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UniProtKB - Q8WWK9 (CKAP2_HUMAN)

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Protein

Cytoskeleton-associated protein 2

Gene

CKAP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Possesses microtubule stabilizing properties. Involved in regulating aneuploidy, cell cycling, and cell death in a p53/TP53-dependent manner (By similarity).By similarity

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • mitotic cytokinesis Source: MGI
  • negative regulation of microtubule depolymerization Source: Ensembl
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
Complete GO annotation...

Keywordsi

Biological processApoptosis, Cell cycle

Enzyme and pathway databases

SIGNORiQ8WWK9.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytoskeleton-associated protein 2
Alternative name(s):
CTCL tumor antigen se20-10
Tumor- and microtubule-associated protein
Gene namesi
Name:CKAP2Imported
Synonyms:LB1Imported, TMAPImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:1990. CKAP2.

Subcellular locationi

  • Cytoplasm › cytoskeleton
  • Cytoplasm › cytoskeleton › spindle
  • Cytoplasm › cytoskeleton › spindle pole

    • Note: Contrary to the ectopically expressed protein, endogenous CKAP2 does not colocalize with microtubules in G1, S and early G2. At late G2 and prophase after separation of duplicated centrosomes, colocalizes with gamma-tubulin and centrosome-proximal microtubules. From prometaphase through anaphase B, colocalizes with mitotic spindle poles and spindle microtubules. During cytokinesis, absent from midbody microtubules.

GO - Cellular componenti

  • centrosome Source: UniProtKB
  • cytoplasmic microtubule Source: Ensembl
  • cytosol Source: HPA
  • microtubule cytoskeleton Source: HPA
  • spindle pole Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

DisGeNETi26586.
OpenTargetsiENSG00000136108.
PharmGKBiPA26526.

Polymorphism and mutation databases

BioMutaiCKAP2.
DMDMi74751579.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002457741 – 683Cytoskeleton-associated protein 2Add BLAST683

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei178PhosphoserineCombined sources1
Modified residuei190PhosphoserineCombined sources1
Modified residuei534PhosphoserineCombined sources1
Modified residuei579PhosphothreonineCombined sources1
Modified residuei582PhosphothreonineCombined sources1
Modified residuei595PhosphoserineCombined sources1
Modified residuei596PhosphothreonineCombined sources1
Modified residuei597PhosphothreonineCombined sources1
Modified residuei599PhosphotyrosineCombined sources1
Modified residuei602PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8WWK9.
MaxQBiQ8WWK9.
PaxDbiQ8WWK9.
PeptideAtlasiQ8WWK9.
PRIDEiQ8WWK9.

PTM databases

iPTMnetiQ8WWK9.
PhosphoSitePlusiQ8WWK9.

Expressioni

Tissue specificityi

Abundant in testis, thymus, and in tumor derived cell lines, while barely detectable in liver, prostate, and kidney.1 Publication

Developmental stagei

Present at the G1/S boundary. Accumulates as cells progress from S to G2 into mitosis. Rapidly degraded during mitosis exit by CDH1-activated anaphase promoting complex/cyclosome (APC/C).1 Publication

Inductioni

Up-regulated in primary human gastric cancers.1 Publication

Gene expression databases

BgeeiENSG00000136108.
ExpressionAtlasiQ8WWK9. baseline and differential.
GenevisibleiQ8WWK9. HS.

Organism-specific databases

HPAiHPA008410.
HPA027821.

Interactioni

Subunit structurei

Associates with alpha- and beta-tubulins.By similarity

Protein-protein interaction databases

BioGridi117755. 34 interactors.
IntActiQ8WWK9. 27 interactors.
MINTiMINT-4989610.
STRINGi9606.ENSP00000367276.

Structurei

3D structure databases

ProteinModelPortaliQ8WWK9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CKAP2 family.Curated

Phylogenomic databases

eggNOGiENOG410IF2W. Eukaryota.
ENOG4111T8P. LUCA.
GeneTreeiENSGT00530000063691.
HOGENOMiHOG000290636.
HOVERGENiHBG107703.
InParanoidiQ8WWK9.
KOiK16769.
OMAiRRHTIAK.
OrthoDBiEOG091G05HU.
PhylomeDBiQ8WWK9.
TreeFamiTF333003.

Family and domain databases

InterProiView protein in InterPro
IPR029197. CKAP2_C.
IPR026165. CKAP2_fam.
PANTHERiPTHR16076. PTHR16076. 1 hit.
PfamiView protein in Pfam
PF15297. CKAP2_C. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 13 Publications (identifier: Q8WWK9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSTPAVPQDL QLPPSQRAQS AFKEQRRQKL KEHLLRRKTL FAYKQENEML 
        60         70         80         90        100
SSSRDQRVVT SEDQVQEGTK VLKLKTKMAD KENMKRPAES KNNTVVGKHC 
       110        120        130        140        150
IPLKPSNELT NSTVVIDTHK PKDSNQTPHL LLTEDDPQSQ HMTLSQAFHL 
       160        170        180        190        200
KNNSKKKQMT TEKQKQDANM PKKPVLGSYR GQIVQSKINS FRKPLQVKDE 
       210        220        230        240        250
SSAATKKLSA TIPKATKPQP VNTSSVTVKS NRSSNMTATT KFVSTTSQNT 
       260        270        280        290        300
QLVRPPIRSH HSNTRDTVKQ GISRTSANVT IRKGPHEKEL LQSKTALSSV 
       310        320        330        340        350
KTSSSQGIIR NKTLSRSIAS EVIARPASLS NDKLMEKSEP VDQRRHTAGK 
       360        370        380        390        400
AIVDSRSAQP KETSEERKAR LSEWKAGKGR VLKRPPNSVV TQHEPAGQNE 
       410        420        430        440        450
KPVGSFWTTM AEEDEQRLFT EKVNNTFSEC LNLINEGCPK EDILVTLNDL 
       460        470        480        490        500
IKNIPDAKKL VKYWICLALI EPITSPIENI IAIYEKAILA GAQPIEEMRH 
       510        520        530        540        550
TIVDILTMKS QEKANLGENM EKSCASKEEV KEVSIEDTGV DVDPEKLEME 
       560        570        580        590        600
SKLHRNLLFQ DCEKEQDNKT KDPTHDVKTP NTETRTSCLI KYNVSTTPYL 
       610        620        630        640        650
QSVKKKVQFD GTNSAFKELK FLTPVRRSRR LQEKTSKLPD MLKDHYPCVS 
       660        670        680 
SLEQLTELGR ETDAFVCRPN AALCRVYYEA DTT
Length:683
Mass (Da):76,987
Last modified:March 1, 2002 - v1
Checksum:i15287A7D860A4B23
GO
Isoform 2 (identifier: Q8WWK9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     53-53: Missing.
     494-495: PI → VR
     496-683: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:494
Mass (Da):55,307
Checksum:iDD773D8CC02C95B6
GO
Isoform 4 (identifier: Q8WWK9-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-51: MSTPAVPQDLQLPPSQRAQSAFKEQRRQKLKEHLLRRKTLFAYKQENEMLS → ML

Show »
Length:634
Mass (Da):71,195
Checksum:i10E49DFCE41416C5
GO
Isoform 3 (identifier: Q8WWK9-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     53-53: Missing.

Note: No experimental confirmation available.
Show »
Length:682
Mass (Da):76,900
Checksum:i44F00A4FFEE1FD98
GO

Sequence cautioni

The sequence AAG33675 differs from that shown. Reason: Frameshift at position 604.Curated
The sequence AAG33675 differs from that shown. Reason: Frameshift at position 607.Curated
The sequence AAH10901 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI05807 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAA91788 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti402P → L in CAB66782 (PubMed:11230166).Curated1
Sequence conflicti531K → Q in BAA91788 (PubMed:14702039).Curated1
Sequence conflicti531K → R in BAB14345 (PubMed:14702039).Curated1
Sequence conflicti559F → L in BAB14345 (PubMed:14702039).Curated1
Sequence conflicti577V → A in BAB14345 (PubMed:14702039).Curated1
Sequence conflicti643K → R in BAA91788 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_054018236M → K1 PublicationCorresponds to variant dbSNP:rs35975899Ensembl.1
Natural variantiVAR_069359323I → V5 PublicationsCorresponds to variant dbSNP:rs7335867Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0556861 – 51MSTPA…NEMLS → ML in isoform 4. 1 PublicationAdd BLAST51
Alternative sequenceiVSP_04710053Missing in isoform 2 and isoform 3. 3 Publications1
Alternative sequenceiVSP_047101494 – 495PI → VR in isoform 2. 1 Publication2
Alternative sequenceiVSP_047102496 – 683Missing in isoform 2. 1 PublicationAdd BLAST188

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y15758 mRNA. Translation: CAC17466.1.
AJ429398 Genomic DNA. Translation: CAD22295.1.
AY062261 mRNA. Translation: AAL47212.1.
AY062262 mRNA. Translation: AAL47213.1.
AK001611 mRNA. Translation: BAA91788.1. Different initiation.
AK022982 mRNA. Translation: BAB14345.1.
AK299083 mRNA. Translation: BAG61147.1.
EF560732 mRNA. Translation: ABQ59042.1.
AL359513 Genomic DNA. Translation: CAH71660.2.
AL359513 Genomic DNA. Translation: CAH71661.2.
BC010901 mRNA. Translation: AAH10901.1. Different initiation.
BC105806 mRNA. Translation: AAI05807.1. Sequence problems.
BC130296 mRNA. Translation: AAI30297.1.
AF177227 mRNA. Translation: AAG33675.1. Frameshift.
AL136848 mRNA. Translation: CAB66782.2.
CCDSiCCDS41893.1. [Q8WWK9-1]
CCDS66557.1. [Q8WWK9-6]
CCDS73578.1. [Q8WWK9-4]
CCDS9435.1. [Q8WWK9-5]
RefSeqiNP_001091995.1. NM_001098525.2. [Q8WWK9-1]
NP_001273615.1. NM_001286686.1. [Q8WWK9-6]
NP_001273616.1. NM_001286687.1. [Q8WWK9-4]
NP_060674.3. NM_018204.4. [Q8WWK9-5]
UniGeneiHs.444028.
Hs.594461.

Genome annotation databases

EnsembliENST00000258607; ENSP00000258607; ENSG00000136108. [Q8WWK9-5]
ENST00000378034; ENSP00000367273; ENSG00000136108. [Q8WWK9-4]
ENST00000378037; ENSP00000367276; ENSG00000136108. [Q8WWK9-1]
ENST00000490903; ENSP00000417830; ENSG00000136108. [Q8WWK9-6]
GeneIDi26586.
KEGGihsa:26586.
UCSCiuc001vgt.4. human. [Q8WWK9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCKAP2_HUMAN
AccessioniPrimary (citable) accession number: Q8WWK9
Secondary accession number(s): A2BDE0
, A5YM58, B4DR35, E9PD90, Q3KRA5, Q5VXB4, Q8IWV5, Q8IWV6, Q96FH9, Q9H012, Q9H0D0, Q9H988, Q9HC49, Q9NVG4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: March 1, 2002
Last modified: June 7, 2017
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families