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Protein

LIM domain only protein 7

Gene

LMO7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-8951664 Neddylation
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Recommended name:
LIM domain only protein 7
Short name:
LMO-7
Alternative name(s):
F-box only protein 20
LOMP
Gene namesi
Name:LMO7
Synonyms:FBX20, FBXO20, KIAA0858
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000136153.19
HGNCiHGNC:6646 LMO7
MIMi604362 gene
neXtProtiNX_Q8WWI1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi4008
OpenTargetsiENSG00000136153
PharmGKBiPA30412

Polymorphism and mutation databases

BioMutaiLMO7
DMDMi308153585

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000758241 – 1683LIM domain only protein 7Add BLAST1683

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei185PhosphotyrosineCombined sources1
Modified residuei246PhosphoserineCombined sources1
Modified residuei257PhosphoserineCombined sources1
Modified residuei276PhosphoserineCombined sources1
Modified residuei342PhosphoserineCombined sources1
Modified residuei704PhosphoserineCombined sources1
Modified residuei706PhosphoserineCombined sources1
Modified residuei709PhosphoserineCombined sources1
Modified residuei751PhosphoserineCombined sources1
Modified residuei805PhosphoserineCombined sources1
Modified residuei867PhosphoserineCombined sources1
Modified residuei873PhosphoserineCombined sources1
Modified residuei879PhosphoserineCombined sources1
Modified residuei895PhosphoserineCombined sources1
Modified residuei913PhosphothreonineCombined sources1
Modified residuei919PhosphoserineCombined sources1
Modified residuei926PhosphoserineCombined sources1
Modified residuei932PhosphothreonineCombined sources1
Modified residuei949PhosphothreonineCombined sources1
Modified residuei956PhosphothreonineCombined sources1
Modified residuei960PhosphoserineCombined sources1
Modified residuei988PhosphoserineCombined sources1
Modified residuei991PhosphoserineCombined sources1
Modified residuei994PhosphoserineCombined sources1
Modified residuei995PhosphoserineCombined sources1
Modified residuei1026PhosphoserineCombined sources1
Modified residuei1032PhosphoserineCombined sources1
Modified residuei1044PhosphoserineCombined sources1
Modified residuei1048PhosphothreonineCombined sources1
Modified residuei1177PhosphoserineCombined sources1
Modified residuei1304PhosphoserineCombined sources1
Modified residuei1307PhosphoserineCombined sources1
Cross-linki1405Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1423PhosphoserineCombined sources1
Modified residuei1454PhosphoserineCombined sources1
Modified residuei1493PhosphoserineCombined sources1
Modified residuei1510PhosphoserineCombined sources1
Modified residuei1516PhosphoserineCombined sources1
Modified residuei1563PhosphoserineCombined sources1
Modified residuei1586PhosphoserineCombined sources1
Modified residuei1593PhosphoserineCombined sources1
Modified residuei1595PhosphoserineCombined sources1
Modified residuei1597PhosphoserineCombined sources1
Modified residuei1601PhosphoserineCombined sources1
Isoform 5 (identifier: Q8WWI1-5)
Modified residuei1N-acetylmethionineCombined sources1
Isoform 3 (identifier: Q8WWI1-3)
Modified residuei342PhosphoserineCombined sources1
Modified residuei345PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8WWI1
MaxQBiQ8WWI1
PaxDbiQ8WWI1
PeptideAtlasiQ8WWI1
PRIDEiQ8WWI1

PTM databases

iPTMnetiQ8WWI1
PhosphoSitePlusiQ8WWI1
SwissPalmiQ8WWI1

Miscellaneous databases

PMAP-CutDBQ5TBK6

Expressioni

Tissue specificityi

Widely expressed. Isoform 2 and isoform 4 are predominantly expressed in brain.2 Publications

Gene expression databases

BgeeiENSG00000136153
CleanExiHS_LMO7
ExpressionAtlasiQ8WWI1 baseline and differential
GenevisibleiQ8WWI1 HS

Organism-specific databases

HPAiHPA020923
HPA050184

Interactioni

Protein-protein interaction databases

BioGridi110193, 53 interactors
CORUMiQ8WWI1
DIPiDIP-33107N
IntActiQ8WWI1, 35 interactors
MINTiQ8WWI1
STRINGi9606.ENSP00000433352

Structurei

Secondary structure

11683
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi1038 – 1046Combined sources9
Beta strandi1056 – 1062Combined sources7
Beta strandi1065 – 1071Combined sources7
Helixi1076 – 1079Combined sources4
Beta strandi1087 – 1091Combined sources5
Helixi1101 – 1114Combined sources14
Beta strandi1116 – 1124Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EAQX-ray1.46A1037-1126[»]
ProteinModelPortaliQ8WWI1
SMRiQ8WWI1
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8WWI1

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini64 – 181Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST118
Domaini1042 – 1128PDZPROSITE-ProRule annotationAdd BLAST87
Domaini1612 – 1678LIM zinc-bindingPROSITE-ProRule annotationAdd BLAST67

Keywords - Domaini

LIM domain

Phylogenomic databases

eggNOGiKOG1704 Eukaryota
ENOG410XP0W LUCA
GeneTreeiENSGT00530000063559
HOVERGENiHBG049143
InParanoidiQ8WWI1
KOiK06084
PhylomeDBiQ8WWI1

Family and domain databases

CDDicd00014 CH, 1 hit
Gene3Di1.10.418.10, 1 hit
InterProiView protein in InterPro
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR031865 DUF4757
IPR029978 LMO-7
IPR001478 PDZ
IPR036034 PDZ_sf
IPR003096 SM22_calponin
IPR001781 Znf_LIM
PANTHERiPTHR15551:SF4 PTHR15551:SF4, 1 hit
PfamiView protein in Pfam
PF00307 CH, 1 hit
PF15949 DUF4757, 2 hits
PF00412 LIM, 1 hit
PF00595 PDZ, 1 hit
PRINTSiPR00888 SM22CALPONIN
SMARTiView protein in SMART
SM00033 CH, 1 hit
SM00132 LIM, 1 hit
SM00228 PDZ, 1 hit
SUPFAMiSSF47576 SSF47576, 1 hit
SSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50021 CH, 1 hit
PS00478 LIM_DOMAIN_1, 1 hit
PS50023 LIM_DOMAIN_2, 1 hit
PS50106 PDZ, 1 hit

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WWI1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKKIRICHIF TFYSWMSYDV LFQRTELGAL EIWRQLICAH VCICVGWLYL
60 70 80 90 100
RDRVCSKKDI ILRTEQNSGR TILIKAVTEK NFETKDFRAS LENGVLLCDL
110 120 130 140 150
INKLKPGVIK KINRLSTPIA GLDNINVFLK ACEQIGLKEA QLFHPGDLQD
160 170 180 190 200
LSNRVTVKQE ETDRRVKNVL ITLYWLGRKA QSNPYYNGPH LNLKAFENLL
210 220 230 240 250
GQALTKALED SSFLKRSGRD SGYGDIWCPE RGEFLAPPRH HKREDSFESL
260 270 280 290 300
DSLGSRSLTS CSSDITLRGG REGFESDTDS EFTFKMQDYN KDDMSYRRIS
310 320 330 340 350
AVEPKTALPF NRFLPNKSRQ PSYVPAPLRK KKPDKHEDNR RSWASPVYTE
360 370 380 390 400
ADGTFSSNQR RIWGTNVENW PTVQGTSKSS CYLEEEKAKT RSIPNIVKDD
410 420 430 440 450
LYVRKLSPVM PNPGNAFDQF LPKCWTPEDV NWKRIKRETY KPWYKEFQGF
460 470 480 490 500
SQFLLLQALQ TYSDDILSSE THTKIDPTSG PRLITRRKNL SYAPGYRRDD
510 520 530 540 550
LEMAALDPDL ENDDFFVRKT GVFHANPYVL RAFEDFRKFS EQDDSVERDI
560 570 580 590 600
ILQCREGELV LPDLEKDDMI VRRIPAQKKE VPLSGAPDRY HPVPFPEPWT
610 620 630 640 650
LPPEIQAKFL CVFERTCPSK EKSNSCRILV PSYRQKKDDM LTRKIQSWKL
660 670 680 690 700
GTTVPPISFT PGPCSEADLK RWEAIREASR LRHKKRLMVE RLFQKIYGEN
710 720 730 740 750
GSKSMSDVSA EDVQNLRQLR YEEMQKIKSQ LKEQDQKWQD DLAKWKDRRK
760 770 780 790 800
SYTSDLQKKK EEREEIEKQA LEKSKRSSKT FKEMLQDRES QNQKSTVPSR
810 820 830 840 850
RRMYSFDDVL EEGKRPPTMT VSEASYQSER VEEKGATYPS EIPKEDSTTF
860 870 880 890 900
AKREDRVTTE IQLPSQSPVE EQSPASLSSL RSRSTQMEST RVSASLPRSY
910 920 930 940 950
RKTDTVRLTS VVTPRPFGSQ TRGISSLPRS YTMDDAWKYN GDVEDIKRTP
960 970 980 990 1000
NNVVSTPAPS PDASQLASSL SSQKEVAATE EDVTRLPSPT SPFSSLSQDQ
1010 1020 1030 1040 1050
AATSKATLSS TSGLDLMSES GEGEISPQRE VSRSQDQFSD MRISINQTPG
1060 1070 1080 1090 1100
KSLDFGFTIK WDIPGIFVAS VEAGSPAEFS QLQVDDEIIA INNTKFSYND
1110 1120 1130 1140 1150
SKEWEEAMAK AQETGHLVMD VRRYGKAGSP ETKWIDATSG IYNSEKSSNL
1160 1170 1180 1190 1200
SVTTDFSESL QSSNIESKEI NGIHDESNAF ESKASESISL KNLKRRSQFF
1210 1220 1230 1240 1250
EQGSSDSVVP DLPVPTISAP SRWVWDQEEE RKRQERWQKE QDRLLQEKYQ
1260 1270 1280 1290 1300
REQEKLREEW QRAKQEAERE NSKYLDEELM VLSSNSMSLT TREPSLATWE
1310 1320 1330 1340 1350
ATWSEGSKSS DREGTRAGEE ERRQPQEEVV HEDQGKKPQD QLVIERERKW
1360 1370 1380 1390 1400
EQQLQEEQEQ KRLQAEAEEQ KRPAEEQKRQ AEIERETSVR IYQYRRPVDS
1410 1420 1430 1440 1450
YDIPKTEEAS SGFLPGDRNK SRSTTELDDY STNKNGNNKY LDQIGNMTSS
1460 1470 1480 1490 1500
QRRSKKEQVP SGAELERQQI LQEMRKRTPL HNDNSWIRQR SASVNKEPVS
1510 1520 1530 1540 1550
LPGIMRRGES LDNLDSPRSN SWRQPPWLNQ PTGFYASSSV QDFSRPPPQL
1560 1570 1580 1590 1600
VSTSNRAYMR NPSSSVPPPS AGSVKTSTTG VATTQSPTPR SHSPSASQSG
1610 1620 1630 1640 1650
SQLRNRSVSG KRICSYCNNI LGKGAAMIIE SLGLCYHLHC FKCVACECDL
1660 1670 1680
GGSSSGAEVR IRNHQLYCND CYLRFKSGRP TAM
Note: No experimental confirmation available.
Length:1,683
Mass (Da):192,696
Last modified:October 5, 2010 - v3
Checksum:i3E79B2AEAC67F6F5
GO
Isoform 2 (identifier: Q8WWI1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1606-1683: RSVSGKRICS...RFKSGRPTAM → SVLPVSVTSE...EEVVAAHVDL

Show »
Length:1,670
Mass (Da):190,876
Checksum:iFC84DAB0587D1AB6
GO
Isoform 3 (identifier: Q8WWI1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     357-690: Missing.

Show »
Length:1,349
Mass (Da):153,670
Checksum:iE5A0EBC6A4894751
GO
Isoform 4 (identifier: Q8WWI1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1606-1683: RSVSGKRICS...RFKSGRPTAM → SWTANRHVM

Show »
Length:1,614
Mass (Da):185,216
Checksum:iE0212DE11E059A39
GO
Isoform 5 (identifier: Q8WWI1-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-285: Missing.
     1606-1670: RSVSGKRICS...IRNHQLYCND → SVLPVSVTSE...EEVVAAHVDL
     1671-1683: Missing.

Show »
Length:1,385
Mass (Da):158,265
Checksum:iBD1DCE8F29152AFC
GO

Sequence cautioni

The sequence AAC96299 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAC96300 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAD33924 differs from that shown. Reason: Frameshift at position 855.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti522V → A in AAF04521 (PubMed:10531035).Curated1
Sequence conflicti613F → L in AAF04521 (PubMed:10531035).Curated1
Sequence conflicti891R → C in AAD33924 (Ref. 6) Curated1
Sequence conflicti943V → I in AAL37480 (PubMed:11935316).Curated1
Sequence conflicti943V → I in AAD33924 (Ref. 6) Curated1
Sequence conflicti1447M → T in AAD33924 (Ref. 6) Curated1
Sequence conflicti1447M → T in AAB86592 (Ref. 6) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036189354T → A in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_036190785L → M in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_0561631547P → Q. Corresponds to variant dbSNP:rs7988661Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0556831 – 285Missing in isoform 5. 1 PublicationAdd BLAST285
Alternative sequenceiVSP_009718357 – 690Missing in isoform 3. 2 PublicationsAdd BLAST334
Alternative sequenceiVSP_0097191606 – 1683RSVSG…RPTAM → SVLPVSVTSEALPQELKSGS ETTNCTATTAISDSNLDGQP PCDVSLHTKALLQIEEEVVA AHVDL in isoform 2. 2 PublicationsAdd BLAST78
Alternative sequenceiVSP_0097201606 – 1683RSVSG…RPTAM → SWTANRHVM in isoform 4. CuratedAdd BLAST78
Alternative sequenceiVSP_0556841606 – 1670RSVSG…LYCND → SVLPVSVTSEALPQELKSGS ETTNCTATTAISDSNLDGQP PCDVSLHTKALLQIEEEVVA AHVDL in isoform 5. 1 PublicationAdd BLAST65
Alternative sequenceiVSP_0556851671 – 1683Missing in isoform 5. 1 PublicationAdd BLAST13

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF330045 mRNA Translation: AAL37480.1
AL137121 Genomic DNA No translation available.
AL137244 Genomic DNA No translation available.
AL137782 Genomic DNA No translation available.
AL359392 Genomic DNA No translation available.
AB020665 mRNA Translation: BAA74881.2
AF174600 mRNA Translation: AAF04521.1
AF144237 mRNA Translation: AAD33924.1 Sequence problems.
U90654 mRNA Translation: AAB86592.1
AF092557
, AF092554, AF092555, AF092556 Genomic DNA Translation: AAC96299.1 Different initiation.
AF092557, AF092554 Genomic DNA Translation: AAC96300.1 Different initiation.
CCDSiCCDS53876.1 [Q8WWI1-5]
CCDS9454.1 [Q8WWI1-3]
PIRiJE0325
RefSeqiNP_001293009.1, NM_001306080.1
NP_001317512.1, NM_001330583.1
NP_005349.3, NM_005358.5 [Q8WWI1-3]
NP_056667.2, NM_015842.2
UniGeneiHs.207631

Genome annotation databases

EnsembliENST00000341547; ENSP00000342112; ENSG00000136153 [Q8WWI1-3]
GeneIDi4008
KEGGihsa:4008
UCSCiuc010thv.4 human [Q8WWI1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiLMO7_HUMAN
AccessioniPrimary (citable) accession number: Q8WWI1
Secondary accession number(s): E9PLH4
, O15462, O95346, Q5TBK6, Q9UKC1, Q9UQM5, Q9Y6A7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: October 5, 2010
Last modified: May 23, 2018
This is version 162 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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