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Protein

LIM domain only protein 7

Gene

LMO7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. ubiquitin-protein transferase activity Source: UniProtKB
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. protein ubiquitination Source: UniProtKB
  2. regulation of cell adhesion Source: InterPro
  3. regulation of signaling Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
LIM domain only protein 7
Short name:
LMO-7
Alternative name(s):
F-box only protein 20
LOMP
Gene namesi
Name:LMO7
Synonyms:FBX20, FBXO20, KIAA0858
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:6646. LMO7.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: ProtInc
  2. focal adhesion Source: UniProtKB
  3. nucleus Source: ProtInc
  4. ubiquitin ligase complex Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30412.

Polymorphism and mutation databases

BioMutaiLMO7.
DMDMi308153585.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 16831683LIM domain only protein 7PRO_0000075824Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei185 – 1851Phosphotyrosine1 Publication
Modified residuei246 – 2461Phosphoserine4 Publications
Modified residuei276 – 2761Phosphoserine2 Publications
Modified residuei342 – 3421Phosphoserine1 Publication
Modified residuei704 – 7041Phosphoserine4 Publications
Modified residuei709 – 7091Phosphoserine1 Publication
Modified residuei751 – 7511Phosphoserine1 Publication
Modified residuei805 – 8051Phosphoserine3 Publications
Modified residuei867 – 8671Phosphoserine4 Publications
Modified residuei873 – 8731Phosphoserine2 Publications
Modified residuei879 – 8791Phosphoserine1 Publication
Modified residuei895 – 8951Phosphoserine2 Publications
Modified residuei913 – 9131Phosphothreonine2 Publications
Modified residuei919 – 9191Phosphoserine2 Publications
Modified residuei926 – 9261Phosphoserine1 Publication
Modified residuei932 – 9321Phosphothreonine1 Publication
Modified residuei949 – 9491Phosphothreonine1 Publication
Modified residuei956 – 9561Phosphothreonine1 Publication
Modified residuei960 – 9601Phosphoserine2 Publications
Modified residuei988 – 9881Phosphoserine4 Publications
Modified residuei991 – 9911Phosphoserine3 Publications
Modified residuei994 – 9941Phosphoserine1 Publication
Modified residuei995 – 9951Phosphoserine1 Publication
Modified residuei1026 – 10261Phosphoserine5 Publications
Modified residuei1032 – 10321Phosphoserine1 Publication
Modified residuei1044 – 10441Phosphoserine1 Publication
Modified residuei1048 – 10481Phosphothreonine4 Publications
Modified residuei1177 – 11771Phosphoserine1 Publication
Modified residuei1304 – 13041Phosphoserine1 Publication
Modified residuei1307 – 13071Phosphoserine1 Publication
Modified residuei1423 – 14231Phosphoserine3 Publications
Modified residuei1510 – 15101Phosphoserine5 Publications
Modified residuei1516 – 15161Phosphoserine1 Publication
Modified residuei1563 – 15631Phosphoserine1 Publication
Modified residuei1586 – 15861Phosphoserine4 Publications
Modified residuei1593 – 15931Phosphoserine3 Publications
Modified residuei1595 – 15951Phosphoserine1 Publication
Modified residuei1597 – 15971Phosphoserine1 Publication
Modified residuei1601 – 16011Phosphoserine2 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ8WWI1.
PaxDbiQ8WWI1.
PRIDEiQ8WWI1.

PTM databases

PhosphoSiteiQ8WWI1.

Miscellaneous databases

PMAP-CutDBQ5TBK6.

Expressioni

Tissue specificityi

Widely expressed. Isoform 2 and isoform 4 are predominantly expressed in brain.2 Publications

Gene expression databases

BgeeiQ8WWI1.
CleanExiHS_LMO7.
ExpressionAtlasiQ8WWI1. baseline and differential.
GenevestigatoriQ8WWI1.

Organism-specific databases

HPAiHPA020923.
HPA050184.

Interactioni

Protein-protein interaction databases

BioGridi110193. 20 interactions.
DIPiDIP-33107N.
IntActiQ8WWI1. 11 interactions.
MINTiMINT-3047522.
STRINGi9606.ENSP00000342112.

Structurei

Secondary structure

1
1683
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi1038 – 10469Combined sources
Beta strandi1056 – 10627Combined sources
Beta strandi1065 – 10717Combined sources
Helixi1076 – 10794Combined sources
Beta strandi1087 – 10915Combined sources
Helixi1101 – 111414Combined sources
Beta strandi1116 – 11249Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2EAQX-ray1.46A1037-1126[»]
ProteinModelPortaliQ8WWI1.
SMRiQ8WWI1. Positions 86-158, 1037-1125.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8WWI1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini54 – 168115CHPROSITE-ProRule annotationAdd
BLAST
Domaini1042 – 112887PDZPROSITE-ProRule annotationAdd
BLAST
Domaini1612 – 167867LIM zinc-bindingPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 CH (calponin-homology) domain.PROSITE-ProRule annotation
Contains 1 LIM zinc-binding domain.PROSITE-ProRule annotation
Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation

Keywords - Domaini

LIM domain

Phylogenomic databases

eggNOGiNOG241186.
GeneTreeiENSGT00530000063559.
HOVERGENiHBG049143.
InParanoidiQ8WWI1.
KOiK06084.
OrthoDBiEOG79SDWD.
PhylomeDBiQ8WWI1.

Family and domain databases

Gene3Di1.10.418.10. 1 hit.
2.10.110.10. 1 hit.
2.30.42.10. 1 hit.
InterProiIPR001715. CH-domain.
IPR029978. LMO-7.
IPR001478. PDZ.
IPR003096. SM22_calponin.
IPR001781. Znf_LIM.
[Graphical view]
PANTHERiPTHR15551:SF4. PTHR15551:SF4. 1 hit.
PfamiPF00307. CH. 1 hit.
PF00412. LIM. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view]
PRINTSiPR00888. SM22CALPONIN.
SMARTiSM00033. CH. 1 hit.
SM00132. LIM. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
SSF50156. SSF50156. 1 hit.
PROSITEiPS50021. CH. 1 hit.
PS00478. LIM_DOMAIN_1. 1 hit.
PS50023. LIM_DOMAIN_2. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WWI1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKKIRICHIF TFYSWMSYDV LFQRTELGAL EIWRQLICAH VCICVGWLYL
60 70 80 90 100
RDRVCSKKDI ILRTEQNSGR TILIKAVTEK NFETKDFRAS LENGVLLCDL
110 120 130 140 150
INKLKPGVIK KINRLSTPIA GLDNINVFLK ACEQIGLKEA QLFHPGDLQD
160 170 180 190 200
LSNRVTVKQE ETDRRVKNVL ITLYWLGRKA QSNPYYNGPH LNLKAFENLL
210 220 230 240 250
GQALTKALED SSFLKRSGRD SGYGDIWCPE RGEFLAPPRH HKREDSFESL
260 270 280 290 300
DSLGSRSLTS CSSDITLRGG REGFESDTDS EFTFKMQDYN KDDMSYRRIS
310 320 330 340 350
AVEPKTALPF NRFLPNKSRQ PSYVPAPLRK KKPDKHEDNR RSWASPVYTE
360 370 380 390 400
ADGTFSSNQR RIWGTNVENW PTVQGTSKSS CYLEEEKAKT RSIPNIVKDD
410 420 430 440 450
LYVRKLSPVM PNPGNAFDQF LPKCWTPEDV NWKRIKRETY KPWYKEFQGF
460 470 480 490 500
SQFLLLQALQ TYSDDILSSE THTKIDPTSG PRLITRRKNL SYAPGYRRDD
510 520 530 540 550
LEMAALDPDL ENDDFFVRKT GVFHANPYVL RAFEDFRKFS EQDDSVERDI
560 570 580 590 600
ILQCREGELV LPDLEKDDMI VRRIPAQKKE VPLSGAPDRY HPVPFPEPWT
610 620 630 640 650
LPPEIQAKFL CVFERTCPSK EKSNSCRILV PSYRQKKDDM LTRKIQSWKL
660 670 680 690 700
GTTVPPISFT PGPCSEADLK RWEAIREASR LRHKKRLMVE RLFQKIYGEN
710 720 730 740 750
GSKSMSDVSA EDVQNLRQLR YEEMQKIKSQ LKEQDQKWQD DLAKWKDRRK
760 770 780 790 800
SYTSDLQKKK EEREEIEKQA LEKSKRSSKT FKEMLQDRES QNQKSTVPSR
810 820 830 840 850
RRMYSFDDVL EEGKRPPTMT VSEASYQSER VEEKGATYPS EIPKEDSTTF
860 870 880 890 900
AKREDRVTTE IQLPSQSPVE EQSPASLSSL RSRSTQMEST RVSASLPRSY
910 920 930 940 950
RKTDTVRLTS VVTPRPFGSQ TRGISSLPRS YTMDDAWKYN GDVEDIKRTP
960 970 980 990 1000
NNVVSTPAPS PDASQLASSL SSQKEVAATE EDVTRLPSPT SPFSSLSQDQ
1010 1020 1030 1040 1050
AATSKATLSS TSGLDLMSES GEGEISPQRE VSRSQDQFSD MRISINQTPG
1060 1070 1080 1090 1100
KSLDFGFTIK WDIPGIFVAS VEAGSPAEFS QLQVDDEIIA INNTKFSYND
1110 1120 1130 1140 1150
SKEWEEAMAK AQETGHLVMD VRRYGKAGSP ETKWIDATSG IYNSEKSSNL
1160 1170 1180 1190 1200
SVTTDFSESL QSSNIESKEI NGIHDESNAF ESKASESISL KNLKRRSQFF
1210 1220 1230 1240 1250
EQGSSDSVVP DLPVPTISAP SRWVWDQEEE RKRQERWQKE QDRLLQEKYQ
1260 1270 1280 1290 1300
REQEKLREEW QRAKQEAERE NSKYLDEELM VLSSNSMSLT TREPSLATWE
1310 1320 1330 1340 1350
ATWSEGSKSS DREGTRAGEE ERRQPQEEVV HEDQGKKPQD QLVIERERKW
1360 1370 1380 1390 1400
EQQLQEEQEQ KRLQAEAEEQ KRPAEEQKRQ AEIERETSVR IYQYRRPVDS
1410 1420 1430 1440 1450
YDIPKTEEAS SGFLPGDRNK SRSTTELDDY STNKNGNNKY LDQIGNMTSS
1460 1470 1480 1490 1500
QRRSKKEQVP SGAELERQQI LQEMRKRTPL HNDNSWIRQR SASVNKEPVS
1510 1520 1530 1540 1550
LPGIMRRGES LDNLDSPRSN SWRQPPWLNQ PTGFYASSSV QDFSRPPPQL
1560 1570 1580 1590 1600
VSTSNRAYMR NPSSSVPPPS AGSVKTSTTG VATTQSPTPR SHSPSASQSG
1610 1620 1630 1640 1650
SQLRNRSVSG KRICSYCNNI LGKGAAMIIE SLGLCYHLHC FKCVACECDL
1660 1670 1680
GGSSSGAEVR IRNHQLYCND CYLRFKSGRP TAM

Note: No experimental confirmation available.

Length:1,683
Mass (Da):192,696
Last modified:October 5, 2010 - v3
Checksum:i3E79B2AEAC67F6F5
GO
Isoform 2 (identifier: Q8WWI1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1606-1683: RSVSGKRICS...RFKSGRPTAM → SVLPVSVTSE...EEVVAAHVDL

Show »
Length:1,670
Mass (Da):190,876
Checksum:iFC84DAB0587D1AB6
GO
Isoform 3 (identifier: Q8WWI1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     357-690: Missing.

Note: Contains a phosphoserine at position 342. Contains a phosphoserine at position 345.4 Publications

Show »
Length:1,349
Mass (Da):153,670
Checksum:iE5A0EBC6A4894751
GO
Isoform 4 (identifier: Q8WWI1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1606-1683: RSVSGKRICS...RFKSGRPTAM → SWTANRHVM

Show »
Length:1,614
Mass (Da):185,216
Checksum:iE0212DE11E059A39
GO
Isoform 5 (identifier: Q8WWI1-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-285: Missing.
     1606-1670: RSVSGKRICS...IRNHQLYCND → SVLPVSVTSE...EEVVAAHVDL
     1671-1683: Missing.

Note: Contains a N-acetylmethionine at position 1.1 Publication

Show »
Length:1,385
Mass (Da):158,265
Checksum:iBD1DCE8F29152AFC
GO

Sequence cautioni

The sequence AAC96299.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAC96300.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAD33924.1 differs from that shown. Reason: Frameshift at position 855. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti522 – 5221V → A in AAF04521 (PubMed:10531035).Curated
Sequence conflicti613 – 6131F → L in AAF04521 (PubMed:10531035).Curated
Sequence conflicti891 – 8911R → C in AAD33924 (Ref. 6) Curated
Sequence conflicti943 – 9431V → I in AAL37480 (PubMed:11935316).Curated
Sequence conflicti943 – 9431V → I in AAD33924 (Ref. 6) Curated
Sequence conflicti1447 – 14471M → T in AAD33924 (Ref. 6) Curated
Sequence conflicti1447 – 14471M → T in AAB86592 (Ref. 6) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti354 – 3541T → A in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_036189
Natural varianti785 – 7851L → M in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_036190
Natural varianti1547 – 15471P → Q.
Corresponds to variant rs7988661 [ dbSNP | Ensembl ].
VAR_056163

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 285285Missing in isoform 5. 1 PublicationVSP_055683Add
BLAST
Alternative sequencei357 – 690334Missing in isoform 3. 2 PublicationsVSP_009718Add
BLAST
Alternative sequencei1606 – 168378RSVSG…RPTAM → SVLPVSVTSEALPQELKSGS ETTNCTATTAISDSNLDGQP PCDVSLHTKALLQIEEEVVA AHVDL in isoform 2. 2 PublicationsVSP_009719Add
BLAST
Alternative sequencei1606 – 168378RSVSG…RPTAM → SWTANRHVM in isoform 4. CuratedVSP_009720Add
BLAST
Alternative sequencei1606 – 167065RSVSG…LYCND → SVLPVSVTSEALPQELKSGS ETTNCTATTAISDSNLDGQP PCDVSLHTKALLQIEEEVVA AHVDL in isoform 5. 1 PublicationVSP_055684Add
BLAST
Alternative sequencei1671 – 168313Missing in isoform 5. 1 PublicationVSP_055685Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF330045 mRNA. Translation: AAL37480.1.
AL137244
, AL137121, AL137782, AL359392 Genomic DNA. Translation: CAI12422.1.
AL137121
, AL137244, AL137782, AL359392 Genomic DNA. Translation: CAI39480.1.
AL137782
, AL137121, AL137244, AL359392 Genomic DNA. Translation: CAI40007.1.
AL359392
, AL137121, AL137244, AL137782 Genomic DNA. Translation: CAI40209.1.
AB020665 mRNA. Translation: BAA74881.2.
AF174600 mRNA. Translation: AAF04521.1.
AF144237 mRNA. Translation: AAD33924.1. Sequence problems.
U90654 mRNA. Translation: AAB86592.1.
AF092557
, AF092554, AF092555, AF092556 Genomic DNA. Translation: AAC96299.1. Different initiation.
AF092557, AF092554 Genomic DNA. Translation: AAC96300.1. Different initiation.
CCDSiCCDS53876.1. [Q8WWI1-5]
CCDS9454.1. [Q8WWI1-3]
PIRiJE0325.
RefSeqiNP_005349.3. NM_005358.5. [Q8WWI1-3]
NP_056667.2. NM_015842.2.
UniGeneiHs.207631.

Genome annotation databases

EnsembliENST00000341547; ENSP00000342112; ENSG00000136153. [Q8WWI1-3]
GeneIDi4008.
KEGGihsa:4008.
UCSCiuc001vjv.3. human.
uc010thv.2. human. [Q8WWI1-3]

Polymorphism and mutation databases

BioMutaiLMO7.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF330045 mRNA. Translation: AAL37480.1.
AL137244
, AL137121, AL137782, AL359392 Genomic DNA. Translation: CAI12422.1.
AL137121
, AL137244, AL137782, AL359392 Genomic DNA. Translation: CAI39480.1.
AL137782
, AL137121, AL137244, AL359392 Genomic DNA. Translation: CAI40007.1.
AL359392
, AL137121, AL137244, AL137782 Genomic DNA. Translation: CAI40209.1.
AB020665 mRNA. Translation: BAA74881.2.
AF174600 mRNA. Translation: AAF04521.1.
AF144237 mRNA. Translation: AAD33924.1. Sequence problems.
U90654 mRNA. Translation: AAB86592.1.
AF092557
, AF092554, AF092555, AF092556 Genomic DNA. Translation: AAC96299.1. Different initiation.
AF092557, AF092554 Genomic DNA. Translation: AAC96300.1. Different initiation.
CCDSiCCDS53876.1. [Q8WWI1-5]
CCDS9454.1. [Q8WWI1-3]
PIRiJE0325.
RefSeqiNP_005349.3. NM_005358.5. [Q8WWI1-3]
NP_056667.2. NM_015842.2.
UniGeneiHs.207631.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2EAQX-ray1.46A1037-1126[»]
ProteinModelPortaliQ8WWI1.
SMRiQ8WWI1. Positions 86-158, 1037-1125.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110193. 20 interactions.
DIPiDIP-33107N.
IntActiQ8WWI1. 11 interactions.
MINTiMINT-3047522.
STRINGi9606.ENSP00000342112.

PTM databases

PhosphoSiteiQ8WWI1.

Polymorphism and mutation databases

BioMutaiLMO7.
DMDMi308153585.

Proteomic databases

MaxQBiQ8WWI1.
PaxDbiQ8WWI1.
PRIDEiQ8WWI1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000341547; ENSP00000342112; ENSG00000136153. [Q8WWI1-3]
GeneIDi4008.
KEGGihsa:4008.
UCSCiuc001vjv.3. human.
uc010thv.2. human. [Q8WWI1-3]

Organism-specific databases

CTDi4008.
GeneCardsiGC13P076194.
HGNCiHGNC:6646. LMO7.
HPAiHPA020923.
HPA050184.
MIMi604362. gene.
neXtProtiNX_Q8WWI1.
PharmGKBiPA30412.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG241186.
GeneTreeiENSGT00530000063559.
HOVERGENiHBG049143.
InParanoidiQ8WWI1.
KOiK06084.
OrthoDBiEOG79SDWD.
PhylomeDBiQ8WWI1.

Miscellaneous databases

ChiTaRSiLMO7. human.
EvolutionaryTraceiQ8WWI1.
GeneWikiiLMO7.
GenomeRNAii4008.
NextBioi15720.
PMAP-CutDBQ5TBK6.
PROiQ8WWI1.
SOURCEiSearch...

Gene expression databases

BgeeiQ8WWI1.
CleanExiHS_LMO7.
ExpressionAtlasiQ8WWI1. baseline and differential.
GenevestigatoriQ8WWI1.

Family and domain databases

Gene3Di1.10.418.10. 1 hit.
2.10.110.10. 1 hit.
2.30.42.10. 1 hit.
InterProiIPR001715. CH-domain.
IPR029978. LMO-7.
IPR001478. PDZ.
IPR003096. SM22_calponin.
IPR001781. Znf_LIM.
[Graphical view]
PANTHERiPTHR15551:SF4. PTHR15551:SF4. 1 hit.
PfamiPF00307. CH. 1 hit.
PF00412. LIM. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view]
PRINTSiPR00888. SM22CALPONIN.
SMARTiSM00033. CH. 1 hit.
SM00132. LIM. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
SSF50156. SSF50156. 1 hit.
PROSITEiPS50021. CH. 1 hit.
PS00478. LIM_DOMAIN_1. 1 hit.
PS50023. LIM_DOMAIN_2. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), TISSUE SPECIFICITY.
    Tissue: Brain and Peripheral blood leukocyte.
  2. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
    Tissue: Brain.
  4. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  5. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 504-758 (ISOFORM 2).
  6. "LOMP, a novel protein that contains a single LIM domain and PDZ domain."
    Mu W., Burt D.R.
    Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 763-1683 (ISOFORM 2).
    Tissue: Brain.
  7. "Analysis of a human cDNA containing a tissue-specific alternatively spliced LIM domain."
    Putilina T., Jaworski C., Gentleman S., McDonald B., Kadiri M., Wong P.
    Biochem. Biophys. Res. Commun. 252:433-439(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 1343-1683 (ISOFORM 3), ALTERNATIVE SPLICING (ISOFORMS 2; 3 AND 4), TISSUE SPECIFICITY.
    Tissue: Pancreas.
  8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-246; SER-1026 AND SER-1510, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
    Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
    Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-867; THR-949; THR-1048 AND SER-1586, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-342 (ISOFORM 3), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."
    Yu L.R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.
    J. Proteome Res. 6:4150-4162(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-873 AND SER-1510, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-246; SER-276; SER-709; SER-867; SER-873; SER-895; THR-913; SER-919; SER-926; THR-932; SER-988; SER-991; SER-995; SER-1026; SER-1044; THR-1048; SER-1423; SER-1563; SER-1586; SER-1593; SER-1595; SER-1597 AND SER-1601, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-342 AND SER-345 (ISOFORM 3), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-185; SER-704; SER-805; THR-956; SER-960; SER-988; SER-1026; SER-1423 AND SER-1586, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-246; SER-276; SER-704; SER-805; SER-867; SER-895; THR-913; SER-919; SER-960; SER-988; SER-991; SER-994; SER-1026; SER-1032; THR-1048; SER-1177; SER-1304; SER-1307; SER-1510; SER-1516; SER-1593 AND SER-1601, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-342 AND SER-345 (ISOFORM 3), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  16. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  17. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-246; SER-704; SER-751; SER-805; THR-1048; SER-1423 AND SER-1510, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-342 (ISOFORM 3), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  18. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1 (ISOFORM 5), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  19. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-342; SER-704; SER-867; SER-879; SER-988; SER-991; SER-1026; SER-1510; SER-1586 AND SER-1593, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  20. "Crystal structure of PDZ domain of KIAA0858 (LIM), ms0793 from homo sapiens."
    RIKEN structural genomics initiative (RSGI)
    Submitted (JUL-2007) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.46 ANGSTROMS) OF 1037-1126.
  21. Cited for: VARIANTS [LARGE SCALE ANALYSIS] ALA-354 AND MET-785.

Entry informationi

Entry nameiLMO7_HUMAN
AccessioniPrimary (citable) accession number: Q8WWI1
Secondary accession number(s): E9PLH4
, O15462, O95346, Q5TBK6, Q9UKC1, Q9UQM5, Q9Y6A7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: October 5, 2010
Last modified: April 29, 2015
This is version 132 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.