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Q8WWM9

- CYGB_HUMAN

UniProt

Q8WWM9 - CYGB_HUMAN

Protein

Cytoglobin

Gene

CYGB

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    May have a protective function during conditions of oxidative stress. May be involved in intracellular oxygen storage or transfer.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi81 – 811Iron (heme distal ligand)PROSITE-ProRule annotation
    Metal bindingi113 – 1131Iron (heme proximal ligand)PROSITE-ProRule annotation

    GO - Molecular functioni

    1. heme binding Source: InterPro
    2. iron ion binding Source: InterPro
    3. oxygen binding Source: InterPro
    4. oxygen transporter activity Source: UniProtKB
    5. peroxidase activity Source: UniProtKB

    GO - Biological processi

    1. oxidation-reduction process Source: GOC
    2. oxygen transport Source: UniProtKB
    3. response to oxidative stress Source: UniProtKB

    Keywords - Biological processi

    Oxygen transport, Transport

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytoglobin
    Alternative name(s):
    Histoglobin
    Short name:
    HGb
    Stellate cell activation-associated protein
    Gene namesi
    Name:CYGB
    Synonyms:STAP
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:16505. CYGB.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. neuronal cell body Source: Ensembl
    3. neuron projection Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA27080.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 190190CytoglobinPRO_0000053384Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi38 – 38Interchain (with C-83)1 Publication
    Disulfide bondi83 – 83Interchain (with C-38)1 Publication

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    MaxQBiQ8WWM9.
    PaxDbiQ8WWM9.
    PRIDEiQ8WWM9.

    PTM databases

    PhosphoSiteiQ8WWM9.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed. Highest expression in heart, stomach, bladder and small intestine.1 Publication

    Gene expression databases

    ArrayExpressiQ8WWM9.
    BgeeiQ8WWM9.
    CleanExiHS_CYGB.
    GenevestigatoriQ8WWM9.

    Organism-specific databases

    HPAiHPA017757.

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked.1 Publication

    Protein-protein interaction databases

    BioGridi125335. 2 interactions.
    IntActiQ8WWM9. 1 interaction.
    STRINGi9606.ENSP00000293230.

    Structurei

    Secondary structure

    1
    190
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi21 – 3515
    Helixi38 – 5215
    Helixi54 – 596
    Turni61 – 655
    Helixi69 – 724
    Helixi76 – 9419
    Turni95 – 973
    Helixi99 – 11517
    Helixi121 – 13818
    Helixi140 – 1423
    Helixi145 – 16824

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1UMOX-ray2.59A/B1-190[»]
    1URVX-ray2.00A/B1-190[»]
    1URYX-ray2.40A/B1-190[»]
    1UT0X-ray2.10A/B1-190[»]
    1UX9X-ray2.40A/B1-190[»]
    1V5HX-ray2.40A1-190[»]
    2DC3X-ray1.68A/B1-190[»]
    3AG0X-ray2.60A1-190[»]
    4B3WX-ray2.80A/B1-190[»]
    ProteinModelPortaliQ8WWM9.
    SMRiQ8WWM9. Positions 17-188.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ8WWM9.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni17 – 167151GlobinAdd
    BLAST

    Sequence similaritiesi

    Belongs to the globin family.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG278586.
    HOGENOMiHOG000112127.
    HOVERGENiHBG100250.
    InParanoidiQ8WWM9.
    OMAiECQSINE.
    OrthoDBiEOG7KSX9V.
    PhylomeDBiQ8WWM9.
    TreeFamiTF332967.

    Family and domain databases

    Gene3Di1.10.490.10. 1 hit.
    InterProiIPR000971. Globin.
    IPR009050. Globin-like.
    IPR012292. Globin_dom.
    IPR013314. Globin_lamprey/hagfish.
    [Graphical view]
    PfamiPF00042. Globin. 1 hit.
    [Graphical view]
    PRINTSiPR01906. FISHGLOBIN.
    SUPFAMiSSF46458. SSF46458. 1 hit.
    PROSITEiPS01033. GLOBIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8WWM9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEKVPGEMEI ERRERSEELS EAERKAVQAM WARLYANCED VGVAILVRFF    50
    VNFPSAKQYF SQFKHMEDPL EMERSPQLRK HACRVMGALN TVVENLHDPD 100
    KVSSVLALVG KAHALKHKVE PVYFKILSGV ILEVVAEEFA SDFPPETQRA 150
    WAKLRGLIYS HVTAAYKEVG WVQQVPNATT PPATLPSSGP 190
    Length:190
    Mass (Da):21,405
    Last modified:March 1, 2002 - v1
    Checksum:iB5D7F9976D0BA118
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti37 – 371N → S in AAH29798. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ315162 mRNA. Translation: CAC86186.1.
    AB057769 mRNA. Translation: BAB87840.1.
    AK098057 mRNA. Translation: BAC05223.1.
    CH471099 Genomic DNA. Translation: EAW89406.1.
    BC029798 mRNA. Translation: AAH29798.1.
    CCDSiCCDS11746.1.
    RefSeqiNP_599030.1. NM_134268.4.
    UniGeneiHs.95120.

    Genome annotation databases

    EnsembliENST00000293230; ENSP00000293230; ENSG00000161544.
    GeneIDi114757.
    KEGGihsa:114757.
    UCSCiuc002jru.2. human.

    Polymorphism databases

    DMDMi21263504.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ315162 mRNA. Translation: CAC86186.1 .
    AB057769 mRNA. Translation: BAB87840.1 .
    AK098057 mRNA. Translation: BAC05223.1 .
    CH471099 Genomic DNA. Translation: EAW89406.1 .
    BC029798 mRNA. Translation: AAH29798.1 .
    CCDSi CCDS11746.1.
    RefSeqi NP_599030.1. NM_134268.4.
    UniGenei Hs.95120.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1UMO X-ray 2.59 A/B 1-190 [» ]
    1URV X-ray 2.00 A/B 1-190 [» ]
    1URY X-ray 2.40 A/B 1-190 [» ]
    1UT0 X-ray 2.10 A/B 1-190 [» ]
    1UX9 X-ray 2.40 A/B 1-190 [» ]
    1V5H X-ray 2.40 A 1-190 [» ]
    2DC3 X-ray 1.68 A/B 1-190 [» ]
    3AG0 X-ray 2.60 A 1-190 [» ]
    4B3W X-ray 2.80 A/B 1-190 [» ]
    ProteinModelPortali Q8WWM9.
    SMRi Q8WWM9. Positions 17-188.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125335. 2 interactions.
    IntActi Q8WWM9. 1 interaction.
    STRINGi 9606.ENSP00000293230.

    PTM databases

    PhosphoSitei Q8WWM9.

    Polymorphism databases

    DMDMi 21263504.

    Proteomic databases

    MaxQBi Q8WWM9.
    PaxDbi Q8WWM9.
    PRIDEi Q8WWM9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000293230 ; ENSP00000293230 ; ENSG00000161544 .
    GeneIDi 114757.
    KEGGi hsa:114757.
    UCSCi uc002jru.2. human.

    Organism-specific databases

    CTDi 114757.
    GeneCardsi GC17M074523.
    HGNCi HGNC:16505. CYGB.
    HPAi HPA017757.
    MIMi 608759. gene.
    neXtProti NX_Q8WWM9.
    PharmGKBi PA27080.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG278586.
    HOGENOMi HOG000112127.
    HOVERGENi HBG100250.
    InParanoidi Q8WWM9.
    OMAi ECQSINE.
    OrthoDBi EOG7KSX9V.
    PhylomeDBi Q8WWM9.
    TreeFami TF332967.

    Miscellaneous databases

    EvolutionaryTracei Q8WWM9.
    GeneWikii Cytoglobin.
    GenomeRNAii 114757.
    NextBioi 79123.
    PROi Q8WWM9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8WWM9.
    Bgeei Q8WWM9.
    CleanExi HS_CYGB.
    Genevestigatori Q8WWM9.

    Family and domain databases

    Gene3Di 1.10.490.10. 1 hit.
    InterProi IPR000971. Globin.
    IPR009050. Globin-like.
    IPR012292. Globin_dom.
    IPR013314. Globin_lamprey/hagfish.
    [Graphical view ]
    Pfami PF00042. Globin. 1 hit.
    [Graphical view ]
    PRINTSi PR01906. FISHGLOBIN.
    SUPFAMi SSF46458. SSF46458. 1 hit.
    PROSITEi PS01033. GLOBIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cytoglobin: a novel globin type ubiquitously expressed in vertebrate tissues."
      Burmester T., Ebner B., Weich B., Hankeln T.
      Mol. Biol. Evol. 19:416-421(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    2. "Characterization of human stellate cell activation-associated protein and its expression in human liver."
      Asahina K., Kawada N., Kristensen D.B., Nakatani K., Seki S., Shiokawa M., Tateno C., Obara M., Yoshizato K.
      Biochim. Biophys. Acta 1577:471-475(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Heart.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    6. "A ubiquitously expressed human hexacoordinate hemoglobin."
      Trent J.T. III, Hargrove M.S.
      J. Biol. Chem. 277:19538-19545(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    7. Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS).
    8. "Crystal structure of cytoglobin: the fourth globin type discovered in man displays heme hexa-coordination."
      de Sanctis D., Dewilde S., Pesce A., Moens L., Ascenzi P., Hankeln T., Burmester T., Bolognesi M.
      J. Mol. Biol. 336:917-927(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS).
    9. "Structural basis of human cytoglobin for ligand binding."
      Sugimoto H., Makino M., Sawai H., Kawada N., Yoshizato K., Shiro Y.
      J. Mol. Biol. 339:873-885(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS).
    10. "High-resolution structure of human cytoglobin: identification of extra N-and C-termini and a new dimerization mode."
      Makino M., Sugimoto H., Sawai H., Kawada N., Yoshizato K., Shiro Y.
      Acta Crystallogr. D 62:671-677(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.68 ANGSTROMS), SUBUNIT, DISULFIDE BONDS.

    Entry informationi

    Entry nameiCYGB_HUMAN
    AccessioniPrimary (citable) accession number: Q8WWM9
    Secondary accession number(s): Q541Y7, Q8N2X5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 27, 2002
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 116 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3