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Q8WWI1

- LMO7_HUMAN

UniProt

Q8WWI1 - LMO7_HUMAN

Protein

LIM domain only protein 7

Gene

LMO7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 126 (01 Oct 2014)
      Sequence version 3 (05 Oct 2010)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. ubiquitin-protein transferase activity Source: UniProtKB
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. protein ubiquitination Source: UniProtKB
    2. single organismal cell-cell adhesion Source: Ensembl

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    LIM domain only protein 7
    Short name:
    LMO-7
    Alternative name(s):
    F-box only protein 20
    LOMP
    Gene namesi
    Name:LMO7
    Synonyms:FBX20, FBXO20, KIAA0858
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 13

    Organism-specific databases

    HGNCiHGNC:6646. LMO7.

    Subcellular locationi

    GO - Cellular componenti

    1. apical plasma membrane Source: Ensembl
    2. cell-cell adherens junction Source: Ensembl
    3. cytoplasm Source: ProtInc
    4. nucleus Source: ProtInc
    5. ubiquitin ligase complex Source: UniProtKB

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30412.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 16831683LIM domain only protein 7PRO_0000075824Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei185 – 1851Phosphotyrosine1 Publication
    Modified residuei246 – 2461Phosphoserine4 Publications
    Modified residuei276 – 2761Phosphoserine2 Publications
    Modified residuei704 – 7041Phosphoserine3 Publications
    Modified residuei709 – 7091Phosphoserine1 Publication
    Modified residuei751 – 7511Phosphoserine1 Publication
    Modified residuei805 – 8051Phosphoserine3 Publications
    Modified residuei867 – 8671Phosphoserine3 Publications
    Modified residuei873 – 8731Phosphoserine2 Publications
    Modified residuei895 – 8951Phosphoserine2 Publications
    Modified residuei913 – 9131Phosphothreonine2 Publications
    Modified residuei919 – 9191Phosphoserine2 Publications
    Modified residuei926 – 9261Phosphoserine1 Publication
    Modified residuei932 – 9321Phosphothreonine1 Publication
    Modified residuei949 – 9491Phosphothreonine1 Publication
    Modified residuei956 – 9561Phosphothreonine1 Publication
    Modified residuei960 – 9601Phosphoserine2 Publications
    Modified residuei988 – 9881Phosphoserine3 Publications
    Modified residuei991 – 9911Phosphoserine2 Publications
    Modified residuei994 – 9941Phosphoserine1 Publication
    Modified residuei995 – 9951Phosphoserine1 Publication
    Modified residuei1026 – 10261Phosphoserine4 Publications
    Modified residuei1032 – 10321Phosphoserine1 Publication
    Modified residuei1044 – 10441Phosphoserine1 Publication
    Modified residuei1048 – 10481Phosphothreonine4 Publications
    Modified residuei1177 – 11771Phosphoserine1 Publication
    Modified residuei1304 – 13041Phosphoserine1 Publication
    Modified residuei1307 – 13071Phosphoserine1 Publication
    Modified residuei1423 – 14231Phosphoserine3 Publications
    Modified residuei1510 – 15101Phosphoserine4 Publications
    Modified residuei1516 – 15161Phosphoserine1 Publication
    Modified residuei1563 – 15631Phosphoserine1 Publication
    Modified residuei1586 – 15861Phosphoserine3 Publications
    Modified residuei1593 – 15931Phosphoserine2 Publications
    Modified residuei1595 – 15951Phosphoserine1 Publication
    Modified residuei1597 – 15971Phosphoserine1 Publication
    Modified residuei1601 – 16011Phosphoserine2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ8WWI1.
    PaxDbiQ8WWI1.
    PRIDEiQ8WWI1.

    PTM databases

    PhosphoSiteiQ8WWI1.

    Miscellaneous databases

    PMAP-CutDBQ5TBK6.

    Expressioni

    Tissue specificityi

    Widely expressed. Isoform 2 and isoform 4 are predominantly expressed in brain.2 Publications

    Gene expression databases

    ArrayExpressiQ8WWI1.
    BgeeiQ8WWI1.
    CleanExiHS_LMO7.
    GenevestigatoriQ8WWI1.

    Organism-specific databases

    HPAiHPA020923.
    HPA050184.

    Interactioni

    Protein-protein interaction databases

    BioGridi110193. 19 interactions.
    DIPiDIP-33107N.
    IntActiQ8WWI1. 11 interactions.
    MINTiMINT-3047522.
    STRINGi9606.ENSP00000342112.

    Structurei

    Secondary structure

    1
    1683
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi1038 – 10469
    Beta strandi1056 – 10627
    Beta strandi1065 – 10717
    Helixi1076 – 10794
    Beta strandi1087 – 10915
    Helixi1101 – 111414
    Beta strandi1116 – 11249

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2EAQX-ray1.46A1037-1126[»]
    ProteinModelPortaliQ8WWI1.
    SMRiQ8WWI1. Positions 86-158, 1037-1125, 1633-1675.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ8WWI1.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini54 – 168115CHPROSITE-ProRule annotationAdd
    BLAST
    Domaini1042 – 112887PDZPROSITE-ProRule annotationAdd
    BLAST
    Domaini1612 – 167867LIM zinc-bindingPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 CH (calponin-homology) domain.PROSITE-ProRule annotation
    Contains 1 LIM zinc-binding domain.PROSITE-ProRule annotation
    Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    LIM domain

    Phylogenomic databases

    eggNOGiNOG241186.
    HOVERGENiHBG049143.
    InParanoidiQ8WWI1.
    KOiK06084.
    OrthoDBiEOG79SDWD.
    PhylomeDBiQ8WWI1.

    Family and domain databases

    Gene3Di1.10.418.10. 1 hit.
    2.10.110.10. 1 hit.
    2.30.42.10. 1 hit.
    InterProiIPR001715. CH-domain.
    IPR001478. PDZ.
    IPR003096. SM22_calponin.
    IPR001781. Znf_LIM.
    [Graphical view]
    PfamiPF00307. CH. 1 hit.
    PF00412. LIM. 1 hit.
    PF00595. PDZ. 1 hit.
    [Graphical view]
    PRINTSiPR00888. SM22CALPONIN.
    SMARTiSM00033. CH. 1 hit.
    SM00132. LIM. 1 hit.
    SM00228. PDZ. 1 hit.
    [Graphical view]
    SUPFAMiSSF47576. SSF47576. 1 hit.
    SSF50156. SSF50156. 1 hit.
    PROSITEiPS50021. CH. 1 hit.
    PS00478. LIM_DOMAIN_1. 1 hit.
    PS50023. LIM_DOMAIN_2. 1 hit.
    PS50106. PDZ. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8WWI1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKKIRICHIF TFYSWMSYDV LFQRTELGAL EIWRQLICAH VCICVGWLYL     50
    RDRVCSKKDI ILRTEQNSGR TILIKAVTEK NFETKDFRAS LENGVLLCDL 100
    INKLKPGVIK KINRLSTPIA GLDNINVFLK ACEQIGLKEA QLFHPGDLQD 150
    LSNRVTVKQE ETDRRVKNVL ITLYWLGRKA QSNPYYNGPH LNLKAFENLL 200
    GQALTKALED SSFLKRSGRD SGYGDIWCPE RGEFLAPPRH HKREDSFESL 250
    DSLGSRSLTS CSSDITLRGG REGFESDTDS EFTFKMQDYN KDDMSYRRIS 300
    AVEPKTALPF NRFLPNKSRQ PSYVPAPLRK KKPDKHEDNR RSWASPVYTE 350
    ADGTFSSNQR RIWGTNVENW PTVQGTSKSS CYLEEEKAKT RSIPNIVKDD 400
    LYVRKLSPVM PNPGNAFDQF LPKCWTPEDV NWKRIKRETY KPWYKEFQGF 450
    SQFLLLQALQ TYSDDILSSE THTKIDPTSG PRLITRRKNL SYAPGYRRDD 500
    LEMAALDPDL ENDDFFVRKT GVFHANPYVL RAFEDFRKFS EQDDSVERDI 550
    ILQCREGELV LPDLEKDDMI VRRIPAQKKE VPLSGAPDRY HPVPFPEPWT 600
    LPPEIQAKFL CVFERTCPSK EKSNSCRILV PSYRQKKDDM LTRKIQSWKL 650
    GTTVPPISFT PGPCSEADLK RWEAIREASR LRHKKRLMVE RLFQKIYGEN 700
    GSKSMSDVSA EDVQNLRQLR YEEMQKIKSQ LKEQDQKWQD DLAKWKDRRK 750
    SYTSDLQKKK EEREEIEKQA LEKSKRSSKT FKEMLQDRES QNQKSTVPSR 800
    RRMYSFDDVL EEGKRPPTMT VSEASYQSER VEEKGATYPS EIPKEDSTTF 850
    AKREDRVTTE IQLPSQSPVE EQSPASLSSL RSRSTQMEST RVSASLPRSY 900
    RKTDTVRLTS VVTPRPFGSQ TRGISSLPRS YTMDDAWKYN GDVEDIKRTP 950
    NNVVSTPAPS PDASQLASSL SSQKEVAATE EDVTRLPSPT SPFSSLSQDQ 1000
    AATSKATLSS TSGLDLMSES GEGEISPQRE VSRSQDQFSD MRISINQTPG 1050
    KSLDFGFTIK WDIPGIFVAS VEAGSPAEFS QLQVDDEIIA INNTKFSYND 1100
    SKEWEEAMAK AQETGHLVMD VRRYGKAGSP ETKWIDATSG IYNSEKSSNL 1150
    SVTTDFSESL QSSNIESKEI NGIHDESNAF ESKASESISL KNLKRRSQFF 1200
    EQGSSDSVVP DLPVPTISAP SRWVWDQEEE RKRQERWQKE QDRLLQEKYQ 1250
    REQEKLREEW QRAKQEAERE NSKYLDEELM VLSSNSMSLT TREPSLATWE 1300
    ATWSEGSKSS DREGTRAGEE ERRQPQEEVV HEDQGKKPQD QLVIERERKW 1350
    EQQLQEEQEQ KRLQAEAEEQ KRPAEEQKRQ AEIERETSVR IYQYRRPVDS 1400
    YDIPKTEEAS SGFLPGDRNK SRSTTELDDY STNKNGNNKY LDQIGNMTSS 1450
    QRRSKKEQVP SGAELERQQI LQEMRKRTPL HNDNSWIRQR SASVNKEPVS 1500
    LPGIMRRGES LDNLDSPRSN SWRQPPWLNQ PTGFYASSSV QDFSRPPPQL 1550
    VSTSNRAYMR NPSSSVPPPS AGSVKTSTTG VATTQSPTPR SHSPSASQSG 1600
    SQLRNRSVSG KRICSYCNNI LGKGAAMIIE SLGLCYHLHC FKCVACECDL 1650
    GGSSSGAEVR IRNHQLYCND CYLRFKSGRP TAM 1683

    Note: No experimental confirmation available.

    Length:1,683
    Mass (Da):192,696
    Last modified:October 5, 2010 - v3
    Checksum:i3E79B2AEAC67F6F5
    GO
    Isoform 2 (identifier: Q8WWI1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1606-1683: RSVSGKRICS...RFKSGRPTAM → SVLPVSVTSE...EEVVAAHVDL

    Show »
    Length:1,670
    Mass (Da):190,876
    Checksum:iFC84DAB0587D1AB6
    GO
    Isoform 3 (identifier: Q8WWI1-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         357-690: Missing.

    Note: Contains a phosphoserine at position 342. Contains a phosphoserine at position 345.

    Show »
    Length:1,349
    Mass (Da):153,670
    Checksum:iE5A0EBC6A4894751
    GO
    Isoform 4 (identifier: Q8WWI1-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1606-1683: RSVSGKRICS...RFKSGRPTAM → SWTANRHVM

    Show »
    Length:1,614
    Mass (Da):185,216
    Checksum:iE0212DE11E059A39
    GO
    Isoform 5 (identifier: Q8WWI1-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-285: Missing.
         1606-1670: RSVSGKRICS...IRNHQLYCND → SVLPVSVTSE...EEVVAAHVDL
         1671-1683: Missing.

    Show »
    Length:1,385
    Mass (Da):158,265
    Checksum:iBD1DCE8F29152AFC
    GO

    Sequence cautioni

    The sequence AAD33924.1 differs from that shown. Reason: Frameshift at position 855.
    The sequence AAC96299.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
    The sequence AAC96300.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti522 – 5221V → A in AAF04521. (PubMed:10531035)Curated
    Sequence conflicti613 – 6131F → L in AAF04521. (PubMed:10531035)Curated
    Sequence conflicti891 – 8911R → C in AAD33924. 1 PublicationCurated
    Sequence conflicti943 – 9431V → I in AAL37480. (PubMed:11935316)Curated
    Sequence conflicti943 – 9431V → I in AAD33924. 1 PublicationCurated
    Sequence conflicti1447 – 14471M → T in AAD33924. 1 PublicationCurated
    Sequence conflicti1447 – 14471M → T in AAB86592. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti354 – 3541T → A in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_036189
    Natural varianti785 – 7851L → M in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_036190
    Natural varianti1547 – 15471P → Q.
    Corresponds to variant rs7988661 [ dbSNP | Ensembl ].
    VAR_056163

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 285285Missing in isoform 5. 1 PublicationVSP_055683Add
    BLAST
    Alternative sequencei357 – 690334Missing in isoform 3. 2 PublicationsVSP_009718Add
    BLAST
    Alternative sequencei1606 – 168378RSVSG…RPTAM → SVLPVSVTSEALPQELKSGS ETTNCTATTAISDSNLDGQP PCDVSLHTKALLQIEEEVVA AHVDL in isoform 2. 2 PublicationsVSP_009719Add
    BLAST
    Alternative sequencei1606 – 168378RSVSG…RPTAM → SWTANRHVM in isoform 4. CuratedVSP_009720Add
    BLAST
    Alternative sequencei1606 – 167065RSVSG…LYCND → SVLPVSVTSEALPQELKSGS ETTNCTATTAISDSNLDGQP PCDVSLHTKALLQIEEEVVA AHVDL in isoform 5. 1 PublicationVSP_055684Add
    BLAST
    Alternative sequencei1671 – 168313Missing in isoform 5. 1 PublicationVSP_055685Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF330045 mRNA. Translation: AAL37480.1.
    AL137244
    , AL137121, AL137782, AL359392 Genomic DNA. Translation: CAI12422.1.
    AL137121
    , AL137244, AL137782, AL359392 Genomic DNA. Translation: CAI39480.1.
    AL137782
    , AL137121, AL137244, AL359392 Genomic DNA. Translation: CAI40007.1.
    AL359392
    , AL137121, AL137244, AL137782 Genomic DNA. Translation: CAI40209.1.
    AB020665 mRNA. Translation: BAA74881.2.
    AF174600 mRNA. Translation: AAF04521.1.
    AF144237 mRNA. Translation: AAD33924.1. Sequence problems.
    U90654 mRNA. Translation: AAB86592.1.
    AF092557
    , AF092554, AF092555, AF092556 Genomic DNA. Translation: AAC96299.1. Different initiation.
    AF092557, AF092554 Genomic DNA. Translation: AAC96300.1. Different initiation.
    CCDSiCCDS9454.1. [Q8WWI1-3]
    PIRiJE0325.
    RefSeqiNP_005349.3. NM_005358.5. [Q8WWI1-3]
    NP_056667.2. NM_015842.2.
    UniGeneiHs.207631.

    Genome annotation databases

    EnsembliENST00000341547; ENSP00000342112; ENSG00000136153. [Q8WWI1-3]
    GeneIDi4008.
    KEGGihsa:4008.
    UCSCiuc010thv.2. human. [Q8WWI1-3]

    Polymorphism databases

    DMDMi308153585.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF330045 mRNA. Translation: AAL37480.1 .
    AL137244
    , AL137121 , AL137782 , AL359392 Genomic DNA. Translation: CAI12422.1 .
    AL137121
    , AL137244 , AL137782 , AL359392 Genomic DNA. Translation: CAI39480.1 .
    AL137782
    , AL137121 , AL137244 , AL359392 Genomic DNA. Translation: CAI40007.1 .
    AL359392
    , AL137121 , AL137244 , AL137782 Genomic DNA. Translation: CAI40209.1 .
    AB020665 mRNA. Translation: BAA74881.2 .
    AF174600 mRNA. Translation: AAF04521.1 .
    AF144237 mRNA. Translation: AAD33924.1 . Sequence problems.
    U90654 mRNA. Translation: AAB86592.1 .
    AF092557
    , AF092554 , AF092555 , AF092556 Genomic DNA. Translation: AAC96299.1 . Different initiation.
    AF092557 , AF092554 Genomic DNA. Translation: AAC96300.1 . Different initiation.
    CCDSi CCDS9454.1. [Q8WWI1-3 ]
    PIRi JE0325.
    RefSeqi NP_005349.3. NM_005358.5. [Q8WWI1-3 ]
    NP_056667.2. NM_015842.2.
    UniGenei Hs.207631.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2EAQ X-ray 1.46 A 1037-1126 [» ]
    ProteinModelPortali Q8WWI1.
    SMRi Q8WWI1. Positions 86-158, 1037-1125, 1633-1675.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110193. 19 interactions.
    DIPi DIP-33107N.
    IntActi Q8WWI1. 11 interactions.
    MINTi MINT-3047522.
    STRINGi 9606.ENSP00000342112.

    PTM databases

    PhosphoSitei Q8WWI1.

    Polymorphism databases

    DMDMi 308153585.

    Proteomic databases

    MaxQBi Q8WWI1.
    PaxDbi Q8WWI1.
    PRIDEi Q8WWI1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000341547 ; ENSP00000342112 ; ENSG00000136153 . [Q8WWI1-3 ]
    GeneIDi 4008.
    KEGGi hsa:4008.
    UCSCi uc010thv.2. human. [Q8WWI1-3 ]

    Organism-specific databases

    CTDi 4008.
    GeneCardsi GC13P076194.
    HGNCi HGNC:6646. LMO7.
    HPAi HPA020923.
    HPA050184.
    MIMi 604362. gene.
    neXtProti NX_Q8WWI1.
    PharmGKBi PA30412.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG241186.
    HOVERGENi HBG049143.
    InParanoidi Q8WWI1.
    KOi K06084.
    OrthoDBi EOG79SDWD.
    PhylomeDBi Q8WWI1.

    Miscellaneous databases

    ChiTaRSi LMO7. human.
    EvolutionaryTracei Q8WWI1.
    GeneWikii LMO7.
    GenomeRNAii 4008.
    NextBioi 15720.
    PMAP-CutDB Q5TBK6.
    PROi Q8WWI1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8WWI1.
    Bgeei Q8WWI1.
    CleanExi HS_LMO7.
    Genevestigatori Q8WWI1.

    Family and domain databases

    Gene3Di 1.10.418.10. 1 hit.
    2.10.110.10. 1 hit.
    2.30.42.10. 1 hit.
    InterProi IPR001715. CH-domain.
    IPR001478. PDZ.
    IPR003096. SM22_calponin.
    IPR001781. Znf_LIM.
    [Graphical view ]
    Pfami PF00307. CH. 1 hit.
    PF00412. LIM. 1 hit.
    PF00595. PDZ. 1 hit.
    [Graphical view ]
    PRINTSi PR00888. SM22CALPONIN.
    SMARTi SM00033. CH. 1 hit.
    SM00132. LIM. 1 hit.
    SM00228. PDZ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47576. SSF47576. 1 hit.
    SSF50156. SSF50156. 1 hit.
    PROSITEi PS50021. CH. 1 hit.
    PS00478. LIM_DOMAIN_1. 1 hit.
    PS50023. LIM_DOMAIN_2. 1 hit.
    PS50106. PDZ. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), TISSUE SPECIFICITY.
      Tissue: Brain and Peripheral blood leukocyte.
    2. "The DNA sequence and analysis of human chromosome 13."
      Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
      Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
      Tissue: Brain.
    4. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
      Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
      DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION.
    5. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 504-758 (ISOFORM 2).
    6. "LOMP, a novel protein that contains a single LIM domain and PDZ domain."
      Mu W., Burt D.R.
      Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 763-1683 (ISOFORM 2).
      Tissue: Brain.
    7. "Analysis of a human cDNA containing a tissue-specific alternatively spliced LIM domain."
      Putilina T., Jaworski C., Gentleman S., McDonald B., Kadiri M., Wong P.
      Biochem. Biophys. Res. Commun. 252:433-439(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 1343-1683 (ISOFORM 3), ALTERNATIVE SPLICING (ISOFORMS 2; 3 AND 4), TISSUE SPECIFICITY.
      Tissue: Pancreas.
    8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-246; SER-1026 AND SER-1510, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
      Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
      Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-867; THR-949; THR-1048 AND SER-1586, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-342 (ISOFORM 3), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."
      Yu L.R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.
      J. Proteome Res. 6:4150-4162(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
      J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-873 AND SER-1510, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    13. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-246; SER-276; SER-709; SER-867; SER-873; SER-895; THR-913; SER-919; SER-926; THR-932; SER-988; SER-991; SER-995; SER-1026; SER-1044; THR-1048; SER-1423; SER-1563; SER-1586; SER-1593; SER-1595; SER-1597 AND SER-1601, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-342 AND SER-345 (ISOFORM 3), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    14. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-185; SER-704; SER-805; THR-956; SER-960; SER-988; SER-1026; SER-1423 AND SER-1586, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-246; SER-276; SER-704; SER-805; SER-867; SER-895; THR-913; SER-919; SER-960; SER-988; SER-991; SER-994; SER-1026; SER-1032; THR-1048; SER-1177; SER-1304; SER-1307; SER-1510; SER-1516; SER-1593 AND SER-1601, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-342 AND SER-345 (ISOFORM 3), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    16. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    17. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-246; SER-704; SER-751; SER-805; THR-1048; SER-1423 AND SER-1510, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-342 (ISOFORM 3), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    18. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    19. "Crystal structure of PDZ domain of KIAA0858 (LIM), ms0793 from homo sapiens."
      RIKEN structural genomics initiative (RSGI)
      Submitted (JUL-2007) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.46 ANGSTROMS) OF 1037-1126.
    20. Cited for: VARIANTS [LARGE SCALE ANALYSIS] ALA-354 AND MET-785.

    Entry informationi

    Entry nameiLMO7_HUMAN
    AccessioniPrimary (citable) accession number: Q8WWI1
    Secondary accession number(s): E9PLH4
    , O15462, O95346, Q5TBK6, Q9UKC1, Q9UQM5, Q9Y6A7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2004
    Last sequence update: October 5, 2010
    Last modified: October 1, 2014
    This is version 126 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 13
      Human chromosome 13: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3