Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3

Gene

ARAP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Acts on ARF6, RAC1, RHOA and CDC42. Plays a role in the internalization of anthrax toxin.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri504 – 52724C4-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • GTPase activator activity Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW
  • phosphatidylinositol-3,4,5-trisphosphate binding Source: UniProtKB
  • phosphatidylinositol-3,4-bisphosphate binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_11051. Rho GTPase cycle.

Names & Taxonomyi

Protein namesi
Recommended name:
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3
Alternative name(s):
Centaurin-delta-3
Short name:
Cnt-d3
Gene namesi
Name:ARAP3
Synonyms:CENTD3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:24097. ARAP3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi307 – 3082RR → AA: Loss of PtdIns(3,4,5)P3 binding. 1 Publication

Organism-specific databases

PharmGKBiPA164715983.

Polymorphism and mutation databases

BioMutaiARAP3.
DMDMi73619965.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15441544Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3PRO_0000074215Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1403 – 14031PhosphotyrosineBy similarity
Modified residuei1408 – 14081PhosphotyrosineBy similarity
Modified residuei1444 – 14441Phosphoserine2 Publications
Modified residuei1480 – 14801Phosphoserine1 Publication

Post-translational modificationi

Tyrosine phosphorylated at a low basal level. PDGF treatment stimulates phosphorylation. Tyrosine phosphorylation is increased in cells that are in the process of becoming attached to a substrate and that start spreading and flattening (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8WWN8.
PaxDbiQ8WWN8.
PeptideAtlasiQ8WWN8.
PRIDEiQ8WWN8.

PTM databases

PhosphoSiteiQ8WWN8.

Expressioni

Gene expression databases

BgeeiQ8WWN8.
CleanExiHS_ARAP3.
ExpressionAtlasiQ8WWN8. baseline and differential.
GenevisibleiQ8WWN8. HS.

Organism-specific databases

HPAiHPA042887.

Interactioni

Subunit structurei

Interacts (via SAM domain) with INPPL1/SHIP2.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
SH3KBP1Q96B972EBI-4402732,EBI-346595

Protein-protein interaction databases

BioGridi122163. 2 interactions.
IntActiQ8WWN8. 1 interaction.
MINTiMINT-8098880.
STRINGi9606.ENSP00000239440.

Structurei

Secondary structure

1
1544
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi9 – 135Combined sources
Helixi14 – 163Combined sources
Helixi19 – 213Combined sources
Helixi22 – 276Combined sources
Helixi33 – 364Combined sources
Helixi41 – 477Combined sources
Helixi52 – 6211Combined sources
Turni63 – 675Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2KG5NMR-A1-80[»]
2LNWNMR-B1404-1412[»]
ProteinModelPortaliQ8WWN8.
SMRiQ8WWN8. Positions 1-80, 293-392, 491-653, 919-1100.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8WWN8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 6865SAMPROSITE-ProRule annotationAdd
BLAST
Domaini287 – 37993PH 1PROSITE-ProRule annotationAdd
BLAST
Domaini394 – 48390PH 2PROSITE-ProRule annotationAdd
BLAST
Domaini480 – 611132Arf-GAPPROSITE-ProRule annotationAdd
BLAST
Domaini907 – 1088182Rho-GAPPROSITE-ProRule annotationAdd
BLAST
Domaini1117 – 121094Ras-associatingPROSITE-ProRule annotationAdd
BLAST
Domaini1223 – 1325103PH 3PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi81 – 13959Pro-richAdd
BLAST
Compositional biasi1462 – 154281Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 Arf-GAP domain.PROSITE-ProRule annotation
Contains 3 PH domains.PROSITE-ProRule annotation
Contains 1 Ras-associating domain.PROSITE-ProRule annotation
Contains 1 Rho-GAP domain.PROSITE-ProRule annotation
Contains 1 SAM (sterile alpha motif) domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri504 – 52724C4-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5347.
GeneTreeiENSGT00800000124095.
HOGENOMiHOG000246988.
HOVERGENiHBG069114.
InParanoidiQ8WWN8.
KOiK12490.
OMAiHEGIYRK.
PhylomeDBiQ8WWN8.
TreeFamiTF105769.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
1.10.555.10. 1 hit.
2.30.29.30. 3 hits.
InterProiIPR001164. ArfGAP.
IPR011993. PH-like_dom.
IPR001849. PH_domain.
IPR000159. Ras-assoc.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR011510. SAM_2.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF01412. ArfGap. 1 hit.
PF00169. PH. 2 hits.
PF00788. RA. 1 hit.
PF00620. RhoGAP. 1 hit.
PF07647. SAM_2. 1 hit.
[Graphical view]
PRINTSiPR00405. REVINTRACTNG.
SMARTiSM00105. ArfGap. 1 hit.
SM00233. PH. 5 hits.
SM00324. RhoGAP. 1 hit.
SM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF48350. SSF48350. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50115. ARFGAP. 1 hit.
PS50003. PH_DOMAIN. 3 hits.
PS50200. RA. 1 hit.
PS50238. RHOGAP. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WWN8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAPQDLDIA VWLATVHLEQ YADTFRRHGL ATAGAARGLG HEELKQLGIS
60 70 80 90 100
ATGHRKRILR LLQTGTEEGS LDPKSDSAME PSPSPAPQAQ PPKPVPKPRT
110 120 130 140 150
VFGGLSGPAT TQRPGLSPAL GGPGVSRSPE PSPRPPPLPT SSSEQSSALN
160 170 180 190 200
TVEMMPNSIY FGLDSRGRAQ AAQDKAPDSS QISAPTPALR PTTGTVHIMD
210 220 230 240 250
PGCLYYGVQP VGTPGAPDRR ESRGVCQGRA EHRLSRQDLE AREDAGYASL
260 270 280 290 300
ELPGDSTLLS PTLETEETSD DLISPYASFS FTADRLTPLL SGWLDKLSPQ
310 320 330 340 350
GNYVFQRRFV QFNGRSLMYF GSDKDPFPKG VIPLTAIEMT RSSKDNKFQV
360 370 380 390 400
ITGQRVFVFR TESEAQRDMW CSTLQSCLKE QRLLGHPRPP QPPRPLRTGM
410 420 430 440 450
LELRGHKAKV FAALSPGELA LYKSEQAFSL GIGICFIELQ GCSVRETKSR
460 470 480 490 500
SFDLLTPHRC FSFTAESGGA RQSWAAALQE AVTETLSDYE VAEKIWSNRA
510 520 530 540 550
NRQCADCGSS RPDWAAVNLG VVICKQCAGQ HRALGSGISK VQSLKLDTSV
560 570 580 590 600
WSNEIVQLFI VLGNDRANRF WAGTLPPGEG LHPDATPGPR GEFISRKYRL
610 620 630 640 650
GLFRKPHPQY PDHSQLLQAL CAAVARPNLL KNMTQLLCVE AFEGEEPWFP
660 670 680 690 700
PAPDGSCPGL LPSDPSPGVY NEVVVRATYS GFLYCSPVSN KAGPSPPRRG
710 720 730 740 750
RDAPPRLWCV LGAALEMFAS ENSPEPLSLI QPQDIVCLGV SPPPTDPGDR
760 770 780 790 800
FPFSFELILA GGRIQHFGTD GADSLEAWTS AVGKWFSPLS CHQLLGPGLL
810 820 830 840 850
RLGRLWLRSP SHTAPAPGLW LSGFGLLRGD HLFLCSAPGP GPPAPEDMVH
860 870 880 890 900
LRRLQEISVV SAADTPDKKE HLVLVETGRT LYLQGEGRLD FTAWNAAIGG
910 920 930 940 950
AAGGGGTGLQ EQQMSRGDIP IIVDACISFV TQHGLRLEGV YRKGGARARS
960 970 980 990 1000
LRLLAEFRRD ARSVKLRPGE HFVEDVTDTL KRFFRELDDP VTSARLLPRW
1010 1020 1030 1040 1050
REAAELPQKN QRLEKYKDVI GCLPRVNRRT LATLIGHLYR VQKCAALNQM
1060 1070 1080 1090 1100
CTRNLALLFA PSVFQTDGRG EHEVRVLQEL IDGYISVFDI DSDQVAQIDL
1110 1120 1130 1140 1150
EVSLITTWKD VQLSQAGDLI MEVYIEQQLP DNCVTLKVSP TLTAEELTNQ
1160 1170 1180 1190 1200
VLEMRGTAAG MDLWVTFEIR EHGELERPLH PKEKVLEQAL QWCQLPEPCS
1210 1220 1230 1240 1250
ASLLLKKVPL AQAGCLFTGI RRESPRVGLL RCREEPPRLL GSRFQERFFL
1260 1270 1280 1290 1300
LRGRCLLLLK EKKSSKPERE WPLEGAKVYL GIRKKLKPPT PWGFTLILEK
1310 1320 1330 1340 1350
MHLYLSCTDE DEMWDWTTSI LKAQHDDQQP VVLRRHSSSD LARQKFGTMP
1360 1370 1380 1390 1400
LLPIRGDDSG ATLLSANQTL RRLHNRRTLS MFFPMKSSQG SVEEQEELEE
1410 1420 1430 1440 1450
PVYEEPVYEE VGAFPELIQD TSTSFSTTRE WTVKPENPLT SQKSLDQPFL
1460 1470 1480 1490 1500
SKSSTLGQEE RPPEPPPGPP SKSSPQARGS LEEQLLQELS SLILRKGETT
1510 1520 1530 1540
AGLGSPSQPS SPQSPSPTGL PTQTPGFPTQ PPCTSSPPSS QPLT
Length:1,544
Mass (Da):169,844
Last modified:March 1, 2002 - v1
Checksum:i40C03A22591B2B6F
GO
Isoform 2 (identifier: Q8WWN8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-338: Missing.
     1371-1383: Missing.

Note: No experimental confirmation available.
Show »
Length:1,193
Mass (Da):131,986
Checksum:i8E101A95C1FB7D24
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti218 – 2181D → H.
Corresponds to variant rs1031904 [ dbSNP | Ensembl ].
VAR_048330
Natural varianti471 – 4711R → W in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_036180
Natural varianti1085 – 10851I → M in a breast cancer sample; somatic mutation. 1 Publication
VAR_036181
Natural varianti1428 – 14281T → P in a breast cancer sample; somatic mutation. 1 Publication
VAR_036182

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 338338Missing in isoform 2. 1 PublicationVSP_056214Add
BLAST
Alternative sequencei1371 – 138313Missing in isoform 2. 1 PublicationVSP_056215Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ310567 mRNA. Translation: CAC83946.1.
AK295768 mRNA. Translation: BAG58593.1.
AC022420 Genomic DNA. No translation available.
CH471062 Genomic DNA. Translation: EAW61904.1.
CH471062 Genomic DNA. Translation: EAW61905.1.
CCDSiCCDS4266.1. [Q8WWN8-1]
PIRiE59431.
RefSeqiNP_071926.4. NM_022481.5. [Q8WWN8-1]
UniGeneiHs.726187.

Genome annotation databases

EnsembliENST00000239440; ENSP00000239440; ENSG00000120318.
ENST00000513878; ENSP00000421468; ENSG00000120318. [Q8WWN8-2]
GeneIDi64411.
KEGGihsa:64411.
UCSCiuc003llm.3. human. [Q8WWN8-1]
uc011dbe.2. human.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ310567 mRNA. Translation: CAC83946.1.
AK295768 mRNA. Translation: BAG58593.1.
AC022420 Genomic DNA. No translation available.
CH471062 Genomic DNA. Translation: EAW61904.1.
CH471062 Genomic DNA. Translation: EAW61905.1.
CCDSiCCDS4266.1. [Q8WWN8-1]
PIRiE59431.
RefSeqiNP_071926.4. NM_022481.5. [Q8WWN8-1]
UniGeneiHs.726187.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2KG5NMR-A1-80[»]
2LNWNMR-B1404-1412[»]
ProteinModelPortaliQ8WWN8.
SMRiQ8WWN8. Positions 1-80, 293-392, 491-653, 919-1100.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122163. 2 interactions.
IntActiQ8WWN8. 1 interaction.
MINTiMINT-8098880.
STRINGi9606.ENSP00000239440.

PTM databases

PhosphoSiteiQ8WWN8.

Polymorphism and mutation databases

BioMutaiARAP3.
DMDMi73619965.

Proteomic databases

MaxQBiQ8WWN8.
PaxDbiQ8WWN8.
PeptideAtlasiQ8WWN8.
PRIDEiQ8WWN8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000239440; ENSP00000239440; ENSG00000120318.
ENST00000513878; ENSP00000421468; ENSG00000120318. [Q8WWN8-2]
GeneIDi64411.
KEGGihsa:64411.
UCSCiuc003llm.3. human. [Q8WWN8-1]
uc011dbe.2. human.

Organism-specific databases

CTDi64411.
GeneCardsiGC05M141032.
HGNCiHGNC:24097. ARAP3.
HPAiHPA042887.
MIMi606647. gene.
neXtProtiNX_Q8WWN8.
PharmGKBiPA164715983.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5347.
GeneTreeiENSGT00800000124095.
HOGENOMiHOG000246988.
HOVERGENiHBG069114.
InParanoidiQ8WWN8.
KOiK12490.
OMAiHEGIYRK.
PhylomeDBiQ8WWN8.
TreeFamiTF105769.

Enzyme and pathway databases

ReactomeiREACT_11051. Rho GTPase cycle.

Miscellaneous databases

ChiTaRSiARAP3. human.
EvolutionaryTraceiQ8WWN8.
GeneWikiiCENTD3.
GenomeRNAii64411.
NextBioi35472348.
PROiQ8WWN8.
SOURCEiSearch...

Gene expression databases

BgeeiQ8WWN8.
CleanExiHS_ARAP3.
ExpressionAtlasiQ8WWN8. baseline and differential.
GenevisibleiQ8WWN8. HS.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
1.10.555.10. 1 hit.
2.30.29.30. 3 hits.
InterProiIPR001164. ArfGAP.
IPR011993. PH-like_dom.
IPR001849. PH_domain.
IPR000159. Ras-assoc.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR011510. SAM_2.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF01412. ArfGap. 1 hit.
PF00169. PH. 2 hits.
PF00788. RA. 1 hit.
PF00620. RhoGAP. 1 hit.
PF07647. SAM_2. 1 hit.
[Graphical view]
PRINTSiPR00405. REVINTRACTNG.
SMARTiSM00105. ArfGap. 1 hit.
SM00233. PH. 5 hits.
SM00324. RhoGAP. 1 hit.
SM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF48350. SSF48350. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50115. ARFGAP. 1 hit.
PS50003. PH_DOMAIN. 3 hits.
PS50200. RA. 1 hit.
PS50238. RHOGAP. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), MUTAGENESIS OF 307-ARG-ARG-308, FUNCTION, INTERACTION WITH PHOSPHATIDYLINOSITOL 3-PHOSPHATE.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Hippocampus.
  3. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "GTPase signaling: bridging the GAP between ARF and Rho."
    Santy L.C., Casanova J.E.
    Curr. Biol. 12:R360-R362(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  6. "EST-based genome-wide gene inactivation identifies ARAP3 as a host protein affecting cellular susceptibility to anthrax toxin."
    Lu Q., Wei W., Kowalski P.E., Chang A.C.Y., Cohen S.N.
    Proc. Natl. Acad. Sci. U.S.A. 101:17246-17251(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: ROLE IN THE INTERNALIZATION OF ANTHRAX TOXIN.
  7. "The PI3K effector Arap3 interacts with the PI(3,4,5)P3 phosphatase SHIP2 in a SAM domain-dependent manner."
    Raaijmakers J.H., Deneubourg L., Rehmann H., de Koning J., Zhang Z., Krugmann S., Erneux C., Bos J.L.
    Cell. Signal. 19:1249-1257(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH INPPL1.
  8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1444, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1444 AND SER-1480, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "The Sam domain of the lipid phosphatase Ship2 adopts a common model to interact with Arap3-Sam and EphA2-Sam."
    Leone M., Cellitti J., Pellecchia M.
    BMC Struct. Biol. 9:59-59(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 1-80, INTERACTION WITH INPPL1.
  11. Cited for: VARIANTS [LARGE SCALE ANALYSIS] TRP-471; MET-1085 AND PRO-1428.

Entry informationi

Entry nameiARAP3_HUMAN
AccessioniPrimary (citable) accession number: Q8WWN8
Secondary accession number(s): B4DIT1, D3DQE3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: March 1, 2002
Last modified: July 22, 2015
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.