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Protein
Submitted name:

Nav1.6

Gene

SCN8A

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. voltage-gated sodium channel activity Source: InterPro

GO - Biological processi

  1. adult walking behavior Source: Ensembl
  2. muscle organ development Source: Ensembl
  3. neuromuscular process Source: Ensembl
  4. response to toxic substance Source: Ensembl
  5. sensory perception of sound Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Nav1.6Imported
Gene namesi
Name:SCN8AImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. dendrite Source: Ensembl
  2. neuronal cell body Source: Ensembl
  3. voltage-gated sodium channel complex Source: InterPro
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiQ8WWN3.
ExpressionAtlasiQ8WWN3. baseline and differential.

Interactioni

Family & Domainsi

Family and domain databases

InterProiIPR001696. Na_channel_asu.
[Graphical view]
PANTHERiPTHR10037:SF132. PTHR10037:SF132. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q8WWN3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
VNLFAGKYHY CFNETSEIRF EIEDVNNKTE CEKLMEGNNT EIRWKNVKIN
60
FDNVGAGYLA LL
Length:62
Mass (Da):7,247
Last modified:March 1, 2002 - v1
Checksum:i9ACE7C630B9B2E6B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei62 – 621Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ310898 mRNA. Translation: CAC84538.1.
UniGeneiHs.436550.
Hs.710638.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ310898 mRNA. Translation: CAC84538.1.
UniGeneiHs.436550.
Hs.710638.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Chemistry

BindingDBiQ8WWN3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

ChiTaRSiSCN8A. human.

Gene expression databases

BgeeiQ8WWN3.
ExpressionAtlasiQ8WWN3. baseline and differential.

Family and domain databases

InterProiIPR001696. Na_channel_asu.
[Graphical view]
PANTHERiPTHR10037:SF132. PTHR10037:SF132. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Upregulation of voltage-gated Na+ channel expression and metastatic potential in human breast cancer: Correlative studies on cell lines and biopsy tissues."
    Diss J.K.J., Fraser S.P., Coombes R.C., Djamgoz M.B.A.
    Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ8WWN3_HUMAN
AccessioniPrimary (citable) accession number: Q8WWN3
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: March 4, 2015
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.