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Protein

GTPase IMAP family member 1

Gene

GIMAP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May regulate lymphocyte survival. Required for normal levels of mature T-lymphocytes and mature B-cells (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei55GTPBy similarity1
Binding sitei190GTP1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi34 – 42GTP9
Nucleotide bindingi153 – 155GTP3

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:G66-30905-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
GTPase IMAP family member 1
Alternative name(s):
Immunity-associated protein 1
Short name:
hIMAP1
Gene namesi
Name:GIMAP1
Synonyms:IMAP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:23237. GIMAP1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 272CytoplasmicSequence analysisAdd BLAST272
Transmembranei273 – 292Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST20
Topological domaini293 – 306LumenalSequence analysisAdd BLAST14

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000213203.
PharmGKBiPA134978698.

Polymorphism and mutation databases

BioMutaiGIMAP1.
DMDMi38372377.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001909841 – 306GTPase IMAP family member 1Add BLAST306

Proteomic databases

EPDiQ8WWP7.
PaxDbiQ8WWP7.
PeptideAtlasiQ8WWP7.
PRIDEiQ8WWP7.

PTM databases

iPTMnetiQ8WWP7.
PhosphoSitePlusiQ8WWP7.

Expressioni

Tissue specificityi

Predominantly expressed in the spleen and to a lesser extent in the lymph nodes. Detected in T-cells.2 Publications

Gene expression databases

BgeeiENSG00000213203.
CleanExiHS_GIMAP1.
ExpressionAtlasiQ8WWP7. baseline and differential.
GenevisibleiQ8WWP7. HS.

Organism-specific databases

HPAiHPA044887.

Interactioni

Protein-protein interaction databases

BioGridi128063. 3 interactors.
IntActiQ8WWP7. 2 interactors.
STRINGi9606.ENSP00000302833.

Structurei

Secondary structure

1306
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi27 – 34Combined sources8
Helixi40 – 48Combined sources9
Beta strandi67 – 73Combined sources7
Beta strandi76 – 82Combined sources7
Helixi91 – 94Combined sources4
Helixi99 – 108Combined sources10
Beta strandi113 – 120Combined sources8
Helixi126 – 139Combined sources14
Helixi141 – 146Combined sources6
Beta strandi147 – 152Combined sources6
Helixi154 – 157Combined sources4
Helixi162 – 168Combined sources7
Helixi172 – 180Combined sources9
Turni181 – 183Combined sources3
Beta strandi185 – 187Combined sources3
Helixi194 – 214Combined sources21
Turni215 – 217Combined sources3
Helixi223 – 230Combined sources8
Helixi231 – 233Combined sources3
Helixi236 – 250Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3V70X-ray2.21A/B25-253[»]
ProteinModelPortaliQ8WWP7.
SMRiQ8WWP7.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8WWP7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 229AIG1-type GAdd BLAST205

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J90P. Eukaryota.
ENOG410Y0H9. LUCA.
GeneTreeiENSGT00760000118989.
HOGENOMiHOG000115747.
HOVERGENiHBG004016.
InParanoidiQ8WWP7.
OMAiSNTENRA.
OrthoDBiEOG091G0I0X.
PhylomeDBiQ8WWP7.
TreeFamiTF330845.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR006703. G_AIG1.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF04548. AIG1. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51720. G_AIG1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8WWP7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGRKMATDE ENVYGLEENA QSRQESTRRL ILVGRTGAGK SATGNSILGQ
60 70 80 90 100
RRFFSRLGAT SVTRACTTGS RRWDKCHVEV VDTPDIFSSQ VSKTDPGCEE
110 120 130 140 150
RGHCYLLSAP GPHALLLVTQ LGRFTAQDQQ AVRQVRDMFG EDVLKWMVIV
160 170 180 190 200
FTRKEDLAGG SLHDYVSNTE NRALRELVAE CGGRVCAFDN RATGREQEAQ
210 220 230 240 250
VEQLLGMVEG LVLEHKGAHY SNEVYELAQV LRWAGPEERL RRVAERVAAR
260 270 280 290 300
VQRRPWGAWL SARLWKWLKS PRSWRLGLAL LLGGALLFWV LLHRRWSEAV

AEVGPD
Length:306
Mass (Da):34,369
Last modified:March 1, 2002 - v1
Checksum:i7C1F620658B95960
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti235G → V in BAC03754 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036301166V → E in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_049530254R → S.Corresponds to variant rs7811263dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ306287 mRNA. Translation: CAC83740.1.
AK091818 mRNA. Translation: BAC03754.1.
AK315127 mRNA. Translation: BAG37580.1.
CH471173 Genomic DNA. Translation: EAW54095.1.
BC040736 mRNA. Translation: AAH40736.1.
CCDSiCCDS5906.1.
RefSeqiNP_570115.1. NM_130759.3.
UniGeneiHs.647079.

Genome annotation databases

EnsembliENST00000307194; ENSP00000302833; ENSG00000213203.
GeneIDi170575.
KEGGihsa:170575.
UCSCiuc003whq.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ306287 mRNA. Translation: CAC83740.1.
AK091818 mRNA. Translation: BAC03754.1.
AK315127 mRNA. Translation: BAG37580.1.
CH471173 Genomic DNA. Translation: EAW54095.1.
BC040736 mRNA. Translation: AAH40736.1.
CCDSiCCDS5906.1.
RefSeqiNP_570115.1. NM_130759.3.
UniGeneiHs.647079.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3V70X-ray2.21A/B25-253[»]
ProteinModelPortaliQ8WWP7.
SMRiQ8WWP7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128063. 3 interactors.
IntActiQ8WWP7. 2 interactors.
STRINGi9606.ENSP00000302833.

PTM databases

iPTMnetiQ8WWP7.
PhosphoSitePlusiQ8WWP7.

Polymorphism and mutation databases

BioMutaiGIMAP1.
DMDMi38372377.

Proteomic databases

EPDiQ8WWP7.
PaxDbiQ8WWP7.
PeptideAtlasiQ8WWP7.
PRIDEiQ8WWP7.

Protocols and materials databases

DNASUi170575.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307194; ENSP00000302833; ENSG00000213203.
GeneIDi170575.
KEGGihsa:170575.
UCSCiuc003whq.4. human.

Organism-specific databases

CTDi170575.
GeneCardsiGIMAP1.
HGNCiHGNC:23237. GIMAP1.
HPAiHPA044887.
MIMi608084. gene.
neXtProtiNX_Q8WWP7.
OpenTargetsiENSG00000213203.
PharmGKBiPA134978698.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J90P. Eukaryota.
ENOG410Y0H9. LUCA.
GeneTreeiENSGT00760000118989.
HOGENOMiHOG000115747.
HOVERGENiHBG004016.
InParanoidiQ8WWP7.
OMAiSNTENRA.
OrthoDBiEOG091G0I0X.
PhylomeDBiQ8WWP7.
TreeFamiTF330845.

Enzyme and pathway databases

BioCyciZFISH:G66-30905-MONOMER.

Miscellaneous databases

ChiTaRSiGIMAP1. human.
EvolutionaryTraceiQ8WWP7.
GenomeRNAii170575.
PROiQ8WWP7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000213203.
CleanExiHS_GIMAP1.
ExpressionAtlasiQ8WWP7. baseline and differential.
GenevisibleiQ8WWP7. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR006703. G_AIG1.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF04548. AIG1. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51720. G_AIG1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGIMA1_HUMAN
AccessioniPrimary (citable) accession number: Q8WWP7
Secondary accession number(s): B2RCI3, Q8NAZ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: March 1, 2002
Last modified: November 30, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.