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Protein

Interactor protein for cytohesin exchange factors 1

Gene

IPCEF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Enhances the promotion of guanine-nucleotide exchange by PSCD2 on ARF6 in a concentration-dependent manner.By similarity

GO - Molecular functioni

  • oxygen transporter activity Source: UniProtKB
  • peroxidase activity Source: UniProtKB
  • protein domain specific binding Source: Ensembl

GO - Biological processi

  • oxygen transport Source: UniProtKB
  • response to oxidative stress Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Interactor protein for cytohesin exchange factors 1
Alternative name(s):
Phosphoinositide-binding protein PIP3-E
Gene namesi
Name:IPCEF1
Synonyms:KIAA0403
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000074706.13.
HGNCiHGNC:21204. IPCEF1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi26034.
OpenTargetsiENSG00000074706.
PharmGKBiPA164721033.

Polymorphism and mutation databases

BioMutaiIPCEF1.
DMDMi74751582.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003266301 – 437Interactor protein for cytohesin exchange factors 1Add BLAST437

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei411PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8WWN9.
PeptideAtlasiQ8WWN9.
PRIDEiQ8WWN9.

PTM databases

iPTMnetiQ8WWN9.
PhosphoSitePlusiQ8WWN9.

Expressioni

Gene expression databases

BgeeiENSG00000074706.
ExpressionAtlasiQ8WWN9. baseline and differential.
GenevisibleiQ8WWN9. HS.

Organism-specific databases

HPAiHPA028708.

Interactioni

Subunit structurei

Interacts with guanine-nucleotide exchange factors PSCD1, PSCD2, PSCD3 and PSCD4.By similarity

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi117500. 6 interactors.
IntActiQ8WWN9. 5 interactors.
STRINGi9606.ENSP00000356189.

Structurei

Secondary structure

1437
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi44 – 50Combined sources7
Beta strandi63 – 70Combined sources8
Beta strandi73 – 79Combined sources7
Beta strandi86 – 90Combined sources5
Beta strandi95 – 98Combined sources4
Beta strandi102 – 104Combined sources3
Beta strandi107 – 111Combined sources5
Beta strandi117 – 121Combined sources5
Helixi125 – 138Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5MR1X-ray1.20A42-142[»]
ProteinModelPortaliQ8WWN9.
SMRiQ8WWN9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 140PHPROSITE-ProRule annotationAdd BLAST100

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi184 – 283Ser-richAdd BLAST100

Phylogenomic databases

eggNOGiENOG410IP6N. Eukaryota.
ENOG41121GN. LUCA.
GeneTreeiENSGT00390000017199.
HOGENOMiHOG000082484.
HOVERGENiHBG107987.
InParanoidiQ8WWN9.
OMAiSFLSNKW.
OrthoDBiEOG091G037J.
PhylomeDBiQ8WWN9.
TreeFamiTF326495.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiView protein in InterPro
IPR011993. PH_dom-like.
IPR001849. PH_domain.
PfamiView protein in Pfam
PF00169. PH. 1 hit.
SMARTiView protein in SMART
SM00233. PH. 1 hit.
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiView protein in PROSITE
PS50003. PH_DOMAIN. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WWN9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTSYMAIDGS ALVPLRQKPR RKTQGFLTMS RRRISCKDLG HADCQGWLYK
60 70 80 90 100
KKEKGSFLSN KWKKFWVILK GSSLYWYSNQ MAEKADGFVN LPDFTVERAS
110 120 130 140 150
ECKKKHAFKI SHPQIKTFYF AAENVQEMNV WLNKLGSAVI HQESTTKDEE
160 170 180 190 200
CYSESEQEDP EIAAETPPPP HASQTQSLTA QQASSSSPSL SGTSYSFSSL
210 220 230 240 250
ENTVKTPSSF PSSLSKERQS LPDTVNSLSA AEDEGQPITF AVQVHSPVPS
260 270 280 290 300
EAGIHKALEN SFVTSESGFL NSLSSDDTSS LSSNHDHLTV PDKPAGSKIM
310 320 330 340 350
DKEETKVSED DEMEKLYKSL EQASLSPLGD RRPSTKKELR KSFVKRCKNP
360 370 380 390 400
SINEKLHKIR TLNSTLKCKE HDLAMINQLL DDPKLTARKY REWKVMNTLL
410 420 430
IQDIYQQQRA SPAPDDTDDT PQELKKSPSS PSVENSI
Length:437
Mass (Da):48,993
Last modified:March 1, 2002 - v1
Checksum:i60BC1790FBBD377C
GO
Isoform 2 (identifier: Q8WWN9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     12-12: L → LQ

Show »
Length:438
Mass (Da):49,121
Checksum:iC5AE0271EAF29540
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti267S → G in CAI46054 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_042410194S → P. Corresponds to variant dbSNP:rs1060390Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03268212L → LQ in isoform 2. 3 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ310566 mRNA. Translation: CAC83949.1.
AK289917 mRNA. Translation: BAF82606.1.
BX647254 mRNA. Translation: CAI46054.1.
AL445220, AL132774 Genomic DNA. Translation: CAH72408.1.
AL132774, AL445220 Genomic DNA. Translation: CAI20459.1.
CH471051 Genomic DNA. Translation: EAW47701.1.
BC105015 mRNA. Translation: AAI05016.1.
BC105043 mRNA. Translation: AAI05044.1.
BC143623 mRNA. Translation: AAI43624.1.
BC143629 mRNA. Translation: AAI43630.1.
AB007863 mRNA. Translation: BAA23699.1.
CCDSiCCDS47509.1. [Q8WWN9-2]
CCDS5245.1. [Q8WWN9-1]
RefSeqiNP_001124171.1. NM_001130699.1. [Q8WWN9-2]
NP_001124172.1. NM_001130700.1. [Q8WWN9-2]
NP_056368.1. NM_015553.2. [Q8WWN9-1]
XP_005266976.1. XM_005266919.4. [Q8WWN9-2]
XP_005266978.1. XM_005266921.4. [Q8WWN9-2]
XP_005266980.1. XM_005266923.3. [Q8WWN9-1]
XP_011534044.1. XM_011535742.2. [Q8WWN9-1]
XP_016866206.1. XM_017010717.1. [Q8WWN9-2]
XP_016866207.1. XM_017010718.1. [Q8WWN9-1]
UniGeneiHs.146100.

Genome annotation databases

EnsembliENST00000265198; ENSP00000265198; ENSG00000074706. [Q8WWN9-1]
ENST00000367220; ENSP00000356189; ENSG00000074706. [Q8WWN9-2]
ENST00000422970; ENSP00000394751; ENSG00000074706. [Q8WWN9-2]
GeneIDi26034.
KEGGihsa:26034.
UCSCiuc003qpw.4. human. [Q8WWN9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiICEF1_HUMAN
AccessioniPrimary (citable) accession number: Q8WWN9
Secondary accession number(s): A8K1K2
, B7ZL78, B7ZL80, O43153, Q5HYL8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: March 1, 2002
Last modified: September 27, 2017
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-29 is the initiator.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references