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Q8WWL7

- CCNB3_HUMAN

UniProt

Q8WWL7 - CCNB3_HUMAN

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Protein

G2/mitotic-specific cyclin-B3

Gene
CCNB3, CYCB3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Cyclins are positive regulatory subunits of the cyclin-dependent kinases (CDKs), and thereby play an essential role in the control of the cell cycle, notably via their destruction during cell division. Its tissue specificity suggest that it may be required during early meiotic prophase I.1 Publication

GO - Molecular functioni

  1. protein binding Source: IntAct

GO - Biological processi

  1. meiotic nuclear division Source: UniProtKB-KW
  2. regulation of cyclin-dependent protein serine/threonine kinase activity Source: InterPro
  3. regulation of G2/M transition of mitotic cell cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Cyclin

Keywords - Biological processi

Cell cycle, Cell division, Meiosis

Enzyme and pathway databases

SignaLinkiQ8WWL7.

Names & Taxonomyi

Protein namesi
Recommended name:
G2/mitotic-specific cyclin-B3
Gene namesi
Name:CCNB3
Synonyms:CYCB3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:18709. CCNB3.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi60 – 601R → A in cycB3XA; prevents its destruction after completion of anaphase; when associated with A-63 and A-68.
Mutagenesisi63 – 631F → A in cycB3XA; prevents its destruction after completion of anaphase; when associated with A-60 and A-68.
Mutagenesisi68 – 681N → A in cycB3XA; prevents its destruction after completion of anaphase; when associated with A-60 and A-63.

Organism-specific databases

PharmGKBiPA38653.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13951395G2/mitotic-specific cyclin-B3PRO_0000080373Add
BLAST

Post-translational modificationi

Ubiquitinated Inferred. Ubiquitination leads to its degradation during anaphase entry, after degradation of CCNB1.

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiQ8WWL7.
PRIDEiQ8WWL7.

PTM databases

PhosphoSiteiQ8WWL7.

Expressioni

Tissue specificityi

Testis specific. In testis, it is expressed in developing germ cells, but not in Leydig cells. Weakly or not expressed in other tissues.2 Publications

Gene expression databases

ArrayExpressiQ8WWL7.
BgeeiQ8WWL7.
CleanExiHS_CCNB3.
GenevestigatoriQ8WWL7.

Organism-specific databases

HPAiHPA000496.

Interactioni

Subunit structurei

Interacts with CDK2 kinase.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CDK2A8UKE62EBI-767764,EBI-767796From a different organism.
Plk4Q647024EBI-767764,EBI-2552433From a different organism.

Protein-protein interaction databases

BioGridi124523. 2 interactions.
IntActiQ8WWL7. 3 interactions.
MINTiMINT-4054013.
STRINGi9606.ENSP00000276014.

Structurei

3D structure databases

ProteinModelPortaliQ8WWL7.
SMRiQ8WWL7. Positions 1127-1370.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi60 – 689D-box

Domaini

The N-terminal destruction box (D-box) probably acts as a recognition signal for degradation via the ubiquitin-proteasome pathway By similarity.1 Publication

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5024.
HOGENOMiHOG000231355.
HOVERGENiHBG050835.
InParanoidiQ8WWL7.
KOiK05868.
OMAiNEMISEP.
OrthoDBiEOG7P2XST.
PhylomeDBiQ8WWL7.
TreeFamiTF101001.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR013763. Cyclin-like.
IPR015452. Cyclin_B3.
IPR004367. Cyclin_C-dom.
IPR006671. Cyclin_N.
[Graphical view]
PANTHERiPTHR10177:SF22. PTHR10177:SF22. 1 hit.
PfamiPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
SMARTiSM00385. CYCLIN. 2 hits.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8WWL7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MLLPLPPQSS KPVPKKSQSS KIVPSHHDPS EKTGENCQTK ISPSSLQESP     50
SSLQGALKKR SAFEDLTNAS QCQPVQPKKE ANKEFVKVVS KKINRNTHAL 100
GLAKKNKRNL KWHKLEVTPV VASTTVVPNI MEKPLILDIS TTSKTPNTEE 150
ASLFRKPLVL KEEPTIEDET LINKSLSLKK CSNHEEVSLL EKLQPLQEES 200
DSDDAFVIEP MTFKKTHKTE EAAITKKTLS LKKKMCASQR KQSCQEESLA 250
VQDVNMEEDS FFMESMSFKK KPKTEESIPT HKLSSLKKKC TIYGKICHFR 300
KPPVLQTTIC GAMSSIKKPT TEKETLFQEL SVLQEKHTTE HEMSILKKSL 350
ALQKTNFKED SLVKESLAFK KKPSTEEAIM MPVILKEQCM TEGKRSRLKP 400
LVLQEITSGE KSLIMKPLSI KEKPSTEKES FSQEPSALQK KHTTQEEVSI 450
LKEPSSLLKS PTEESPFDEA LAFTKKCTIE EAPPTKKPLI LKRKHATQGT 500
MSHLKKPLIL QTTSGEKSLI KEPLPFKEEK VSLKKKCTTQ EMMSICPELL 550
DFQDMIGEDK NSFFMEPMSF RKNPTTEETV LTKTSLSLQE KKITQGKMSH 600
LKKPLVLQKI TSEEESFYKK LLPFKMKSTT EEKFLSQEPS ALKEKHTTLQ 650
EVSLSKESLA IQEKATTEEE FSQELFSLHV KHTNKSGSLF QEALVLQEKT 700
DAEEDSLKNL LALQEKSTME EESLINKLLA LKEELSAEAA TNIQTQLSLK 750
KKSTSHGKVF FLKKQLALNE TINEEEFLNK QPLALEGYPS IAEGETLFKK 800
LLAMQEEPSI EKEAVLKEPT IDTEAHFKEP LALQEEPSTE KEAVLKEPSV 850
DTEAHFKETL ALQEKPSIEQ EALFKRHSAL WEKPSTEKET IFKESLDLQE 900
KPSIKKETLL KKPLALKMST INEAVLFEDM IALNEKPTTG KELSFKEPLA 950
LQESPTYKED TFLKTLLVPQ VGTSPNVSST APESITSKSS IATMTSVGKS 1000
GTINEAFLFE DMITLNEKPT TGKELSFKEP LALQESPTCK EDTFLETFLI 1050
PQIGTSPYVF STTPESITEK SSIATMTSVG KSRTTTESSA CESASDKPVS 1100
PQAKGTPKEI TPREDIDEDS SDPSFNPMYA KEIFSYMKER EEQFILTDYM 1150
NRQIEITSDM RAILVDWLVE VQVSFEMTHE TLYLAVKLVD LYLMKAVCKK 1200
DKLQLLGATA FMIAAKFEEH NSPRVDDFVY ICDDNYQRSE VLSMEINILN 1250
VLKCDINIPI AYHFLRRYAR CIHTNMKTLT LSRYICEMTL QEYHYVQEKA 1300
SKLAAASLLL ALYMKKLGYW VPFLEHYSGY SISELHPLVR QLNKLLTFSS 1350
YDSLKAVYYK YSHPVFFEVA KIPALDMLKL EEILNCDCEA QGLVL 1395
Length:1,395
Mass (Da):157,916
Last modified:October 14, 2008 - v2
Checksum:i454552BC5A67E34E
GO
Isoform 2 (identifier: Q8WWL7-2) [UniParc]FASTAAdd to Basket

Also known as: Variant 1

The sequence of this isoform differs from the canonical sequence as follows:
     69-1172: Missing.

Show »
Length:291
Mass (Da):33,275
Checksum:iCC00FC3079181B7E
GO
Isoform 3 (identifier: Q8WWL7-3) [UniParc]FASTAAdd to Basket

Also known as: Variant 2

The sequence of this isoform differs from the canonical sequence as follows:
     112-1395: Missing.

Show »
Length:111
Mass (Da):12,195
Checksum:i0D8F2ACB1016D226
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti597 – 5971K → T in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_036580
Natural varianti1001 – 10011G → R.
Corresponds to variant rs6614336 [ dbSNP | Ensembl ].
VAR_047027

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei69 – 11721104Missing in isoform 2. VSP_010514Add
BLAST
Alternative sequencei112 – 13951284Missing in isoform 3. VSP_010515Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti295 – 2951K → R in CAC40024. 1 Publication
Sequence conflicti331 – 3311S → F in CAC94915. 1 Publication
Sequence conflicti396 – 3961S → P in CAC40024. 1 Publication
Sequence conflicti493 – 4931R → K in CAC40024. 1 Publication
Sequence conflicti573 – 5731N → S in CAC40024. 1 Publication
Sequence conflicti597 – 5971K → E in CAC40024. 1 Publication
Sequence conflicti774 – 7741E → K in CAC94915. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ416458 mRNA. Translation: CAC94915.1.
AJ314764 mRNA. Translation: CAC40024.1.
AJ314765 mRNA. Translation: CAC40025.1.
AJ314766 mRNA. Translation: CAC40026.1.
AL591367, BX323840 Genomic DNA. Translation: CAI41320.1.
AL591367, BX323840 Genomic DNA. Translation: CAI41321.1.
BX323840, AL591367 Genomic DNA. Translation: CAI43220.1.
BX323840, AL591367 Genomic DNA. Translation: CAI43221.1.
CH471180 Genomic DNA. Translation: EAW89922.1.
CH471180 Genomic DNA. Translation: EAW89923.1.
AL137550 mRNA. Translation: CAB70806.1.
CCDSiCCDS14331.1. [Q8WWL7-1]
CCDS14332.1. [Q8WWL7-2]
PIRiT46391.
RefSeqiNP_149020.2. NM_033031.2. [Q8WWL7-1]
NP_391990.1. NM_033670.2. [Q8WWL7-2]
UniGeneiHs.130310.
Hs.722420.
Hs.722421.
Hs.740165.

Genome annotation databases

EnsembliENST00000276014; ENSP00000276014; ENSG00000147082. [Q8WWL7-1]
ENST00000348603; ENSP00000338682; ENSG00000147082. [Q8WWL7-2]
ENST00000376038; ENSP00000365206; ENSG00000147082. [Q8WWL7-2]
ENST00000376042; ENSP00000365210; ENSG00000147082. [Q8WWL7-1]
ENST00000476167; ENSP00000431645; ENSG00000147082. [Q8WWL7-3]
ENST00000593643; ENSP00000471254; ENSG00000268264. [Q8WWL7-2]
ENST00000594292; ENSP00000472548; ENSG00000268264. [Q8WWL7-1]
ENST00000595350; ENSP00000470817; ENSG00000268264. [Q8WWL7-3]
ENST00000596541; ENSP00000471997; ENSG00000269438. [Q8WWL7-1]
ENST00000597115; ENSP00000469069; ENSG00000268264. [Q8WWL7-1]
ENST00000598186; ENSP00000472565; ENSG00000269438. [Q8WWL7-3]
ENST00000598566; ENSP00000471440; ENSG00000268264. [Q8WWL7-2]
ENST00000599832; ENSP00000470722; ENSG00000269438. [Q8WWL7-1]
ENST00000601442; ENSP00000472573; ENSG00000269438. [Q8WWL7-2]
ENST00000602116; ENSP00000468921; ENSG00000269438. [Q8WWL7-2]
GeneIDi85417.
KEGGihsa:85417.
UCSCiuc004dox.4. human. [Q8WWL7-1]
uc004doz.3. human. [Q8WWL7-2]

Polymorphism databases

DMDMi209572596.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ416458 mRNA. Translation: CAC94915.1 .
AJ314764 mRNA. Translation: CAC40024.1 .
AJ314765 mRNA. Translation: CAC40025.1 .
AJ314766 mRNA. Translation: CAC40026.1 .
AL591367 , BX323840 Genomic DNA. Translation: CAI41320.1 .
AL591367 , BX323840 Genomic DNA. Translation: CAI41321.1 .
BX323840 , AL591367 Genomic DNA. Translation: CAI43220.1 .
BX323840 , AL591367 Genomic DNA. Translation: CAI43221.1 .
CH471180 Genomic DNA. Translation: EAW89922.1 .
CH471180 Genomic DNA. Translation: EAW89923.1 .
AL137550 mRNA. Translation: CAB70806.1 .
CCDSi CCDS14331.1. [Q8WWL7-1 ]
CCDS14332.1. [Q8WWL7-2 ]
PIRi T46391.
RefSeqi NP_149020.2. NM_033031.2. [Q8WWL7-1 ]
NP_391990.1. NM_033670.2. [Q8WWL7-2 ]
UniGenei Hs.130310.
Hs.722420.
Hs.722421.
Hs.740165.

3D structure databases

ProteinModelPortali Q8WWL7.
SMRi Q8WWL7. Positions 1127-1370.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 124523. 2 interactions.
IntActi Q8WWL7. 3 interactions.
MINTi MINT-4054013.
STRINGi 9606.ENSP00000276014.

Chemistry

BindingDBi Q8WWL7.
ChEMBLi CHEMBL2094127.

PTM databases

PhosphoSitei Q8WWL7.

Polymorphism databases

DMDMi 209572596.

Proteomic databases

PaxDbi Q8WWL7.
PRIDEi Q8WWL7.

Protocols and materials databases

DNASUi 85417.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000276014 ; ENSP00000276014 ; ENSG00000147082 . [Q8WWL7-1 ]
ENST00000348603 ; ENSP00000338682 ; ENSG00000147082 . [Q8WWL7-2 ]
ENST00000376038 ; ENSP00000365206 ; ENSG00000147082 . [Q8WWL7-2 ]
ENST00000376042 ; ENSP00000365210 ; ENSG00000147082 . [Q8WWL7-1 ]
ENST00000476167 ; ENSP00000431645 ; ENSG00000147082 . [Q8WWL7-3 ]
ENST00000593643 ; ENSP00000471254 ; ENSG00000268264 . [Q8WWL7-2 ]
ENST00000594292 ; ENSP00000472548 ; ENSG00000268264 . [Q8WWL7-1 ]
ENST00000595350 ; ENSP00000470817 ; ENSG00000268264 . [Q8WWL7-3 ]
ENST00000596541 ; ENSP00000471997 ; ENSG00000269438 . [Q8WWL7-1 ]
ENST00000597115 ; ENSP00000469069 ; ENSG00000268264 . [Q8WWL7-1 ]
ENST00000598186 ; ENSP00000472565 ; ENSG00000269438 . [Q8WWL7-3 ]
ENST00000598566 ; ENSP00000471440 ; ENSG00000268264 . [Q8WWL7-2 ]
ENST00000599832 ; ENSP00000470722 ; ENSG00000269438 . [Q8WWL7-1 ]
ENST00000601442 ; ENSP00000472573 ; ENSG00000269438 . [Q8WWL7-2 ]
ENST00000602116 ; ENSP00000468921 ; ENSG00000269438 . [Q8WWL7-2 ]
GeneIDi 85417.
KEGGi hsa:85417.
UCSCi uc004dox.4. human. [Q8WWL7-1 ]
uc004doz.3. human. [Q8WWL7-2 ]

Organism-specific databases

CTDi 85417.
GeneCardsi GC0XP049967.
HGNCi HGNC:18709. CCNB3.
HPAi HPA000496.
MIMi 300456. gene.
neXtProti NX_Q8WWL7.
PharmGKBi PA38653.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5024.
HOGENOMi HOG000231355.
HOVERGENi HBG050835.
InParanoidi Q8WWL7.
KOi K05868.
OMAi NEMISEP.
OrthoDBi EOG7P2XST.
PhylomeDBi Q8WWL7.
TreeFami TF101001.

Enzyme and pathway databases

SignaLinki Q8WWL7.

Miscellaneous databases

GenomeRNAii 85417.
NextBioi 75998.
PROi Q8WWL7.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8WWL7.
Bgeei Q8WWL7.
CleanExi HS_CCNB3.
Genevestigatori Q8WWL7.

Family and domain databases

Gene3Di 1.10.472.10. 2 hits.
InterProi IPR013763. Cyclin-like.
IPR015452. Cyclin_B3.
IPR004367. Cyclin_C-dom.
IPR006671. Cyclin_N.
[Graphical view ]
PANTHERi PTHR10177:SF22. PTHR10177:SF22. 1 hit.
Pfami PF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view ]
SMARTi SM00385. CYCLIN. 2 hits.
[Graphical view ]
SUPFAMi SSF47954. SSF47954. 2 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization and expression of mammalian cyclin b3, a prepachytene meiotic cyclin."
    Nguyen T.B., Manova K., Capodieci P., Lindon C., Bottega S., Wang X.-Y., Refik-Rogers J., Pines J., Wolgemuth D.J., Koff A.
    J. Biol. Chem. 277:41960-41969(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, DOMAIN, TISSUE SPECIFICITY, MUTANT CYCB3XA, INTERACTION WITH CDK2.
    Tissue: Testis.
  2. "Molecular cloning, gene localization, and structure of human cyclin B3."
    Lozano J.-C., Perret E., Schatt P., Arnould C., Peaucellier G., Picard A.
    Biochem. Biophys. Res. Commun. 291:406-413(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
    Tissue: Placenta.
  3. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1249-1395 (ISOFORM 1).
    Tissue: Testis.
  6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-597.

Entry informationi

Entry nameiCCNB3_HUMAN
AccessioniPrimary (citable) accession number: Q8WWL7
Secondary accession number(s): B1AQI5
, B1AQI6, Q96SB5, Q96SB6, Q96SB7, Q9NT38
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: October 14, 2008
Last modified: July 9, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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