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Protein

Cytoglobin

Gene

CYGB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May have a protective function during conditions of oxidative stress. May be involved in intracellular oxygen storage or transfer.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi81Iron (heme distal ligand)PROSITE-ProRule annotation1
Metal bindingi113Iron (heme proximal ligand)PROSITE-ProRule annotation1

GO - Molecular functioni

  • catalase activity Source: Ensembl
  • fatty acid peroxidase activity Source: Ensembl
  • heme binding Source: Ensembl
  • iron ion binding Source: InterPro
  • nitric oxide dioxygenase activity Source: Reactome
  • oxygen binding Source: InterPro
  • oxygen transporter activity Source: UniProtKB
  • peroxidase activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Oxygen transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000161544-MONOMER.
ReactomeiR-HSA-203615. eNOS activation.

Protein family/group databases

TCDBi1.A.107.1.5. the pore-forming globin (globin) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytoglobin
Alternative name(s):
Histoglobin
Short name:
HGb
Stellate cell activation-associated protein
Gene namesi
Name:CYGB
Synonyms:STAP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:16505. CYGB.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi114757.
OpenTargetsiENSG00000161544.
PharmGKBiPA27080.

Polymorphism and mutation databases

BioMutaiCYGB.
DMDMi21263504.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000533841 – 190CytoglobinAdd BLAST190

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi38Interchain (with C-83)1 Publication
Disulfide bondi83Interchain (with C-38)1 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiQ8WWM9.
MaxQBiQ8WWM9.
PaxDbiQ8WWM9.
PeptideAtlasiQ8WWM9.
PRIDEiQ8WWM9.

PTM databases

iPTMnetiQ8WWM9.
PhosphoSitePlusiQ8WWM9.

Expressioni

Tissue specificityi

Ubiquitously expressed. Highest expression in heart, stomach, bladder and small intestine.1 Publication

Gene expression databases

BgeeiENSG00000161544.
CleanExiHS_CYGB.
ExpressionAtlasiQ8WWM9. baseline and differential.
GenevisibleiQ8WWM9. HS.

Organism-specific databases

HPAiHPA017757.
HPA061642.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
DDI1Q8WTU03EBI-6309037,EBI-748248

Protein-protein interaction databases

BioGridi125335. 4 interactors.
IntActiQ8WWM9. 3 interactors.
STRINGi9606.ENSP00000293230.

Structurei

Secondary structure

1190
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi7 – 15Combined sources9
Helixi21 – 35Combined sources15
Helixi38 – 52Combined sources15
Helixi54 – 59Combined sources6
Turni61 – 65Combined sources5
Helixi69 – 72Combined sources4
Helixi76 – 94Combined sources19
Turni95 – 97Combined sources3
Helixi99 – 115Combined sources17
Helixi121 – 138Combined sources18
Helixi140 – 142Combined sources3
Helixi145 – 168Combined sources24

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UMOX-ray2.59A/B1-190[»]
1URVX-ray2.00A/B1-190[»]
1URYX-ray2.40A/B1-190[»]
1UT0X-ray2.10A/B1-190[»]
1UX9X-ray2.40A/B1-190[»]
1V5HX-ray2.40A1-190[»]
2DC3X-ray1.68A/B1-190[»]
3AG0X-ray2.60A1-190[»]
4B3WX-ray2.80A/B1-190[»]
ProteinModelPortaliQ8WWM9.
SMRiQ8WWM9.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8WWM9.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni17 – 167GlobinAdd BLAST151

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3378. Eukaryota.
COG1018. LUCA.
GeneTreeiENSGT00730000110844.
HOGENOMiHOG000112127.
HOVERGENiHBG100250.
InParanoidiQ8WWM9.
OMAiTHVTAAY.
PhylomeDBiQ8WWM9.
TreeFamiTF332967.

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR013314. Globin_lamprey/hagfish.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR01906. FISHGLOBIN.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8WWM9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKVPGEMEI ERRERSEELS EAERKAVQAM WARLYANCED VGVAILVRFF
60 70 80 90 100
VNFPSAKQYF SQFKHMEDPL EMERSPQLRK HACRVMGALN TVVENLHDPD
110 120 130 140 150
KVSSVLALVG KAHALKHKVE PVYFKILSGV ILEVVAEEFA SDFPPETQRA
160 170 180 190
WAKLRGLIYS HVTAAYKEVG WVQQVPNATT PPATLPSSGP
Length:190
Mass (Da):21,405
Last modified:March 1, 2002 - v1
Checksum:iB5D7F9976D0BA118
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti37N → S in AAH29798 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ315162 mRNA. Translation: CAC86186.1.
AB057769 mRNA. Translation: BAB87840.1.
AK098057 mRNA. Translation: BAC05223.1.
CH471099 Genomic DNA. Translation: EAW89406.1.
BC029798 mRNA. Translation: AAH29798.1.
CCDSiCCDS11746.1.
RefSeqiNP_599030.1. NM_134268.4.
UniGeneiHs.95120.

Genome annotation databases

EnsembliENST00000293230; ENSP00000293230; ENSG00000161544.
GeneIDi114757.
KEGGihsa:114757.
UCSCiuc002jru.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ315162 mRNA. Translation: CAC86186.1.
AB057769 mRNA. Translation: BAB87840.1.
AK098057 mRNA. Translation: BAC05223.1.
CH471099 Genomic DNA. Translation: EAW89406.1.
BC029798 mRNA. Translation: AAH29798.1.
CCDSiCCDS11746.1.
RefSeqiNP_599030.1. NM_134268.4.
UniGeneiHs.95120.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UMOX-ray2.59A/B1-190[»]
1URVX-ray2.00A/B1-190[»]
1URYX-ray2.40A/B1-190[»]
1UT0X-ray2.10A/B1-190[»]
1UX9X-ray2.40A/B1-190[»]
1V5HX-ray2.40A1-190[»]
2DC3X-ray1.68A/B1-190[»]
3AG0X-ray2.60A1-190[»]
4B3WX-ray2.80A/B1-190[»]
ProteinModelPortaliQ8WWM9.
SMRiQ8WWM9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125335. 4 interactors.
IntActiQ8WWM9. 3 interactors.
STRINGi9606.ENSP00000293230.

Protein family/group databases

TCDBi1.A.107.1.5. the pore-forming globin (globin) family.

PTM databases

iPTMnetiQ8WWM9.
PhosphoSitePlusiQ8WWM9.

Polymorphism and mutation databases

BioMutaiCYGB.
DMDMi21263504.

Proteomic databases

EPDiQ8WWM9.
MaxQBiQ8WWM9.
PaxDbiQ8WWM9.
PeptideAtlasiQ8WWM9.
PRIDEiQ8WWM9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000293230; ENSP00000293230; ENSG00000161544.
GeneIDi114757.
KEGGihsa:114757.
UCSCiuc002jru.3. human.

Organism-specific databases

CTDi114757.
DisGeNETi114757.
GeneCardsiCYGB.
HGNCiHGNC:16505. CYGB.
HPAiHPA017757.
HPA061642.
MIMi608759. gene.
neXtProtiNX_Q8WWM9.
OpenTargetsiENSG00000161544.
PharmGKBiPA27080.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3378. Eukaryota.
COG1018. LUCA.
GeneTreeiENSGT00730000110844.
HOGENOMiHOG000112127.
HOVERGENiHBG100250.
InParanoidiQ8WWM9.
OMAiTHVTAAY.
PhylomeDBiQ8WWM9.
TreeFamiTF332967.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000161544-MONOMER.
ReactomeiR-HSA-203615. eNOS activation.

Miscellaneous databases

EvolutionaryTraceiQ8WWM9.
GeneWikiiCytoglobin.
GenomeRNAii114757.
PROiQ8WWM9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000161544.
CleanExiHS_CYGB.
ExpressionAtlasiQ8WWM9. baseline and differential.
GenevisibleiQ8WWM9. HS.

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR013314. Globin_lamprey/hagfish.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR01906. FISHGLOBIN.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCYGB_HUMAN
AccessioniPrimary (citable) accession number: Q8WWM9
Secondary accession number(s): Q541Y7, Q8N2X5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: March 1, 2002
Last modified: November 30, 2016
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.