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Q8WWM9

- CYGB_HUMAN

UniProt

Q8WWM9 - CYGB_HUMAN

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Protein

Cytoglobin

Gene

CYGB

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May have a protective function during conditions of oxidative stress. May be involved in intracellular oxygen storage or transfer.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi81 – 811Iron (heme distal ligand)PROSITE-ProRule annotation
Metal bindingi113 – 1131Iron (heme proximal ligand)PROSITE-ProRule annotation

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. iron ion binding Source: InterPro
  3. oxygen binding Source: InterPro
  4. oxygen transporter activity Source: UniProtKB
  5. peroxidase activity Source: UniProtKB

GO - Biological processi

  1. oxidation-reduction process Source: GOC
  2. oxygen transport Source: UniProtKB
  3. response to oxidative stress Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Oxygen transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytoglobin
Alternative name(s):
Histoglobin
Short name:
HGb
Stellate cell activation-associated protein
Gene namesi
Name:CYGB
Synonyms:STAP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:16505. CYGB.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. neuronal cell body Source: Ensembl
  3. neuron projection Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27080.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 190190CytoglobinPRO_0000053384Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi38 – 38Interchain (with C-83)1 Publication
Disulfide bondi83 – 83Interchain (with C-38)1 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiQ8WWM9.
PaxDbiQ8WWM9.
PRIDEiQ8WWM9.

PTM databases

PhosphoSiteiQ8WWM9.

Expressioni

Tissue specificityi

Ubiquitously expressed. Highest expression in heart, stomach, bladder and small intestine.1 Publication

Gene expression databases

BgeeiQ8WWM9.
CleanExiHS_CYGB.
ExpressionAtlasiQ8WWM9. baseline and differential.
GenevestigatoriQ8WWM9.

Organism-specific databases

HPAiHPA017757.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.1 Publication

Protein-protein interaction databases

BioGridi125335. 2 interactions.
IntActiQ8WWM9. 1 interaction.
STRINGi9606.ENSP00000293230.

Structurei

Secondary structure

1
190
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi21 – 3515
Helixi38 – 5215
Helixi54 – 596
Turni61 – 655
Helixi69 – 724
Helixi76 – 9419
Turni95 – 973
Helixi99 – 11517
Helixi121 – 13818
Helixi140 – 1423
Helixi145 – 16824

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1UMOX-ray2.59A/B1-190[»]
1URVX-ray2.00A/B1-190[»]
1URYX-ray2.40A/B1-190[»]
1UT0X-ray2.10A/B1-190[»]
1UX9X-ray2.40A/B1-190[»]
1V5HX-ray2.40A1-190[»]
2DC3X-ray1.68A/B1-190[»]
3AG0X-ray2.60A1-190[»]
4B3WX-ray2.80A/B1-190[»]
ProteinModelPortaliQ8WWM9.
SMRiQ8WWM9. Positions 17-188.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8WWM9.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni17 – 167151GlobinAdd
BLAST

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG278586.
GeneTreeiENSGT00730000110844.
HOGENOMiHOG000112127.
HOVERGENiHBG100250.
InParanoidiQ8WWM9.
OMAiECQSINE.
OrthoDBiEOG7KSX9V.
PhylomeDBiQ8WWM9.
TreeFamiTF332967.

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin_dom.
IPR013314. Globin_lamprey/hagfish.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR01906. FISHGLOBIN.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8WWM9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEKVPGEMEI ERRERSEELS EAERKAVQAM WARLYANCED VGVAILVRFF
60 70 80 90 100
VNFPSAKQYF SQFKHMEDPL EMERSPQLRK HACRVMGALN TVVENLHDPD
110 120 130 140 150
KVSSVLALVG KAHALKHKVE PVYFKILSGV ILEVVAEEFA SDFPPETQRA
160 170 180 190
WAKLRGLIYS HVTAAYKEVG WVQQVPNATT PPATLPSSGP
Length:190
Mass (Da):21,405
Last modified:March 1, 2002 - v1
Checksum:iB5D7F9976D0BA118
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti37 – 371N → S in AAH29798. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ315162 mRNA. Translation: CAC86186.1.
AB057769 mRNA. Translation: BAB87840.1.
AK098057 mRNA. Translation: BAC05223.1.
CH471099 Genomic DNA. Translation: EAW89406.1.
BC029798 mRNA. Translation: AAH29798.1.
CCDSiCCDS11746.1.
RefSeqiNP_599030.1. NM_134268.4.
UniGeneiHs.95120.

Genome annotation databases

EnsembliENST00000293230; ENSP00000293230; ENSG00000161544.
GeneIDi114757.
KEGGihsa:114757.
UCSCiuc002jru.2. human.

Polymorphism databases

DMDMi21263504.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ315162 mRNA. Translation: CAC86186.1 .
AB057769 mRNA. Translation: BAB87840.1 .
AK098057 mRNA. Translation: BAC05223.1 .
CH471099 Genomic DNA. Translation: EAW89406.1 .
BC029798 mRNA. Translation: AAH29798.1 .
CCDSi CCDS11746.1.
RefSeqi NP_599030.1. NM_134268.4.
UniGenei Hs.95120.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1UMO X-ray 2.59 A/B 1-190 [» ]
1URV X-ray 2.00 A/B 1-190 [» ]
1URY X-ray 2.40 A/B 1-190 [» ]
1UT0 X-ray 2.10 A/B 1-190 [» ]
1UX9 X-ray 2.40 A/B 1-190 [» ]
1V5H X-ray 2.40 A 1-190 [» ]
2DC3 X-ray 1.68 A/B 1-190 [» ]
3AG0 X-ray 2.60 A 1-190 [» ]
4B3W X-ray 2.80 A/B 1-190 [» ]
ProteinModelPortali Q8WWM9.
SMRi Q8WWM9. Positions 17-188.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 125335. 2 interactions.
IntActi Q8WWM9. 1 interaction.
STRINGi 9606.ENSP00000293230.

PTM databases

PhosphoSitei Q8WWM9.

Polymorphism databases

DMDMi 21263504.

Proteomic databases

MaxQBi Q8WWM9.
PaxDbi Q8WWM9.
PRIDEi Q8WWM9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000293230 ; ENSP00000293230 ; ENSG00000161544 .
GeneIDi 114757.
KEGGi hsa:114757.
UCSCi uc002jru.2. human.

Organism-specific databases

CTDi 114757.
GeneCardsi GC17M074523.
HGNCi HGNC:16505. CYGB.
HPAi HPA017757.
MIMi 608759. gene.
neXtProti NX_Q8WWM9.
PharmGKBi PA27080.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG278586.
GeneTreei ENSGT00730000110844.
HOGENOMi HOG000112127.
HOVERGENi HBG100250.
InParanoidi Q8WWM9.
OMAi ECQSINE.
OrthoDBi EOG7KSX9V.
PhylomeDBi Q8WWM9.
TreeFami TF332967.

Miscellaneous databases

EvolutionaryTracei Q8WWM9.
GeneWikii Cytoglobin.
GenomeRNAii 114757.
NextBioi 79123.
PROi Q8WWM9.
SOURCEi Search...

Gene expression databases

Bgeei Q8WWM9.
CleanExi HS_CYGB.
ExpressionAtlasi Q8WWM9. baseline and differential.
Genevestigatori Q8WWM9.

Family and domain databases

Gene3Di 1.10.490.10. 1 hit.
InterProi IPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin_dom.
IPR013314. Globin_lamprey/hagfish.
[Graphical view ]
Pfami PF00042. Globin. 1 hit.
[Graphical view ]
PRINTSi PR01906. FISHGLOBIN.
SUPFAMi SSF46458. SSF46458. 1 hit.
PROSITEi PS01033. GLOBIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cytoglobin: a novel globin type ubiquitously expressed in vertebrate tissues."
    Burmester T., Ebner B., Weich B., Hankeln T.
    Mol. Biol. Evol. 19:416-421(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "Characterization of human stellate cell activation-associated protein and its expression in human liver."
    Asahina K., Kawada N., Kristensen D.B., Nakatani K., Seki S., Shiokawa M., Tateno C., Obara M., Yoshizato K.
    Biochim. Biophys. Acta 1577:471-475(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Heart.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  6. "A ubiquitously expressed human hexacoordinate hemoglobin."
    Trent J.T. III, Hargrove M.S.
    J. Biol. Chem. 277:19538-19545(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  7. Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS).
  8. "Crystal structure of cytoglobin: the fourth globin type discovered in man displays heme hexa-coordination."
    de Sanctis D., Dewilde S., Pesce A., Moens L., Ascenzi P., Hankeln T., Burmester T., Bolognesi M.
    J. Mol. Biol. 336:917-927(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS).
  9. "Structural basis of human cytoglobin for ligand binding."
    Sugimoto H., Makino M., Sawai H., Kawada N., Yoshizato K., Shiro Y.
    J. Mol. Biol. 339:873-885(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS).
  10. "High-resolution structure of human cytoglobin: identification of extra N-and C-termini and a new dimerization mode."
    Makino M., Sugimoto H., Sawai H., Kawada N., Yoshizato K., Shiro Y.
    Acta Crystallogr. D 62:671-677(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.68 ANGSTROMS), SUBUNIT, DISULFIDE BONDS.

Entry informationi

Entry nameiCYGB_HUMAN
AccessioniPrimary (citable) accession number: Q8WWM9
Secondary accession number(s): Q541Y7, Q8N2X5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: March 1, 2002
Last modified: October 29, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3