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Protein

Choline transporter-like protein 1

Gene

SLC44A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Choline transporter. May be involved in membrane synthesis and myelin production.1 Publication

GO - Molecular functioni

  • choline transmembrane transporter activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiR-HSA-1483191. Synthesis of PC.
R-HSA-425366. Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds.
R-HSA-6798163. Choline catabolism.

Protein family/group databases

TCDBi2.A.92.1.6. the choline transporter-like (ctl) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Choline transporter-like protein 1
Alternative name(s):
CDw92
Solute carrier family 44 member 1
CD_antigen: CD92
Gene namesi
Name:SLC44A1
Synonyms:CD92, CDW92, CTL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:18798. SLC44A1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 30CytoplasmicSequence analysisAdd BLAST29
Transmembranei31 – 51HelicalSequence analysisAdd BLAST21
Topological domaini52 – 212Mitochondrial intermembraneSequence analysisAdd BLAST161
Transmembranei213 – 233HelicalSequence analysisAdd BLAST21
Topological domaini234 – 238CytoplasmicSequence analysis5
Transmembranei239 – 259HelicalSequence analysisAdd BLAST21
Topological domaini260 – 288Mitochondrial intermembraneSequence analysisAdd BLAST29
Transmembranei289 – 309HelicalSequence analysisAdd BLAST21
Topological domaini310 – 315CytoplasmicSequence analysis6
Transmembranei316 – 336HelicalSequence analysisAdd BLAST21
Topological domaini337 – 338Mitochondrial intermembraneSequence analysis2
Transmembranei339 – 359HelicalSequence analysisAdd BLAST21
Topological domaini360 – 380CytoplasmicSequence analysisAdd BLAST21
Transmembranei381 – 401HelicalSequence analysisAdd BLAST21
Topological domaini402 – 537Mitochondrial intermembraneSequence analysisAdd BLAST136
Transmembranei538 – 558HelicalSequence analysisAdd BLAST21
Topological domaini559 – 566CytoplasmicSequence analysis8
Transmembranei567 – 587HelicalSequence analysisAdd BLAST21
Topological domaini588 – 653Mitochondrial intermembraneSequence analysisAdd BLAST66

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: UniProtKB
  • membrane Source: UniProtKB
  • mitochondrial outer membrane Source: Reactome
  • mitochondrion Source: HPA
  • nucleoplasm Source: HPA
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi23446.
OpenTargetsiENSG00000070214.
PharmGKBiPA134958011.

Chemistry databases

DrugBankiDB00122. Choline.
GuidetoPHARMACOLOGYi1204.

Polymorphism and mutation databases

BioMutaiSLC44A1.
DMDMi73918923.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00001917122 – 657Choline transporter-like protein 1Add BLAST656

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycine1 Publication1
Modified residuei652PhosphoserineCombined sources1

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

EPDiQ8WWI5.
MaxQBiQ8WWI5.
PaxDbiQ8WWI5.
PeptideAtlasiQ8WWI5.
PRIDEiQ8WWI5.

PTM databases

iPTMnetiQ8WWI5.
PhosphoSitePlusiQ8WWI5.
SwissPalmiQ8WWI5.

Expressioni

Tissue specificityi

Expressed in various cells of the hematopoietic system.1 Publication

Gene expression databases

BgeeiENSG00000070214.
CleanExiHS_SLC44A1.
ExpressionAtlasiQ8WWI5. baseline and differential.
GenevisibleiQ8WWI5. HS.

Organism-specific databases

HPAiHPA064714.

Interactioni

Protein-protein interaction databases

BioGridi117012. 11 interactors.
IntActiQ8WWI5. 4 interactors.
MINTiMINT-8247377.
STRINGi9606.ENSP00000363852.

Structurei

3D structure databases

ProteinModelPortaliQ8WWI5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi474 – 492Cys-richAdd BLAST19

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1362. Eukaryota.
ENOG410XS0P. LUCA.
GeneTreeiENSGT00550000074521.
HOGENOMiHOG000231655.
HOVERGENiHBG080361.
InParanoidiQ8WWI5.
KOiK06515.
OMAiICGFTIV.
OrthoDBiEOG091G0CMQ.
PhylomeDBiQ8WWI5.
TreeFamiTF313325.

Family and domain databases

InterProiIPR007603. Choline_transptr-like.
[Graphical view]
PANTHERiPTHR12385. PTHR12385. 1 hit.
PfamiPF04515. Choline_transpo. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WWI5-1) [UniParc]FASTAAdd to basket
Also known as: A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGCCSSASSA AQSSKREWKP LEDRSCTDIP WLLLFILFCI GMGFICGFSI
60 70 80 90 100
ATGAAARLVS GYDSYGNICG QKNTKLEAIP NSGMDHTQRK YVFFLDPCNL
110 120 130 140 150
DLINRKIKSV ALCVAACPRQ ELKTLSDVQK FAEINGSALC SYNLKPSEYT
160 170 180 190 200
TSPKSSVLCP KLPVPASAPI PFFHRCAPVN ISCYAKFAEA LITFVSDNSV
210 220 230 240 250
LHRLISGVMT SKEIILGLCL LSLVLSMILM VIIRYISRVL VWILTILVIL
260 270 280 290 300
GSLGGTGVLW WLYAKQRRSP KETVTPEQLQ IAEDNLRALL IYAISATVFT
310 320 330 340 350
VILFLIMLVM RKRVALTIAL FHVAGKVFIH LPLLVFQPFW TFFALVLFWV
360 370 380 390 400
YWIMTLLFLG TTGSPVQNEQ GFVEFKISGP LQYMWWYHVV GLIWISEFIL
410 420 430 440 450
ACQQMTVAGA VVTYYFTRDK RNLPFTPILA SVNRLIRYHL GTVAKGSFII
460 470 480 490 500
TLVKIPRMIL MYIHSQLKGK ENACARCVLK SCICCLWCLE KCLNYLNQNA
510 520 530 540 550
YTATAINSTN FCTSAKDAFV ILVENALRVA TINTVGDFML FLGKVLIVCS
560 570 580 590 600
TGLAGIMLLN YQQDYTVWVL PLIIVCLFAF LVAHCFLSIY EMVVDVLFLC
610 620 630 640 650
FAIDTKYNDG SPGREFYMDK VLMEFVENSR KAMKEAGKGG VADSRELKPM

ASGASSA
Length:657
Mass (Da):73,302
Last modified:March 1, 2002 - v1
Checksum:i10D70CAB8E33E3AC
GO
Isoform 2 (identifier: Q8WWI5-2) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     651-654: ASGA → LKKR
     655-657: Missing.

Show »
Length:654
Mass (Da):73,296
Checksum:i625565695C5DA9F0
GO
Isoform 3 (identifier: Q8WWI5-3) [UniParc]FASTAAdd to basket
Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
     651-652: AS → IK
     653-657: Missing.

Show »
Length:652
Mass (Da):73,012
Checksum:iD56E2C5DA9F0188A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti79I → V in CAC82175 (PubMed:11698453).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048837644S → A.1 PublicationCorresponds to variant rs3199966dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_015424651 – 654ASGA → LKKR in isoform 2. Curated4
Alternative sequenceiVSP_015426651 – 652AS → IK in isoform 3. 1 Publication2
Alternative sequenceiVSP_015427653 – 657Missing in isoform 3. 1 Publication5
Alternative sequenceiVSP_015425655 – 657Missing in isoform 2. Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ245620 Genomic DNA. Translation: CAB75541.2.
AJ272365 mRNA. Translation: CAC82175.1.
AJ420812 mRNA. Translation: CAD12764.1.
AL161627, AL450265, AL590368 Genomic DNA. Translation: CAI13069.1.
AL161627, AL450265, AL590368 Genomic DNA. Translation: CAI13070.1.
AL161627, AL450265, AL590368 Genomic DNA. Translation: CAI13071.1.
AL450265, AL161627, AL590368 Genomic DNA. Translation: CAI14395.1.
AL450265, AL161627, AL590368 Genomic DNA. Translation: CAI14396.1.
AL450265, AL161627, AL590368 Genomic DNA. Translation: CAI14397.1.
AL590368, AL161627, AL450265 Genomic DNA. Translation: CAH73434.1.
AL590368, AL161627, AL450265 Genomic DNA. Translation: CAH73435.1.
AL590368, AL161627, AL450265 Genomic DNA. Translation: CAH73436.1.
BC018213 mRNA. Translation: AAH18213.1.
BC049203 mRNA. Translation: AAH49203.1.
CCDSiCCDS6763.1. [Q8WWI5-1]
CCDS75868.1. [Q8WWI5-3]
CCDS83390.1. [Q8WWI5-2]
RefSeqiNP_001273659.1. NM_001286730.1. [Q8WWI5-3]
NP_001317660.1. NM_001330731.1.
NP_536856.2. NM_080546.4. [Q8WWI5-1]
UniGeneiHs.573495.

Genome annotation databases

EnsembliENST00000374720; ENSP00000363852; ENSG00000070214. [Q8WWI5-1]
ENST00000374723; ENSP00000363855; ENSG00000070214. [Q8WWI5-3]
ENST00000374724; ENSP00000363856; ENSG00000070214. [Q8WWI5-2]
ENST00000470972; ENSP00000433072; ENSG00000070214. [Q8WWI5-1]
GeneIDi23446.
KEGGihsa:23446.
UCSCiuc004bcn.5. human. [Q8WWI5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ245620 Genomic DNA. Translation: CAB75541.2.
AJ272365 mRNA. Translation: CAC82175.1.
AJ420812 mRNA. Translation: CAD12764.1.
AL161627, AL450265, AL590368 Genomic DNA. Translation: CAI13069.1.
AL161627, AL450265, AL590368 Genomic DNA. Translation: CAI13070.1.
AL161627, AL450265, AL590368 Genomic DNA. Translation: CAI13071.1.
AL450265, AL161627, AL590368 Genomic DNA. Translation: CAI14395.1.
AL450265, AL161627, AL590368 Genomic DNA. Translation: CAI14396.1.
AL450265, AL161627, AL590368 Genomic DNA. Translation: CAI14397.1.
AL590368, AL161627, AL450265 Genomic DNA. Translation: CAH73434.1.
AL590368, AL161627, AL450265 Genomic DNA. Translation: CAH73435.1.
AL590368, AL161627, AL450265 Genomic DNA. Translation: CAH73436.1.
BC018213 mRNA. Translation: AAH18213.1.
BC049203 mRNA. Translation: AAH49203.1.
CCDSiCCDS6763.1. [Q8WWI5-1]
CCDS75868.1. [Q8WWI5-3]
CCDS83390.1. [Q8WWI5-2]
RefSeqiNP_001273659.1. NM_001286730.1. [Q8WWI5-3]
NP_001317660.1. NM_001330731.1.
NP_536856.2. NM_080546.4. [Q8WWI5-1]
UniGeneiHs.573495.

3D structure databases

ProteinModelPortaliQ8WWI5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117012. 11 interactors.
IntActiQ8WWI5. 4 interactors.
MINTiMINT-8247377.
STRINGi9606.ENSP00000363852.

Chemistry databases

DrugBankiDB00122. Choline.
GuidetoPHARMACOLOGYi1204.

Protein family/group databases

TCDBi2.A.92.1.6. the choline transporter-like (ctl) family.

PTM databases

iPTMnetiQ8WWI5.
PhosphoSitePlusiQ8WWI5.
SwissPalmiQ8WWI5.

Polymorphism and mutation databases

BioMutaiSLC44A1.
DMDMi73918923.

Proteomic databases

EPDiQ8WWI5.
MaxQBiQ8WWI5.
PaxDbiQ8WWI5.
PeptideAtlasiQ8WWI5.
PRIDEiQ8WWI5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374720; ENSP00000363852; ENSG00000070214. [Q8WWI5-1]
ENST00000374723; ENSP00000363855; ENSG00000070214. [Q8WWI5-3]
ENST00000374724; ENSP00000363856; ENSG00000070214. [Q8WWI5-2]
ENST00000470972; ENSP00000433072; ENSG00000070214. [Q8WWI5-1]
GeneIDi23446.
KEGGihsa:23446.
UCSCiuc004bcn.5. human. [Q8WWI5-1]

Organism-specific databases

CTDi23446.
DisGeNETi23446.
GeneCardsiSLC44A1.
HGNCiHGNC:18798. SLC44A1.
HPAiHPA064714.
MIMi606105. gene.
neXtProtiNX_Q8WWI5.
OpenTargetsiENSG00000070214.
PharmGKBiPA134958011.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1362. Eukaryota.
ENOG410XS0P. LUCA.
GeneTreeiENSGT00550000074521.
HOGENOMiHOG000231655.
HOVERGENiHBG080361.
InParanoidiQ8WWI5.
KOiK06515.
OMAiICGFTIV.
OrthoDBiEOG091G0CMQ.
PhylomeDBiQ8WWI5.
TreeFamiTF313325.

Enzyme and pathway databases

ReactomeiR-HSA-1483191. Synthesis of PC.
R-HSA-425366. Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds.
R-HSA-6798163. Choline catabolism.

Miscellaneous databases

ChiTaRSiSLC44A1. human.
GeneWikiiSLC44A1.
GenomeRNAii23446.
PROiQ8WWI5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000070214.
CleanExiHS_SLC44A1.
ExpressionAtlasiQ8WWI5. baseline and differential.
GenevisibleiQ8WWI5. HS.

Family and domain databases

InterProiIPR007603. Choline_transptr-like.
[Graphical view]
PANTHERiPTHR12385. PTHR12385. 1 hit.
PfamiPF04515. Choline_transpo. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCTL1_HUMAN
AccessioniPrimary (citable) accession number: Q8WWI5
Secondary accession number(s): A6NLZ9
, Q5VUB3, Q8WVB0, Q96KU3, Q9NY69
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: March 1, 2002
Last modified: November 30, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.