCDKPIPECA 200
ALLCPENSRC SPSTEDENKL ECKCLPNYRG DGKYCDPINP CLRKICHPHA 250
HCTYLGPNRH SCTCQEGYRG DGQVCLPVDP CQINFGNCPT KSTVCKYDGP 300
GQSHCECKEH YQNFVPGVGC SMTDICKSDN PCHRNANCTT VAPGRTECIC 350
QKGYVGDGLT CYGNIMERLR ELNTEPRGKW QGRLTSFISL LDKAYAWPLS 400
KLGPFTVLLP TDKGLKGFNV NELLVDNKAA QYFVKLHIIA GQMNIEYMNN 450
TDMFYTLTGK SGEIFNSDKD NQIKLKLHGG KKKVKIIQGD IIASNGLLHI 500
LDRAMDKLEP TFESNNEQTI MTMLQPRYSK FRSLLEETNL GHALDEDGVG 550
GPYTIFVPNN EALNNMKDGT LDYLLSPEGS RKLLELVRYH IVPFTQLEVA 600
TLISTPHIRS MANQLIQFNT TDNGQILAND VAMEEIEITA KNGRIYTLTG 650
VLIPPSIVPI LPHRCDETKR EMKLGTCVSC SLVYWSRCPA NSEPTALFTH 700
RCVYSGRFGS LKSGCARYCN ATVKIPKCCK GFYGPDCNQC PGGFSNPCSG 750
NGQCADSLGG NGTCICEEGF QGSQCQFCSD PNKYGPRCNK KCLCVHGTCN 800
NRIDSDGACL TGTCRDGSAG RLCDKQTSAC GPYVQFCHIH ATCEYSNGTA 850
SCICKAGYEG DGTLCSEMDP CTGLTPGGCS RNAECIKTGT GTHTCVCQQG 900
WTGNGRDCSE INNCLLPSAG GCHDNASCLY VGPGQNECEC KKGFRGNGID 950
CEPITSCLEQ TGKCHPLASC QSTSSGVWSC VCQEGYEGDG FLCYGNAAVE 1000
LSFLSEAAIF NRWINNASLQ PTLSATSNLT VLVPSQQATE DMDQDEKSFW 1050
LSQSNIPALI KYHMLLGTYR VADLQTLSSS DMLATSLQGN FLHLAKVDGN 1100
ITIEGASIVD GDNAATNGVI HIINKVLVPQ RRLTGSLPNL LMRLEQMPDY 1150
SIFRGYIIQY NLANAIEAAD AYTVFAPNNN AIENYIREKK VLSLEEDVLR 1200
YHVVLEEKLL KNDLHNGMHR ETMLGFSYFL SFFLHNDQLY VNEAPINYTN 1250
VATDKGVIHG LGKVLEIQKN RCDNNDTTII RGRCRTCSSE LTCPFGTKSL 1300
GNEKRRCIYT SYFMGRRTLF IGCQPKCVRT VITRECCAGF FGPQCQPCPG 1350
NAQNVCFGNG ICLDGVNGTG VCECGEGFSG TACETCTEGK YGIHCDQACS 1400
CVHGRCNQGP LGDGSCDCDV GWRGVHCDNA TTEDNCNGTC HTSANCLTNS 1450
DGTASCKCAA GFQGNGTICT AINACEISNG GCSAKADCKR TTPGRRVCTC 1500
KAGYTGDGIV CLEINPCLEN HGGCDKNAEC TQTGPNQAAC NCLPAYTGDG 1550
KVCTLINVCL TKNGGCSEFA ICNHTGQVER TCTCKPNYIG DGFTCRGSIY 1600
QELPKNPKTS QYFFQLQEHF VKDLVGPGPF TVFAPLSAAF DEEARVKDWD 1650
KYGLMPQVLR YHVVACHQLL LENLKLISNA TSLQGEPIVI SVSQSTVYIN 1700
NKAKIISSDI ISTNGIVHII DKLLSPKNLL ITPKDNSGRI LQNLTTLATN 1750
NGYIKFSNLI QDSGLLSVIT DPIHTPVTLF WPTDQALHAL PAEQQDFLFN 1800
QDNKDKLKEY LKFHVIRDAK VLAVDLPTST AWKTLQGSEL SVKCGAGRDI 1850
GDLFLNGQTC RIVQRELLFD LGVAYGIDCL LIDPTLGGRC DTFTTFDASG 1900
ECGSCVNTPS CPRWSKPKGV KQKCLYNLPF KRNLEGCRER CSLVIQIPRC 1950
CKGYFGRDCQ ACPGGPDAPC NNRGVCLDQY SATGECKCNT GFNGTACEMC 2000
WPGRFGPDCL PCGCSDHGQC DDGITGSGQC LCETGWTGPS CDTQAVLPAV 2050
CTPPCSAHAT CKENNTCECN LDYEGDGITC TVVDFCKQDN GGCAKVARCS 2100
QKGTKVSCSC QKGYKGDGHS CTEIDPCADG LNGGCHEHAT CKMTGPGKHK 2150
CECKSHYVGD GLNCEPEQLP IDRCLQDNGQ CHADAKCVDL HFQDTTVGVF 2200
HLRSPLGQYK LTFDKAREAC ANEAATMATY NQLSYAQKAK YHLCSAGWLE 2250
TGRVAYPTAF ASQNCGSGVV GIVDYGPRPN KSEMWDVFCY RMKDVNCTCK 2300
VGYVGDGFSC SGNLLQVLMS FPSLTNFLTE VLAYSNSSAR GRAFLEHLTD 2350
LSIRGTLFVP QNSGLGENET LSGRDIEHHL ANVSMFFYND LVNGTTLQTR 2400
LGSKLLITAS QDPLQPTETR FVDGRAILQW DIFASNGIIH VISRPLKAPP 2450
APVTLTHTGL GAGIFFAIIL VTGAVALAAY SYFRINRRTI GFQHFESEED 2500
INVAALGKQQ PENISNPLYE STTSAPPEPS YDPFTDSEER QLEGNDPLRT 2550
L 2551
Length:2,551
Mass (Da):276,988
Last modified:April 17, 2007 - v3
Checksum:i3ACB6A6C3CB80044
GO

Sequence cautioni

The sequence BAD18723.1 differs from that shown. Reason: Frameshift at positions 240, 253, 588 and 1586.
The sequence AAF82398.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti110 – 1101I → V.
Corresponds to variant rs17034186 [ dbSNP | Ensembl ].
VAR_048995
Natural varianti306 – 3061E → K.
Corresponds to variant rs12319476 [ dbSNP | Ensembl ].
VAR_048996
Natural varianti510 – 5101P → H.2 Publications
Corresponds to variant rs1609860 [ dbSNP | Ensembl ].
VAR_019541
Natural varianti787 – 7871R → Q.
Corresponds to variant rs17034336 [ dbSNP | Ensembl ].
VAR_048997
Natural varianti881 – 8811R → H.
Corresponds to variant rs7973658 [ dbSNP | Ensembl ].
VAR_048998
Natural varianti1736 – 17361N → T.
Corresponds to variant rs17034433 [ dbSNP | Ensembl ].
VAR_048999
Natural varianti2039 – 20391P → T.2 Publications
Corresponds to variant rs7306642 [ dbSNP | Ensembl ].
VAR_049000
Natural varianti2401 – 24011L → V.2 Publications
Corresponds to variant rs2271637 [ dbSNP | Ensembl ].
VAR_049001
Natural varianti2519 – 25191Y → S.
Corresponds to variant rs3751197 [ dbSNP | Ensembl ].
VAR_049002

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti67 – 671G → R in BAD18723. 1 Publication
Sequence conflicti152 – 1521D → A in BAD18723. 1 Publication
Sequence conflicti887 – 8871K → N in BAD18723. 1 Publication
Sequence conflicti1136 – 11361S → L AA sequence 1 Publication
Sequence conflicti1151 – 11511S → P in CAC82105. 1 Publication
Sequence conflicti1276 – 12761D → A in CAC82105. 1 Publication
Sequence conflicti1522 – 15221G → C in BAD18723. 1 Publication
Sequence conflicti1557 – 15571N → Y in AAO39681. 1 Publication
Sequence conflicti1599 – 16002IY → HE in AAF82398. 1 Publication
Sequence conflicti1854 – 18541F → S in BAD18723. 1 Publication
Sequence conflicti2249 – 22491L → V in BAD18723. 1 Publication
Sequence conflicti2253 – 22531R → G in BAD18723. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ295695 mRNA. Translation: CAC82105.1.
AB052958 mRNA. Translation: BAC15608.1.
AY311388 mRNA. Translation: AAP74958.1.
AK024503 mRNA. Translation: BAB15793.1.
AK074051 mRNA. Translation: BAB84877.1.
AK160380 mRNA. Translation: BAD18723.1. Frameshift.
AY227444 mRNA. Translation: AAO39681.1.
AF160476 mRNA. Translation: AAF82398.1. Different initiation.
CCDSiCCDS31888.1.
RefSeqiNP_060034.9. NM_017564.9.
UniGeneiHs.408249.

Genome annotation databases

EnsembliENST00000388887; ENSP00000373539; ENSG00000136011.
GeneIDi55576.
KEGGihsa:55576.
UCSCiuc001tjw.3. human.

Polymorphism databases

DMDMi145559531.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ295695 mRNA. Translation: CAC82105.1 .
AB052958 mRNA. Translation: BAC15608.1 .
AY311388 mRNA. Translation: AAP74958.1 .
AK024503 mRNA. Translation: BAB15793.1 .
AK074051 mRNA. Translation: BAB84877.1 .
AK160380 mRNA. Translation: BAD18723.1 . Frameshift.
AY227444 mRNA. Translation: AAO39681.1 .
AF160476 mRNA. Translation: AAF82398.1 . Different initiation.
CCDSi CCDS31888.1.
RefSeqi NP_060034.9. NM_017564.9.
UniGenei Hs.408249.

3D structure databases

ProteinModelPortali Q8WWQ8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120727. 7 interactions.
IntActi Q8WWQ8. 2 interactions.
MINTi MINT-6542238.
STRINGi 9606.ENSP00000373539.

PTM databases

PhosphoSitei Q8WWQ8.

Polymorphism databases

DMDMi 145559531.

Proteomic databases

MaxQBi Q8WWQ8.
PaxDbi Q8WWQ8.
PRIDEi Q8WWQ8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000388887 ; ENSP00000373539 ; ENSG00000136011 .
GeneIDi 55576.
KEGGi hsa:55576.
UCSCi uc001tjw.3. human.

Organism-specific databases

CTDi 55576.
GeneCardsi GC12P103981.
HGNCi HGNC:18629. STAB2.
HPAi HPA026871.
MIMi 608561. gene.
neXtProti NX_Q8WWQ8.
PharmGKBi PA38611.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2335.
HOVERGENi HBG079218.
InParanoidi Q8WWQ8.
OMAi IPKCCKG.
OrthoDBi EOG7PS1DH.
PhylomeDBi Q8WWQ8.
TreeFami TF331489.

Enzyme and pathway databases

Reactomei REACT_120996. Hyaluronan uptake and degradation.
REACT_164002. Scavenging by Class H Receptors.

Miscellaneous databases

GeneWikii STAB2.
GenomeRNAii 55576.
NextBioi 60076.
PROi Q8WWQ8.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8WWQ8.
Bgeei Q8WWQ8.
CleanExi HS_STAB2.
Genevestigatori Q8WWQ8.

Family and domain databases

Gene3Di 2.30.180.10. 7 hits.
2.40.155.10. 8 hits.
3.10.100.10. 1 hit.
InterProi IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR024731. EGF_dom_MSP1-like.
IPR002049. EGF_laminin.
IPR000782. FAS1_domain.
IPR023413. GFP_like.
IPR000538. Link.
[Graphical view ]
Pfami PF12947. EGF_3. 7 hits.
PF02469. Fasciclin. 7 hits.
PF00193. Xlink. 1 hit.
[Graphical view ]
SMARTi SM00181. EGF. 20 hits.
SM00554. FAS1. 7 hits.
SM00445. LINK. 1 hit.
[Graphical view ]
SUPFAMi SSF56436. SSF56436. 1 hit.
SSF82153. SSF82153. 7 hits.
PROSITEi PS00022. EGF_1. 7 hits.
PS01186. EGF_2. 16 hits.
PS50026. EGF_3. 21 hits.
PS01248. EGF_LAM_1. 2 hits.
PS50213. FAS1. 7 hits.
PS01241. LINK_1. 1 hit.
PS50963. LINK_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT HIS-510.
  2. "FEEL-1, a novel scavenger receptor with in vitro bacteria-binding and angiogenesis-modulating activities."
    Adachi H., Tsujimoto M.
    J. Biol. Chem. 277:34264-34270(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, VARIANT HIS-510.
  3. "FEX2, a novel cell adhesion molecule of Fas-1 superfamily mediates cell-cell interaction."
    Park S.-Y., Kim I.-S.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 35-2551, VARIANT THR-2039.
    Tissue: Spleen.
  5. "The nucleotide sequence of a long cDNA clone isolated from human spleen."
    Jikuya H., Takano J., Nomura N., Kikuno R., Nagase T., Ohara O.
    Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 35-2551, VARIANTS THR-2039 AND VAL-2401.
    Tissue: Spleen.
  6. "Purification and molecular identification of the human hyaluronan receptor for endocytosis."
    Zhou B., McGary C.T., Weigel J.A., Saxena A., Weigel P.H.
    Glycobiology 13:339-349(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1136-2551, PROTEIN SEQUENCE OF 1136-1144; 1257-1269; 1597-1605; 1623-1645; 1652-1660; 1813-1817; 1834-1843; 1914-1918; 1953-1957; 2204-2217; 2211-2215 AND 2355-2367, TISSUE SPECIFICITY.
  7. "Molecular cloning and characterization of human FELL sharing homology with CD44."
    Tao Q., Zhang W., Cao X.
    Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1599-2551, VARIANT VAL-2401.
  8. "Expression, processing, and glycosaminoglycan binding activity of the recombinant human 315-kDa hyaluronic acid receptor for endocytosis (HARE)."
    Harris E.N., Kyosseva S.V., Weigel J.A., Weigel P.H.
    J. Biol. Chem. 282:2785-2797(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1136-1144, GLYCOSYLATION, SUBCELLULAR LOCATION, FUNCTION.
  9. Cited for: FUNCTION, TISSUE SPECIFICITY.
  10. "Endocytic function, glycosaminoglycan specificity, and antibody sensitivity of the recombinant human 190-kDa hyaluronan receptor for endocytosis (HARE)."
    Harris E.N., Weigel J.A., Weigel P.H.
    J. Biol. Chem. 279:36201-36209(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  11. "Stabilin-1 and stabilin-2 are both directed into the early endocytic pathway in hepatic sinusoidal endothelium via interactions with clathrin/AP-2, independent of ligand binding."
    Hansen B., Longati P., Elvevold K., Nedredal G.-I., Schledzewski K., Olsen R., Falkowski M., Kzhyshkowska J., Carlsson F., Johansson S., Smedsroed B., Goerdt S., Johansson S., McCourt P.
    Exp. Cell Res. 303:160-173(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  12. "Stabilin-2 is involved in lymphocyte adhesion to the hepatic sinusoidal endothelium via the interaction with alphaMbeta2 integrin."
    Jung M.Y., Park S.Y., Kim I.S.
    J. Leukoc. Biol. 82:1156-1165(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, FUNCTION, TISSUE SPECIFICITY, INTERACTION WITH ALPHA-M/BETA-2 [ITGAM/ITGB2] INTEGRIN.
  13. Erratum
    Jung M.Y., Park S.Y., Kim I.S.
    J. Leukoc. Biol. 83:438-438(2008)
  14. "Rapid cell corpse clearance by stabilin-2, a membrane phosphatidylserine receptor."
    Park S.Y., Jung M.Y., Kim H.J., Lee S.J., Kim S.Y., Lee B.H., Kwon T.H., Park R.W., Kim I.S.
    Cell Death Differ. 15:192-201(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  15. "Thymosin beta4 is involved in stabilin-2-mediated apoptotic cell engulfment."
    Lee S.J., So I.S., Park S.Y., Kim I.S.
    FEBS Lett. 582:2161-2166(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TMSB4X.
  16. "Requirement of adaptor protein GULP during stabilin-2-mediated cell corpse engulfment."
    Park S.Y., Kang K.B., Thapa N., Kim S.Y., Lee S.J., Kim I.S.
    J. Biol. Chem. 283:10593-10600(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH GULP1.
  17. "The human hyaluronan receptor for endocytosis (HARE/Stabilin-2) is a systemic clearance receptor for heparin."
    Harris E.N., Weigel J.A., Weigel P.H.
    J. Biol. Chem. 283:17341-17350(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  18. "Epidermal growth factor-like domain repeat of stabilin-2 recognizes phosphatidylserine during cell corpse clearance."
    Park S.-Y., Kim S.-Y., Jung M.-Y., Bae D.-J., Kim I.-S.
    Mol. Cell. Biol. 28:5288-5298(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  19. "Rat and human HARE/stabilin-2 are clearance receptors for high- and low-molecular-weight heparins."
    Harris E.N., Baggenstoss B.A., Weigel P.H.
    Am. J. Physiol. 296:G1191-G1199(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  20. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1743.
    Tissue: Liver.

Entry informationi

Entry nameiSTAB2_HUMAN
AccessioniPrimary (citable) accession number: Q8WWQ8
Secondary accession number(s): Q6ZMK2
, Q7Z5N9, Q86UR4, Q8IUG9, Q8TES1, Q9H7H7, Q9NRY3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: April 17, 2007
Last modified: September 3, 2014
This is version 120 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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