Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8WWQ2

- HPSE2_HUMAN

UniProt

Q8WWQ2 - HPSE2_HUMAN

Protein

Inactive heparanase-2

Gene

HPSE2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 3 (06 Feb 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Binds heparin and heparan sulfate with high affinity, but lacks heparanase activity. Inhibits HPSE, possibly by competing for its substrates (in vitro).1 Publication

    GO - Molecular functioni

    1. heparanase activity Source: UniProtKB
    2. heparan sulfate proteoglycan binding Source: UniProtKB

    GO - Biological processi

    1. carbohydrate metabolic process Source: Reactome
    2. glycosaminoglycan catabolic process Source: Reactome
    3. glycosaminoglycan metabolic process Source: Reactome
    4. small molecule metabolic process Source: Reactome

    Enzyme and pathway databases

    ReactomeiREACT_120752. HS-GAG degradation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Inactive heparanase-2
    Short name:
    Hpa2
    Gene namesi
    Name:HPSE2
    Synonyms:HPA2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:18374. HPSE2.

    Subcellular locationi

    Secretedextracellular spaceextracellular matrix 1 Publication

    GO - Cellular componenti

    1. intracellular Source: UniProtKB
    2. plasma membrane Source: Reactome
    3. proteinaceous extracellular matrix Source: UniProtKB

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    Pathology & Biotechi

    Involvement in diseasei

    Urofacial syndrome 1 (UFS1) [MIM:236730]: A rare autosomal recessive disorder characterized by facial grimacing when attempting to smile and failure of the urinary bladder to void completely despite a lack of anatomical bladder outflow obstruction or overt neurological damage. Affected individuals often have reflux of infected urine from the bladder to the upper renal tract, with a risk of kidney damage and renal failure.2 Publications
    Note: The disease is caused by mutations affecting the gene represented in this entry.

    Organism-specific databases

    MIMi236730. phenotype.
    Orphaneti2704. Ochoa syndrome.
    PharmGKBiPA38533.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 4141Sequence AnalysisAdd
    BLAST
    Chaini42 – 592551Inactive heparanase-2PRO_0000068140Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi254 – 2541N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi392 – 3921N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ8WWQ2.
    PRIDEiQ8WWQ2.

    PTM databases

    PhosphoSiteiQ8WWQ2.

    Expressioni

    Tissue specificityi

    Widely expressed, with the highest expression in brain, mammary gland, prostate, small intestine, testis and uterus. In the central nervous system, expressed in the spinal chord, caudate nucleus, thalamus, substantia nigra, medulla oblongata, putamen and pons. In the urinary bladder, expressed in longitudinal and circular layers of detrusor muscle. Found both in normal and cancer tissues.2 Publications

    Developmental stagei

    Expressed in the developing forebrain, diencephalon, midbrain, hind brain and spinal cord at Carnagie stage 16 (CS16, 6 weeks of gestation) and CS21 (8 weeks).1 Publication

    Gene expression databases

    BgeeiQ8WWQ2.
    CleanExiHS_HPSE2.
    GenevestigatoriQ8WWQ2.

    Organism-specific databases

    HPAiHPA044603.

    Interactioni

    Subunit structurei

    Interacts with HPSE. Interacts with SDC1 (via glycan chains).1 Publication

    Protein-protein interaction databases

    STRINGi9606.ENSP00000359583.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8WWQ2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 79 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG72789.
    HOVERGENiHBG081606.
    InParanoidiQ8WWQ2.
    KOiK07965.
    OMAiVNTKSPV.
    OrthoDBiEOG7BZVRW.
    PhylomeDBiQ8WWQ2.
    TreeFamiTF328999.

    Family and domain databases

    Gene3Di3.20.20.80. 1 hit.
    InterProiIPR005199. Glyco_hydro_79.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PANTHERiPTHR14363. PTHR14363. 1 hit.
    PfamiPF03662. Glyco_hydro_79n. 1 hit.
    [Graphical view]
    SUPFAMiSSF51445. SSF51445. 2 hits.

    Sequences (4)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8WWQ2-1) [UniParc]FASTAAdd to Basket

    Also known as: HPA2c

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRVLCAFPEA MPSSNSRPPA CLAPGALYLA LLLHLSLSSQ AGDRRPLPVD    50
    RAAGLKEKTL ILLDVSTKNP VRTVNENFLS LQLDPSIIHD GWLDFLSSKR 100
    LVTLARGLSP AFLRFGGKRT DFLQFQNLRN PAKSRGGPGP DYYLKNYEDD 150
    IVRSDVALDK QKGCKIAQHP DVMLELQREK AAQMHLVLLK EQFSNTYSNL 200
    ILTARSLDKL YNFADCSGLH LIFALNALRR NPNNSWNSSS ALSLLKYSAS 250
    KKYNISWELG NEPNNYRTMH GRAVNGSQLG KDYIQLKSLL QPIRIYSRAS 300
    LYGPNIGRPR KNVIALLDGF MKVAGSTVDA VTWQHCYIDG RVVKVMDFLK 350
    TRLLDTLSDQ IRKIQKVVNT YTPGKKIWLE GVVTTSAGGT NNLSDSYAAG 400
    FLWLNTLGML ANQGIDVVIR HSFFDHGYNH LVDQNFNPLP DYWLSLLYKR 450
    LIGPKVLAVH VAGLQRKPRP GRVIRDKLRI YAHCTNHHNH NYVRGSITLF 500
    IINLHRSRKK IKLAGTLRDK LVHQYLLQPY GQEGLKSKSV QLNGQPLVMV 550
    DDGTLPELKP RPLRAGRTLV IPPVTMGFYV VKNVNALACR YR 592
    Length:592
    Mass (Da):66,596
    Last modified:February 6, 2007 - v3
    Checksum:i95C384AD9A6C868E
    GO
    Isoform 2 (identifier: Q8WWQ2-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         539-548: SVQLNGQPLV → TQRCQYCGII
         549-592: Missing.

    Show »
    Length:548
    Mass (Da):61,816
    Checksum:i2572C68423CD2C51
    GO
    Isoform 3 (identifier: Q8WWQ2-3) [UniParc]FASTAAdd to Basket

    Also known as: HPA2b

    The sequence of this isoform differs from the canonical sequence as follows:
         204-261: Missing.

    Show »
    Length:534
    Mass (Da):60,080
    Checksum:iC3DE5E900CAB9BC4
    GO
    Isoform 4 (identifier: Q8WWQ2-4) [UniParc]FASTAAdd to Basket

    Also known as: HPA2a

    The sequence of this isoform differs from the canonical sequence as follows:
         150-261: Missing.

    Show »
    Length:480
    Mass (Da):53,917
    Checksum:iF75F89F67AD95C83
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti12 – 121P → L in CAC82492. 1 PublicationCurated
    Sequence conflicti213 – 2131F → S in CAC82491. 1 PublicationCurated
    Sequence conflicti213 – 2131F → S in CAC82492. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti315 – 3151A → T.
    Corresponds to variant rs17110744 [ dbSNP | Ensembl ].
    VAR_030472
    Natural varianti579 – 5791Y → F.2 Publications
    Corresponds to variant rs10883100 [ dbSNP | Ensembl ].
    VAR_023601

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei150 – 261112Missing in isoform 4. 1 PublicationVSP_015850Add
    BLAST
    Alternative sequencei204 – 26158Missing in isoform 3. 1 PublicationVSP_015851Add
    BLAST
    Alternative sequencei539 – 54810SVQLNGQPLV → TQRCQYCGII in isoform 2. 1 PublicationVSP_015852
    Alternative sequencei549 – 59244Missing in isoform 2. 1 PublicationVSP_015853Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF282885 mRNA. Translation: AAG23421.1.
    AF282886 mRNA. Translation: AAG23422.1.
    AF282887 mRNA. Translation: AAG23423.1.
    AJ299719 mRNA. Translation: CAC82491.1.
    AJ299720 mRNA. Translation: CAC82492.1.
    AL590036
    , AL139243, AL356220, AL356268, AL445251 Genomic DNA. Translation: CAH73137.1.
    AL139243
    , AL356220, AL356268, AL445251, AL590036 Genomic DNA. Translation: CAI14146.1.
    AL356268
    , AL139243, AL356220, AL445251, AL590036 Genomic DNA. Translation: CAH70448.1.
    AL445251
    , AL139243, AL356220, AL356268, AL590036 Genomic DNA. Translation: CAI16472.1.
    AL356220
    , AL139243, AL356268, AL445251, AL590036 Genomic DNA. Translation: CAI17160.1.
    AL590036
    , AL139243, AL356220, AL356268, AL445251 Genomic DNA. Translation: CAH73139.1.
    AL356220
    , AL356268, AL139243, AL445251, AL590036 Genomic DNA. Translation: CAI17162.1.
    AL356268
    , AL139243, AL356220, AL445251, AL590036 Genomic DNA. Translation: CAH70450.1.
    AL445251
    , AL139243, AL356220, AL356268, AL590036 Genomic DNA. Translation: CAI16474.1.
    AL139243
    , AL356220, AL356268, AL445251, AL590036 Genomic DNA. Translation: CAI14148.1.
    AL590036
    , AL139243, AL356220, AL356268, AL445251 Genomic DNA. Translation: CAH73138.1.
    AL356220
    , AL139243, AL356268, AL445251, AL590036 Genomic DNA. Translation: CAI17161.1.
    AL356268
    , AL139243, AL356220, AL445251, AL590036 Genomic DNA. Translation: CAH70449.1.
    AL445251
    , AL139243, AL356220, AL356268, AL590036 Genomic DNA. Translation: CAI16473.1.
    AL139243
    , AL356220, AL356268, AL445251, AL590036 Genomic DNA. Translation: CAI14147.1.
    CCDSiCCDS53566.1. [Q8WWQ2-4]
    CCDS53567.1. [Q8WWQ2-3]
    CCDS53568.1. [Q8WWQ2-2]
    CCDS7477.1. [Q8WWQ2-1]
    PIRiJC7506.
    RefSeqiNP_001159716.1. NM_001166244.1. [Q8WWQ2-3]
    NP_001159717.1. NM_001166245.1. [Q8WWQ2-4]
    NP_001159718.1. NM_001166246.1. [Q8WWQ2-2]
    NP_068600.4. NM_021828.4. [Q8WWQ2-1]
    UniGeneiHs.500750.
    Hs.676960.
    Hs.689544.

    Genome annotation databases

    EnsembliENST00000370546; ENSP00000359577; ENSG00000172987. [Q8WWQ2-2]
    ENST00000370549; ENSP00000359580; ENSG00000172987. [Q8WWQ2-3]
    ENST00000370552; ENSP00000359583; ENSG00000172987. [Q8WWQ2-1]
    ENST00000404542; ENSP00000384384; ENSG00000172987. [Q8WWQ2-4]
    GeneIDi60495.
    KEGGihsa:60495.
    UCSCiuc001kpn.2. human. [Q8WWQ2-1]
    uc001kpo.2. human. [Q8WWQ2-3]
    uc009xwc.2. human. [Q8WWQ2-2]
    uc009xwd.2. human. [Q8WWQ2-4]

    Polymorphism databases

    DMDMi125987832.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF282885 mRNA. Translation: AAG23421.1 .
    AF282886 mRNA. Translation: AAG23422.1 .
    AF282887 mRNA. Translation: AAG23423.1 .
    AJ299719 mRNA. Translation: CAC82491.1 .
    AJ299720 mRNA. Translation: CAC82492.1 .
    AL590036
    , AL139243 , AL356220 , AL356268 , AL445251 Genomic DNA. Translation: CAH73137.1 .
    AL139243
    , AL356220 , AL356268 , AL445251 , AL590036 Genomic DNA. Translation: CAI14146.1 .
    AL356268
    , AL139243 , AL356220 , AL445251 , AL590036 Genomic DNA. Translation: CAH70448.1 .
    AL445251
    , AL139243 , AL356220 , AL356268 , AL590036 Genomic DNA. Translation: CAI16472.1 .
    AL356220
    , AL139243 , AL356268 , AL445251 , AL590036 Genomic DNA. Translation: CAI17160.1 .
    AL590036
    , AL139243 , AL356220 , AL356268 , AL445251 Genomic DNA. Translation: CAH73139.1 .
    AL356220
    , AL356268 , AL139243 , AL445251 , AL590036 Genomic DNA. Translation: CAI17162.1 .
    AL356268
    , AL139243 , AL356220 , AL445251 , AL590036 Genomic DNA. Translation: CAH70450.1 .
    AL445251
    , AL139243 , AL356220 , AL356268 , AL590036 Genomic DNA. Translation: CAI16474.1 .
    AL139243
    , AL356220 , AL356268 , AL445251 , AL590036 Genomic DNA. Translation: CAI14148.1 .
    AL590036
    , AL139243 , AL356220 , AL356268 , AL445251 Genomic DNA. Translation: CAH73138.1 .
    AL356220
    , AL139243 , AL356268 , AL445251 , AL590036 Genomic DNA. Translation: CAI17161.1 .
    AL356268
    , AL139243 , AL356220 , AL445251 , AL590036 Genomic DNA. Translation: CAH70449.1 .
    AL445251
    , AL139243 , AL356220 , AL356268 , AL590036 Genomic DNA. Translation: CAI16473.1 .
    AL139243
    , AL356220 , AL356268 , AL445251 , AL590036 Genomic DNA. Translation: CAI14147.1 .
    CCDSi CCDS53566.1. [Q8WWQ2-4 ]
    CCDS53567.1. [Q8WWQ2-3 ]
    CCDS53568.1. [Q8WWQ2-2 ]
    CCDS7477.1. [Q8WWQ2-1 ]
    PIRi JC7506.
    RefSeqi NP_001159716.1. NM_001166244.1. [Q8WWQ2-3 ]
    NP_001159717.1. NM_001166245.1. [Q8WWQ2-4 ]
    NP_001159718.1. NM_001166246.1. [Q8WWQ2-2 ]
    NP_068600.4. NM_021828.4. [Q8WWQ2-1 ]
    UniGenei Hs.500750.
    Hs.676960.
    Hs.689544.

    3D structure databases

    ProteinModelPortali Q8WWQ2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000359583.

    PTM databases

    PhosphoSitei Q8WWQ2.

    Polymorphism databases

    DMDMi 125987832.

    Proteomic databases

    PaxDbi Q8WWQ2.
    PRIDEi Q8WWQ2.

    Protocols and materials databases

    DNASUi 60495.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000370546 ; ENSP00000359577 ; ENSG00000172987 . [Q8WWQ2-2 ]
    ENST00000370549 ; ENSP00000359580 ; ENSG00000172987 . [Q8WWQ2-3 ]
    ENST00000370552 ; ENSP00000359583 ; ENSG00000172987 . [Q8WWQ2-1 ]
    ENST00000404542 ; ENSP00000384384 ; ENSG00000172987 . [Q8WWQ2-4 ]
    GeneIDi 60495.
    KEGGi hsa:60495.
    UCSCi uc001kpn.2. human. [Q8WWQ2-1 ]
    uc001kpo.2. human. [Q8WWQ2-3 ]
    uc009xwc.2. human. [Q8WWQ2-2 ]
    uc009xwd.2. human. [Q8WWQ2-4 ]

    Organism-specific databases

    CTDi 60495.
    GeneCardsi GC10M100208.
    GeneReviewsi HPSE2.
    HGNCi HGNC:18374. HPSE2.
    HPAi HPA044603.
    MIMi 236730. phenotype.
    613469. gene.
    neXtProti NX_Q8WWQ2.
    Orphaneti 2704. Ochoa syndrome.
    PharmGKBi PA38533.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG72789.
    HOVERGENi HBG081606.
    InParanoidi Q8WWQ2.
    KOi K07965.
    OMAi VNTKSPV.
    OrthoDBi EOG7BZVRW.
    PhylomeDBi Q8WWQ2.
    TreeFami TF328999.

    Enzyme and pathway databases

    Reactomei REACT_120752. HS-GAG degradation.

    Miscellaneous databases

    GeneWikii HPSE2.
    GenomeRNAii 60495.
    NextBioi 65399.
    PROi Q8WWQ2.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8WWQ2.
    CleanExi HS_HPSE2.
    Genevestigatori Q8WWQ2.

    Family and domain databases

    Gene3Di 3.20.20.80. 1 hit.
    InterProi IPR005199. Glyco_hydro_79.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    PANTHERi PTHR14363. PTHR14363. 1 hit.
    Pfami PF03662. Glyco_hydro_79n. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51445. SSF51445. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 3 AND 4), VARIANT PHE-579, TISSUE SPECIFICITY.
      Tissue: Heart.
    2. Legoux P., Legoux R., O'Brien D., Salome M.
      Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANT PHE-579.
      Tissue: Prostate.
    3. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: INVOLVEMENT IN UFS1.
    5. Cited for: INVOLVEMENT IN UFS1, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    6. "Heparanase 2 interacts with heparan sulfate with high affinity and inhibits heparanase activity."
      Levy-Adam F., Feld S., Cohen-Kaplan V., Shteingauz A., Gross M., Arvatz G., Naroditsky I., Ilan N., Doweck I., Vlodavsky I.
      J. Biol. Chem. 285:28010-28019(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH HPSE, ABSENCE OF HEPARANASE ACTIVITY.

    Entry informationi

    Entry nameiHPSE2_HUMAN
    AccessioniPrimary (citable) accession number: Q8WWQ2
    Secondary accession number(s): Q5VUH4
    , Q5VUH5, Q5VUH6, Q8WWQ1, Q9HB37, Q9HB38, Q9HB39
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 25, 2005
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 96 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3