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Protein
Submitted name:

Nav1.5

Gene

SCN5A

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. ion channel activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ion channelUniRule annotation

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
Nav1.5Imported
Gene namesi
Name:SCN5AImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PRIDEiQ8WWN6.

Interactioni

Protein-protein interaction databases

MINTiMINT-1406914.

Structurei

3D structure databases

ProteinModelPortaliQ8WWN6.
SMRiQ8WWN6. Positions 3-88.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

TransmembraneUniRule annotation

Phylogenomic databases

HOGENOMiHOG000197795.

Family and domain databases

InterProiIPR005821. Ion_trans_dom.
IPR008053. Na_channel_a5su.
[Graphical view]
PANTHERiPTHR10037:SF178. PTHR10037:SF178. 1 hit.
PfamiPF00520. Ion_trans. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q8WWN6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAQHDPPPWT KYVEYVSENI KLGNLSALRT FRVLRALKTI SVIPGLKTIV
60 70 80 90 100
GALIQSVKKL ADVMVLTVFC LSVFALIGLQ LFMGNLRHKC VRNFTALNGT
110
NGSVEADGLV WES
Length:113
Mass (Da):12,445
Last modified:March 1, 2002 - v1
Checksum:i2A0200A0BFBE0353
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei113 – 1131Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ310893 mRNA. Translation: CAC84525.1.
UniGeneiHs.517898.

Genome annotation databases

UCSCiuc010hhl.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ310893 mRNA. Translation: CAC84525.1.
UniGeneiHs.517898.

3D structure databases

ProteinModelPortaliQ8WWN6.
SMRiQ8WWN6. Positions 3-88.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1406914.

Proteomic databases

PRIDEiQ8WWN6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiuc010hhl.1. human.

Phylogenomic databases

HOGENOMiHOG000197795.

Family and domain databases

InterProiIPR005821. Ion_trans_dom.
IPR008053. Na_channel_a5su.
[Graphical view]
PANTHERiPTHR10037:SF178. PTHR10037:SF178. 1 hit.
PfamiPF00520. Ion_trans. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Upregulation of voltage-gated Na+ channel expression and metastatic potential in human breast cancer: Correlative studies on cell lines and biopsy tissues."
    Diss J.K.J., Fraser S.P., Coombes R.C., Djamgoz M.B.A.
    Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Biopsy sample 8Imported.
    Tissue: BreastImported.

Entry informationi

Entry nameiQ8WWN6_HUMAN
AccessioniPrimary (citable) accession number: Q8WWN6
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: January 7, 2015
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.