Q8WWI1 (LMO7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
LIM domain only protein 7
Short name=LMO-7

Alternative name(s):
F-box only protein 20
LOMP

Gene names

Name:	LMO7
Synonyms:	FBX20, FBXO20, KIAA0858

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1683 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Tissue specificity	Widely expressed. Isoform 2 and isoform 4 are predominantly expressed in brain. Ref.1 Ref.7
Sequence similarities	Contains 1 CH (calponin-homology) domain. Contains 1 LIM zinc-binding domain. Contains 1 PDZ (DHR) domain.
Sequence caution	The sequence AAC96299.1 differs from that shown. Reason: Erroneous initiation. The sequence AAC96300.1 differs from that shown. Reason: Erroneous initiation. The sequence AAD33924.1 differs from that shown. Reason: Frameshift at position 855. The sequence BAA74881.2 differs from that shown. Reason: Intron retention.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	LIM domain
Ligand	Metal-binding Zinc
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Traceable author statement Ref.7. Source: ProtInc nucleus Traceable author statement Ref.7. Source: ProtInc ubiquitin ligase complex Non-traceable author statement Ref.5. Source: UniProtKB
Molecular_function	ubiquitin-protein ligase activity Non-traceable author statement Ref.5. Source: UniProtKB zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8WWI1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: No experimental confirmation available.

Isoform 2 (identifier: Q8WWI1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1606-1683: RSVSGKRICS...RFKSGRPTAM → SVLPVSVTSE...EEVVAAHVDL

Isoform 3 (identifier: Q8WWI1-3)

The sequence of this isoform differs from the canonical sequence as follows:
     357-690: Missing.

Note: Contains a phosphoserine at position 342. Contains a phosphoserine at position 345.

Isoform 4 (identifier: Q8WWI1-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1606-1683: RSVSGKRICS...RFKSGRPTAM → SWTANRHVM

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1683

1683

LIM domain only protein 7

PRO_0000075824

Regions

Domain

54 – 168

115

CH

Domain

1042 – 1128

87

PDZ

Domain

1612 – 1678

67

LIM zinc-binding

Amino acid modifications

Modified residue

185

1

Phosphotyrosine Ref.14

Modified residue

246

1

Phosphoserine Ref.8 Ref.13 Ref.15 Ref.17

Modified residue

276

1

Phosphoserine Ref.13 Ref.15

Modified residue

704

1

Phosphoserine Ref.14 Ref.15 Ref.17

Modified residue

709

1

Phosphoserine Ref.13

Modified residue

751

1

Phosphoserine Ref.17

Modified residue

805

1

Phosphoserine Ref.14 Ref.15 Ref.17

Modified residue

867

1

Phosphoserine Ref.9 Ref.13 Ref.15

Modified residue

873

1

Phosphoserine Ref.12 Ref.13

Modified residue

895

1

Phosphoserine Ref.13 Ref.15

Modified residue

913

1

Phosphothreonine Ref.13 Ref.15

Modified residue

919

1

Phosphoserine Ref.13 Ref.15

Modified residue

926

1

Phosphoserine Ref.13

Modified residue

932

1

Phosphothreonine Ref.13

Modified residue

949

1

Phosphothreonine Ref.9

Modified residue

956

1

Phosphothreonine Ref.14

Modified residue

960

1

Phosphoserine Ref.14 Ref.15

Modified residue

988

1

Phosphoserine Ref.13 Ref.14 Ref.15

Modified residue

991

1

Phosphoserine Ref.13 Ref.15

Modified residue

994

1

Phosphoserine Ref.15

Modified residue

995

1

Phosphoserine Ref.13

Modified residue

1026

1

Phosphoserine Ref.8 Ref.13 Ref.14 Ref.15

Modified residue

1032

1

Phosphoserine Ref.15

Modified residue

1044

1

Phosphoserine Ref.13

Modified residue

1048

1

Phosphothreonine Ref.9 Ref.13 Ref.15 Ref.17

Modified residue

1177

1

Phosphoserine Ref.15

Modified residue

1304

1

Phosphoserine Ref.15

Modified residue

1307

1

Phosphoserine Ref.15

Modified residue

1423

1

Phosphoserine Ref.13 Ref.14 Ref.17

Modified residue

1510

1

Phosphoserine Ref.8 Ref.12 Ref.15 Ref.17

Modified residue

1516

1

Phosphoserine Ref.15

Modified residue

1563

1

Phosphoserine Ref.13

Modified residue

1586

1

Phosphoserine Ref.9 Ref.13 Ref.14

Modified residue

1593

1

Phosphoserine Ref.13 Ref.15

Modified residue

1595

1

Phosphoserine Ref.13

Modified residue

1597

1

Phosphoserine Ref.13

Modified residue

1601

1

Phosphoserine Ref.13 Ref.15

Natural variations

Alternative sequence

357 – 690

334

Missing in isoform 3.

VSP_009718

Alternative sequence

1606 – 1683

78

RSVSG…RPTAM → SVLPVSVTSEALPQELKSGS ETTNCTATTAISDSNLDGQP PCDVSLHTKALLQIEEEVVA AHVDL in isoform 2.

VSP_009719

Alternative sequence

1606 – 1683

78

RSVSG…RPTAM → SWTANRHVM in isoform 4.

VSP_009720

Natural variant

354

1

T → A in a colorectal cancer sample; somatic mutation. Ref.19

VAR_036189

Natural variant

785

1

L → M in a colorectal cancer sample; somatic mutation. Ref.19

VAR_036190

Natural variant

1547

1

P → Q.
Corresponds to variant rs7988661 [ dbSNP | Ensembl ].

VAR_056163

Experimental info

Sequence conflict

522

1

V → A in AAF04521. Ref.5

Sequence conflict

613

1

F → L in AAF04521. Ref.5

Sequence conflict

891

1

R → C in AAD33924. Ref.6

Sequence conflict

943

1

V → I in AAL37480. Ref.1

Sequence conflict

943

1

V → I in AAD33924. Ref.6

Sequence conflict

1447

1

M → T in AAD33924. Ref.6

Sequence conflict

1447

1

M → T in AAB86592. Ref.6

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

1683

Helix Strand Turn

Details...

Beta strand

1038 – 1046

9

Beta strand

1056 – 1062

7

Beta strand

1065 – 1071

7

Helix

1076 – 1079

4

Beta strand

1087 – 1091

5

Helix

1101 – 1114

14

Beta strand

1116 – 1124

9

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 5, 2010. Version 3. Checksum: 3E79B2AEAC67F6F5	FASTA	1,683	192,696
	10 20 30 40 50 60 MKKIRICHIF TFYSWMSYDV LFQRTELGAL EIWRQLICAH VCICVGWLYL RDRVCSKKDI 70 80 90 100 110 120 ILRTEQNSGR TILIKAVTEK NFETKDFRAS LENGVLLCDL INKLKPGVIK KINRLSTPIA 130 140 150 160 170 180 GLDNINVFLK ACEQIGLKEA QLFHPGDLQD LSNRVTVKQE ETDRRVKNVL ITLYWLGRKA 190 200 210 220 230 240 QSNPYYNGPH LNLKAFENLL GQALTKALED SSFLKRSGRD SGYGDIWCPE RGEFLAPPRH 250 260 270 280 290 300 HKREDSFESL DSLGSRSLTS CSSDITLRGG REGFESDTDS EFTFKMQDYN KDDMSYRRIS 310 320 330 340 350 360 AVEPKTALPF NRFLPNKSRQ PSYVPAPLRK KKPDKHEDNR RSWASPVYTE ADGTFSSNQR 370 380 390 400 410 420 RIWGTNVENW PTVQGTSKSS CYLEEEKAKT RSIPNIVKDD LYVRKLSPVM PNPGNAFDQF 430 440 450 460 470 480 LPKCWTPEDV NWKRIKRETY KPWYKEFQGF SQFLLLQALQ TYSDDILSSE THTKIDPTSG 490 500 510 520 530 540 PRLITRRKNL SYAPGYRRDD LEMAALDPDL ENDDFFVRKT GVFHANPYVL RAFEDFRKFS 550 560 570 580 590 600 EQDDSVERDI ILQCREGELV LPDLEKDDMI VRRIPAQKKE VPLSGAPDRY HPVPFPEPWT 610 620 630 640 650 660 LPPEIQAKFL CVFERTCPSK EKSNSCRILV PSYRQKKDDM LTRKIQSWKL GTTVPPISFT 670 680 690 700 710 720 PGPCSEADLK RWEAIREASR LRHKKRLMVE RLFQKIYGEN GSKSMSDVSA EDVQNLRQLR 730 740 750 760 770 780 YEEMQKIKSQ LKEQDQKWQD DLAKWKDRRK SYTSDLQKKK EEREEIEKQA LEKSKRSSKT 790 800 810 820 830 840 FKEMLQDRES QNQKSTVPSR RRMYSFDDVL EEGKRPPTMT VSEASYQSER VEEKGATYPS 850 860 870 880 890 900 EIPKEDSTTF AKREDRVTTE IQLPSQSPVE EQSPASLSSL RSRSTQMEST RVSASLPRSY 910 920 930 940 950 960 RKTDTVRLTS VVTPRPFGSQ TRGISSLPRS YTMDDAWKYN GDVEDIKRTP NNVVSTPAPS 970 980 990 1000 1010 1020 PDASQLASSL SSQKEVAATE EDVTRLPSPT SPFSSLSQDQ AATSKATLSS TSGLDLMSES 1030 1040 1050 1060 1070 1080 GEGEISPQRE VSRSQDQFSD MRISINQTPG KSLDFGFTIK WDIPGIFVAS VEAGSPAEFS 1090 1100 1110 1120 1130 1140 QLQVDDEIIA INNTKFSYND SKEWEEAMAK AQETGHLVMD VRRYGKAGSP ETKWIDATSG 1150 1160 1170 1180 1190 1200 IYNSEKSSNL SVTTDFSESL QSSNIESKEI NGIHDESNAF ESKASESISL KNLKRRSQFF 1210 1220 1230 1240 1250 1260 EQGSSDSVVP DLPVPTISAP SRWVWDQEEE RKRQERWQKE QDRLLQEKYQ REQEKLREEW 1270 1280 1290 1300 1310 1320 QRAKQEAERE NSKYLDEELM VLSSNSMSLT TREPSLATWE ATWSEGSKSS DREGTRAGEE 1330 1340 1350 1360 1370 1380 ERRQPQEEVV HEDQGKKPQD QLVIERERKW EQQLQEEQEQ KRLQAEAEEQ KRPAEEQKRQ 1390 1400 1410 1420 1430 1440 AEIERETSVR IYQYRRPVDS YDIPKTEEAS SGFLPGDRNK SRSTTELDDY STNKNGNNKY 1450 1460 1470 1480 1490 1500 LDQIGNMTSS QRRSKKEQVP SGAELERQQI LQEMRKRTPL HNDNSWIRQR SASVNKEPVS 1510 1520 1530 1540 1550 1560 LPGIMRRGES LDNLDSPRSN SWRQPPWLNQ PTGFYASSSV QDFSRPPPQL VSTSNRAYMR 1570 1580 1590 1600 1610 1620 NPSSSVPPPS AGSVKTSTTG VATTQSPTPR SHSPSASQSG SQLRNRSVSG KRICSYCNNI 1630 1640 1650 1660 1670 1680 LGKGAAMIIE SLGLCYHLHC FKCVACECDL GGSSSGAEVR IRNHQLYCND CYLRFKSGRP TAM
	Isoform 2 [UniParc]. Checksum: FC84DAB0587D1AB6	FASTA	1,670	190,876
	10 20 30 40 50 60 MKKIRICHIF TFYSWMSYDV LFQRTELGAL EIWRQLICAH VCICVGWLYL RDRVCSKKDI 70 80 90 100 110 120 ILRTEQNSGR TILIKAVTEK NFETKDFRAS LENGVLLCDL INKLKPGVIK KINRLSTPIA 130 140 150 160 170 180 GLDNINVFLK ACEQIGLKEA QLFHPGDLQD LSNRVTVKQE ETDRRVKNVL ITLYWLGRKA 190 200 210 220 230 240 QSNPYYNGPH LNLKAFENLL GQALTKALED SSFLKRSGRD SGYGDIWCPE RGEFLAPPRH 250 260 270 280 290 300 HKREDSFESL DSLGSRSLTS CSSDITLRGG REGFESDTDS EFTFKMQDYN KDDMSYRRIS 310 320 330 340 350 360 AVEPKTALPF NRFLPNKSRQ PSYVPAPLRK KKPDKHEDNR RSWASPVYTE ADGTFSSNQR 370 380 390 400 410 420 RIWGTNVENW PTVQGTSKSS CYLEEEKAKT RSIPNIVKDD LYVRKLSPVM PNPGNAFDQF 430 440 450 460 470 480 LPKCWTPEDV NWKRIKRETY KPWYKEFQGF SQFLLLQALQ TYSDDILSSE THTKIDPTSG 490 500 510 520 530 540 PRLITRRKNL SYAPGYRRDD LEMAALDPDL ENDDFFVRKT GVFHANPYVL RAFEDFRKFS 550 560 570 580 590 600 EQDDSVERDI ILQCREGELV LPDLEKDDMI VRRIPAQKKE VPLSGAPDRY HPVPFPEPWT 610 620 630 640 650 660 LPPEIQAKFL CVFERTCPSK EKSNSCRILV PSYRQKKDDM LTRKIQSWKL GTTVPPISFT 670 680 690 700 710 720 PGPCSEADLK RWEAIREASR LRHKKRLMVE RLFQKIYGEN GSKSMSDVSA EDVQNLRQLR 730 740 750 760 770 780 YEEMQKIKSQ LKEQDQKWQD DLAKWKDRRK SYTSDLQKKK EEREEIEKQA LEKSKRSSKT 790 800 810 820 830 840 FKEMLQDRES QNQKSTVPSR RRMYSFDDVL EEGKRPPTMT VSEASYQSER VEEKGATYPS 850 860 870 880 890 900 EIPKEDSTTF AKREDRVTTE IQLPSQSPVE EQSPASLSSL RSRSTQMEST RVSASLPRSY 910 920 930 940 950 960 RKTDTVRLTS VVTPRPFGSQ TRGISSLPRS YTMDDAWKYN GDVEDIKRTP NNVVSTPAPS 970 980 990 1000 1010 1020 PDASQLASSL SSQKEVAATE EDVTRLPSPT SPFSSLSQDQ AATSKATLSS TSGLDLMSES 1030 1040 1050 1060 1070 1080 GEGEISPQRE VSRSQDQFSD MRISINQTPG KSLDFGFTIK WDIPGIFVAS VEAGSPAEFS 1090 1100 1110 1120 1130 1140 QLQVDDEIIA INNTKFSYND SKEWEEAMAK AQETGHLVMD VRRYGKAGSP ETKWIDATSG 1150 1160 1170 1180 1190 1200 IYNSEKSSNL SVTTDFSESL QSSNIESKEI NGIHDESNAF ESKASESISL KNLKRRSQFF 1210 1220 1230 1240 1250 1260 EQGSSDSVVP DLPVPTISAP SRWVWDQEEE RKRQERWQKE QDRLLQEKYQ REQEKLREEW 1270 1280 1290 1300 1310 1320 QRAKQEAERE NSKYLDEELM VLSSNSMSLT TREPSLATWE ATWSEGSKSS DREGTRAGEE 1330 1340 1350 1360 1370 1380 ERRQPQEEVV HEDQGKKPQD QLVIERERKW EQQLQEEQEQ KRLQAEAEEQ KRPAEEQKRQ 1390 1400 1410 1420 1430 1440 AEIERETSVR IYQYRRPVDS YDIPKTEEAS SGFLPGDRNK SRSTTELDDY STNKNGNNKY 1450 1460 1470 1480 1490 1500 LDQIGNMTSS QRRSKKEQVP SGAELERQQI LQEMRKRTPL HNDNSWIRQR SASVNKEPVS 1510 1520 1530 1540 1550 1560 LPGIMRRGES LDNLDSPRSN SWRQPPWLNQ PTGFYASSSV QDFSRPPPQL VSTSNRAYMR 1570 1580 1590 1600 1610 1620 NPSSSVPPPS AGSVKTSTTG VATTQSPTPR SHSPSASQSG SQLRNSVLPV SVTSEALPQE 1630 1640 1650 1660 1670 LKSGSETTNC TATTAISDSN LDGQPPCDVS LHTKALLQIE EEVVAAHVDL
	Isoform 3 [UniParc]. Checksum: E5A0EBC6A4894751	FASTA	1,349	153,670
	10 20 30 40 50 60 MKKIRICHIF TFYSWMSYDV LFQRTELGAL EIWRQLICAH VCICVGWLYL RDRVCSKKDI 70 80 90 100 110 120 ILRTEQNSGR TILIKAVTEK NFETKDFRAS LENGVLLCDL INKLKPGVIK KINRLSTPIA 130 140 150 160 170 180 GLDNINVFLK ACEQIGLKEA QLFHPGDLQD LSNRVTVKQE ETDRRVKNVL ITLYWLGRKA 190 200 210 220 230 240 QSNPYYNGPH LNLKAFENLL GQALTKALED SSFLKRSGRD SGYGDIWCPE RGEFLAPPRH 250 260 270 280 290 300 HKREDSFESL DSLGSRSLTS CSSDITLRGG REGFESDTDS EFTFKMQDYN KDDMSYRRIS 310 320 330 340 350 360 AVEPKTALPF NRFLPNKSRQ PSYVPAPLRK KKPDKHEDNR RSWASPVYTE ADGTFSRLFQ 370 380 390 400 410 420 KIYGENGSKS MSDVSAEDVQ NLRQLRYEEM QKIKSQLKEQ DQKWQDDLAK WKDRRKSYTS 430 440 450 460 470 480 DLQKKKEERE EIEKQALEKS KRSSKTFKEM LQDRESQNQK STVPSRRRMY SFDDVLEEGK 490 500 510 520 530 540 RPPTMTVSEA SYQSERVEEK GATYPSEIPK EDSTTFAKRE DRVTTEIQLP SQSPVEEQSP 550 560 570 580 590 600 ASLSSLRSRS TQMESTRVSA SLPRSYRKTD TVRLTSVVTP RPFGSQTRGI SSLPRSYTMD 610 620 630 640 650 660 DAWKYNGDVE DIKRTPNNVV STPAPSPDAS QLASSLSSQK EVAATEEDVT RLPSPTSPFS 670 680 690 700 710 720 SLSQDQAATS KATLSSTSGL DLMSESGEGE ISPQREVSRS QDQFSDMRIS INQTPGKSLD 730 740 750 760 770 780 FGFTIKWDIP GIFVASVEAG SPAEFSQLQV DDEIIAINNT KFSYNDSKEW EEAMAKAQET 790 800 810 820 830 840 GHLVMDVRRY GKAGSPETKW IDATSGIYNS EKSSNLSVTT DFSESLQSSN IESKEINGIH 850 860 870 880 890 900 DESNAFESKA SESISLKNLK RRSQFFEQGS SDSVVPDLPV PTISAPSRWV WDQEEERKRQ 910 920 930 940 950 960 ERWQKEQDRL LQEKYQREQE KLREEWQRAK QEAERENSKY LDEELMVLSS NSMSLTTREP 970 980 990 1000 1010 1020 SLATWEATWS EGSKSSDREG TRAGEEERRQ PQEEVVHEDQ GKKPQDQLVI ERERKWEQQL 1030 1040 1050 1060 1070 1080 QEEQEQKRLQ AEAEEQKRPA EEQKRQAEIE RETSVRIYQY RRPVDSYDIP KTEEASSGFL 1090 1100 1110 1120 1130 1140 PGDRNKSRST TELDDYSTNK NGNNKYLDQI GNMTSSQRRS KKEQVPSGAE LERQQILQEM 1150 1160 1170 1180 1190 1200 RKRTPLHNDN SWIRQRSASV NKEPVSLPGI MRRGESLDNL DSPRSNSWRQ PPWLNQPTGF 1210 1220 1230 1240 1250 1260 YASSSVQDFS RPPPQLVSTS NRAYMRNPSS SVPPPSAGSV KTSTTGVATT QSPTPRSHSP 1270 1280 1290 1300 1310 1320 SASQSGSQLR NRSVSGKRIC SYCNNILGKG AAMIIESLGL CYHLHCFKCV ACECDLGGSS 1330 1340 SGAEVRIRNH QLYCNDCYLR FKSGRPTAM
	Isoform 4 [UniParc]. Checksum: E0212DE11E059A39	FASTA	1,614	185,216
	10 20 30 40 50 60 MKKIRICHIF TFYSWMSYDV LFQRTELGAL EIWRQLICAH VCICVGWLYL RDRVCSKKDI 70 80 90 100 110 120 ILRTEQNSGR TILIKAVTEK NFETKDFRAS LENGVLLCDL INKLKPGVIK KINRLSTPIA 130 140 150 160 170 180 GLDNINVFLK ACEQIGLKEA QLFHPGDLQD LSNRVTVKQE ETDRRVKNVL ITLYWLGRKA 190 200 210 220 230 240 QSNPYYNGPH LNLKAFENLL GQALTKALED SSFLKRSGRD SGYGDIWCPE RGEFLAPPRH 250 260 270 280 290 300 HKREDSFESL DSLGSRSLTS CSSDITLRGG REGFESDTDS EFTFKMQDYN KDDMSYRRIS 310 320 330 340 350 360 AVEPKTALPF NRFLPNKSRQ PSYVPAPLRK KKPDKHEDNR RSWASPVYTE ADGTFSSNQR 370 380 390 400 410 420 RIWGTNVENW PTVQGTSKSS CYLEEEKAKT RSIPNIVKDD LYVRKLSPVM PNPGNAFDQF 430 440 450 460 470 480 LPKCWTPEDV NWKRIKRETY KPWYKEFQGF SQFLLLQALQ TYSDDILSSE THTKIDPTSG 490 500 510 520 530 540 PRLITRRKNL SYAPGYRRDD LEMAALDPDL ENDDFFVRKT GVFHANPYVL RAFEDFRKFS 550 560 570 580 590 600 EQDDSVERDI ILQCREGELV LPDLEKDDMI VRRIPAQKKE VPLSGAPDRY HPVPFPEPWT 610 620 630 640 650 660 LPPEIQAKFL CVFERTCPSK EKSNSCRILV PSYRQKKDDM LTRKIQSWKL GTTVPPISFT 670 680 690 700 710 720 PGPCSEADLK RWEAIREASR LRHKKRLMVE RLFQKIYGEN GSKSMSDVSA EDVQNLRQLR 730 740 750 760 770 780 YEEMQKIKSQ LKEQDQKWQD DLAKWKDRRK SYTSDLQKKK EEREEIEKQA LEKSKRSSKT 790 800 810 820 830 840 FKEMLQDRES QNQKSTVPSR RRMYSFDDVL EEGKRPPTMT VSEASYQSER VEEKGATYPS 850 860 870 880 890 900 EIPKEDSTTF AKREDRVTTE IQLPSQSPVE EQSPASLSSL RSRSTQMEST RVSASLPRSY 910 920 930 940 950 960 RKTDTVRLTS VVTPRPFGSQ TRGISSLPRS YTMDDAWKYN GDVEDIKRTP NNVVSTPAPS 970 980 990 1000 1010 1020 PDASQLASSL SSQKEVAATE EDVTRLPSPT SPFSSLSQDQ AATSKATLSS TSGLDLMSES 1030 1040 1050 1060 1070 1080 GEGEISPQRE VSRSQDQFSD MRISINQTPG KSLDFGFTIK WDIPGIFVAS VEAGSPAEFS 1090 1100 1110 1120 1130 1140 QLQVDDEIIA INNTKFSYND SKEWEEAMAK AQETGHLVMD VRRYGKAGSP ETKWIDATSG 1150 1160 1170 1180 1190 1200 IYNSEKSSNL SVTTDFSESL QSSNIESKEI NGIHDESNAF ESKASESISL KNLKRRSQFF 1210 1220 1230 1240 1250 1260 EQGSSDSVVP DLPVPTISAP SRWVWDQEEE RKRQERWQKE QDRLLQEKYQ REQEKLREEW 1270 1280 1290 1300 1310 1320 QRAKQEAERE NSKYLDEELM VLSSNSMSLT TREPSLATWE ATWSEGSKSS DREGTRAGEE 1330 1340 1350 1360 1370 1380 ERRQPQEEVV HEDQGKKPQD QLVIERERKW EQQLQEEQEQ KRLQAEAEEQ KRPAEEQKRQ 1390 1400 1410 1420 1430 1440 AEIERETSVR IYQYRRPVDS YDIPKTEEAS SGFLPGDRNK SRSTTELDDY STNKNGNNKY 1450 1460 1470 1480 1490 1500 LDQIGNMTSS QRRSKKEQVP SGAELERQQI LQEMRKRTPL HNDNSWIRQR SASVNKEPVS 1510 1520 1530 1540 1550 1560 LPGIMRRGES LDNLDSPRSN SWRQPPWLNQ PTGFYASSSV QDFSRPPPQL VSTSNRAYMR 1570 1580 1590 1600 1610 NPSSSVPPPS AGSVKTSTTG VATTQSPTPR SHSPSASQSG SQLRNSWTAN RHVM

References

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[1]	"A genomic map of a 6-Mb region at 13q21-q22 implicated in cancer development: identification and characterization of candidate genes." Rozenblum E., Vahteristo P., Sandberg T., Bergthorsson J.T., Syrjakoski K., Weaver D., Haraldsson K., Johannsdottir H.K., Vehmanen P., Nigam S., Golberger N., Robbins C., Pak E., Dutra A., Gillander E., Stephan D.A., Bailey-Wilson J., Juo S.-H.H. , Kainu T., Arason A., Barkardottir R.B., Nevanlinna H., Borg A., Kallioniemi O.-P. Hum. Genet. 110:111-121(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), TISSUE SPECIFICITY. Tissue: Brain and Peripheral blood leukocyte.
[2]	"The DNA sequence and analysis of human chromosome 13." Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T. Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 123-1349 (ISOFORM 2). Tissue: Brain.
[4]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SEQUENCE REVISION.
[5]	"Identification of a family of human F-box proteins." Cenciarelli C., Chiaur D.S., Guardavaccaro D., Parks W., Vidal M., Pagano M. Curr. Biol. 9:1177-1179(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 504-758 (ISOFORM 2).
[6]	"LOMP, a novel protein that contains a single LIM domain and PDZ domain." Mu W., Burt D.R. Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 763-1683 (ISOFORM 2). Tissue: Brain.
[7]	"Analysis of a human cDNA containing a tissue-specific alternatively spliced LIM domain." Putilina T., Jaworski C., Gentleman S., McDonald B., Kadiri M., Wong P. Biochem. Biophys. Res. Commun. 252:433-439(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 1343-1683 (ISOFORM 3), ALTERNATIVE SPLICING (ISOFORMS 2; 3 AND 4), TISSUE SPECIFICITY. Tissue: Pancreas.
[8]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-246; SER-1026 AND SER-1510, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"A probability-based approach for high-throughput protein phosphorylation analysis and site localization." Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P. Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-867; THR-949; THR-1048 AND SER-1586, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-342 (ISOFORM 3), MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[10]	"Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra." Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D. J. Proteome Res. 6:4150-4162(2007) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[11]	"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[12]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-873 AND SER-1510, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[13]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-246; SER-276; SER-709; SER-867; SER-873; SER-895; THR-913; SER-919; SER-926; THR-932; SER-988; SER-991; SER-995; SER-1026; SER-1044; THR-1048; SER-1423; SER-1563; SER-1586; SER-1593; SER-1595; SER-1597 AND SER-1601, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-342 AND SER-345 (ISOFORM 3), MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[14]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-185; SER-704; SER-805; THR-956; SER-960; SER-988; SER-1026; SER-1423 AND SER-1586, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[15]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-246; SER-276; SER-704; SER-805; SER-867; SER-895; THR-913; SER-919; SER-960; SER-988; SER-991; SER-994; SER-1026; SER-1032; THR-1048; SER-1177; SER-1304; SER-1307; SER-1510; SER-1516; SER-1593 AND SER-1601, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-342 AND SER-345 (ISOFORM 3), MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[16]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[17]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-246; SER-704; SER-751; SER-805; THR-1048; SER-1423 AND SER-1510, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-342 (ISOFORM 3), MASS SPECTROMETRY.
[18]	"Crystal structure of PDZ domain of KIAA0858 (LIM), ms0793 from homo sapiens." RIKEN structural genomics initiative (RSGI) Submitted (JUL-2007) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (1.46 ANGSTROMS) OF 1037-1126.
[19]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] ALA-354 AND MET-785.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF330045 mRNA. Translation: AAL37480.1.
AL137244 , AL137121, AL137782, AL359392 Genomic DNA. Translation: CAI12422.1.
AL137121 , AL137244, AL137782, AL359392 Genomic DNA. Translation: CAI39480.1.
AL137782 , AL137121, AL137244, AL359392 Genomic DNA. Translation: CAI40007.1.
AL359392 , AL137121, AL137244, AL137782 Genomic DNA. Translation: CAI40209.1.
AB020665 mRNA. Translation: BAA74881.2. Sequence problems.
AF174600 mRNA. Translation: AAF04521.1.
AF144237 mRNA. Translation: AAD33924.1. Sequence problems.
U90654 mRNA. Translation: AAB86592.1.
AF092557 , AF092554, AF092555, AF092556 Genomic DNA. Translation: AAC96299.1. Different initiation.
AF092557, AF092554 Genomic DNA. Translation: AAC96300.1. Different initiation.

IPI

IPI00291802.
IPI00409590.
IPI00409591.
IPI00409593.

PIR

JE0325.

RefSeq

NP_005349.3. NM_005358.5.
NP_056667.2. NM_015842.2.

UniGene

Hs.207631.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2EAQ	X-ray	1.46	A	1037-1126	[»]

ProteinModelPortal

Q8WWI1.

SMR

Q8WWI1. Positions 86-158, 1037-1125.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-33107N.

IntAct

Q8WWI1. 8 interactions.

MINT

MINT-3047522.

STRING

9606.ENSP00000342112.

PTM databases

PhosphoSite

Q8WWI1.

Polymorphism databases

DMDM

308153585.

Proteomic databases

PaxDb

Q8WWI1.

PRIDE

Q8WWI1.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000341547; ENSP00000342112; ENSG00000136153.

GeneID

4008.

KEGG

hsa:4008.

UCSC

uc010thv.2. human.

Organism-specific databases

CTD

4008.

GeneCards

GC13P076194.

HGNC

HGNC:6646. LMO7.

HPA

HPA020923.

MIM

604362. gene.

neXtProt

NX_Q8WWI1.

PharmGKB

PA30412.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG241186.

HOVERGEN

HBG049143.

InParanoid

Q8WWI1.

KO

K06084.

OrthoDB

EOG49GKFQ.

Gene expression databases

ArrayExpress

Q8WWI1.

Bgee

Q8WWI1.

CleanEx

HS_LMO7.

Genevestigator

Q8WWI1.

GermOnline

ENSG00000136153. Homo sapiens.

Family and domain databases

Gene3D

1.10.418.10. 1 hit.
2.10.110.10. 1 hit.

InterPro

IPR001715. CH-domain.
IPR001478. PDZ.
IPR003096. SM22_calponin.
IPR001781. Znf_LIM.
[Graphical view]

Pfam

PF00307. CH. 1 hit.
PF00412. LIM. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view]

PRINTS

PR00888. SM22CALPONIN.

SMART

SM00033. CH. 1 hit.
SM00132. LIM. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view]

SUPFAM

SSF47576. Calponin-homology. 1 hit.
SSF50156. PDZ. 1 hit.

PROSITE

PS50021. CH. 1 hit.
PS00478. LIM_DOMAIN_1. 1 hit.
PS50023. LIM_DOMAIN_2. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

LMO7. human.

EvolutionaryTrace

Q8WWI1.

GenomeRNAi

4008.

NextBio

15720.

PMAP-CutDB

Q5TBK6.

SOURCE

Search...

Entry information

Entry name

LMO7_HUMAN

Accession

Primary (citable) accession number: Q8WWI1
Secondary accession number(s): O15462 , O95346, Q5TBK6, Q9UKC1, Q9UQM5, Q9Y6A7

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2004
Last sequence update:	October 5, 2010
Last modified:	May 1, 2013
This is version 112 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.