Q8WWI5 (CTL1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Choline transporter-like protein 1

Alternative name(s):
CDw92
Solute carrier family 44 member 1
CD_antigen=CD92

Gene names

Name:	SLC44A1
Synonyms:	CD92, CDW92, CTL1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	657 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Choline transporter. May be involved in membrane synthesis and myelin production. Ref.7
Subcellular location	Cell membrane; Multi-pass membrane protein. Mitochondrion outer membrane; Multi-pass membrane protein Ref.7.
Tissue specificity	Expressed in various cells of the hematopoietic system. Ref.2
Sequence similarities	Belongs to the CTL (choline transporter-like) family.

Ontologies

Keywords
Biological process	Transport
Cellular component	Cell membrane Membrane Mitochondrion Mitochondrion outer membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
PTM	Lipoprotein Myristate Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	phosphatidylcholine biosynthetic process Traceable author statement. Source: Reactome
Cellular_component	integral to membrane Traceable author statement Ref.1. Source: UniProtKB mitochondrial outer membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Traceable author statement. Source: Reactome
Molecular_function	choline transmembrane transporter activity Traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8WWI5-1)

Also known as: A;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8WWI5-2)

Also known as: B;

The sequence of this isoform differs from the canonical sequence as follows:
     651-654: ASGA → LKKR
     655-657: Missing.

Isoform 3 (identifier: Q8WWI5-3)

Also known as: C;

The sequence of this isoform differs from the canonical sequence as follows:
     651-652: AS → IK
     653-657: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 657	657	Choline transporter-like protein 1		PRO_0000191712
Regions
	Topological domain	1 – 30	30	Cytoplasmic Potential
	Transmembrane	31 – 51	21	Helical; Potential
	Topological domain	52 – 212	161	Mitochondrial intermembrane Potential
	Transmembrane	213 – 233	21	Helical; Potential
	Topological domain	234 – 238	5	Cytoplasmic Potential
	Transmembrane	239 – 259	21	Helical; Potential
	Topological domain	260 – 288	29	Mitochondrial intermembrane Potential
	Transmembrane	289 – 309	21	Helical; Potential
	Topological domain	310 – 315	6	Cytoplasmic Potential
	Transmembrane	316 – 336	21	Helical; Potential
	Topological domain	337 – 338	2	Mitochondrial intermembrane Potential
	Transmembrane	339 – 359	21	Helical; Potential
	Topological domain	360 – 380	21	Cytoplasmic Potential
	Transmembrane	381 – 401	21	Helical; Potential
	Topological domain	402 – 537	136	Mitochondrial intermembrane Potential
	Transmembrane	538 – 558	21	Helical; Potential
	Topological domain	559 – 566	8	Cytoplasmic Potential
	Transmembrane	567 – 587	21	Helical; Potential
	Topological domain	588 – 653	66	Mitochondrial intermembrane Potential
	Compositional bias	474 – 492	19	Cys-rich
Amino acid modifications
	Modified residue	652	1	Phosphoserine Ref.6
	Lipidation	2	1	N-myristoyl glycine
Natural variations
	Alternative sequence	651 – 654	4	ASGA → LKKR in isoform 2.		VSP_015424
	Alternative sequence	651 – 652	2	AS → IK in isoform 3.		VSP_015426
	Alternative sequence	653 – 657	5	Missing in isoform 3.		VSP_015427
	Alternative sequence	655 – 657	3	Missing in isoform 2.		VSP_015425
	Natural variant	644	1	S → A. Ref.2 Corresponds to variant rs3199966 [ dbSNP | Ensembl ].		VAR_048837
Experimental info
	Sequence conflict	79	1	I → V in CAC82175. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (A) [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 10D70CAB8E33E3AC	FASTA	657	73,302
	10 20 30 40 50 60 MGCCSSASSA AQSSKREWKP LEDRSCTDIP WLLLFILFCI GMGFICGFSI ATGAAARLVS 70 80 90 100 110 120 GYDSYGNICG QKNTKLEAIP NSGMDHTQRK YVFFLDPCNL DLINRKIKSV ALCVAACPRQ 130 140 150 160 170 180 ELKTLSDVQK FAEINGSALC SYNLKPSEYT TSPKSSVLCP KLPVPASAPI PFFHRCAPVN 190 200 210 220 230 240 ISCYAKFAEA LITFVSDNSV LHRLISGVMT SKEIILGLCL LSLVLSMILM VIIRYISRVL 250 260 270 280 290 300 VWILTILVIL GSLGGTGVLW WLYAKQRRSP KETVTPEQLQ IAEDNLRALL IYAISATVFT 310 320 330 340 350 360 VILFLIMLVM RKRVALTIAL FHVAGKVFIH LPLLVFQPFW TFFALVLFWV YWIMTLLFLG 370 380 390 400 410 420 TTGSPVQNEQ GFVEFKISGP LQYMWWYHVV GLIWISEFIL ACQQMTVAGA VVTYYFTRDK 430 440 450 460 470 480 RNLPFTPILA SVNRLIRYHL GTVAKGSFII TLVKIPRMIL MYIHSQLKGK ENACARCVLK 490 500 510 520 530 540 SCICCLWCLE KCLNYLNQNA YTATAINSTN FCTSAKDAFV ILVENALRVA TINTVGDFML 550 560 570 580 590 600 FLGKVLIVCS TGLAGIMLLN YQQDYTVWVL PLIIVCLFAF LVAHCFLSIY EMVVDVLFLC 610 620 630 640 650 FAIDTKYNDG SPGREFYMDK VLMEFVENSR KAMKEAGKGG VADSRELKPM ASGASSA
	Isoform 2 (B) [UniParc]. Checksum: 625565695C5DA9F0	FASTA	654	73,296
	10 20 30 40 50 60 MGCCSSASSA AQSSKREWKP LEDRSCTDIP WLLLFILFCI GMGFICGFSI ATGAAARLVS 70 80 90 100 110 120 GYDSYGNICG QKNTKLEAIP NSGMDHTQRK YVFFLDPCNL DLINRKIKSV ALCVAACPRQ 130 140 150 160 170 180 ELKTLSDVQK FAEINGSALC SYNLKPSEYT TSPKSSVLCP KLPVPASAPI PFFHRCAPVN 190 200 210 220 230 240 ISCYAKFAEA LITFVSDNSV LHRLISGVMT SKEIILGLCL LSLVLSMILM VIIRYISRVL 250 260 270 280 290 300 VWILTILVIL GSLGGTGVLW WLYAKQRRSP KETVTPEQLQ IAEDNLRALL IYAISATVFT 310 320 330 340 350 360 VILFLIMLVM RKRVALTIAL FHVAGKVFIH LPLLVFQPFW TFFALVLFWV YWIMTLLFLG 370 380 390 400 410 420 TTGSPVQNEQ GFVEFKISGP LQYMWWYHVV GLIWISEFIL ACQQMTVAGA VVTYYFTRDK 430 440 450 460 470 480 RNLPFTPILA SVNRLIRYHL GTVAKGSFII TLVKIPRMIL MYIHSQLKGK ENACARCVLK 490 500 510 520 530 540 SCICCLWCLE KCLNYLNQNA YTATAINSTN FCTSAKDAFV ILVENALRVA TINTVGDFML 550 560 570 580 590 600 FLGKVLIVCS TGLAGIMLLN YQQDYTVWVL PLIIVCLFAF LVAHCFLSIY EMVVDVLFLC 610 620 630 640 650 FAIDTKYNDG SPGREFYMDK VLMEFVENSR KAMKEAGKGG VADSRELKPM LKKR
	Isoform 3 (C) [UniParc]. Checksum: D56E2C5DA9F0188A	FASTA	652	73,012
	10 20 30 40 50 60 MGCCSSASSA AQSSKREWKP LEDRSCTDIP WLLLFILFCI GMGFICGFSI ATGAAARLVS 70 80 90 100 110 120 GYDSYGNICG QKNTKLEAIP NSGMDHTQRK YVFFLDPCNL DLINRKIKSV ALCVAACPRQ 130 140 150 160 170 180 ELKTLSDVQK FAEINGSALC SYNLKPSEYT TSPKSSVLCP KLPVPASAPI PFFHRCAPVN 190 200 210 220 230 240 ISCYAKFAEA LITFVSDNSV LHRLISGVMT SKEIILGLCL LSLVLSMILM VIIRYISRVL 250 260 270 280 290 300 VWILTILVIL GSLGGTGVLW WLYAKQRRSP KETVTPEQLQ IAEDNLRALL IYAISATVFT 310 320 330 340 350 360 VILFLIMLVM RKRVALTIAL FHVAGKVFIH LPLLVFQPFW TFFALVLFWV YWIMTLLFLG 370 380 390 400 410 420 TTGSPVQNEQ GFVEFKISGP LQYMWWYHVV GLIWISEFIL ACQQMTVAGA VVTYYFTRDK 430 440 450 460 470 480 RNLPFTPILA SVNRLIRYHL GTVAKGSFII TLVKIPRMIL MYIHSQLKGK ENACARCVLK 490 500 510 520 530 540 SCICCLWCLE KCLNYLNQNA YTATAINSTN FCTSAKDAFV ILVENALRVA TINTVGDFML 550 560 570 580 590 600 FLGKVLIVCS TGLAGIMLLN YQQDYTVWVL PLIIVCLFAF LVAHCFLSIY EMVVDVLFLC 610 620 630 640 650 FAIDTKYNDG SPGREFYMDK VLMEFVENSR KAMKEAGKGG VADSRELKPM IK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"An electric lobe suppressor for a yeast choline transport mutation belongs to a new family of transporter-like proteins." O'Regan S., Traiffort E., Ruat M., Cha N., Compaore D., Meunier F.-M. Proc. Natl. Acad. Sci. U.S.A. 97:1835-1840(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORM 2). Tissue: Ewing sarcoma.
[2]	"Characterization of CDw92 as a member of the choline transporter-like protein family regulated specifically on dendritic cells." Wille S., Szekeres A., Majdic O., Prager E., Staffler G., Stoeckl J., Kunthalert D., Prieschl E.E., Baumruker T., Burtscher H., Zlabinger G.J., Knapp W., Stockinger H. J. Immunol. 167:5795-5804(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), TISSUE SPECIFICITY, VARIANT ALA-644.
[3]	"Molecular characterization of the family of choline transporter-like proteins and their splice variants." Traiffort E., Ruat M., O'Regan S., Meunier F.-M. J. Neurochem. 92:1116-1125(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Ewing sarcoma.
[4]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Eye and Lung.
[6]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-652, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[7]	"The solute carrier 44A1 is a mitochondrial protein and mediates choline transport." Michel V., Bakovic M. FASEB J. 23:2749-2758(2009) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, TOPOLOGY, SUBCELLULAR LOCATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ245620 Genomic DNA. Translation: CAB75541.2. AJ272365 mRNA. Translation: CAC82175.1. AJ420812 mRNA. Translation: CAD12764.1. AL161627, AL450265, AL590368 Genomic DNA. Translation: CAI13069.1. AL161627, AL450265, AL590368 Genomic DNA. Translation: CAI13070.1. AL161627, AL450265, AL590368 Genomic DNA. Translation: CAI13071.1. AL450265, AL161627, AL590368 Genomic DNA. Translation: CAI14395.1. AL450265, AL161627, AL590368 Genomic DNA. Translation: CAI14396.1. AL450265, AL161627, AL590368 Genomic DNA. Translation: CAI14397.1. AL590368, AL161627, AL450265 Genomic DNA. Translation: CAH73434.1. AL590368, AL161627, AL450265 Genomic DNA. Translation: CAH73435.1. AL590368, AL161627, AL450265 Genomic DNA. Translation: CAH73436.1. BC018213 mRNA. Translation: AAH18213.1. BC049203 mRNA. Translation: AAH49203.1.
IPI	IPI00005068. IPI00221393. IPI00642657.
RefSeq	NP_536856.2. NM_080546.3.
UniGene	Hs.573495.
3D structure databases
ProteinModelPortal	Q8WWI5.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000363852.
PTM databases
PhosphoSite	Q8WWI5.
Polymorphism databases
DMDM	73918923.
Proteomic databases
PaxDb	Q8WWI5.
PRIDE	Q8WWI5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000374720; ENSP00000363852; ENSG00000070214. ENST00000374723; ENSP00000363855; ENSG00000070214. ENST00000374724; ENSP00000363856; ENSG00000070214. ENST00000470972; ENSP00000433072; ENSG00000070214.
GeneID	23446.
KEGG	hsa:23446.
UCSC	uc004bcn.3. human. uc004bco.1. human.
Organism-specific databases
CTD	23446.
GeneCards	GC09P108006.
HGNC	HGNC:18798. SLC44A1.
MIM	606105. gene.
neXtProt	NX_Q8WWI5.
PharmGKB	PA134958011.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG310633.
HOGENOM	HOG000231655.
HOVERGEN	HBG080361.
InParanoid	Q8WWI5.
KO	K06515.
OMA	CEDKTIN.
PhylomeDB	Q8WWI5.
Enzyme and pathway databases
Reactome	REACT_111217. Metabolism. REACT_15518. Transmembrane transport of small molecules. REACT_20679. Amine compound SLC transporters.
Gene expression databases
ArrayExpress	Q8WWI5.
Bgee	Q8WWI5.
CleanEx	HS_SLC44A1.
Genevestigator	Q8WWI5.
GermOnline	ENSG00000070214. Homo sapiens.
Family and domain databases
InterPro	IPR007603. Choline_transptr-like. [Graphical view]
PANTHER	PTHR12385. PTHR12385. 1 hit.
Pfam	PF04515. Choline_transpo. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	SLC44A1. human.
DrugBank	DB00122. Choline.
GenomeRNAi	23446.
NextBio	45724.
SOURCE	Search...

Entry information

Entry name

CTL1_HUMAN

Accession

Primary (citable) accession number: Q8WWI5
Secondary accession number(s): A6NLZ9 , Q5VUB3, Q8WVB0, Q96KU3, Q9NY69

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 30, 2005
Last sequence update:	March 1, 2002
Last modified:	April 3, 2013
This is version 91 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.