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Protein

GTPase IMAP family member 1

Gene

GIMAP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May regulate lymphocyte survival. Required for normal levels of mature T-lymphocytes and mature B-cells (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei55 – 551GTPBy similarity
Binding sitei190 – 1901GTP

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi34 – 429GTP
Nucleotide bindingi153 – 1553GTP

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GTPase IMAP family member 1
Alternative name(s):
Immunity-associated protein 1
Short name:
hIMAP1
Gene namesi
Name:GIMAP1
Synonyms:IMAP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:23237. GIMAP1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 272272CytoplasmicSequence analysisAdd
BLAST
Transmembranei273 – 29220Helical; Anchor for type IV membrane proteinSequence analysisAdd
BLAST
Topological domaini293 – 30614LumenalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134978698.

Polymorphism and mutation databases

BioMutaiGIMAP1.
DMDMi38372377.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 306306GTPase IMAP family member 1PRO_0000190984Add
BLAST

Proteomic databases

EPDiQ8WWP7.
PaxDbiQ8WWP7.
PRIDEiQ8WWP7.

PTM databases

iPTMnetiQ8WWP7.
PhosphoSiteiQ8WWP7.

Expressioni

Tissue specificityi

Predominantly expressed in the spleen and to a lesser extent in the lymph nodes. Detected in T-cells.2 Publications

Gene expression databases

BgeeiQ8WWP7.
CleanExiHS_GIMAP1.
ExpressionAtlasiQ8WWP7. baseline and differential.
GenevisibleiQ8WWP7. HS.

Organism-specific databases

HPAiHPA044887.

Interactioni

Protein-protein interaction databases

BioGridi128063. 3 interactions.
STRINGi9606.ENSP00000302833.

Structurei

Secondary structure

1
306
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi27 – 348Combined sources
Helixi40 – 489Combined sources
Beta strandi67 – 737Combined sources
Beta strandi76 – 827Combined sources
Helixi91 – 944Combined sources
Helixi99 – 10810Combined sources
Beta strandi113 – 1208Combined sources
Helixi126 – 13914Combined sources
Helixi141 – 1466Combined sources
Beta strandi147 – 1526Combined sources
Helixi154 – 1574Combined sources
Helixi162 – 1687Combined sources
Helixi172 – 1809Combined sources
Turni181 – 1833Combined sources
Beta strandi185 – 1873Combined sources
Helixi194 – 21421Combined sources
Turni215 – 2173Combined sources
Helixi223 – 2308Combined sources
Helixi231 – 2333Combined sources
Helixi236 – 25015Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3V70X-ray2.21A/B25-253[»]
ProteinModelPortaliQ8WWP7.
SMRiQ8WWP7. Positions 26-251.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8WWP7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 229205AIG1-type GAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J90P. Eukaryota.
ENOG410Y0H9. LUCA.
GeneTreeiENSGT00760000118989.
HOGENOMiHOG000115747.
HOVERGENiHBG004016.
InParanoidiQ8WWP7.
OMAiSNTENRA.
OrthoDBiEOG7XM2Z9.
PhylomeDBiQ8WWP7.
TreeFamiTF330845.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR006703. G_AIG1.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF04548. AIG1. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51720. G_AIG1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8WWP7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGRKMATDE ENVYGLEENA QSRQESTRRL ILVGRTGAGK SATGNSILGQ
60 70 80 90 100
RRFFSRLGAT SVTRACTTGS RRWDKCHVEV VDTPDIFSSQ VSKTDPGCEE
110 120 130 140 150
RGHCYLLSAP GPHALLLVTQ LGRFTAQDQQ AVRQVRDMFG EDVLKWMVIV
160 170 180 190 200
FTRKEDLAGG SLHDYVSNTE NRALRELVAE CGGRVCAFDN RATGREQEAQ
210 220 230 240 250
VEQLLGMVEG LVLEHKGAHY SNEVYELAQV LRWAGPEERL RRVAERVAAR
260 270 280 290 300
VQRRPWGAWL SARLWKWLKS PRSWRLGLAL LLGGALLFWV LLHRRWSEAV

AEVGPD
Length:306
Mass (Da):34,369
Last modified:March 1, 2002 - v1
Checksum:i7C1F620658B95960
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti235 – 2351G → V in BAC03754 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti166 – 1661V → E in a breast cancer sample; somatic mutation. 1 Publication
VAR_036301
Natural varianti254 – 2541R → S.
Corresponds to variant rs7811263 [ dbSNP | Ensembl ].
VAR_049530

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ306287 mRNA. Translation: CAC83740.1.
AK091818 mRNA. Translation: BAC03754.1.
AK315127 mRNA. Translation: BAG37580.1.
CH471173 Genomic DNA. Translation: EAW54095.1.
BC040736 mRNA. Translation: AAH40736.1.
CCDSiCCDS5906.1.
RefSeqiNP_570115.1. NM_130759.3.
UniGeneiHs.647079.

Genome annotation databases

EnsembliENST00000307194; ENSP00000302833; ENSG00000213203.
GeneIDi170575.
KEGGihsa:170575.
UCSCiuc003whq.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ306287 mRNA. Translation: CAC83740.1.
AK091818 mRNA. Translation: BAC03754.1.
AK315127 mRNA. Translation: BAG37580.1.
CH471173 Genomic DNA. Translation: EAW54095.1.
BC040736 mRNA. Translation: AAH40736.1.
CCDSiCCDS5906.1.
RefSeqiNP_570115.1. NM_130759.3.
UniGeneiHs.647079.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3V70X-ray2.21A/B25-253[»]
ProteinModelPortaliQ8WWP7.
SMRiQ8WWP7. Positions 26-251.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128063. 3 interactions.
STRINGi9606.ENSP00000302833.

PTM databases

iPTMnetiQ8WWP7.
PhosphoSiteiQ8WWP7.

Polymorphism and mutation databases

BioMutaiGIMAP1.
DMDMi38372377.

Proteomic databases

EPDiQ8WWP7.
PaxDbiQ8WWP7.
PRIDEiQ8WWP7.

Protocols and materials databases

DNASUi170575.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307194; ENSP00000302833; ENSG00000213203.
GeneIDi170575.
KEGGihsa:170575.
UCSCiuc003whq.4. human.

Organism-specific databases

CTDi170575.
GeneCardsiGIMAP1.
HGNCiHGNC:23237. GIMAP1.
HPAiHPA044887.
MIMi608084. gene.
neXtProtiNX_Q8WWP7.
PharmGKBiPA134978698.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J90P. Eukaryota.
ENOG410Y0H9. LUCA.
GeneTreeiENSGT00760000118989.
HOGENOMiHOG000115747.
HOVERGENiHBG004016.
InParanoidiQ8WWP7.
OMAiSNTENRA.
OrthoDBiEOG7XM2Z9.
PhylomeDBiQ8WWP7.
TreeFamiTF330845.

Miscellaneous databases

ChiTaRSiGIMAP1. human.
EvolutionaryTraceiQ8WWP7.
GenomeRNAii170575.
NextBioi89045.
PROiQ8WWP7.
SOURCEiSearch...

Gene expression databases

BgeeiQ8WWP7.
CleanExiHS_GIMAP1.
ExpressionAtlasiQ8WWP7. baseline and differential.
GenevisibleiQ8WWP7. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR006703. G_AIG1.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF04548. AIG1. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51720. G_AIG1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Human ortholog to mouse gene imap38 encoding an ER-localizable G-protein belongs to a gene family clustered on chromosome 7q32-36."
    Stamm O., Kruecken J., Schmitt-Wrede H.-P., Benten W.P.M., Wunderlich F.
    Gene 282:159-167(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Spleen.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung and Thalamus.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Blood.
  5. Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Crystal structure of human GTPase IMAP family member 1."
    Structural genomics consortium (SGC)
    Submitted (MAR-2010) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.21 ANGSTROMS) OF 25-253 IN COMPLEX WITH GDP.
  8. Cited for: VARIANT [LARGE SCALE ANALYSIS] GLU-166.

Entry informationi

Entry nameiGIMA1_HUMAN
AccessioniPrimary (citable) accession number: Q8WWP7
Secondary accession number(s): B2RCI3, Q8NAZ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: March 1, 2002
Last modified: May 11, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.