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Q8WWI5

- CTL1_HUMAN

UniProt

Q8WWI5 - CTL1_HUMAN

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Protein

Choline transporter-like protein 1

Gene

SLC44A1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Choline transporter. May be involved in membrane synthesis and myelin production.1 Publication

GO - Molecular functioni

  1. choline transmembrane transporter activity Source: UniProtKB

GO - Biological processi

  1. choline transport Source: UniProtKB
  2. glycerophospholipid biosynthetic process Source: Reactome
  3. phosphatidylcholine biosynthetic process Source: Reactome
  4. phospholipid metabolic process Source: Reactome
  5. small molecule metabolic process Source: Reactome
  6. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiREACT_121238. Synthesis of PC.
REACT_19305. Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds.

Protein family/group databases

TCDBi2.A.92.1.6. the choline transporter-like (ctl) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Choline transporter-like protein 1
Alternative name(s):
CDw92
Solute carrier family 44 member 1
CD_antigen: CD92
Gene namesi
Name:SLC44A1
Synonyms:CD92, CDW92, CTL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:18798. SLC44A1.

Subcellular locationi

Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication. Mitochondrion outer membrane 1 Publication; Multi-pass membrane protein 1 Publication

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. integral component of membrane Source: UniProtKB
  3. membrane Source: UniProtKB
  4. mitochondrial outer membrane Source: UniProtKB-KW
  5. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134958011.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 657656Choline transporter-like protein 1PRO_0000191712Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycineBy similarity
Modified residuei652 – 6521Phosphoserine1 Publication

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

MaxQBiQ8WWI5.
PaxDbiQ8WWI5.
PRIDEiQ8WWI5.

PTM databases

PhosphoSiteiQ8WWI5.

Expressioni

Tissue specificityi

Expressed in various cells of the hematopoietic system.1 Publication

Gene expression databases

BgeeiQ8WWI5.
CleanExiHS_SLC44A1.
ExpressionAtlasiQ8WWI5. baseline and differential.
GenevestigatoriQ8WWI5.

Interactioni

Protein-protein interaction databases

BioGridi117012. 9 interactions.
IntActiQ8WWI5. 4 interactions.
MINTiMINT-8247377.
STRINGi9606.ENSP00000363852.

Structurei

3D structure databases

ProteinModelPortaliQ8WWI5.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 3029CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini52 – 212161Mitochondrial intermembraneSequence AnalysisAdd
BLAST
Topological domaini234 – 2385CytoplasmicSequence Analysis
Topological domaini260 – 28829Mitochondrial intermembraneSequence AnalysisAdd
BLAST
Topological domaini310 – 3156CytoplasmicSequence Analysis
Topological domaini337 – 3382Mitochondrial intermembraneSequence Analysis
Topological domaini360 – 38021CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini402 – 537136Mitochondrial intermembraneSequence AnalysisAdd
BLAST
Topological domaini559 – 5668CytoplasmicSequence Analysis
Topological domaini588 – 65366Mitochondrial intermembraneSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei31 – 5121HelicalSequence AnalysisAdd
BLAST
Transmembranei213 – 23321HelicalSequence AnalysisAdd
BLAST
Transmembranei239 – 25921HelicalSequence AnalysisAdd
BLAST
Transmembranei289 – 30921HelicalSequence AnalysisAdd
BLAST
Transmembranei316 – 33621HelicalSequence AnalysisAdd
BLAST
Transmembranei339 – 35921HelicalSequence AnalysisAdd
BLAST
Transmembranei381 – 40121HelicalSequence AnalysisAdd
BLAST
Transmembranei538 – 55821HelicalSequence AnalysisAdd
BLAST
Transmembranei567 – 58721HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi474 – 49219Cys-richAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG310633.
GeneTreeiENSGT00550000074521.
HOGENOMiHOG000231655.
HOVERGENiHBG080361.
InParanoidiQ8WWI5.
KOiK06515.
OMAiEKCLSYL.
OrthoDBiEOG72JWFP.
PhylomeDBiQ8WWI5.
TreeFamiTF313325.

Family and domain databases

InterProiIPR007603. Choline_transptr-like.
[Graphical view]
PANTHERiPTHR12385. PTHR12385. 1 hit.
PfamiPF04515. Choline_transpo. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8WWI5-1) [UniParc]FASTAAdd to Basket

Also known as: A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGCCSSASSA AQSSKREWKP LEDRSCTDIP WLLLFILFCI GMGFICGFSI
60 70 80 90 100
ATGAAARLVS GYDSYGNICG QKNTKLEAIP NSGMDHTQRK YVFFLDPCNL
110 120 130 140 150
DLINRKIKSV ALCVAACPRQ ELKTLSDVQK FAEINGSALC SYNLKPSEYT
160 170 180 190 200
TSPKSSVLCP KLPVPASAPI PFFHRCAPVN ISCYAKFAEA LITFVSDNSV
210 220 230 240 250
LHRLISGVMT SKEIILGLCL LSLVLSMILM VIIRYISRVL VWILTILVIL
260 270 280 290 300
GSLGGTGVLW WLYAKQRRSP KETVTPEQLQ IAEDNLRALL IYAISATVFT
310 320 330 340 350
VILFLIMLVM RKRVALTIAL FHVAGKVFIH LPLLVFQPFW TFFALVLFWV
360 370 380 390 400
YWIMTLLFLG TTGSPVQNEQ GFVEFKISGP LQYMWWYHVV GLIWISEFIL
410 420 430 440 450
ACQQMTVAGA VVTYYFTRDK RNLPFTPILA SVNRLIRYHL GTVAKGSFII
460 470 480 490 500
TLVKIPRMIL MYIHSQLKGK ENACARCVLK SCICCLWCLE KCLNYLNQNA
510 520 530 540 550
YTATAINSTN FCTSAKDAFV ILVENALRVA TINTVGDFML FLGKVLIVCS
560 570 580 590 600
TGLAGIMLLN YQQDYTVWVL PLIIVCLFAF LVAHCFLSIY EMVVDVLFLC
610 620 630 640 650
FAIDTKYNDG SPGREFYMDK VLMEFVENSR KAMKEAGKGG VADSRELKPM

ASGASSA
Length:657
Mass (Da):73,302
Last modified:March 1, 2002 - v1
Checksum:i10D70CAB8E33E3AC
GO
Isoform 2 (identifier: Q8WWI5-2) [UniParc]FASTAAdd to Basket

Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     651-654: ASGA → LKKR
     655-657: Missing.

Show »
Length:654
Mass (Da):73,296
Checksum:i625565695C5DA9F0
GO
Isoform 3 (identifier: Q8WWI5-3) [UniParc]FASTAAdd to Basket

Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
     651-652: AS → IK
     653-657: Missing.

Show »
Length:652
Mass (Da):73,012
Checksum:iD56E2C5DA9F0188A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti79 – 791I → V in CAC82175. (PubMed:11698453)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti644 – 6441S → A.1 Publication
Corresponds to variant rs3199966 [ dbSNP | Ensembl ].
VAR_048837

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei651 – 6544ASGA → LKKR in isoform 2. CuratedVSP_015424
Alternative sequencei651 – 6522AS → IK in isoform 3. 1 PublicationVSP_015426
Alternative sequencei653 – 6575Missing in isoform 3. 1 PublicationVSP_015427
Alternative sequencei655 – 6573Missing in isoform 2. CuratedVSP_015425

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ245620 Genomic DNA. Translation: CAB75541.2.
AJ272365 mRNA. Translation: CAC82175.1.
AJ420812 mRNA. Translation: CAD12764.1.
AL161627, AL450265, AL590368 Genomic DNA. Translation: CAI13069.1.
AL161627, AL450265, AL590368 Genomic DNA. Translation: CAI13070.1.
AL161627, AL450265, AL590368 Genomic DNA. Translation: CAI13071.1.
AL450265, AL161627, AL590368 Genomic DNA. Translation: CAI14395.1.
AL450265, AL161627, AL590368 Genomic DNA. Translation: CAI14396.1.
AL450265, AL161627, AL590368 Genomic DNA. Translation: CAI14397.1.
AL590368, AL161627, AL450265 Genomic DNA. Translation: CAH73434.1.
AL590368, AL161627, AL450265 Genomic DNA. Translation: CAH73435.1.
AL590368, AL161627, AL450265 Genomic DNA. Translation: CAH73436.1.
BC018213 mRNA. Translation: AAH18213.1.
BC049203 mRNA. Translation: AAH49203.1.
CCDSiCCDS6763.1. [Q8WWI5-1]
CCDS75868.1. [Q8WWI5-3]
RefSeqiNP_001273659.1. NM_001286730.1. [Q8WWI5-3]
NP_536856.2. NM_080546.4. [Q8WWI5-1]
UniGeneiHs.573495.

Genome annotation databases

EnsembliENST00000374720; ENSP00000363852; ENSG00000070214. [Q8WWI5-1]
ENST00000374723; ENSP00000363855; ENSG00000070214. [Q8WWI5-3]
ENST00000374724; ENSP00000363856; ENSG00000070214. [Q8WWI5-2]
ENST00000470972; ENSP00000433072; ENSG00000070214. [Q8WWI5-1]
GeneIDi23446.
KEGGihsa:23446.
UCSCiuc004bcn.3. human. [Q8WWI5-1]

Polymorphism databases

DMDMi73918923.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ245620 Genomic DNA. Translation: CAB75541.2 .
AJ272365 mRNA. Translation: CAC82175.1 .
AJ420812 mRNA. Translation: CAD12764.1 .
AL161627 , AL450265 , AL590368 Genomic DNA. Translation: CAI13069.1 .
AL161627 , AL450265 , AL590368 Genomic DNA. Translation: CAI13070.1 .
AL161627 , AL450265 , AL590368 Genomic DNA. Translation: CAI13071.1 .
AL450265 , AL161627 , AL590368 Genomic DNA. Translation: CAI14395.1 .
AL450265 , AL161627 , AL590368 Genomic DNA. Translation: CAI14396.1 .
AL450265 , AL161627 , AL590368 Genomic DNA. Translation: CAI14397.1 .
AL590368 , AL161627 , AL450265 Genomic DNA. Translation: CAH73434.1 .
AL590368 , AL161627 , AL450265 Genomic DNA. Translation: CAH73435.1 .
AL590368 , AL161627 , AL450265 Genomic DNA. Translation: CAH73436.1 .
BC018213 mRNA. Translation: AAH18213.1 .
BC049203 mRNA. Translation: AAH49203.1 .
CCDSi CCDS6763.1. [Q8WWI5-1 ]
CCDS75868.1. [Q8WWI5-3 ]
RefSeqi NP_001273659.1. NM_001286730.1. [Q8WWI5-3 ]
NP_536856.2. NM_080546.4. [Q8WWI5-1 ]
UniGenei Hs.573495.

3D structure databases

ProteinModelPortali Q8WWI5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117012. 9 interactions.
IntActi Q8WWI5. 4 interactions.
MINTi MINT-8247377.
STRINGi 9606.ENSP00000363852.

Chemistry

DrugBanki DB00122. Choline.
GuidetoPHARMACOLOGYi 1204.

Protein family/group databases

TCDBi 2.A.92.1.6. the choline transporter-like (ctl) family.

PTM databases

PhosphoSitei Q8WWI5.

Polymorphism databases

DMDMi 73918923.

Proteomic databases

MaxQBi Q8WWI5.
PaxDbi Q8WWI5.
PRIDEi Q8WWI5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000374720 ; ENSP00000363852 ; ENSG00000070214 . [Q8WWI5-1 ]
ENST00000374723 ; ENSP00000363855 ; ENSG00000070214 . [Q8WWI5-3 ]
ENST00000374724 ; ENSP00000363856 ; ENSG00000070214 . [Q8WWI5-2 ]
ENST00000470972 ; ENSP00000433072 ; ENSG00000070214 . [Q8WWI5-1 ]
GeneIDi 23446.
KEGGi hsa:23446.
UCSCi uc004bcn.3. human. [Q8WWI5-1 ]

Organism-specific databases

CTDi 23446.
GeneCardsi GC09P108006.
HGNCi HGNC:18798. SLC44A1.
MIMi 606105. gene.
neXtProti NX_Q8WWI5.
PharmGKBi PA134958011.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG310633.
GeneTreei ENSGT00550000074521.
HOGENOMi HOG000231655.
HOVERGENi HBG080361.
InParanoidi Q8WWI5.
KOi K06515.
OMAi EKCLSYL.
OrthoDBi EOG72JWFP.
PhylomeDBi Q8WWI5.
TreeFami TF313325.

Enzyme and pathway databases

Reactomei REACT_121238. Synthesis of PC.
REACT_19305. Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds.

Miscellaneous databases

ChiTaRSi SLC44A1. human.
GeneWikii SLC44A1.
GenomeRNAii 23446.
NextBioi 45724.
PROi Q8WWI5.
SOURCEi Search...

Gene expression databases

Bgeei Q8WWI5.
CleanExi HS_SLC44A1.
ExpressionAtlasi Q8WWI5. baseline and differential.
Genevestigatori Q8WWI5.

Family and domain databases

InterProi IPR007603. Choline_transptr-like.
[Graphical view ]
PANTHERi PTHR12385. PTHR12385. 1 hit.
Pfami PF04515. Choline_transpo. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "An electric lobe suppressor for a yeast choline transport mutation belongs to a new family of transporter-like proteins."
    O'Regan S., Traiffort E., Ruat M., Cha N., Compaore D., Meunier F.-M.
    Proc. Natl. Acad. Sci. U.S.A. 97:1835-1840(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORM 2).
    Tissue: Ewing sarcoma.
  2. "Characterization of CDw92 as a member of the choline transporter-like protein family regulated specifically on dendritic cells."
    Wille S., Szekeres A., Majdic O., Prager E., Staffler G., Stoeckl J., Kunthalert D., Prieschl E.E., Baumruker T., Burtscher H., Zlabinger G.J., Knapp W., Stockinger H.
    J. Immunol. 167:5795-5804(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), TISSUE SPECIFICITY, VARIANT ALA-644.
  3. "Molecular characterization of the family of choline transporter-like proteins and their splice variants."
    Traiffort E., Ruat M., O'Regan S., Meunier F.-M.
    J. Neurochem. 92:1116-1125(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Ewing sarcoma.
  4. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Eye and Lung.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-652, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "The solute carrier 44A1 is a mitochondrial protein and mediates choline transport."
    Michel V., Bakovic M.
    FASEB J. 23:2749-2758(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TOPOLOGY, SUBCELLULAR LOCATION.
  8. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCTL1_HUMAN
AccessioniPrimary (citable) accession number: Q8WWI5
Secondary accession number(s): A6NLZ9
, Q5VUB3, Q8WVB0, Q96KU3, Q9NY69
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: March 1, 2002
Last modified: October 29, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3