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Q8WWM9 (CYGB_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytoglobin
Alternative name(s):
Histoglobin
Short name=HGb
Stellate cell activation-associated protein
Gene names
Name:CYGB
Synonyms:STAP
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length190 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May have a protective function during conditions of oxidative stress. May be involved in intracellular oxygen storage or transfer.

Subunit structure

Homodimer; disulfide-linked. Ref.10

Subcellular location

Cytoplasm By similarity.

Tissue specificity

Ubiquitously expressed. Highest expression in heart, stomach, bladder and small intestine. Ref.6

Sequence similarities

Belongs to the globin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 190190Cytoglobin
PRO_0000053384

Regions

Region17 – 167151Globin

Sites

Metal binding811Iron (heme distal ligand) By similarity
Metal binding1131Iron (heme proximal ligand) By similarity

Amino acid modifications

Disulfide bond38Interchain (with C-83) Ref.10
Disulfide bond83Interchain (with C-38) Ref.10

Experimental info

Sequence conflict371N → S in AAH29798. Ref.5

Secondary structure

...................... 190
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q8WWM9 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: B5D7F9976D0BA118

FASTA19021,405
        10         20         30         40         50         60 
MEKVPGEMEI ERRERSEELS EAERKAVQAM WARLYANCED VGVAILVRFF VNFPSAKQYF 

        70         80         90        100        110        120 
SQFKHMEDPL EMERSPQLRK HACRVMGALN TVVENLHDPD KVSSVLALVG KAHALKHKVE 

       130        140        150        160        170        180 
PVYFKILSGV ILEVVAEEFA SDFPPETQRA WAKLRGLIYS HVTAAYKEVG WVQQVPNATT 

       190 
PPATLPSSGP 

« Hide

References

« Hide 'large scale' references
[1]"Cytoglobin: a novel globin type ubiquitously expressed in vertebrate tissues."
Burmester T., Ebner B., Weich B., Hankeln T.
Mol. Biol. Evol. 19:416-421(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[2]"Characterization of human stellate cell activation-associated protein and its expression in human liver."
Asahina K., Kawada N., Kristensen D.B., Nakatani K., Seki S., Shiokawa M., Tateno C., Obara M., Yoshizato K.
Biochim. Biophys. Acta 1577:471-475(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Heart.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[6]"A ubiquitously expressed human hexacoordinate hemoglobin."
Trent J.T. III, Hargrove M.S.
J. Biol. Chem. 277:19538-19545(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[7]"Mapping protein matrix cavities in human cytoglobin through Xe atom binding."
de Sanctis D., Dewilde S., Pesce A., Moens L., Ascenzi P., Hankeln T., Burmester T., Bolognesi M.
Biochem. Biophys. Res. Commun. 316:1217-1221(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS).
[8]"Crystal structure of cytoglobin: the fourth globin type discovered in man displays heme hexa-coordination."
de Sanctis D., Dewilde S., Pesce A., Moens L., Ascenzi P., Hankeln T., Burmester T., Bolognesi M.
J. Mol. Biol. 336:917-927(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS).
[9]"Structural basis of human cytoglobin for ligand binding."
Sugimoto H., Makino M., Sawai H., Kawada N., Yoshizato K., Shiro Y.
J. Mol. Biol. 339:873-885(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS).
[10]"High-resolution structure of human cytoglobin: identification of extra N-and C-termini and a new dimerization mode."
Makino M., Sugimoto H., Sawai H., Kawada N., Yoshizato K., Shiro Y.
Acta Crystallogr. D 62:671-677(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.68 ANGSTROMS), SUBUNIT, DISULFIDE BONDS.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ315162 mRNA. Translation: CAC86186.1.
AB057769 mRNA. Translation: BAB87840.1.
AK098057 mRNA. Translation: BAC05223.1.
CH471099 Genomic DNA. Translation: EAW89406.1.
BC029798 mRNA. Translation: AAH29798.1.
CCDSCCDS11746.1.
RefSeqNP_599030.1. NM_134268.4.
UniGeneHs.95120.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1UMOX-ray2.59A/B1-190[»]
1URVX-ray2.00A/B1-190[»]
1URYX-ray2.40A/B1-190[»]
1UT0X-ray2.10A/B1-190[»]
1UX9X-ray2.40A/B1-190[»]
1V5HX-ray2.40A1-190[»]
2DC3X-ray1.68A/B1-190[»]
3AG0X-ray2.60A1-190[»]
4B3WX-ray2.80A/B1-190[»]
ProteinModelPortalQ8WWM9.
SMRQ8WWM9. Positions 17-188.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid125335. 2 interactions.
IntActQ8WWM9. 1 interaction.
STRING9606.ENSP00000293230.

PTM databases

PhosphoSiteQ8WWM9.

Polymorphism databases

DMDM21263504.

Proteomic databases

MaxQBQ8WWM9.
PaxDbQ8WWM9.
PRIDEQ8WWM9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000293230; ENSP00000293230; ENSG00000161544.
GeneID114757.
KEGGhsa:114757.
UCSCuc002jru.2. human.

Organism-specific databases

CTD114757.
GeneCardsGC17M074523.
HGNCHGNC:16505. CYGB.
HPAHPA017757.
MIM608759. gene.
neXtProtNX_Q8WWM9.
PharmGKBPA27080.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG278586.
HOGENOMHOG000112127.
HOVERGENHBG100250.
InParanoidQ8WWM9.
OMAECQSINE.
OrthoDBEOG7KSX9V.
PhylomeDBQ8WWM9.
TreeFamTF332967.

Gene expression databases

ArrayExpressQ8WWM9.
BgeeQ8WWM9.
CleanExHS_CYGB.
GenevestigatorQ8WWM9.

Family and domain databases

Gene3D1.10.490.10. 1 hit.
InterProIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin_dom.
IPR013314. Globin_lamprey/hagfish.
[Graphical view]
PfamPF00042. Globin. 1 hit.
[Graphical view]
PRINTSPR01906. FISHGLOBIN.
SUPFAMSSF46458. SSF46458. 1 hit.
PROSITEPS01033. GLOBIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ8WWM9.
GeneWikiCytoglobin.
GenomeRNAi114757.
NextBio79123.
PROQ8WWM9.
SOURCESearch...

Entry information

Entry nameCYGB_HUMAN
AccessionPrimary (citable) accession number: Q8WWM9
Secondary accession number(s): Q541Y7, Q8N2X5
Entry history
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: March 1, 2002
Last modified: July 9, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM