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Protein

Cytoglobin

Gene

CYGB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May have a protective function during conditions of oxidative stress. May be involved in intracellular oxygen storage or transfer.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi81 – 811Iron (heme distal ligand)PROSITE-ProRule annotation
Metal bindingi113 – 1131Iron (heme proximal ligand)PROSITE-ProRule annotation

GO - Molecular functioni

  • catalase activity Source: Ensembl
  • fatty acid peroxidase activity Source: Ensembl
  • heme binding Source: Ensembl
  • iron ion binding Source: InterPro
  • nitric oxide dioxygenase activity Source: Reactome
  • oxygen binding Source: InterPro
  • oxygen transporter activity Source: UniProtKB
  • peroxidase activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Oxygen transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_12477. eNOS activation.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytoglobin
Alternative name(s):
Histoglobin
Short name:
HGb
Stellate cell activation-associated protein
Gene namesi
Name:CYGB
Synonyms:STAP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:16505. CYGB.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27080.

Polymorphism and mutation databases

BioMutaiCYGB.
DMDMi21263504.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 190190CytoglobinPRO_0000053384Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi38 – 38Interchain (with C-83)1 Publication
Disulfide bondi83 – 83Interchain (with C-38)1 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiQ8WWM9.
PaxDbiQ8WWM9.
PRIDEiQ8WWM9.

PTM databases

PhosphoSiteiQ8WWM9.

Expressioni

Tissue specificityi

Ubiquitously expressed. Highest expression in heart, stomach, bladder and small intestine.1 Publication

Gene expression databases

BgeeiQ8WWM9.
CleanExiHS_CYGB.
ExpressionAtlasiQ8WWM9. baseline and differential.
GenevisibleiQ8WWM9. HS.

Organism-specific databases

HPAiHPA017757.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
DDI1Q8WTU03EBI-6309037,EBI-748248

Protein-protein interaction databases

BioGridi125335. 3 interactions.
IntActiQ8WWM9. 2 interactions.
STRINGi9606.ENSP00000293230.

Structurei

Secondary structure

1
190
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi7 – 159Combined sources
Helixi21 – 3515Combined sources
Helixi38 – 5215Combined sources
Helixi54 – 596Combined sources
Turni61 – 655Combined sources
Helixi69 – 724Combined sources
Helixi76 – 9419Combined sources
Turni95 – 973Combined sources
Helixi99 – 11517Combined sources
Helixi121 – 13818Combined sources
Helixi140 – 1423Combined sources
Helixi145 – 16824Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1UMOX-ray2.59A/B1-190[»]
1URVX-ray2.00A/B1-190[»]
1URYX-ray2.40A/B1-190[»]
1UT0X-ray2.10A/B1-190[»]
1UX9X-ray2.40A/B1-190[»]
1V5HX-ray2.40A1-190[»]
2DC3X-ray1.68A/B1-190[»]
3AG0X-ray2.60A1-190[»]
4B3WX-ray2.80A/B1-190[»]
ProteinModelPortaliQ8WWM9.
SMRiQ8WWM9. Positions 17-188.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8WWM9.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni17 – 167151GlobinAdd
BLAST

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG278586.
GeneTreeiENSGT00730000110844.
HOGENOMiHOG000112127.
HOVERGENiHBG100250.
InParanoidiQ8WWM9.
OMAiTHVTAAY.
OrthoDBiEOG7KSX9V.
PhylomeDBiQ8WWM9.
TreeFamiTF332967.

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR013314. Globin_lamprey/hagfish.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR01906. FISHGLOBIN.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8WWM9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKVPGEMEI ERRERSEELS EAERKAVQAM WARLYANCED VGVAILVRFF
60 70 80 90 100
VNFPSAKQYF SQFKHMEDPL EMERSPQLRK HACRVMGALN TVVENLHDPD
110 120 130 140 150
KVSSVLALVG KAHALKHKVE PVYFKILSGV ILEVVAEEFA SDFPPETQRA
160 170 180 190
WAKLRGLIYS HVTAAYKEVG WVQQVPNATT PPATLPSSGP
Length:190
Mass (Da):21,405
Last modified:March 1, 2002 - v1
Checksum:iB5D7F9976D0BA118
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti37 – 371N → S in AAH29798 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ315162 mRNA. Translation: CAC86186.1.
AB057769 mRNA. Translation: BAB87840.1.
AK098057 mRNA. Translation: BAC05223.1.
CH471099 Genomic DNA. Translation: EAW89406.1.
BC029798 mRNA. Translation: AAH29798.1.
CCDSiCCDS11746.1.
RefSeqiNP_599030.1. NM_134268.4.
UniGeneiHs.95120.

Genome annotation databases

EnsembliENST00000293230; ENSP00000293230; ENSG00000161544.
GeneIDi114757.
KEGGihsa:114757.
UCSCiuc002jru.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ315162 mRNA. Translation: CAC86186.1.
AB057769 mRNA. Translation: BAB87840.1.
AK098057 mRNA. Translation: BAC05223.1.
CH471099 Genomic DNA. Translation: EAW89406.1.
BC029798 mRNA. Translation: AAH29798.1.
CCDSiCCDS11746.1.
RefSeqiNP_599030.1. NM_134268.4.
UniGeneiHs.95120.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1UMOX-ray2.59A/B1-190[»]
1URVX-ray2.00A/B1-190[»]
1URYX-ray2.40A/B1-190[»]
1UT0X-ray2.10A/B1-190[»]
1UX9X-ray2.40A/B1-190[»]
1V5HX-ray2.40A1-190[»]
2DC3X-ray1.68A/B1-190[»]
3AG0X-ray2.60A1-190[»]
4B3WX-ray2.80A/B1-190[»]
ProteinModelPortaliQ8WWM9.
SMRiQ8WWM9. Positions 17-188.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125335. 3 interactions.
IntActiQ8WWM9. 2 interactions.
STRINGi9606.ENSP00000293230.

PTM databases

PhosphoSiteiQ8WWM9.

Polymorphism and mutation databases

BioMutaiCYGB.
DMDMi21263504.

Proteomic databases

MaxQBiQ8WWM9.
PaxDbiQ8WWM9.
PRIDEiQ8WWM9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000293230; ENSP00000293230; ENSG00000161544.
GeneIDi114757.
KEGGihsa:114757.
UCSCiuc002jru.2. human.

Organism-specific databases

CTDi114757.
GeneCardsiGC17M074523.
HGNCiHGNC:16505. CYGB.
HPAiHPA017757.
MIMi608759. gene.
neXtProtiNX_Q8WWM9.
PharmGKBiPA27080.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG278586.
GeneTreeiENSGT00730000110844.
HOGENOMiHOG000112127.
HOVERGENiHBG100250.
InParanoidiQ8WWM9.
OMAiTHVTAAY.
OrthoDBiEOG7KSX9V.
PhylomeDBiQ8WWM9.
TreeFamiTF332967.

Enzyme and pathway databases

ReactomeiREACT_12477. eNOS activation.

Miscellaneous databases

EvolutionaryTraceiQ8WWM9.
GeneWikiiCytoglobin.
GenomeRNAii114757.
NextBioi79123.
PROiQ8WWM9.
SOURCEiSearch...

Gene expression databases

BgeeiQ8WWM9.
CleanExiHS_CYGB.
ExpressionAtlasiQ8WWM9. baseline and differential.
GenevisibleiQ8WWM9. HS.

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR013314. Globin_lamprey/hagfish.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR01906. FISHGLOBIN.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cytoglobin: a novel globin type ubiquitously expressed in vertebrate tissues."
    Burmester T., Ebner B., Weich B., Hankeln T.
    Mol. Biol. Evol. 19:416-421(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "Characterization of human stellate cell activation-associated protein and its expression in human liver."
    Asahina K., Kawada N., Kristensen D.B., Nakatani K., Seki S., Shiokawa M., Tateno C., Obara M., Yoshizato K.
    Biochim. Biophys. Acta 1577:471-475(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Heart.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  6. "A ubiquitously expressed human hexacoordinate hemoglobin."
    Trent J.T. III, Hargrove M.S.
    J. Biol. Chem. 277:19538-19545(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  7. Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS).
  8. "Crystal structure of cytoglobin: the fourth globin type discovered in man displays heme hexa-coordination."
    de Sanctis D., Dewilde S., Pesce A., Moens L., Ascenzi P., Hankeln T., Burmester T., Bolognesi M.
    J. Mol. Biol. 336:917-927(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS).
  9. "Structural basis of human cytoglobin for ligand binding."
    Sugimoto H., Makino M., Sawai H., Kawada N., Yoshizato K., Shiro Y.
    J. Mol. Biol. 339:873-885(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS).
  10. "High-resolution structure of human cytoglobin: identification of extra N-and C-termini and a new dimerization mode."
    Makino M., Sugimoto H., Sawai H., Kawada N., Yoshizato K., Shiro Y.
    Acta Crystallogr. D 62:671-677(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.68 ANGSTROMS), SUBUNIT, DISULFIDE BONDS.

Entry informationi

Entry nameiCYGB_HUMAN
AccessioniPrimary (citable) accession number: Q8WWM9
Secondary accession number(s): Q541Y7, Q8N2X5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: March 1, 2002
Last modified: July 22, 2015
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.