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Q8WWL7

- CCNB3_HUMAN

UniProt

Q8WWL7 - CCNB3_HUMAN

Protein

G2/mitotic-specific cyclin-B3

Gene

CCNB3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 2 (14 Oct 2008)
      Previous versions | rss
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    Functioni

    Cyclins are positive regulatory subunits of the cyclin-dependent kinases (CDKs), and thereby play an essential role in the control of the cell cycle, notably via their destruction during cell division. Its tissue specificity suggest that it may be required during early meiotic prophase I.1 Publication

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. meiotic nuclear division Source: UniProtKB-KW
    2. regulation of cyclin-dependent protein serine/threonine kinase activity Source: InterPro
    3. regulation of G2/M transition of mitotic cell cycle Source: InterPro

    Keywords - Molecular functioni

    Cyclin

    Keywords - Biological processi

    Cell cycle, Cell division, Meiosis

    Enzyme and pathway databases

    SignaLinkiQ8WWL7.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    G2/mitotic-specific cyclin-B3
    Gene namesi
    Name:CCNB3
    Synonyms:CYCB3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:18709. CCNB3.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. nucleus Source: HPA

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi60 – 601R → A in cycB3XA; prevents its destruction after completion of anaphase; when associated with A-63 and A-68.
    Mutagenesisi63 – 631F → A in cycB3XA; prevents its destruction after completion of anaphase; when associated with A-60 and A-68.
    Mutagenesisi68 – 681N → A in cycB3XA; prevents its destruction after completion of anaphase; when associated with A-60 and A-63.

    Organism-specific databases

    PharmGKBiPA38653.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 13951395G2/mitotic-specific cyclin-B3PRO_0000080373Add
    BLAST

    Post-translational modificationi

    Ubiquitinated Probable. Ubiquitination leads to its degradation during anaphase entry, after degradation of CCNB1.Curated

    Keywords - PTMi

    Ubl conjugation

    Proteomic databases

    PaxDbiQ8WWL7.
    PRIDEiQ8WWL7.

    PTM databases

    PhosphoSiteiQ8WWL7.

    Expressioni

    Tissue specificityi

    Testis specific. In testis, it is expressed in developing germ cells, but not in Leydig cells. Weakly or not expressed in other tissues.2 Publications

    Gene expression databases

    ArrayExpressiQ8WWL7.
    BgeeiQ8WWL7.
    CleanExiHS_CCNB3.
    GenevestigatoriQ8WWL7.

    Organism-specific databases

    HPAiHPA000496.

    Interactioni

    Subunit structurei

    Interacts with CDK2 kinase.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CDK2A8UKE62EBI-767764,EBI-767796From a different organism.
    Plk4Q647024EBI-767764,EBI-2552433From a different organism.

    Protein-protein interaction databases

    BioGridi124523. 2 interactions.
    IntActiQ8WWL7. 3 interactions.
    MINTiMINT-4054013.
    STRINGi9606.ENSP00000276014.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8WWL7.
    SMRiQ8WWL7. Positions 1127-1370.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi60 – 689D-box

    Domaini

    The N-terminal destruction box (D-box) probably acts as a recognition signal for degradation via the ubiquitin-proteasome pathway.By similarity

    Sequence similaritiesi

    Belongs to the cyclin family. Cyclin AB subfamily.Curated

    Phylogenomic databases

    eggNOGiCOG5024.
    HOGENOMiHOG000231355.
    HOVERGENiHBG050835.
    InParanoidiQ8WWL7.
    KOiK05868.
    OMAiNEMISEP.
    OrthoDBiEOG7P2XST.
    PhylomeDBiQ8WWL7.
    TreeFamiTF101001.

    Family and domain databases

    Gene3Di1.10.472.10. 2 hits.
    InterProiIPR013763. Cyclin-like.
    IPR015452. Cyclin_B3.
    IPR004367. Cyclin_C-dom.
    IPR006671. Cyclin_N.
    [Graphical view]
    PANTHERiPTHR10177:SF22. PTHR10177:SF22. 1 hit.
    PfamiPF02984. Cyclin_C. 1 hit.
    PF00134. Cyclin_N. 1 hit.
    [Graphical view]
    SMARTiSM00385. CYCLIN. 2 hits.
    [Graphical view]
    SUPFAMiSSF47954. SSF47954. 2 hits.

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8WWL7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLLPLPPQSS KPVPKKSQSS KIVPSHHDPS EKTGENCQTK ISPSSLQESP     50
    SSLQGALKKR SAFEDLTNAS QCQPVQPKKE ANKEFVKVVS KKINRNTHAL 100
    GLAKKNKRNL KWHKLEVTPV VASTTVVPNI MEKPLILDIS TTSKTPNTEE 150
    ASLFRKPLVL KEEPTIEDET LINKSLSLKK CSNHEEVSLL EKLQPLQEES 200
    DSDDAFVIEP MTFKKTHKTE EAAITKKTLS LKKKMCASQR KQSCQEESLA 250
    VQDVNMEEDS FFMESMSFKK KPKTEESIPT HKLSSLKKKC TIYGKICHFR 300
    KPPVLQTTIC GAMSSIKKPT TEKETLFQEL SVLQEKHTTE HEMSILKKSL 350
    ALQKTNFKED SLVKESLAFK KKPSTEEAIM MPVILKEQCM TEGKRSRLKP 400
    LVLQEITSGE KSLIMKPLSI KEKPSTEKES FSQEPSALQK KHTTQEEVSI 450
    LKEPSSLLKS PTEESPFDEA LAFTKKCTIE EAPPTKKPLI LKRKHATQGT 500
    MSHLKKPLIL QTTSGEKSLI KEPLPFKEEK VSLKKKCTTQ EMMSICPELL 550
    DFQDMIGEDK NSFFMEPMSF RKNPTTEETV LTKTSLSLQE KKITQGKMSH 600
    LKKPLVLQKI TSEEESFYKK LLPFKMKSTT EEKFLSQEPS ALKEKHTTLQ 650
    EVSLSKESLA IQEKATTEEE FSQELFSLHV KHTNKSGSLF QEALVLQEKT 700
    DAEEDSLKNL LALQEKSTME EESLINKLLA LKEELSAEAA TNIQTQLSLK 750
    KKSTSHGKVF FLKKQLALNE TINEEEFLNK QPLALEGYPS IAEGETLFKK 800
    LLAMQEEPSI EKEAVLKEPT IDTEAHFKEP LALQEEPSTE KEAVLKEPSV 850
    DTEAHFKETL ALQEKPSIEQ EALFKRHSAL WEKPSTEKET IFKESLDLQE 900
    KPSIKKETLL KKPLALKMST INEAVLFEDM IALNEKPTTG KELSFKEPLA 950
    LQESPTYKED TFLKTLLVPQ VGTSPNVSST APESITSKSS IATMTSVGKS 1000
    GTINEAFLFE DMITLNEKPT TGKELSFKEP LALQESPTCK EDTFLETFLI 1050
    PQIGTSPYVF STTPESITEK SSIATMTSVG KSRTTTESSA CESASDKPVS 1100
    PQAKGTPKEI TPREDIDEDS SDPSFNPMYA KEIFSYMKER EEQFILTDYM 1150
    NRQIEITSDM RAILVDWLVE VQVSFEMTHE TLYLAVKLVD LYLMKAVCKK 1200
    DKLQLLGATA FMIAAKFEEH NSPRVDDFVY ICDDNYQRSE VLSMEINILN 1250
    VLKCDINIPI AYHFLRRYAR CIHTNMKTLT LSRYICEMTL QEYHYVQEKA 1300
    SKLAAASLLL ALYMKKLGYW VPFLEHYSGY SISELHPLVR QLNKLLTFSS 1350
    YDSLKAVYYK YSHPVFFEVA KIPALDMLKL EEILNCDCEA QGLVL 1395
    Length:1,395
    Mass (Da):157,916
    Last modified:October 14, 2008 - v2
    Checksum:i454552BC5A67E34E
    GO
    Isoform 2 (identifier: Q8WWL7-2) [UniParc]FASTAAdd to Basket

    Also known as: Variant 1

    The sequence of this isoform differs from the canonical sequence as follows:
         69-1172: Missing.

    Show »
    Length:291
    Mass (Da):33,275
    Checksum:iCC00FC3079181B7E
    GO
    Isoform 3 (identifier: Q8WWL7-3) [UniParc]FASTAAdd to Basket

    Also known as: Variant 2

    The sequence of this isoform differs from the canonical sequence as follows:
         112-1395: Missing.

    Show »
    Length:111
    Mass (Da):12,195
    Checksum:i0D8F2ACB1016D226
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti295 – 2951K → R in CAC40024. (PubMed:11846420)Curated
    Sequence conflicti331 – 3311S → F in CAC94915. (PubMed:12185076)Curated
    Sequence conflicti396 – 3961S → P in CAC40024. (PubMed:11846420)Curated
    Sequence conflicti493 – 4931R → K in CAC40024. (PubMed:11846420)Curated
    Sequence conflicti573 – 5731N → S in CAC40024. (PubMed:11846420)Curated
    Sequence conflicti597 – 5971K → E in CAC40024. (PubMed:11846420)Curated
    Sequence conflicti774 – 7741E → K in CAC94915. (PubMed:12185076)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti597 – 5971K → T in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_036580
    Natural varianti1001 – 10011G → R.
    Corresponds to variant rs6614336 [ dbSNP | Ensembl ].
    VAR_047027

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei69 – 11721104Missing in isoform 2. 1 PublicationVSP_010514Add
    BLAST
    Alternative sequencei112 – 13951284Missing in isoform 3. 1 PublicationVSP_010515Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ416458 mRNA. Translation: CAC94915.1.
    AJ314764 mRNA. Translation: CAC40024.1.
    AJ314765 mRNA. Translation: CAC40025.1.
    AJ314766 mRNA. Translation: CAC40026.1.
    AL591367, BX323840 Genomic DNA. Translation: CAI41320.1.
    AL591367, BX323840 Genomic DNA. Translation: CAI41321.1.
    BX323840, AL591367 Genomic DNA. Translation: CAI43220.1.
    BX323840, AL591367 Genomic DNA. Translation: CAI43221.1.
    CH471180 Genomic DNA. Translation: EAW89922.1.
    CH471180 Genomic DNA. Translation: EAW89923.1.
    AL137550 mRNA. Translation: CAB70806.1.
    CCDSiCCDS14331.1. [Q8WWL7-1]
    CCDS14332.1. [Q8WWL7-2]
    PIRiT46391.
    RefSeqiNP_149020.2. NM_033031.2. [Q8WWL7-1]
    NP_391990.1. NM_033670.2. [Q8WWL7-2]
    UniGeneiHs.130310.
    Hs.722420.
    Hs.722421.
    Hs.740165.

    Genome annotation databases

    EnsembliENST00000276014; ENSP00000276014; ENSG00000147082. [Q8WWL7-1]
    ENST00000348603; ENSP00000338682; ENSG00000147082. [Q8WWL7-2]
    ENST00000376038; ENSP00000365206; ENSG00000147082. [Q8WWL7-2]
    ENST00000376042; ENSP00000365210; ENSG00000147082. [Q8WWL7-1]
    ENST00000476167; ENSP00000431645; ENSG00000147082. [Q8WWL7-3]
    GeneIDi85417.
    KEGGihsa:85417.
    UCSCiuc004dox.4. human. [Q8WWL7-1]
    uc004doz.3. human. [Q8WWL7-2]

    Polymorphism databases

    DMDMi209572596.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ416458 mRNA. Translation: CAC94915.1 .
    AJ314764 mRNA. Translation: CAC40024.1 .
    AJ314765 mRNA. Translation: CAC40025.1 .
    AJ314766 mRNA. Translation: CAC40026.1 .
    AL591367 , BX323840 Genomic DNA. Translation: CAI41320.1 .
    AL591367 , BX323840 Genomic DNA. Translation: CAI41321.1 .
    BX323840 , AL591367 Genomic DNA. Translation: CAI43220.1 .
    BX323840 , AL591367 Genomic DNA. Translation: CAI43221.1 .
    CH471180 Genomic DNA. Translation: EAW89922.1 .
    CH471180 Genomic DNA. Translation: EAW89923.1 .
    AL137550 mRNA. Translation: CAB70806.1 .
    CCDSi CCDS14331.1. [Q8WWL7-1 ]
    CCDS14332.1. [Q8WWL7-2 ]
    PIRi T46391.
    RefSeqi NP_149020.2. NM_033031.2. [Q8WWL7-1 ]
    NP_391990.1. NM_033670.2. [Q8WWL7-2 ]
    UniGenei Hs.130310.
    Hs.722420.
    Hs.722421.
    Hs.740165.

    3D structure databases

    ProteinModelPortali Q8WWL7.
    SMRi Q8WWL7. Positions 1127-1370.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124523. 2 interactions.
    IntActi Q8WWL7. 3 interactions.
    MINTi MINT-4054013.
    STRINGi 9606.ENSP00000276014.

    Chemistry

    BindingDBi Q8WWL7.
    ChEMBLi CHEMBL2094127.

    PTM databases

    PhosphoSitei Q8WWL7.

    Polymorphism databases

    DMDMi 209572596.

    Proteomic databases

    PaxDbi Q8WWL7.
    PRIDEi Q8WWL7.

    Protocols and materials databases

    DNASUi 85417.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000276014 ; ENSP00000276014 ; ENSG00000147082 . [Q8WWL7-1 ]
    ENST00000348603 ; ENSP00000338682 ; ENSG00000147082 . [Q8WWL7-2 ]
    ENST00000376038 ; ENSP00000365206 ; ENSG00000147082 . [Q8WWL7-2 ]
    ENST00000376042 ; ENSP00000365210 ; ENSG00000147082 . [Q8WWL7-1 ]
    ENST00000476167 ; ENSP00000431645 ; ENSG00000147082 . [Q8WWL7-3 ]
    GeneIDi 85417.
    KEGGi hsa:85417.
    UCSCi uc004dox.4. human. [Q8WWL7-1 ]
    uc004doz.3. human. [Q8WWL7-2 ]

    Organism-specific databases

    CTDi 85417.
    GeneCardsi GC0XP049967.
    HGNCi HGNC:18709. CCNB3.
    HPAi HPA000496.
    MIMi 300456. gene.
    neXtProti NX_Q8WWL7.
    PharmGKBi PA38653.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5024.
    HOGENOMi HOG000231355.
    HOVERGENi HBG050835.
    InParanoidi Q8WWL7.
    KOi K05868.
    OMAi NEMISEP.
    OrthoDBi EOG7P2XST.
    PhylomeDBi Q8WWL7.
    TreeFami TF101001.

    Enzyme and pathway databases

    SignaLinki Q8WWL7.

    Miscellaneous databases

    GenomeRNAii 85417.
    NextBioi 75998.
    PROi Q8WWL7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8WWL7.
    Bgeei Q8WWL7.
    CleanExi HS_CCNB3.
    Genevestigatori Q8WWL7.

    Family and domain databases

    Gene3Di 1.10.472.10. 2 hits.
    InterProi IPR013763. Cyclin-like.
    IPR015452. Cyclin_B3.
    IPR004367. Cyclin_C-dom.
    IPR006671. Cyclin_N.
    [Graphical view ]
    PANTHERi PTHR10177:SF22. PTHR10177:SF22. 1 hit.
    Pfami PF02984. Cyclin_C. 1 hit.
    PF00134. Cyclin_N. 1 hit.
    [Graphical view ]
    SMARTi SM00385. CYCLIN. 2 hits.
    [Graphical view ]
    SUPFAMi SSF47954. SSF47954. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Characterization and expression of mammalian cyclin b3, a prepachytene meiotic cyclin."
      Nguyen T.B., Manova K., Capodieci P., Lindon C., Bottega S., Wang X.-Y., Refik-Rogers J., Pines J., Wolgemuth D.J., Koff A.
      J. Biol. Chem. 277:41960-41969(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, DOMAIN, TISSUE SPECIFICITY, MUTANT CYCB3XA, INTERACTION WITH CDK2.
      Tissue: Testis.
    2. "Molecular cloning, gene localization, and structure of human cyclin B3."
      Lozano J.-C., Perret E., Schatt P., Arnould C., Peaucellier G., Picard A.
      Biochem. Biophys. Res. Commun. 291:406-413(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
      Tissue: Placenta.
    3. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1249-1395 (ISOFORM 1).
      Tissue: Testis.
    6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-597.

    Entry informationi

    Entry nameiCCNB3_HUMAN
    AccessioniPrimary (citable) accession number: Q8WWL7
    Secondary accession number(s): B1AQI5
    , B1AQI6, Q96SB5, Q96SB6, Q96SB7, Q9NT38
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2004
    Last sequence update: October 14, 2008
    Last modified: October 1, 2014
    This is version 112 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3