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Q8WWI5

- CTL1_HUMAN

UniProt

Q8WWI5 - CTL1_HUMAN

Protein

Choline transporter-like protein 1

Gene

SLC44A1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Choline transporter. May be involved in membrane synthesis and myelin production.1 Publication

    GO - Molecular functioni

    1. choline transmembrane transporter activity Source: UniProtKB

    GO - Biological processi

    1. choline transport Source: UniProtKB
    2. glycerophospholipid biosynthetic process Source: Reactome
    3. phosphatidylcholine biosynthetic process Source: Reactome
    4. phospholipid metabolic process Source: Reactome
    5. small molecule metabolic process Source: Reactome
    6. transmembrane transport Source: Reactome

    Keywords - Biological processi

    Transport

    Enzyme and pathway databases

    ReactomeiREACT_121238. Synthesis of PC.
    REACT_19305. Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds.

    Protein family/group databases

    TCDBi2.A.92.1.6. the choline transporter-like (ctl) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Choline transporter-like protein 1
    Alternative name(s):
    CDw92
    Solute carrier family 44 member 1
    CD_antigen: CD92
    Gene namesi
    Name:SLC44A1
    Synonyms:CD92, CDW92, CTL1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:18798. SLC44A1.

    Subcellular locationi

    Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication. Mitochondrion outer membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. integral component of membrane Source: UniProtKB
    3. membrane Source: UniProtKB
    4. mitochondrial outer membrane Source: UniProtKB-SubCell
    5. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane, Mitochondrion, Mitochondrion outer membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134958011.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 657656Choline transporter-like protein 1PRO_0000191712Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi2 – 21N-myristoyl glycineBy similarity
    Modified residuei652 – 6521Phosphoserine1 Publication

    Keywords - PTMi

    Lipoprotein, Myristate, Phosphoprotein

    Proteomic databases

    MaxQBiQ8WWI5.
    PaxDbiQ8WWI5.
    PRIDEiQ8WWI5.

    PTM databases

    PhosphoSiteiQ8WWI5.

    Expressioni

    Tissue specificityi

    Expressed in various cells of the hematopoietic system.1 Publication

    Gene expression databases

    ArrayExpressiQ8WWI5.
    BgeeiQ8WWI5.
    CleanExiHS_SLC44A1.
    GenevestigatoriQ8WWI5.

    Interactioni

    Protein-protein interaction databases

    BioGridi117012. 5 interactions.
    IntActiQ8WWI5. 4 interactions.
    MINTiMINT-8247377.
    STRINGi9606.ENSP00000363852.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8WWI5.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini2 – 3029CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini52 – 212161Mitochondrial intermembraneSequence AnalysisAdd
    BLAST
    Topological domaini234 – 2385CytoplasmicSequence Analysis
    Topological domaini260 – 28829Mitochondrial intermembraneSequence AnalysisAdd
    BLAST
    Topological domaini310 – 3156CytoplasmicSequence Analysis
    Topological domaini337 – 3382Mitochondrial intermembraneSequence Analysis
    Topological domaini360 – 38021CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini402 – 537136Mitochondrial intermembraneSequence AnalysisAdd
    BLAST
    Topological domaini559 – 5668CytoplasmicSequence Analysis
    Topological domaini588 – 65366Mitochondrial intermembraneSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei31 – 5121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei213 – 23321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei239 – 25921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei289 – 30921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei316 – 33621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei339 – 35921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei381 – 40121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei538 – 55821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei567 – 58721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi474 – 49219Cys-richAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG310633.
    HOGENOMiHOG000231655.
    HOVERGENiHBG080361.
    InParanoidiQ8WWI5.
    KOiK06515.
    OMAiEKCLSYL.
    OrthoDBiEOG72JWFP.
    PhylomeDBiQ8WWI5.
    TreeFamiTF313325.

    Family and domain databases

    InterProiIPR007603. Choline_transptr-like.
    [Graphical view]
    PANTHERiPTHR12385. PTHR12385. 1 hit.
    PfamiPF04515. Choline_transpo. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8WWI5-1) [UniParc]FASTAAdd to Basket

    Also known as: A

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGCCSSASSA AQSSKREWKP LEDRSCTDIP WLLLFILFCI GMGFICGFSI    50
    ATGAAARLVS GYDSYGNICG QKNTKLEAIP NSGMDHTQRK YVFFLDPCNL 100
    DLINRKIKSV ALCVAACPRQ ELKTLSDVQK FAEINGSALC SYNLKPSEYT 150
    TSPKSSVLCP KLPVPASAPI PFFHRCAPVN ISCYAKFAEA LITFVSDNSV 200
    LHRLISGVMT SKEIILGLCL LSLVLSMILM VIIRYISRVL VWILTILVIL 250
    GSLGGTGVLW WLYAKQRRSP KETVTPEQLQ IAEDNLRALL IYAISATVFT 300
    VILFLIMLVM RKRVALTIAL FHVAGKVFIH LPLLVFQPFW TFFALVLFWV 350
    YWIMTLLFLG TTGSPVQNEQ GFVEFKISGP LQYMWWYHVV GLIWISEFIL 400
    ACQQMTVAGA VVTYYFTRDK RNLPFTPILA SVNRLIRYHL GTVAKGSFII 450
    TLVKIPRMIL MYIHSQLKGK ENACARCVLK SCICCLWCLE KCLNYLNQNA 500
    YTATAINSTN FCTSAKDAFV ILVENALRVA TINTVGDFML FLGKVLIVCS 550
    TGLAGIMLLN YQQDYTVWVL PLIIVCLFAF LVAHCFLSIY EMVVDVLFLC 600
    FAIDTKYNDG SPGREFYMDK VLMEFVENSR KAMKEAGKGG VADSRELKPM 650
    ASGASSA 657
    Length:657
    Mass (Da):73,302
    Last modified:March 1, 2002 - v1
    Checksum:i10D70CAB8E33E3AC
    GO
    Isoform 2 (identifier: Q8WWI5-2) [UniParc]FASTAAdd to Basket

    Also known as: B

    The sequence of this isoform differs from the canonical sequence as follows:
         651-654: ASGA → LKKR
         655-657: Missing.

    Show »
    Length:654
    Mass (Da):73,296
    Checksum:i625565695C5DA9F0
    GO
    Isoform 3 (identifier: Q8WWI5-3) [UniParc]FASTAAdd to Basket

    Also known as: C

    The sequence of this isoform differs from the canonical sequence as follows:
         651-652: AS → IK
         653-657: Missing.

    Show »
    Length:652
    Mass (Da):73,012
    Checksum:iD56E2C5DA9F0188A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti79 – 791I → V in CAC82175. (PubMed:11698453)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti644 – 6441S → A.1 Publication
    Corresponds to variant rs3199966 [ dbSNP | Ensembl ].
    VAR_048837

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei651 – 6544ASGA → LKKR in isoform 2. CuratedVSP_015424
    Alternative sequencei651 – 6522AS → IK in isoform 3. 1 PublicationVSP_015426
    Alternative sequencei653 – 6575Missing in isoform 3. 1 PublicationVSP_015427
    Alternative sequencei655 – 6573Missing in isoform 2. CuratedVSP_015425

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ245620 Genomic DNA. Translation: CAB75541.2.
    AJ272365 mRNA. Translation: CAC82175.1.
    AJ420812 mRNA. Translation: CAD12764.1.
    AL161627, AL450265, AL590368 Genomic DNA. Translation: CAI13069.1.
    AL161627, AL450265, AL590368 Genomic DNA. Translation: CAI13070.1.
    AL161627, AL450265, AL590368 Genomic DNA. Translation: CAI13071.1.
    AL450265, AL161627, AL590368 Genomic DNA. Translation: CAI14395.1.
    AL450265, AL161627, AL590368 Genomic DNA. Translation: CAI14396.1.
    AL450265, AL161627, AL590368 Genomic DNA. Translation: CAI14397.1.
    AL590368, AL161627, AL450265 Genomic DNA. Translation: CAH73434.1.
    AL590368, AL161627, AL450265 Genomic DNA. Translation: CAH73435.1.
    AL590368, AL161627, AL450265 Genomic DNA. Translation: CAH73436.1.
    BC018213 mRNA. Translation: AAH18213.1.
    BC049203 mRNA. Translation: AAH49203.1.
    CCDSiCCDS6763.1. [Q8WWI5-1]
    RefSeqiNP_001273659.1. NM_001286730.1. [Q8WWI5-3]
    NP_536856.2. NM_080546.4. [Q8WWI5-1]
    UniGeneiHs.573495.

    Genome annotation databases

    EnsembliENST00000374720; ENSP00000363852; ENSG00000070214. [Q8WWI5-1]
    ENST00000374723; ENSP00000363855; ENSG00000070214. [Q8WWI5-3]
    ENST00000374724; ENSP00000363856; ENSG00000070214. [Q8WWI5-2]
    ENST00000470972; ENSP00000433072; ENSG00000070214. [Q8WWI5-1]
    GeneIDi23446.
    KEGGihsa:23446.
    UCSCiuc004bcn.3. human. [Q8WWI5-1]

    Polymorphism databases

    DMDMi73918923.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ245620 Genomic DNA. Translation: CAB75541.2 .
    AJ272365 mRNA. Translation: CAC82175.1 .
    AJ420812 mRNA. Translation: CAD12764.1 .
    AL161627 , AL450265 , AL590368 Genomic DNA. Translation: CAI13069.1 .
    AL161627 , AL450265 , AL590368 Genomic DNA. Translation: CAI13070.1 .
    AL161627 , AL450265 , AL590368 Genomic DNA. Translation: CAI13071.1 .
    AL450265 , AL161627 , AL590368 Genomic DNA. Translation: CAI14395.1 .
    AL450265 , AL161627 , AL590368 Genomic DNA. Translation: CAI14396.1 .
    AL450265 , AL161627 , AL590368 Genomic DNA. Translation: CAI14397.1 .
    AL590368 , AL161627 , AL450265 Genomic DNA. Translation: CAH73434.1 .
    AL590368 , AL161627 , AL450265 Genomic DNA. Translation: CAH73435.1 .
    AL590368 , AL161627 , AL450265 Genomic DNA. Translation: CAH73436.1 .
    BC018213 mRNA. Translation: AAH18213.1 .
    BC049203 mRNA. Translation: AAH49203.1 .
    CCDSi CCDS6763.1. [Q8WWI5-1 ]
    RefSeqi NP_001273659.1. NM_001286730.1. [Q8WWI5-3 ]
    NP_536856.2. NM_080546.4. [Q8WWI5-1 ]
    UniGenei Hs.573495.

    3D structure databases

    ProteinModelPortali Q8WWI5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117012. 5 interactions.
    IntActi Q8WWI5. 4 interactions.
    MINTi MINT-8247377.
    STRINGi 9606.ENSP00000363852.

    Chemistry

    DrugBanki DB00122. Choline.
    GuidetoPHARMACOLOGYi 1204.

    Protein family/group databases

    TCDBi 2.A.92.1.6. the choline transporter-like (ctl) family.

    PTM databases

    PhosphoSitei Q8WWI5.

    Polymorphism databases

    DMDMi 73918923.

    Proteomic databases

    MaxQBi Q8WWI5.
    PaxDbi Q8WWI5.
    PRIDEi Q8WWI5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000374720 ; ENSP00000363852 ; ENSG00000070214 . [Q8WWI5-1 ]
    ENST00000374723 ; ENSP00000363855 ; ENSG00000070214 . [Q8WWI5-3 ]
    ENST00000374724 ; ENSP00000363856 ; ENSG00000070214 . [Q8WWI5-2 ]
    ENST00000470972 ; ENSP00000433072 ; ENSG00000070214 . [Q8WWI5-1 ]
    GeneIDi 23446.
    KEGGi hsa:23446.
    UCSCi uc004bcn.3. human. [Q8WWI5-1 ]

    Organism-specific databases

    CTDi 23446.
    GeneCardsi GC09P108006.
    HGNCi HGNC:18798. SLC44A1.
    MIMi 606105. gene.
    neXtProti NX_Q8WWI5.
    PharmGKBi PA134958011.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG310633.
    HOGENOMi HOG000231655.
    HOVERGENi HBG080361.
    InParanoidi Q8WWI5.
    KOi K06515.
    OMAi EKCLSYL.
    OrthoDBi EOG72JWFP.
    PhylomeDBi Q8WWI5.
    TreeFami TF313325.

    Enzyme and pathway databases

    Reactomei REACT_121238. Synthesis of PC.
    REACT_19305. Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds.

    Miscellaneous databases

    ChiTaRSi SLC44A1. human.
    GeneWikii SLC44A1.
    GenomeRNAii 23446.
    NextBioi 45724.
    PROi Q8WWI5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8WWI5.
    Bgeei Q8WWI5.
    CleanExi HS_SLC44A1.
    Genevestigatori Q8WWI5.

    Family and domain databases

    InterProi IPR007603. Choline_transptr-like.
    [Graphical view ]
    PANTHERi PTHR12385. PTHR12385. 1 hit.
    Pfami PF04515. Choline_transpo. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "An electric lobe suppressor for a yeast choline transport mutation belongs to a new family of transporter-like proteins."
      O'Regan S., Traiffort E., Ruat M., Cha N., Compaore D., Meunier F.-M.
      Proc. Natl. Acad. Sci. U.S.A. 97:1835-1840(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORM 2).
      Tissue: Ewing sarcoma.
    2. "Characterization of CDw92 as a member of the choline transporter-like protein family regulated specifically on dendritic cells."
      Wille S., Szekeres A., Majdic O., Prager E., Staffler G., Stoeckl J., Kunthalert D., Prieschl E.E., Baumruker T., Burtscher H., Zlabinger G.J., Knapp W., Stockinger H.
      J. Immunol. 167:5795-5804(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), TISSUE SPECIFICITY, VARIANT ALA-644.
    3. "Molecular characterization of the family of choline transporter-like proteins and their splice variants."
      Traiffort E., Ruat M., O'Regan S., Meunier F.-M.
      J. Neurochem. 92:1116-1125(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Ewing sarcoma.
    4. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Eye and Lung.
    6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-652, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. "The solute carrier 44A1 is a mitochondrial protein and mediates choline transport."
      Michel V., Bakovic M.
      FASEB J. 23:2749-2758(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TOPOLOGY, SUBCELLULAR LOCATION.
    8. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
      Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCTL1_HUMAN
    AccessioniPrimary (citable) accession number: Q8WWI5
    Secondary accession number(s): A6NLZ9
    , Q5VUB3, Q8WVB0, Q96KU3, Q9NY69
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 30, 2005
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3