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Protein

X antigen family member 5

Gene

XAGE5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Names & Taxonomyi

Protein namesi
Recommended name:
X antigen family member 5
Short name:
XAGE-5
Alternative name(s):
Cancer/testis antigen 12.5
Short name:
CT12.5
G antigen family D member 5
Gene namesi
Name:XAGE5
Synonyms:GAGED5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:30930. XAGE5.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134961730.

Polymorphism and mutation databases

BioMutaiXAGE5.
DMDMi27805770.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 108108X antigen family member 5PRO_0000148352Add
BLAST

Proteomic databases

PaxDbiQ8WWM1.
PRIDEiQ8WWM1.

Expressioni

Gene expression databases

BgeeiQ8WWM1.
CleanExiHS_XAGE5.
ExpressionAtlasiQ8WWM1. baseline and differential.

Organism-specific databases

HPAiHPA052507.
HPA059045.

Structurei

3D structure databases

ProteinModelPortaliQ8WWM1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GAGE family.Curated

Phylogenomic databases

eggNOGiENOG410KC5M. Eukaryota.
ENOG41112V3. LUCA.
GeneTreeiENSGT00840000129924.
HOGENOMiHOG000237345.
HOVERGENiHBG056227.
InParanoidiQ8WWM1.
OMAiDSPDVQG.
PhylomeDBiQ8WWM1.
TreeFamiTF340669.

Family and domain databases

InterProiIPR031320. GAGE.
IPR008625. GAGE_fam.
[Graphical view]
PANTHERiPTHR14047. PTHR14047. 1 hit.
PfamiPF05831. GAGE. 1 hit.
[Graphical view]
SMARTiSM01379. GAGE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8WWM1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWRGRRYRP RRCLRLAQLV GPMLEPSVPE PQQEEPPTES QDHTPGQKRE
60 70 80 90 100
DDQGAAEIQV PNLEADLQEL SQSKTGDECG DSPDVQGKIL PKSEQFKMPE

GGEGKPQL
Length:108
Mass (Da):12,077
Last modified:March 1, 2002 - v1
Checksum:iE3CD91E5C9241628
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ318894 Genomic DNA. Translation: CAC83015.1.
AL445236 Genomic DNA. Translation: CAI41618.1.
BC069129 mRNA. Translation: AAH69129.1.
CCDSiCCDS14346.1.
RefSeqiNP_570131.1. NM_130775.2.
XP_005262051.1. XM_005261994.3.
UniGeneiHs.356874.

Genome annotation databases

EnsembliENST00000351072; ENSP00000342240; ENSG00000171405.
ENST00000375501; ENSP00000364651; ENSG00000171405.
GeneIDi170627.
KEGGihsa:170627.
UCSCiuc064zio.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ318894 Genomic DNA. Translation: CAC83015.1.
AL445236 Genomic DNA. Translation: CAI41618.1.
BC069129 mRNA. Translation: AAH69129.1.
CCDSiCCDS14346.1.
RefSeqiNP_570131.1. NM_130775.2.
XP_005262051.1. XM_005261994.3.
UniGeneiHs.356874.

3D structure databases

ProteinModelPortaliQ8WWM1.
ModBaseiSearch...
MobiDBiSearch...

Polymorphism and mutation databases

BioMutaiXAGE5.
DMDMi27805770.

Proteomic databases

PaxDbiQ8WWM1.
PRIDEiQ8WWM1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000351072; ENSP00000342240; ENSG00000171405.
ENST00000375501; ENSP00000364651; ENSG00000171405.
GeneIDi170627.
KEGGihsa:170627.
UCSCiuc064zio.1. human.

Organism-specific databases

CTDi170627.
GeneCardsiXAGE5.
H-InvDBHIX0077163.
HGNCiHGNC:30930. XAGE5.
HPAiHPA052507.
HPA059045.
neXtProtiNX_Q8WWM1.
PharmGKBiPA134961730.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410KC5M. Eukaryota.
ENOG41112V3. LUCA.
GeneTreeiENSGT00840000129924.
HOGENOMiHOG000237345.
HOVERGENiHBG056227.
InParanoidiQ8WWM1.
OMAiDSPDVQG.
PhylomeDBiQ8WWM1.
TreeFamiTF340669.

Miscellaneous databases

GenomeRNAii170627.
NextBioi89076.
PROiQ8WWM1.

Gene expression databases

BgeeiQ8WWM1.
CleanExiHS_XAGE5.
ExpressionAtlasiQ8WWM1. baseline and differential.

Family and domain databases

InterProiIPR031320. GAGE.
IPR008625. GAGE_fam.
[Graphical view]
PANTHERiPTHR14047. PTHR14047. 1 hit.
PfamiPF05831. GAGE. 1 hit.
[Graphical view]
SMARTiSM01379. GAGE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The XAGE family of cancer/testis-associated genes: alignment and expression profile in normal tissues, melanoma lesions and Ewing's sarcoma."
    Zendman A.J.W., van Kraats A.A., Weidle U.H., Ruiter D.J., van Muijen G.N.P.
    Int. J. Cancer 99:361-369(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiXAGE5_HUMAN
AccessioniPrimary (citable) accession number: Q8WWM1
Secondary accession number(s): Q5JS81
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 17, 2003
Last sequence update: March 1, 2002
Last modified: May 11, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.