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Q8WWI5 (CTL1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Choline transporter-like protein 1
Alternative name(s):
CDw92
Solute carrier family 44 member 1
CD_antigen=CD92
Gene names
Name:SLC44A1
Synonyms:CD92, CDW92, CTL1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length657 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Choline transporter. May be involved in membrane synthesis and myelin production. Ref.7

Subcellular location

Cell membrane; Multi-pass membrane protein. Mitochondrion outer membrane; Multi-pass membrane protein Ref.7.

Tissue specificity

Expressed in various cells of the hematopoietic system. Ref.2

Sequence similarities

Belongs to the CTL (choline transporter-like) family.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8WWI5-1)

Also known as: A;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8WWI5-2)

Also known as: B;

The sequence of this isoform differs from the canonical sequence as follows:
     651-654: ASGA → LKKR
     655-657: Missing.
Isoform 3 (identifier: Q8WWI5-3)

Also known as: C;

The sequence of this isoform differs from the canonical sequence as follows:
     651-652: AS → IK
     653-657: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 657656Choline transporter-like protein 1
PRO_0000191712

Regions

Topological domain2 – 3029Cytoplasmic Potential
Transmembrane31 – 5121Helical; Potential
Topological domain52 – 212161Mitochondrial intermembrane Potential
Transmembrane213 – 23321Helical; Potential
Topological domain234 – 2385Cytoplasmic Potential
Transmembrane239 – 25921Helical; Potential
Topological domain260 – 28829Mitochondrial intermembrane Potential
Transmembrane289 – 30921Helical; Potential
Topological domain310 – 3156Cytoplasmic Potential
Transmembrane316 – 33621Helical; Potential
Topological domain337 – 3382Mitochondrial intermembrane Potential
Transmembrane339 – 35921Helical; Potential
Topological domain360 – 38021Cytoplasmic Potential
Transmembrane381 – 40121Helical; Potential
Topological domain402 – 537136Mitochondrial intermembrane Potential
Transmembrane538 – 55821Helical; Potential
Topological domain559 – 5668Cytoplasmic Potential
Transmembrane567 – 58721Helical; Potential
Topological domain588 – 65366Mitochondrial intermembrane Potential
Compositional bias474 – 49219Cys-rich

Amino acid modifications

Modified residue6521Phosphoserine Ref.6
Lipidation21N-myristoyl glycine By similarity

Natural variations

Alternative sequence651 – 6544ASGA → LKKR in isoform 2.
VSP_015424
Alternative sequence651 – 6522AS → IK in isoform 3.
VSP_015426
Alternative sequence653 – 6575Missing in isoform 3.
VSP_015427
Alternative sequence655 – 6573Missing in isoform 2.
VSP_015425
Natural variant6441S → A. Ref.2
Corresponds to variant rs3199966 [ dbSNP | Ensembl ].
VAR_048837

Experimental info

Sequence conflict791I → V in CAC82175. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (A) [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 10D70CAB8E33E3AC

FASTA65773,302
        10         20         30         40         50         60 
MGCCSSASSA AQSSKREWKP LEDRSCTDIP WLLLFILFCI GMGFICGFSI ATGAAARLVS 

        70         80         90        100        110        120 
GYDSYGNICG QKNTKLEAIP NSGMDHTQRK YVFFLDPCNL DLINRKIKSV ALCVAACPRQ 

       130        140        150        160        170        180 
ELKTLSDVQK FAEINGSALC SYNLKPSEYT TSPKSSVLCP KLPVPASAPI PFFHRCAPVN 

       190        200        210        220        230        240 
ISCYAKFAEA LITFVSDNSV LHRLISGVMT SKEIILGLCL LSLVLSMILM VIIRYISRVL 

       250        260        270        280        290        300 
VWILTILVIL GSLGGTGVLW WLYAKQRRSP KETVTPEQLQ IAEDNLRALL IYAISATVFT 

       310        320        330        340        350        360 
VILFLIMLVM RKRVALTIAL FHVAGKVFIH LPLLVFQPFW TFFALVLFWV YWIMTLLFLG 

       370        380        390        400        410        420 
TTGSPVQNEQ GFVEFKISGP LQYMWWYHVV GLIWISEFIL ACQQMTVAGA VVTYYFTRDK 

       430        440        450        460        470        480 
RNLPFTPILA SVNRLIRYHL GTVAKGSFII TLVKIPRMIL MYIHSQLKGK ENACARCVLK 

       490        500        510        520        530        540 
SCICCLWCLE KCLNYLNQNA YTATAINSTN FCTSAKDAFV ILVENALRVA TINTVGDFML 

       550        560        570        580        590        600 
FLGKVLIVCS TGLAGIMLLN YQQDYTVWVL PLIIVCLFAF LVAHCFLSIY EMVVDVLFLC 

       610        620        630        640        650 
FAIDTKYNDG SPGREFYMDK VLMEFVENSR KAMKEAGKGG VADSRELKPM ASGASSA 

« Hide

Isoform 2 (B) [UniParc].

Checksum: 625565695C5DA9F0
Show »

FASTA65473,296
Isoform 3 (C) [UniParc].

Checksum: D56E2C5DA9F0188A
Show »

FASTA65273,012

References

« Hide 'large scale' references
[1]"An electric lobe suppressor for a yeast choline transport mutation belongs to a new family of transporter-like proteins."
O'Regan S., Traiffort E., Ruat M., Cha N., Compaore D., Meunier F.-M.
Proc. Natl. Acad. Sci. U.S.A. 97:1835-1840(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORM 2).
Tissue: Ewing sarcoma.
[2]"Characterization of CDw92 as a member of the choline transporter-like protein family regulated specifically on dendritic cells."
Wille S., Szekeres A., Majdic O., Prager E., Staffler G., Stoeckl J., Kunthalert D., Prieschl E.E., Baumruker T., Burtscher H., Zlabinger G.J., Knapp W., Stockinger H.
J. Immunol. 167:5795-5804(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), TISSUE SPECIFICITY, VARIANT ALA-644.
[3]"Molecular characterization of the family of choline transporter-like proteins and their splice variants."
Traiffort E., Ruat M., O'Regan S., Meunier F.-M.
J. Neurochem. 92:1116-1125(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Ewing sarcoma.
[4]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Eye and Lung.
[6]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-652, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[7]"The solute carrier 44A1 is a mitochondrial protein and mediates choline transport."
Michel V., Bakovic M.
FASEB J. 23:2749-2758(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TOPOLOGY, SUBCELLULAR LOCATION.
[8]"Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ245620 Genomic DNA. Translation: CAB75541.2.
AJ272365 mRNA. Translation: CAC82175.1.
AJ420812 mRNA. Translation: CAD12764.1.
AL161627, AL450265, AL590368 Genomic DNA. Translation: CAI13069.1.
AL161627, AL450265, AL590368 Genomic DNA. Translation: CAI13070.1.
AL161627, AL450265, AL590368 Genomic DNA. Translation: CAI13071.1.
AL450265, AL161627, AL590368 Genomic DNA. Translation: CAI14395.1.
AL450265, AL161627, AL590368 Genomic DNA. Translation: CAI14396.1.
AL450265, AL161627, AL590368 Genomic DNA. Translation: CAI14397.1.
AL590368, AL161627, AL450265 Genomic DNA. Translation: CAH73434.1.
AL590368, AL161627, AL450265 Genomic DNA. Translation: CAH73435.1.
AL590368, AL161627, AL450265 Genomic DNA. Translation: CAH73436.1.
BC018213 mRNA. Translation: AAH18213.1.
BC049203 mRNA. Translation: AAH49203.1.
CCDSCCDS6763.1. [Q8WWI5-1]
RefSeqNP_001273659.1. NM_001286730.1. [Q8WWI5-3]
NP_536856.2. NM_080546.4. [Q8WWI5-1]
UniGeneHs.573495.

3D structure databases

ProteinModelPortalQ8WWI5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid117012. 5 interactions.
IntActQ8WWI5. 4 interactions.
MINTMINT-8247377.
STRING9606.ENSP00000363852.

Chemistry

DrugBankDB00122. Choline.
GuidetoPHARMACOLOGY1204.

Protein family/group databases

TCDB2.A.92.1.6. the choline transporter-like (ctl) family.

PTM databases

PhosphoSiteQ8WWI5.

Polymorphism databases

DMDM73918923.

Proteomic databases

MaxQBQ8WWI5.
PaxDbQ8WWI5.
PRIDEQ8WWI5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000374720; ENSP00000363852; ENSG00000070214. [Q8WWI5-1]
ENST00000374723; ENSP00000363855; ENSG00000070214. [Q8WWI5-3]
ENST00000374724; ENSP00000363856; ENSG00000070214. [Q8WWI5-2]
ENST00000470972; ENSP00000433072; ENSG00000070214. [Q8WWI5-1]
GeneID23446.
KEGGhsa:23446.
UCSCuc004bcn.3. human. [Q8WWI5-1]

Organism-specific databases

CTD23446.
GeneCardsGC09P108006.
HGNCHGNC:18798. SLC44A1.
MIM606105. gene.
neXtProtNX_Q8WWI5.
PharmGKBPA134958011.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG310633.
HOGENOMHOG000231655.
HOVERGENHBG080361.
InParanoidQ8WWI5.
KOK06515.
OMAEKCLSYL.
OrthoDBEOG72JWFP.
PhylomeDBQ8WWI5.
TreeFamTF313325.

Enzyme and pathway databases

ReactomeREACT_111217. Metabolism.
REACT_15518. Transmembrane transport of small molecules.
REACT_20679. Amine compound SLC transporters.

Gene expression databases

ArrayExpressQ8WWI5.
BgeeQ8WWI5.
CleanExHS_SLC44A1.
GenevestigatorQ8WWI5.

Family and domain databases

InterProIPR007603. Choline_transptr-like.
[Graphical view]
PANTHERPTHR12385. PTHR12385. 1 hit.
PfamPF04515. Choline_transpo. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSLC44A1. human.
GeneWikiSLC44A1.
GenomeRNAi23446.
NextBio45724.
PROQ8WWI5.
SOURCESearch...

Entry information

Entry nameCTL1_HUMAN
AccessionPrimary (citable) accession number: Q8WWI5
Secondary accession number(s): A6NLZ9 expand/collapse secondary AC list , Q5VUB3, Q8WVB0, Q96KU3, Q9NY69
Entry history
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: March 1, 2002
Last modified: July 9, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries