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Protein

Interactor protein for cytohesin exchange factors 1

Gene

IPCEF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Enhances the promotion of guanine-nucleotide exchange by PSCD2 on ARF6 in a concentration-dependent manner.By similarity

Caution

It is uncertain whether Met-1 or Met-29 is the initiator.Curated

GO - Molecular functioni

  • oxygen carrier activity Source: UniProtKB
  • peroxidase activity Source: UniProtKB

GO - Biological processi

  • oxygen transport Source: UniProtKB
  • response to oxidative stress Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Interactor protein for cytohesin exchange factors 1
Alternative name(s):
Phosphoinositide-binding protein PIP3-E
Gene namesi
Name:IPCEF1
Synonyms:KIAA0403
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000074706.13
HGNCiHGNC:21204 IPCEF1
neXtProtiNX_Q8WWN9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi26034
OpenTargetsiENSG00000074706
PharmGKBiPA164721033

Polymorphism and mutation databases

BioMutaiIPCEF1
DMDMi74751582

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003266301 – 437Interactor protein for cytohesin exchange factors 1Add BLAST437

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei411PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8WWN9
PeptideAtlasiQ8WWN9
PRIDEiQ8WWN9

PTM databases

iPTMnetiQ8WWN9
PhosphoSitePlusiQ8WWN9

Expressioni

Gene expression databases

BgeeiENSG00000074706
ExpressionAtlasiQ8WWN9 baseline and differential
GenevisibleiQ8WWN9 HS

Organism-specific databases

HPAiHPA028708

Interactioni

Subunit structurei

Interacts with guanine-nucleotide exchange factors PSCD1, PSCD2, PSCD3 and PSCD4 (By similarity). Interacts (via C-terminus) with cytohesin-2 CYTH2 (PubMed:22085542).By similarity1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi117500, 6 interactors
IntActiQ8WWN9, 5 interactors
STRINGi9606.ENSP00000356189

Structurei

Secondary structure

1437
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi44 – 50Combined sources7
Beta strandi63 – 70Combined sources8
Beta strandi73 – 79Combined sources7
Beta strandi86 – 90Combined sources5
Beta strandi95 – 98Combined sources4
Beta strandi102 – 104Combined sources3
Beta strandi107 – 111Combined sources5
Beta strandi117 – 121Combined sources5
Helixi125 – 138Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5MR1X-ray1.20A42-142[»]
ProteinModelPortaliQ8WWN9
SMRiQ8WWN9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 140PHPROSITE-ProRule annotationAdd BLAST100

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni315 – 320CRAC domain6
Regioni339 – 348CRAC domain10
Regioni389 – 437Required for interaction with CYTH21 PublicationAdd BLAST49

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi184 – 283Ser-richAdd BLAST100

Phylogenomic databases

eggNOGiENOG410IP6N Eukaryota
ENOG41121GN LUCA
GeneTreeiENSGT00390000017199
HOGENOMiHOG000082484
HOVERGENiHBG107987
InParanoidiQ8WWN9
OMAiSFLSNKW
OrthoDBiEOG091G037J
PhylomeDBiQ8WWN9
TreeFamiTF326495

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PfamiView protein in Pfam
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform IPCEF1-1 (identifier: Q8WWN9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTSYMAIDGS ALVPLRQKPR RKTQGFLTMS RRRISCKDLG HADCQGWLYK
60 70 80 90 100
KKEKGSFLSN KWKKFWVILK GSSLYWYSNQ MAEKADGFVN LPDFTVERAS
110 120 130 140 150
ECKKKHAFKI SHPQIKTFYF AAENVQEMNV WLNKLGSAVI HQESTTKDEE
160 170 180 190 200
CYSESEQEDP EIAAETPPPP HASQTQSLTA QQASSSSPSL SGTSYSFSSL
210 220 230 240 250
ENTVKTPSSF PSSLSKERQS LPDTVNSLSA AEDEGQPITF AVQVHSPVPS
260 270 280 290 300
EAGIHKALEN SFVTSESGFL NSLSSDDTSS LSSNHDHLTV PDKPAGSKIM
310 320 330 340 350
DKEETKVSED DEMEKLYKSL EQASLSPLGD RRPSTKKELR KSFVKRCKNP
360 370 380 390 400
SINEKLHKIR TLNSTLKCKE HDLAMINQLL DDPKLTARKY REWKVMNTLL
410 420 430
IQDIYQQQRA SPAPDDTDDT PQELKKSPSS PSVENSI
Length:437
Mass (Da):48,993
Last modified:March 1, 2002 - v1
Checksum:i60BC1790FBBD377C
GO
Isoform IPCEF1-2 (identifier: Q8WWN9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     12-12: L → LQ

Show »
Length:438
Mass (Da):49,121
Checksum:iC5AE0271EAF29540
GO
Isoform CNK3-IPCEF1-1 (identifier: G9CGD6-1) [UniParc]FASTAAdd to basket
Also known as: CNK3/IPCEF1 Long-1
The sequence of this isoform can be found in the external entry G9CGD6.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: Based on a naturally occurring readthrough transcript which produces an CNK3/IPCEF1 fusion protein.1 Publication
Length:899
Mass (Da):100,365
GO
Isoform CNK3-IPCEF1-2 (identifier: G9CGD6-2) [UniParc]FASTAAdd to basket
Also known as: CNK3/IPCEF1 Long-2
The sequence of this isoform can be found in the external entry G9CGD6.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: Based on a naturally occurring readthrough transcript which produces an CNK3/IPCEF1 fusion protein.1 Publication
Length:900
Mass (Da):100,493
GO
Isoform CNK3-IPCEF1-3 (identifier: G9CGD6-3) [UniParc]FASTAAdd to basket
Also known as: CNK3/IPCEF1 Short
The sequence of this isoform can be found in the external entry G9CGD6.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: Based on a naturally occurring readthrough transcript which produces an CNK3/IPCEF1 fusion protein. Major isoform found in CaCo2-cells.1 Publication
Length:830
Mass (Da):92,057
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti267S → G in CAI46054 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_042410194S → P. Corresponds to variant dbSNP:rs1060390Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03268212L → LQ in isoform IPCEF1-2. 3 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ310566 mRNA Translation: CAC83949.1
AK289917 mRNA Translation: BAF82606.1
BX647254 mRNA Translation: CAI46054.1
AL445220 Genomic DNA No translation available.
AL033376 Genomic DNA No translation available.
AL132774 Genomic DNA No translation available.
KF510943 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47701.1
CH471051 Genomic DNA Translation: EAW47702.1
BC105015 mRNA Translation: AAI05016.1
BC105043 mRNA Translation: AAI05044.1
BC143623 mRNA Translation: AAI43624.1
BC143629 mRNA Translation: AAI43630.1
AB007863 mRNA Translation: BAA23699.1
CCDSiCCDS47509.1 [Q8WWN9-2]
CCDS5245.1 [Q8WWN9-1]
RefSeqiNP_001124171.1, NM_001130699.1 [Q8WWN9-2]
NP_001124172.1, NM_001130700.1 [Q8WWN9-2]
NP_056368.1, NM_015553.2 [Q8WWN9-1]
XP_005266976.1, XM_005266919.4 [Q8WWN9-2]
XP_005266978.1, XM_005266921.4 [Q8WWN9-2]
XP_005266980.1, XM_005266923.3 [Q8WWN9-1]
XP_011534044.1, XM_011535742.2 [Q8WWN9-1]
XP_016866206.1, XM_017010717.1 [Q8WWN9-2]
XP_016866207.1, XM_017010718.1 [Q8WWN9-1]
UniGeneiHs.146100

Genome annotation databases

EnsembliENST00000265198; ENSP00000265198; ENSG00000074706 [Q8WWN9-1]
ENST00000367220; ENSP00000356189; ENSG00000074706 [Q8WWN9-2]
ENST00000422970; ENSP00000394751; ENSG00000074706 [Q8WWN9-2]
GeneIDi26034
KEGGihsa:26034
UCSCiuc003qpw.4 human [Q8WWN9-1]
uc063skh.1 human

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiICEF1_HUMAN
AccessioniPrimary (citable) accession number: Q8WWN9
Secondary accession number(s): A8K1K2
, B7ZL78, B7ZL80, G3V132, O43153, Q5HYL8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: March 1, 2002
Last modified: March 28, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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