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Q8WWN8

- ARAP3_HUMAN

UniProt

Q8WWN8 - ARAP3_HUMAN

Protein

Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3

Gene

ARAP3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Acts on ARF6, RAC1, RHOA and CDC42. Plays a role in the internalization of anthrax toxin.2 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri504 – 52724C4-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ARF GTPase activator activity Source: UniProtKB
    2. phosphatidylinositol-3,4,5-trisphosphate binding Source: UniProtKB
    3. phosphatidylinositol-3,4-bisphosphate binding Source: UniProtKB
    4. protein binding Source: IntAct
    5. Rho GTPase activator activity Source: UniProtKB
    6. zinc ion binding Source: InterPro

    GO - Biological processi

    1. cytoskeleton organization Source: UniProtKB
    2. negative regulation of cell migration Source: UniProtKB
    3. negative regulation of Rac protein signal transduction Source: Ensembl
    4. negative regulation of Rho protein signal transduction Source: UniProtKB
    5. regulation of ARF GTPase activity Source: InterPro
    6. regulation of cell shape Source: UniProtKB
    7. regulation of small GTPase mediated signal transduction Source: Reactome
    8. small GTPase mediated signal transduction Source: Reactome
    9. vesicle-mediated transport Source: UniProtKB

    Keywords - Molecular functioni

    GTPase activation

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_11051. Rho GTPase cycle.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3
    Alternative name(s):
    Centaurin-delta-3
    Short name:
    Cnt-d3
    Gene namesi
    Name:ARAP3
    Synonyms:CENTD3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:24097. ARAP3.

    Subcellular locationi

    Cytoplasm By similarity. Cytoplasmcytoskeleton By similarity. Cell membrane By similarity; Peripheral membrane protein By similarity. Cell projectionlamellipodium By similarity. Cell projectionruffle By similarity
    Note: Cytoplasmic, and associated with F-actin-rich membrane ruffles and lamellipodia.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. cytoskeleton Source: UniProtKB-SubCell
    3. cytosol Source: Reactome
    4. lamellipodium Source: UniProtKB
    5. plasma membrane Source: UniProtKB-SubCell
    6. ruffle Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi307 – 3082RR → AA: Loss of PtdIns(3,4,5)P3 binding. 1 Publication

    Organism-specific databases

    PharmGKBiPA164715983.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 15441544Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3PRO_0000074215Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1403 – 14031PhosphotyrosineBy similarity
    Modified residuei1408 – 14081PhosphotyrosineBy similarity
    Modified residuei1444 – 14441Phosphoserine2 Publications
    Modified residuei1480 – 14801Phosphoserine1 Publication

    Post-translational modificationi

    Tyrosine phosphorylated at a low basal level. PDGF treatment stimulates phosphorylation. Tyrosine phosphorylation is increased in cells that are in the process of becoming attached to a substrate and that start spreading and flattening By similarity.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ8WWN8.
    PaxDbiQ8WWN8.
    PeptideAtlasiQ8WWN8.
    PRIDEiQ8WWN8.

    PTM databases

    PhosphoSiteiQ8WWN8.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8WWN8.
    BgeeiQ8WWN8.
    CleanExiHS_ARAP3.
    GenevestigatoriQ8WWN8.

    Organism-specific databases

    HPAiHPA042887.

    Interactioni

    Subunit structurei

    Interacts (via SAM domain) with INPPL1/SHIP2.3 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    SH3KBP1Q96B972EBI-4402732,EBI-346595

    Protein-protein interaction databases

    BioGridi122163. 3 interactions.
    IntActiQ8WWN8. 1 interaction.
    MINTiMINT-8098880.
    STRINGi9606.ENSP00000239440.

    Structurei

    Secondary structure

    1
    1544
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi9 – 135
    Helixi14 – 163
    Helixi19 – 213
    Helixi22 – 276
    Helixi33 – 364
    Helixi41 – 477
    Helixi52 – 6211
    Turni63 – 675

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2KG5NMR-A1-80[»]
    2LNWNMR-B1404-1412[»]
    ProteinModelPortaliQ8WWN8.
    SMRiQ8WWN8. Positions 1-80, 293-485, 491-653, 906-1100.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ8WWN8.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 6865SAMPROSITE-ProRule annotationAdd
    BLAST
    Domaini287 – 37993PH 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini394 – 48390PH 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini480 – 611132Arf-GAPPROSITE-ProRule annotationAdd
    BLAST
    Domaini907 – 1088182Rho-GAPPROSITE-ProRule annotationAdd
    BLAST
    Domaini1117 – 121094Ras-associatingPROSITE-ProRule annotationAdd
    BLAST
    Domaini1223 – 1325103PH 3PROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi81 – 13959Pro-richAdd
    BLAST
    Compositional biasi1462 – 154281Pro-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 Arf-GAP domain.PROSITE-ProRule annotation
    Contains 3 PH domains.PROSITE-ProRule annotation
    Contains 1 Ras-associating domain.PROSITE-ProRule annotation
    Contains 1 Rho-GAP domain.PROSITE-ProRule annotation
    Contains 1 SAM (sterile alpha motif) domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri504 – 52724C4-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5347.
    HOGENOMiHOG000246988.
    HOVERGENiHBG069114.
    InParanoidiQ8WWN8.
    KOiK12490.
    OMAiTQLLCVE.
    PhylomeDBiQ8WWN8.
    TreeFamiTF105769.

    Family and domain databases

    Gene3Di1.10.150.50. 1 hit.
    1.10.555.10. 1 hit.
    2.30.29.30. 3 hits.
    InterProiIPR001164. ArfGAP.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR000159. Ras-assoc.
    IPR008936. Rho_GTPase_activation_prot.
    IPR000198. RhoGAP_dom.
    IPR001660. SAM.
    IPR013761. SAM/pointed.
    IPR011510. SAM_2.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view]
    PfamiPF01412. ArfGap. 1 hit.
    PF00169. PH. 2 hits.
    PF00788. RA. 1 hit.
    PF00620. RhoGAP. 1 hit.
    PF07647. SAM_2. 1 hit.
    [Graphical view]
    PRINTSiPR00405. REVINTRACTNG.
    SMARTiSM00105. ArfGap. 1 hit.
    SM00233. PH. 5 hits.
    SM00324. RhoGAP. 1 hit.
    SM00454. SAM. 1 hit.
    [Graphical view]
    SUPFAMiSSF47769. SSF47769. 1 hit.
    SSF48350. SSF48350. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEiPS50115. ARFGAP. 1 hit.
    PS50003. PH_DOMAIN. 3 hits.
    PS50200. RA. 1 hit.
    PS50238. RHOGAP. 1 hit.
    PS50105. SAM_DOMAIN. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8WWN8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAPQDLDIA VWLATVHLEQ YADTFRRHGL ATAGAARGLG HEELKQLGIS     50
    ATGHRKRILR LLQTGTEEGS LDPKSDSAME PSPSPAPQAQ PPKPVPKPRT 100
    VFGGLSGPAT TQRPGLSPAL GGPGVSRSPE PSPRPPPLPT SSSEQSSALN 150
    TVEMMPNSIY FGLDSRGRAQ AAQDKAPDSS QISAPTPALR PTTGTVHIMD 200
    PGCLYYGVQP VGTPGAPDRR ESRGVCQGRA EHRLSRQDLE AREDAGYASL 250
    ELPGDSTLLS PTLETEETSD DLISPYASFS FTADRLTPLL SGWLDKLSPQ 300
    GNYVFQRRFV QFNGRSLMYF GSDKDPFPKG VIPLTAIEMT RSSKDNKFQV 350
    ITGQRVFVFR TESEAQRDMW CSTLQSCLKE QRLLGHPRPP QPPRPLRTGM 400
    LELRGHKAKV FAALSPGELA LYKSEQAFSL GIGICFIELQ GCSVRETKSR 450
    SFDLLTPHRC FSFTAESGGA RQSWAAALQE AVTETLSDYE VAEKIWSNRA 500
    NRQCADCGSS RPDWAAVNLG VVICKQCAGQ HRALGSGISK VQSLKLDTSV 550
    WSNEIVQLFI VLGNDRANRF WAGTLPPGEG LHPDATPGPR GEFISRKYRL 600
    GLFRKPHPQY PDHSQLLQAL CAAVARPNLL KNMTQLLCVE AFEGEEPWFP 650
    PAPDGSCPGL LPSDPSPGVY NEVVVRATYS GFLYCSPVSN KAGPSPPRRG 700
    RDAPPRLWCV LGAALEMFAS ENSPEPLSLI QPQDIVCLGV SPPPTDPGDR 750
    FPFSFELILA GGRIQHFGTD GADSLEAWTS AVGKWFSPLS CHQLLGPGLL 800
    RLGRLWLRSP SHTAPAPGLW LSGFGLLRGD HLFLCSAPGP GPPAPEDMVH 850
    LRRLQEISVV SAADTPDKKE HLVLVETGRT LYLQGEGRLD FTAWNAAIGG 900
    AAGGGGTGLQ EQQMSRGDIP IIVDACISFV TQHGLRLEGV YRKGGARARS 950
    LRLLAEFRRD ARSVKLRPGE HFVEDVTDTL KRFFRELDDP VTSARLLPRW 1000
    REAAELPQKN QRLEKYKDVI GCLPRVNRRT LATLIGHLYR VQKCAALNQM 1050
    CTRNLALLFA PSVFQTDGRG EHEVRVLQEL IDGYISVFDI DSDQVAQIDL 1100
    EVSLITTWKD VQLSQAGDLI MEVYIEQQLP DNCVTLKVSP TLTAEELTNQ 1150
    VLEMRGTAAG MDLWVTFEIR EHGELERPLH PKEKVLEQAL QWCQLPEPCS 1200
    ASLLLKKVPL AQAGCLFTGI RRESPRVGLL RCREEPPRLL GSRFQERFFL 1250
    LRGRCLLLLK EKKSSKPERE WPLEGAKVYL GIRKKLKPPT PWGFTLILEK 1300
    MHLYLSCTDE DEMWDWTTSI LKAQHDDQQP VVLRRHSSSD LARQKFGTMP 1350
    LLPIRGDDSG ATLLSANQTL RRLHNRRTLS MFFPMKSSQG SVEEQEELEE 1400
    PVYEEPVYEE VGAFPELIQD TSTSFSTTRE WTVKPENPLT SQKSLDQPFL 1450
    SKSSTLGQEE RPPEPPPGPP SKSSPQARGS LEEQLLQELS SLILRKGETT 1500
    AGLGSPSQPS SPQSPSPTGL PTQTPGFPTQ PPCTSSPPSS QPLT 1544
    Length:1,544
    Mass (Da):169,844
    Last modified:March 1, 2002 - v1
    Checksum:i40C03A22591B2B6F
    GO
    Isoform 2 (identifier: Q8WWN8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-338: Missing.
         1371-1383: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,193
    Mass (Da):131,986
    Checksum:i8E101A95C1FB7D24
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti218 – 2181D → H.
    Corresponds to variant rs1031904 [ dbSNP | Ensembl ].
    VAR_048330
    Natural varianti471 – 4711R → W in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_036180
    Natural varianti1085 – 10851I → M in a breast cancer sample; somatic mutation. 1 Publication
    VAR_036181
    Natural varianti1428 – 14281T → P in a breast cancer sample; somatic mutation. 1 Publication
    VAR_036182

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 338338Missing in isoform 2. 1 PublicationVSP_056214Add
    BLAST
    Alternative sequencei1371 – 138313Missing in isoform 2. 1 PublicationVSP_056215Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ310567 mRNA. Translation: CAC83946.1.
    AK295768 mRNA. Translation: BAG58593.1.
    AC022420 Genomic DNA. No translation available.
    CH471062 Genomic DNA. Translation: EAW61904.1.
    CH471062 Genomic DNA. Translation: EAW61905.1.
    CCDSiCCDS4266.1.
    PIRiE59431.
    RefSeqiNP_071926.4. NM_022481.5.
    UniGeneiHs.726187.

    Genome annotation databases

    EnsembliENST00000239440; ENSP00000239440; ENSG00000120318.
    ENST00000513878; ENSP00000421468; ENSG00000120318.
    GeneIDi64411.
    KEGGihsa:64411.
    UCSCiuc003llm.3. human.

    Polymorphism databases

    DMDMi73619965.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ310567 mRNA. Translation: CAC83946.1 .
    AK295768 mRNA. Translation: BAG58593.1 .
    AC022420 Genomic DNA. No translation available.
    CH471062 Genomic DNA. Translation: EAW61904.1 .
    CH471062 Genomic DNA. Translation: EAW61905.1 .
    CCDSi CCDS4266.1.
    PIRi E59431.
    RefSeqi NP_071926.4. NM_022481.5.
    UniGenei Hs.726187.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2KG5 NMR - A 1-80 [» ]
    2LNW NMR - B 1404-1412 [» ]
    ProteinModelPortali Q8WWN8.
    SMRi Q8WWN8. Positions 1-80, 293-485, 491-653, 906-1100.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122163. 3 interactions.
    IntActi Q8WWN8. 1 interaction.
    MINTi MINT-8098880.
    STRINGi 9606.ENSP00000239440.

    PTM databases

    PhosphoSitei Q8WWN8.

    Polymorphism databases

    DMDMi 73619965.

    Proteomic databases

    MaxQBi Q8WWN8.
    PaxDbi Q8WWN8.
    PeptideAtlasi Q8WWN8.
    PRIDEi Q8WWN8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000239440 ; ENSP00000239440 ; ENSG00000120318 .
    ENST00000513878 ; ENSP00000421468 ; ENSG00000120318 .
    GeneIDi 64411.
    KEGGi hsa:64411.
    UCSCi uc003llm.3. human.

    Organism-specific databases

    CTDi 64411.
    GeneCardsi GC05M141032.
    HGNCi HGNC:24097. ARAP3.
    HPAi HPA042887.
    MIMi 606647. gene.
    neXtProti NX_Q8WWN8.
    PharmGKBi PA164715983.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5347.
    HOGENOMi HOG000246988.
    HOVERGENi HBG069114.
    InParanoidi Q8WWN8.
    KOi K12490.
    OMAi TQLLCVE.
    PhylomeDBi Q8WWN8.
    TreeFami TF105769.

    Enzyme and pathway databases

    Reactomei REACT_11051. Rho GTPase cycle.

    Miscellaneous databases

    ChiTaRSi ARAP3. human.
    EvolutionaryTracei Q8WWN8.
    GeneWikii CENTD3.
    GenomeRNAii 64411.
    NextBioi 66374.
    PROi Q8WWN8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8WWN8.
    Bgeei Q8WWN8.
    CleanExi HS_ARAP3.
    Genevestigatori Q8WWN8.

    Family and domain databases

    Gene3Di 1.10.150.50. 1 hit.
    1.10.555.10. 1 hit.
    2.30.29.30. 3 hits.
    InterProi IPR001164. ArfGAP.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR000159. Ras-assoc.
    IPR008936. Rho_GTPase_activation_prot.
    IPR000198. RhoGAP_dom.
    IPR001660. SAM.
    IPR013761. SAM/pointed.
    IPR011510. SAM_2.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view ]
    Pfami PF01412. ArfGap. 1 hit.
    PF00169. PH. 2 hits.
    PF00788. RA. 1 hit.
    PF00620. RhoGAP. 1 hit.
    PF07647. SAM_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00405. REVINTRACTNG.
    SMARTi SM00105. ArfGap. 1 hit.
    SM00233. PH. 5 hits.
    SM00324. RhoGAP. 1 hit.
    SM00454. SAM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47769. SSF47769. 1 hit.
    SSF48350. SSF48350. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEi PS50115. ARFGAP. 1 hit.
    PS50003. PH_DOMAIN. 3 hits.
    PS50200. RA. 1 hit.
    PS50238. RHOGAP. 1 hit.
    PS50105. SAM_DOMAIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), MUTAGENESIS OF 307-ARG-ARG-308, FUNCTION, INTERACTION WITH PHOSPHATIDYLINOSITOL 3-PHOSPHATE.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Hippocampus.
    3. "The DNA sequence and comparative analysis of human chromosome 5."
      Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
      , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
      Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "GTPase signaling: bridging the GAP between ARF and Rho."
      Santy L.C., Casanova J.E.
      Curr. Biol. 12:R360-R362(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    6. "EST-based genome-wide gene inactivation identifies ARAP3 as a host protein affecting cellular susceptibility to anthrax toxin."
      Lu Q., Wei W., Kowalski P.E., Chang A.C.Y., Cohen S.N.
      Proc. Natl. Acad. Sci. U.S.A. 101:17246-17251(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: ROLE IN THE INTERNALIZATION OF ANTHRAX TOXIN.
    7. "The PI3K effector Arap3 interacts with the PI(3,4,5)P3 phosphatase SHIP2 in a SAM domain-dependent manner."
      Raaijmakers J.H., Deneubourg L., Rehmann H., de Koning J., Zhang Z., Krugmann S., Erneux C., Bos J.L.
      Cell. Signal. 19:1249-1257(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH INPPL1.
    8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1444, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1444 AND SER-1480, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "The Sam domain of the lipid phosphatase Ship2 adopts a common model to interact with Arap3-Sam and EphA2-Sam."
      Leone M., Cellitti J., Pellecchia M.
      BMC Struct. Biol. 9:59-59(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 1-80, INTERACTION WITH INPPL1.
    12. Cited for: VARIANTS [LARGE SCALE ANALYSIS] TRP-471; MET-1085 AND PRO-1428.

    Entry informationi

    Entry nameiARAP3_HUMAN
    AccessioniPrimary (citable) accession number: Q8WWN8
    Secondary accession number(s): B4DIT1, D3DQE3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2005
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3