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Q8WWI1

- LMO7_HUMAN

UniProt

Q8WWI1 - LMO7_HUMAN

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Protein
LIM domain only protein 7
Gene
LMO7, FBX20, FBXO20, KIAA0858
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. ubiquitin-protein transferase activity Source: UniProtKB
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. protein ubiquitination Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
LIM domain only protein 7
Short name:
LMO-7
Alternative name(s):
F-box only protein 20
LOMP
Gene namesi
Name:LMO7
Synonyms:FBX20, FBXO20, KIAA0858
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 13

Organism-specific databases

HGNCiHGNC:6646. LMO7.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: ProtInc
  2. nucleus Source: ProtInc
  3. ubiquitin ligase complex Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30412.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 16831683LIM domain only protein 7
PRO_0000075824Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei185 – 1851Phosphotyrosine1 Publication
Modified residuei246 – 2461Phosphoserine4 Publications
Modified residuei276 – 2761Phosphoserine2 Publications
Modified residuei704 – 7041Phosphoserine3 Publications
Modified residuei709 – 7091Phosphoserine1 Publication
Modified residuei751 – 7511Phosphoserine1 Publication
Modified residuei805 – 8051Phosphoserine3 Publications
Modified residuei867 – 8671Phosphoserine3 Publications
Modified residuei873 – 8731Phosphoserine2 Publications
Modified residuei895 – 8951Phosphoserine2 Publications
Modified residuei913 – 9131Phosphothreonine2 Publications
Modified residuei919 – 9191Phosphoserine2 Publications
Modified residuei926 – 9261Phosphoserine1 Publication
Modified residuei932 – 9321Phosphothreonine1 Publication
Modified residuei949 – 9491Phosphothreonine1 Publication
Modified residuei956 – 9561Phosphothreonine1 Publication
Modified residuei960 – 9601Phosphoserine2 Publications
Modified residuei988 – 9881Phosphoserine3 Publications
Modified residuei991 – 9911Phosphoserine2 Publications
Modified residuei994 – 9941Phosphoserine1 Publication
Modified residuei995 – 9951Phosphoserine1 Publication
Modified residuei1026 – 10261Phosphoserine4 Publications
Modified residuei1032 – 10321Phosphoserine1 Publication
Modified residuei1044 – 10441Phosphoserine1 Publication
Modified residuei1048 – 10481Phosphothreonine4 Publications
Modified residuei1177 – 11771Phosphoserine1 Publication
Modified residuei1304 – 13041Phosphoserine1 Publication
Modified residuei1307 – 13071Phosphoserine1 Publication
Modified residuei1423 – 14231Phosphoserine3 Publications
Modified residuei1510 – 15101Phosphoserine4 Publications
Modified residuei1516 – 15161Phosphoserine1 Publication
Modified residuei1563 – 15631Phosphoserine1 Publication
Modified residuei1586 – 15861Phosphoserine3 Publications
Modified residuei1593 – 15931Phosphoserine2 Publications
Modified residuei1595 – 15951Phosphoserine1 Publication
Modified residuei1597 – 15971Phosphoserine1 Publication
Modified residuei1601 – 16011Phosphoserine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8WWI1.
PaxDbiQ8WWI1.
PRIDEiQ8WWI1.

PTM databases

PhosphoSiteiQ8WWI1.

Miscellaneous databases

PMAP-CutDBQ5TBK6.

Expressioni

Tissue specificityi

Widely expressed. Isoform 2 and isoform 4 are predominantly expressed in brain.2 Publications

Gene expression databases

ArrayExpressiQ8WWI1.
BgeeiQ8WWI1.
CleanExiHS_LMO7.
GenevestigatoriQ8WWI1.

Organism-specific databases

HPAiHPA020923.
HPA050184.

Interactioni

Protein-protein interaction databases

BioGridi110193. 19 interactions.
DIPiDIP-33107N.
IntActiQ8WWI1. 11 interactions.
MINTiMINT-3047522.
STRINGi9606.ENSP00000342112.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi1038 – 10469
Beta strandi1056 – 10627
Beta strandi1065 – 10717
Helixi1076 – 10794
Beta strandi1087 – 10915
Helixi1101 – 111414
Beta strandi1116 – 11249

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2EAQX-ray1.46A1037-1126[»]
ProteinModelPortaliQ8WWI1.
SMRiQ8WWI1. Positions 86-158, 1037-1125, 1633-1675.

Miscellaneous databases

EvolutionaryTraceiQ8WWI1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini54 – 168115CH
Add
BLAST
Domaini1042 – 112887PDZ
Add
BLAST
Domaini1612 – 167867LIM zinc-binding
Add
BLAST

Sequence similaritiesi

Contains 1 PDZ (DHR) domain.

Keywords - Domaini

LIM domain

Phylogenomic databases

eggNOGiNOG241186.
HOVERGENiHBG049143.
InParanoidiQ8WWI1.
KOiK06084.
OrthoDBiEOG79SDWD.
PhylomeDBiQ8WWI1.

Family and domain databases

Gene3Di1.10.418.10. 1 hit.
2.10.110.10. 1 hit.
2.30.42.10. 1 hit.
InterProiIPR001715. CH-domain.
IPR001478. PDZ.
IPR003096. SM22_calponin.
IPR001781. Znf_LIM.
[Graphical view]
PfamiPF00307. CH. 1 hit.
PF00412. LIM. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view]
PRINTSiPR00888. SM22CALPONIN.
SMARTiSM00033. CH. 1 hit.
SM00132. LIM. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
SSF50156. SSF50156. 1 hit.
PROSITEiPS50021. CH. 1 hit.
PS00478. LIM_DOMAIN_1. 1 hit.
PS50023. LIM_DOMAIN_2. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8WWI1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MKKIRICHIF TFYSWMSYDV LFQRTELGAL EIWRQLICAH VCICVGWLYL     50
RDRVCSKKDI ILRTEQNSGR TILIKAVTEK NFETKDFRAS LENGVLLCDL 100
INKLKPGVIK KINRLSTPIA GLDNINVFLK ACEQIGLKEA QLFHPGDLQD 150
LSNRVTVKQE ETDRRVKNVL ITLYWLGRKA QSNPYYNGPH LNLKAFENLL 200
GQALTKALED SSFLKRSGRD SGYGDIWCPE RGEFLAPPRH HKREDSFESL 250
DSLGSRSLTS CSSDITLRGG REGFESDTDS EFTFKMQDYN KDDMSYRRIS 300
AVEPKTALPF NRFLPNKSRQ PSYVPAPLRK KKPDKHEDNR RSWASPVYTE 350
ADGTFSSNQR RIWGTNVENW PTVQGTSKSS CYLEEEKAKT RSIPNIVKDD 400
LYVRKLSPVM PNPGNAFDQF LPKCWTPEDV NWKRIKRETY KPWYKEFQGF 450
SQFLLLQALQ TYSDDILSSE THTKIDPTSG PRLITRRKNL SYAPGYRRDD 500
LEMAALDPDL ENDDFFVRKT GVFHANPYVL RAFEDFRKFS EQDDSVERDI 550
ILQCREGELV LPDLEKDDMI VRRIPAQKKE VPLSGAPDRY HPVPFPEPWT 600
LPPEIQAKFL CVFERTCPSK EKSNSCRILV PSYRQKKDDM LTRKIQSWKL 650
GTTVPPISFT PGPCSEADLK RWEAIREASR LRHKKRLMVE RLFQKIYGEN 700
GSKSMSDVSA EDVQNLRQLR YEEMQKIKSQ LKEQDQKWQD DLAKWKDRRK 750
SYTSDLQKKK EEREEIEKQA LEKSKRSSKT FKEMLQDRES QNQKSTVPSR 800
RRMYSFDDVL EEGKRPPTMT VSEASYQSER VEEKGATYPS EIPKEDSTTF 850
AKREDRVTTE IQLPSQSPVE EQSPASLSSL RSRSTQMEST RVSASLPRSY 900
RKTDTVRLTS VVTPRPFGSQ TRGISSLPRS YTMDDAWKYN GDVEDIKRTP 950
NNVVSTPAPS PDASQLASSL SSQKEVAATE EDVTRLPSPT SPFSSLSQDQ 1000
AATSKATLSS TSGLDLMSES GEGEISPQRE VSRSQDQFSD MRISINQTPG 1050
KSLDFGFTIK WDIPGIFVAS VEAGSPAEFS QLQVDDEIIA INNTKFSYND 1100
SKEWEEAMAK AQETGHLVMD VRRYGKAGSP ETKWIDATSG IYNSEKSSNL 1150
SVTTDFSESL QSSNIESKEI NGIHDESNAF ESKASESISL KNLKRRSQFF 1200
EQGSSDSVVP DLPVPTISAP SRWVWDQEEE RKRQERWQKE QDRLLQEKYQ 1250
REQEKLREEW QRAKQEAERE NSKYLDEELM VLSSNSMSLT TREPSLATWE 1300
ATWSEGSKSS DREGTRAGEE ERRQPQEEVV HEDQGKKPQD QLVIERERKW 1350
EQQLQEEQEQ KRLQAEAEEQ KRPAEEQKRQ AEIERETSVR IYQYRRPVDS 1400
YDIPKTEEAS SGFLPGDRNK SRSTTELDDY STNKNGNNKY LDQIGNMTSS 1450
QRRSKKEQVP SGAELERQQI LQEMRKRTPL HNDNSWIRQR SASVNKEPVS 1500
LPGIMRRGES LDNLDSPRSN SWRQPPWLNQ PTGFYASSSV QDFSRPPPQL 1550
VSTSNRAYMR NPSSSVPPPS AGSVKTSTTG VATTQSPTPR SHSPSASQSG 1600
SQLRNRSVSG KRICSYCNNI LGKGAAMIIE SLGLCYHLHC FKCVACECDL 1650
GGSSSGAEVR IRNHQLYCND CYLRFKSGRP TAM 1683

Note: No experimental confirmation available.

Length:1,683
Mass (Da):192,696
Last modified:October 5, 2010 - v3
Checksum:i3E79B2AEAC67F6F5
GO
Isoform 2 (identifier: Q8WWI1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1606-1683: RSVSGKRICS...RFKSGRPTAM → SVLPVSVTSE...EEVVAAHVDL

Show »
Length:1,670
Mass (Da):190,876
Checksum:iFC84DAB0587D1AB6
GO
Isoform 3 (identifier: Q8WWI1-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     357-690: Missing.

Note: Contains a phosphoserine at position 342. Contains a phosphoserine at position 345.

Show »
Length:1,349
Mass (Da):153,670
Checksum:iE5A0EBC6A4894751
GO
Isoform 4 (identifier: Q8WWI1-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1606-1683: RSVSGKRICS...RFKSGRPTAM → SWTANRHVM

Show »
Length:1,614
Mass (Da):185,216
Checksum:iE0212DE11E059A39
GO
Isoform 5 (identifier: Q8WWI1-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-285: Missing.
     1606-1670: RSVSGKRICS...IRNHQLYCND → SVLPVSVTSE...EEVVAAHVDL
     1671-1683: Missing.

Show »
Length:1,385
Mass (Da):158,265
Checksum:iBD1DCE8F29152AFC
GO

Sequence cautioni

The sequence AAD33924.1 differs from that shown. Reason: Frameshift at position 855.
The sequence AAC96299.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
The sequence AAC96300.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti354 – 3541T → A in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_036189
Natural varianti785 – 7851L → M in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_036190
Natural varianti1547 – 15471P → Q.
Corresponds to variant rs7988661 [ dbSNP | Ensembl ].
VAR_056163

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 285285Missing in isoform 5.
VSP_055683Add
BLAST
Alternative sequencei357 – 690334Missing in isoform 3.
VSP_009718Add
BLAST
Alternative sequencei1606 – 168378RSVSG…RPTAM → SVLPVSVTSEALPQELKSGS ETTNCTATTAISDSNLDGQP PCDVSLHTKALLQIEEEVVA AHVDL in isoform 2.
VSP_009719Add
BLAST
Alternative sequencei1606 – 168378RSVSG…RPTAM → SWTANRHVM in isoform 4.
VSP_009720Add
BLAST
Alternative sequencei1606 – 167065RSVSG…LYCND → SVLPVSVTSEALPQELKSGS ETTNCTATTAISDSNLDGQP PCDVSLHTKALLQIEEEVVA AHVDL in isoform 5.
VSP_055684Add
BLAST
Alternative sequencei1671 – 168313Missing in isoform 5.
VSP_055685Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti522 – 5221V → A in AAF04521. 1 Publication
Sequence conflicti613 – 6131F → L in AAF04521. 1 Publication
Sequence conflicti891 – 8911R → C in AAD33924. 1 Publication
Sequence conflicti943 – 9431V → I in AAL37480. 1 Publication
Sequence conflicti943 – 9431V → I in AAD33924. 1 Publication
Sequence conflicti1447 – 14471M → T in AAD33924. 1 Publication
Sequence conflicti1447 – 14471M → T in AAB86592. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF330045 mRNA. Translation: AAL37480.1.
AL137244
, AL137121, AL137782, AL359392 Genomic DNA. Translation: CAI12422.1.
AL137121
, AL137244, AL137782, AL359392 Genomic DNA. Translation: CAI39480.1.
AL137782
, AL137121, AL137244, AL359392 Genomic DNA. Translation: CAI40007.1.
AL359392
, AL137121, AL137244, AL137782 Genomic DNA. Translation: CAI40209.1.
AB020665 mRNA. Translation: BAA74881.2.
AF174600 mRNA. Translation: AAF04521.1.
AF144237 mRNA. Translation: AAD33924.1. Sequence problems.
U90654 mRNA. Translation: AAB86592.1.
AF092557
, AF092554, AF092555, AF092556 Genomic DNA. Translation: AAC96299.1. Different initiation.
AF092557, AF092554 Genomic DNA. Translation: AAC96300.1. Different initiation.
CCDSiCCDS9454.1. [Q8WWI1-3]
PIRiJE0325.
RefSeqiNP_005349.3. NM_005358.5. [Q8WWI1-3]
NP_056667.2. NM_015842.2.
UniGeneiHs.207631.

Genome annotation databases

EnsembliENST00000341547; ENSP00000342112; ENSG00000136153. [Q8WWI1-3]
GeneIDi4008.
KEGGihsa:4008.
UCSCiuc010thv.2. human. [Q8WWI1-3]

Polymorphism databases

DMDMi308153585.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF330045 mRNA. Translation: AAL37480.1 .
AL137244
, AL137121 , AL137782 , AL359392 Genomic DNA. Translation: CAI12422.1 .
AL137121
, AL137244 , AL137782 , AL359392 Genomic DNA. Translation: CAI39480.1 .
AL137782
, AL137121 , AL137244 , AL359392 Genomic DNA. Translation: CAI40007.1 .
AL359392
, AL137121 , AL137244 , AL137782 Genomic DNA. Translation: CAI40209.1 .
AB020665 mRNA. Translation: BAA74881.2 .
AF174600 mRNA. Translation: AAF04521.1 .
AF144237 mRNA. Translation: AAD33924.1 . Sequence problems.
U90654 mRNA. Translation: AAB86592.1 .
AF092557
, AF092554 , AF092555 , AF092556 Genomic DNA. Translation: AAC96299.1 . Different initiation.
AF092557 , AF092554 Genomic DNA. Translation: AAC96300.1 . Different initiation.
CCDSi CCDS9454.1. [Q8WWI1-3 ]
PIRi JE0325.
RefSeqi NP_005349.3. NM_005358.5. [Q8WWI1-3 ]
NP_056667.2. NM_015842.2.
UniGenei Hs.207631.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2EAQ X-ray 1.46 A 1037-1126 [» ]
ProteinModelPortali Q8WWI1.
SMRi Q8WWI1. Positions 86-158, 1037-1125, 1633-1675.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110193. 19 interactions.
DIPi DIP-33107N.
IntActi Q8WWI1. 11 interactions.
MINTi MINT-3047522.
STRINGi 9606.ENSP00000342112.

PTM databases

PhosphoSitei Q8WWI1.

Polymorphism databases

DMDMi 308153585.

Proteomic databases

MaxQBi Q8WWI1.
PaxDbi Q8WWI1.
PRIDEi Q8WWI1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000341547 ; ENSP00000342112 ; ENSG00000136153 . [Q8WWI1-3 ]
GeneIDi 4008.
KEGGi hsa:4008.
UCSCi uc010thv.2. human. [Q8WWI1-3 ]

Organism-specific databases

CTDi 4008.
GeneCardsi GC13P076194.
HGNCi HGNC:6646. LMO7.
HPAi HPA020923.
HPA050184.
MIMi 604362. gene.
neXtProti NX_Q8WWI1.
PharmGKBi PA30412.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG241186.
HOVERGENi HBG049143.
InParanoidi Q8WWI1.
KOi K06084.
OrthoDBi EOG79SDWD.
PhylomeDBi Q8WWI1.

Miscellaneous databases

ChiTaRSi LMO7. human.
EvolutionaryTracei Q8WWI1.
GeneWikii LMO7.
GenomeRNAii 4008.
NextBioi 15720.
PMAP-CutDB Q5TBK6.
PROi Q8WWI1.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8WWI1.
Bgeei Q8WWI1.
CleanExi HS_LMO7.
Genevestigatori Q8WWI1.

Family and domain databases

Gene3Di 1.10.418.10. 1 hit.
2.10.110.10. 1 hit.
2.30.42.10. 1 hit.
InterProi IPR001715. CH-domain.
IPR001478. PDZ.
IPR003096. SM22_calponin.
IPR001781. Znf_LIM.
[Graphical view ]
Pfami PF00307. CH. 1 hit.
PF00412. LIM. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view ]
PRINTSi PR00888. SM22CALPONIN.
SMARTi SM00033. CH. 1 hit.
SM00132. LIM. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view ]
SUPFAMi SSF47576. SSF47576. 1 hit.
SSF50156. SSF50156. 1 hit.
PROSITEi PS50021. CH. 1 hit.
PS00478. LIM_DOMAIN_1. 1 hit.
PS50023. LIM_DOMAIN_2. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), TISSUE SPECIFICITY.
    Tissue: Brain and Peripheral blood leukocyte.
  2. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
    Tissue: Brain.
  4. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  5. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 504-758 (ISOFORM 2).
  6. "LOMP, a novel protein that contains a single LIM domain and PDZ domain."
    Mu W., Burt D.R.
    Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 763-1683 (ISOFORM 2).
    Tissue: Brain.
  7. "Analysis of a human cDNA containing a tissue-specific alternatively spliced LIM domain."
    Putilina T., Jaworski C., Gentleman S., McDonald B., Kadiri M., Wong P.
    Biochem. Biophys. Res. Commun. 252:433-439(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 1343-1683 (ISOFORM 3), ALTERNATIVE SPLICING (ISOFORMS 2; 3 AND 4), TISSUE SPECIFICITY.
    Tissue: Pancreas.
  8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-246; SER-1026 AND SER-1510, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
    Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
    Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-867; THR-949; THR-1048 AND SER-1586, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-342 (ISOFORM 3), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."
    Yu L.R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.
    J. Proteome Res. 6:4150-4162(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-873 AND SER-1510, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-246; SER-276; SER-709; SER-867; SER-873; SER-895; THR-913; SER-919; SER-926; THR-932; SER-988; SER-991; SER-995; SER-1026; SER-1044; THR-1048; SER-1423; SER-1563; SER-1586; SER-1593; SER-1595; SER-1597 AND SER-1601, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-342 AND SER-345 (ISOFORM 3), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-185; SER-704; SER-805; THR-956; SER-960; SER-988; SER-1026; SER-1423 AND SER-1586, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-246; SER-276; SER-704; SER-805; SER-867; SER-895; THR-913; SER-919; SER-960; SER-988; SER-991; SER-994; SER-1026; SER-1032; THR-1048; SER-1177; SER-1304; SER-1307; SER-1510; SER-1516; SER-1593 AND SER-1601, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-342 AND SER-345 (ISOFORM 3), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  16. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  17. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-246; SER-704; SER-751; SER-805; THR-1048; SER-1423 AND SER-1510, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-342 (ISOFORM 3), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  18. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  19. "Crystal structure of PDZ domain of KIAA0858 (LIM), ms0793 from homo sapiens."
    RIKEN structural genomics initiative (RSGI)
    Submitted (JUL-2007) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.46 ANGSTROMS) OF 1037-1126.
  20. Cited for: VARIANTS [LARGE SCALE ANALYSIS] ALA-354 AND MET-785.

Entry informationi

Entry nameiLMO7_HUMAN
AccessioniPrimary (citable) accession number: Q8WWI1
Secondary accession number(s): E9PLH4
, O15462, O95346, Q5TBK6, Q9UKC1, Q9UQM5, Q9Y6A7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: October 5, 2010
Last modified: September 3, 2014
This is version 125 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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