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Protein

Interactor protein for cytohesin exchange factors 1

Gene

IPCEF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Enhances the promotion of guanine-nucleotide exchange by PSCD2 on ARF6 in a concentration-dependent manner.By similarity

GO - Molecular functioni

  • oxygen transporter activity Source: UniProtKB
  • peroxidase activity Source: UniProtKB

GO - Biological processi

  • oxygen transport Source: UniProtKB
  • response to oxidative stress Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Interactor protein for cytohesin exchange factors 1
Alternative name(s):
Phosphoinositide-binding protein PIP3-E
Gene namesi
Name:IPCEF1
Synonyms:KIAA0403
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:21204. IPCEF1.

Subcellular locationi

  • Cytoplasm By similarity
  • Cell membrane By similarity

  • Note: Translocated with PSCD2 to the plasma membrane upon epidermal growth factor (EGF) stimulation.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164721033.

Polymorphism and mutation databases

BioMutaiIPCEF1.
DMDMi74751582.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 437437Interactor protein for cytohesin exchange factors 1PRO_0000326630Add
BLAST

Proteomic databases

PaxDbiQ8WWN9.
PeptideAtlasiQ8WWN9.
PRIDEiQ8WWN9.

PTM databases

iPTMnetiQ8WWN9.
PhosphoSiteiQ8WWN9.

Expressioni

Gene expression databases

BgeeiQ8WWN9.
ExpressionAtlasiQ8WWN9. baseline and differential.
GenevisibleiQ8WWN9. HS.

Organism-specific databases

HPAiHPA028708.

Interactioni

Subunit structurei

Interacts with guanine-nucleotide exchange factors PSCD1, PSCD2, PSCD3 and PSCD4.By similarity

Protein-protein interaction databases

BioGridi117500. 6 interactions.
STRINGi9606.ENSP00000356189.

Structurei

3D structure databases

ProteinModelPortaliQ8WWN9.
SMRiQ8WWN9. Positions 45-144.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini41 – 140100PHPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi184 – 283100Ser-richAdd
BLAST

Sequence similaritiesi

Contains 1 PH domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IP6N. Eukaryota.
ENOG41121GN. LUCA.
GeneTreeiENSGT00390000017199.
HOGENOMiHOG000082484.
HOVERGENiHBG107987.
InParanoidiQ8WWN9.
OrthoDBiEOG71ZP0W.
PhylomeDBiQ8WWN9.
TreeFamiTF326495.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WWN9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTSYMAIDGS ALVPLRQKPR RKTQGFLTMS RRRISCKDLG HADCQGWLYK
60 70 80 90 100
KKEKGSFLSN KWKKFWVILK GSSLYWYSNQ MAEKADGFVN LPDFTVERAS
110 120 130 140 150
ECKKKHAFKI SHPQIKTFYF AAENVQEMNV WLNKLGSAVI HQESTTKDEE
160 170 180 190 200
CYSESEQEDP EIAAETPPPP HASQTQSLTA QQASSSSPSL SGTSYSFSSL
210 220 230 240 250
ENTVKTPSSF PSSLSKERQS LPDTVNSLSA AEDEGQPITF AVQVHSPVPS
260 270 280 290 300
EAGIHKALEN SFVTSESGFL NSLSSDDTSS LSSNHDHLTV PDKPAGSKIM
310 320 330 340 350
DKEETKVSED DEMEKLYKSL EQASLSPLGD RRPSTKKELR KSFVKRCKNP
360 370 380 390 400
SINEKLHKIR TLNSTLKCKE HDLAMINQLL DDPKLTARKY REWKVMNTLL
410 420 430
IQDIYQQQRA SPAPDDTDDT PQELKKSPSS PSVENSI
Length:437
Mass (Da):48,993
Last modified:March 1, 2002 - v1
Checksum:i60BC1790FBBD377C
GO
Isoform 2 (identifier: Q8WWN9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     12-12: L → LQ

Show »
Length:438
Mass (Da):49,121
Checksum:iC5AE0271EAF29540
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti267 – 2671S → G in CAI46054 (PubMed:17974005).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti194 – 1941S → P.
Corresponds to variant rs1060390 [ dbSNP | Ensembl ].
VAR_042410

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei12 – 121L → LQ in isoform 2. 3 PublicationsVSP_032682

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ310566 mRNA. Translation: CAC83949.1.
AK289917 mRNA. Translation: BAF82606.1.
BX647254 mRNA. Translation: CAI46054.1.
AL445220, AL132774 Genomic DNA. Translation: CAH72408.1.
AL132774, AL445220 Genomic DNA. Translation: CAI20459.1.
CH471051 Genomic DNA. Translation: EAW47701.1.
BC105015 mRNA. Translation: AAI05016.1.
BC105043 mRNA. Translation: AAI05044.1.
BC143623 mRNA. Translation: AAI43624.1.
BC143629 mRNA. Translation: AAI43630.1.
AB007863 mRNA. Translation: BAA23699.1.
CCDSiCCDS47509.1. [Q8WWN9-2]
CCDS5245.1. [Q8WWN9-1]
RefSeqiNP_001124171.1. NM_001130699.1. [Q8WWN9-2]
NP_001124172.1. NM_001130700.1. [Q8WWN9-2]
NP_056368.1. NM_015553.2. [Q8WWN9-1]
XP_005266976.1. XM_005266919.3. [Q8WWN9-2]
XP_005266977.1. XM_005266920.3. [Q8WWN9-2]
XP_005266978.1. XM_005266921.3. [Q8WWN9-2]
XP_005266979.1. XM_005266922.3. [Q8WWN9-2]
XP_005266980.1. XM_005266923.2. [Q8WWN9-1]
XP_011534041.1. XM_011535739.1. [Q8WWN9-2]
XP_011534042.1. XM_011535740.1. [Q8WWN9-2]
XP_011534043.1. XM_011535741.1. [Q8WWN9-2]
XP_011534044.1. XM_011535742.1. [Q8WWN9-1]
UniGeneiHs.146100.

Genome annotation databases

EnsembliENST00000265198; ENSP00000265198; ENSG00000074706. [Q8WWN9-1]
ENST00000367220; ENSP00000356189; ENSG00000074706. [Q8WWN9-2]
ENST00000422970; ENSP00000394751; ENSG00000074706. [Q8WWN9-2]
GeneIDi26034.
KEGGihsa:26034.
UCSCiuc003qpw.4. human. [Q8WWN9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ310566 mRNA. Translation: CAC83949.1.
AK289917 mRNA. Translation: BAF82606.1.
BX647254 mRNA. Translation: CAI46054.1.
AL445220, AL132774 Genomic DNA. Translation: CAH72408.1.
AL132774, AL445220 Genomic DNA. Translation: CAI20459.1.
CH471051 Genomic DNA. Translation: EAW47701.1.
BC105015 mRNA. Translation: AAI05016.1.
BC105043 mRNA. Translation: AAI05044.1.
BC143623 mRNA. Translation: AAI43624.1.
BC143629 mRNA. Translation: AAI43630.1.
AB007863 mRNA. Translation: BAA23699.1.
CCDSiCCDS47509.1. [Q8WWN9-2]
CCDS5245.1. [Q8WWN9-1]
RefSeqiNP_001124171.1. NM_001130699.1. [Q8WWN9-2]
NP_001124172.1. NM_001130700.1. [Q8WWN9-2]
NP_056368.1. NM_015553.2. [Q8WWN9-1]
XP_005266976.1. XM_005266919.3. [Q8WWN9-2]
XP_005266977.1. XM_005266920.3. [Q8WWN9-2]
XP_005266978.1. XM_005266921.3. [Q8WWN9-2]
XP_005266979.1. XM_005266922.3. [Q8WWN9-2]
XP_005266980.1. XM_005266923.2. [Q8WWN9-1]
XP_011534041.1. XM_011535739.1. [Q8WWN9-2]
XP_011534042.1. XM_011535740.1. [Q8WWN9-2]
XP_011534043.1. XM_011535741.1. [Q8WWN9-2]
XP_011534044.1. XM_011535742.1. [Q8WWN9-1]
UniGeneiHs.146100.

3D structure databases

ProteinModelPortaliQ8WWN9.
SMRiQ8WWN9. Positions 45-144.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117500. 6 interactions.
STRINGi9606.ENSP00000356189.

PTM databases

iPTMnetiQ8WWN9.
PhosphoSiteiQ8WWN9.

Polymorphism and mutation databases

BioMutaiIPCEF1.
DMDMi74751582.

Proteomic databases

PaxDbiQ8WWN9.
PeptideAtlasiQ8WWN9.
PRIDEiQ8WWN9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265198; ENSP00000265198; ENSG00000074706. [Q8WWN9-1]
ENST00000367220; ENSP00000356189; ENSG00000074706. [Q8WWN9-2]
ENST00000422970; ENSP00000394751; ENSG00000074706. [Q8WWN9-2]
GeneIDi26034.
KEGGihsa:26034.
UCSCiuc003qpw.4. human. [Q8WWN9-1]

Organism-specific databases

CTDi26034.
GeneCardsiIPCEF1.
HGNCiHGNC:21204. IPCEF1.
HPAiHPA028708.
neXtProtiNX_Q8WWN9.
PharmGKBiPA164721033.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IP6N. Eukaryota.
ENOG41121GN. LUCA.
GeneTreeiENSGT00390000017199.
HOGENOMiHOG000082484.
HOVERGENiHBG107987.
InParanoidiQ8WWN9.
OrthoDBiEOG71ZP0W.
PhylomeDBiQ8WWN9.
TreeFamiTF326495.

Miscellaneous databases

GenomeRNAii26034.
PROiQ8WWN9.

Gene expression databases

BgeeiQ8WWN9.
ExpressionAtlasiQ8WWN9. baseline and differential.
GenevisibleiQ8WWN9. HS.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH PHOSPHATIDYLINOSITOL 3-PHOSPHATE.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Corpus callosum.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Endometrium.
  4. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain.
  7. "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro."
    Ishikawa K., Nagase T., Nakajima D., Seki N., Ohira M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 4:307-313(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 22-437.
    Tissue: Brain.

Entry informationi

Entry nameiICEF1_HUMAN
AccessioniPrimary (citable) accession number: Q8WWN9
Secondary accession number(s): A8K1K2
, B7ZL78, B7ZL80, O43153, Q5HYL8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: March 1, 2002
Last modified: July 6, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-29 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.