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Q8WWI1 (LMO7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 124. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
LIM domain only protein 7

Short name=LMO-7
Alternative name(s):
F-box only protein 20
LOMP
Gene names
Name:LMO7
Synonyms:FBX20, FBXO20, KIAA0858
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1683 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Tissue specificity

Widely expressed. Isoform 2 and isoform 4 are predominantly expressed in brain. Ref.1 Ref.7

Sequence similarities

Contains 1 CH (calponin-homology) domain.

Contains 1 LIM zinc-binding domain.

Contains 1 PDZ (DHR) domain.

Sequence caution

The sequence AAC96299.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAC96300.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAD33924.1 differs from that shown. Reason: Frameshift at position 855.

The sequence BAA74881.2 differs from that shown. Reason: Intron retention.

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8WWI1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: No experimental confirmation available.
Isoform 2 (identifier: Q8WWI1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1606-1683: RSVSGKRICS...RFKSGRPTAM → SVLPVSVTSE...EEVVAAHVDL
Isoform 3 (identifier: Q8WWI1-3)

The sequence of this isoform differs from the canonical sequence as follows:
     357-690: Missing.
Note: Contains a phosphoserine at position 342. Contains a phosphoserine at position 345.
Isoform 4 (identifier: Q8WWI1-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1606-1683: RSVSGKRICS...RFKSGRPTAM → SWTANRHVM

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 16831683LIM domain only protein 7
PRO_0000075824

Regions

Domain54 – 168115CH
Domain1042 – 112887PDZ
Domain1612 – 167867LIM zinc-binding

Amino acid modifications

Modified residue1851Phosphotyrosine Ref.14
Modified residue2461Phosphoserine Ref.8 Ref.13 Ref.15 Ref.17
Modified residue2761Phosphoserine Ref.13 Ref.15
Modified residue7041Phosphoserine Ref.14 Ref.15 Ref.17
Modified residue7091Phosphoserine Ref.13
Modified residue7511Phosphoserine Ref.17
Modified residue8051Phosphoserine Ref.14 Ref.15 Ref.17
Modified residue8671Phosphoserine Ref.9 Ref.13 Ref.15
Modified residue8731Phosphoserine Ref.12 Ref.13
Modified residue8951Phosphoserine Ref.13 Ref.15
Modified residue9131Phosphothreonine Ref.13 Ref.15
Modified residue9191Phosphoserine Ref.13 Ref.15
Modified residue9261Phosphoserine Ref.13
Modified residue9321Phosphothreonine Ref.13
Modified residue9491Phosphothreonine Ref.9
Modified residue9561Phosphothreonine Ref.14
Modified residue9601Phosphoserine Ref.14 Ref.15
Modified residue9881Phosphoserine Ref.13 Ref.14 Ref.15
Modified residue9911Phosphoserine Ref.13 Ref.15
Modified residue9941Phosphoserine Ref.15
Modified residue9951Phosphoserine Ref.13
Modified residue10261Phosphoserine Ref.8 Ref.13 Ref.14 Ref.15
Modified residue10321Phosphoserine Ref.15
Modified residue10441Phosphoserine Ref.13
Modified residue10481Phosphothreonine Ref.9 Ref.13 Ref.15 Ref.17
Modified residue11771Phosphoserine Ref.15
Modified residue13041Phosphoserine Ref.15
Modified residue13071Phosphoserine Ref.15
Modified residue14231Phosphoserine Ref.13 Ref.14 Ref.17
Modified residue15101Phosphoserine Ref.8 Ref.12 Ref.15 Ref.17
Modified residue15161Phosphoserine Ref.15
Modified residue15631Phosphoserine Ref.13
Modified residue15861Phosphoserine Ref.9 Ref.13 Ref.14
Modified residue15931Phosphoserine Ref.13 Ref.15
Modified residue15951Phosphoserine Ref.13
Modified residue15971Phosphoserine Ref.13
Modified residue16011Phosphoserine Ref.13 Ref.15

Natural variations

Alternative sequence357 – 690334Missing in isoform 3.
VSP_009718
Alternative sequence1606 – 168378RSVSG…RPTAM → SVLPVSVTSEALPQELKSGS ETTNCTATTAISDSNLDGQP PCDVSLHTKALLQIEEEVVA AHVDL in isoform 2.
VSP_009719
Alternative sequence1606 – 168378RSVSG…RPTAM → SWTANRHVM in isoform 4.
VSP_009720
Natural variant3541T → A in a colorectal cancer sample; somatic mutation. Ref.20
VAR_036189
Natural variant7851L → M in a colorectal cancer sample; somatic mutation. Ref.20
VAR_036190
Natural variant15471P → Q.
Corresponds to variant rs7988661 [ dbSNP | Ensembl ].
VAR_056163

Experimental info

Sequence conflict5221V → A in AAF04521. Ref.5
Sequence conflict6131F → L in AAF04521. Ref.5
Sequence conflict8911R → C in AAD33924. Ref.6
Sequence conflict9431V → I in AAL37480. Ref.1
Sequence conflict9431V → I in AAD33924. Ref.6
Sequence conflict14471M → T in AAD33924. Ref.6
Sequence conflict14471M → T in AAB86592. Ref.6

Secondary structure

............... 1683
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 5, 2010. Version 3.
Checksum: 3E79B2AEAC67F6F5

FASTA1,683192,696
        10         20         30         40         50         60 
MKKIRICHIF TFYSWMSYDV LFQRTELGAL EIWRQLICAH VCICVGWLYL RDRVCSKKDI 

        70         80         90        100        110        120 
ILRTEQNSGR TILIKAVTEK NFETKDFRAS LENGVLLCDL INKLKPGVIK KINRLSTPIA 

       130        140        150        160        170        180 
GLDNINVFLK ACEQIGLKEA QLFHPGDLQD LSNRVTVKQE ETDRRVKNVL ITLYWLGRKA 

       190        200        210        220        230        240 
QSNPYYNGPH LNLKAFENLL GQALTKALED SSFLKRSGRD SGYGDIWCPE RGEFLAPPRH 

       250        260        270        280        290        300 
HKREDSFESL DSLGSRSLTS CSSDITLRGG REGFESDTDS EFTFKMQDYN KDDMSYRRIS 

       310        320        330        340        350        360 
AVEPKTALPF NRFLPNKSRQ PSYVPAPLRK KKPDKHEDNR RSWASPVYTE ADGTFSSNQR 

       370        380        390        400        410        420 
RIWGTNVENW PTVQGTSKSS CYLEEEKAKT RSIPNIVKDD LYVRKLSPVM PNPGNAFDQF 

       430        440        450        460        470        480 
LPKCWTPEDV NWKRIKRETY KPWYKEFQGF SQFLLLQALQ TYSDDILSSE THTKIDPTSG 

       490        500        510        520        530        540 
PRLITRRKNL SYAPGYRRDD LEMAALDPDL ENDDFFVRKT GVFHANPYVL RAFEDFRKFS 

       550        560        570        580        590        600 
EQDDSVERDI ILQCREGELV LPDLEKDDMI VRRIPAQKKE VPLSGAPDRY HPVPFPEPWT 

       610        620        630        640        650        660 
LPPEIQAKFL CVFERTCPSK EKSNSCRILV PSYRQKKDDM LTRKIQSWKL GTTVPPISFT 

       670        680        690        700        710        720 
PGPCSEADLK RWEAIREASR LRHKKRLMVE RLFQKIYGEN GSKSMSDVSA EDVQNLRQLR 

       730        740        750        760        770        780 
YEEMQKIKSQ LKEQDQKWQD DLAKWKDRRK SYTSDLQKKK EEREEIEKQA LEKSKRSSKT 

       790        800        810        820        830        840 
FKEMLQDRES QNQKSTVPSR RRMYSFDDVL EEGKRPPTMT VSEASYQSER VEEKGATYPS 

       850        860        870        880        890        900 
EIPKEDSTTF AKREDRVTTE IQLPSQSPVE EQSPASLSSL RSRSTQMEST RVSASLPRSY 

       910        920        930        940        950        960 
RKTDTVRLTS VVTPRPFGSQ TRGISSLPRS YTMDDAWKYN GDVEDIKRTP NNVVSTPAPS 

       970        980        990       1000       1010       1020 
PDASQLASSL SSQKEVAATE EDVTRLPSPT SPFSSLSQDQ AATSKATLSS TSGLDLMSES 

      1030       1040       1050       1060       1070       1080 
GEGEISPQRE VSRSQDQFSD MRISINQTPG KSLDFGFTIK WDIPGIFVAS VEAGSPAEFS 

      1090       1100       1110       1120       1130       1140 
QLQVDDEIIA INNTKFSYND SKEWEEAMAK AQETGHLVMD VRRYGKAGSP ETKWIDATSG 

      1150       1160       1170       1180       1190       1200 
IYNSEKSSNL SVTTDFSESL QSSNIESKEI NGIHDESNAF ESKASESISL KNLKRRSQFF 

      1210       1220       1230       1240       1250       1260 
EQGSSDSVVP DLPVPTISAP SRWVWDQEEE RKRQERWQKE QDRLLQEKYQ REQEKLREEW 

      1270       1280       1290       1300       1310       1320 
QRAKQEAERE NSKYLDEELM VLSSNSMSLT TREPSLATWE ATWSEGSKSS DREGTRAGEE 

      1330       1340       1350       1360       1370       1380 
ERRQPQEEVV HEDQGKKPQD QLVIERERKW EQQLQEEQEQ KRLQAEAEEQ KRPAEEQKRQ 

      1390       1400       1410       1420       1430       1440 
AEIERETSVR IYQYRRPVDS YDIPKTEEAS SGFLPGDRNK SRSTTELDDY STNKNGNNKY 

      1450       1460       1470       1480       1490       1500 
LDQIGNMTSS QRRSKKEQVP SGAELERQQI LQEMRKRTPL HNDNSWIRQR SASVNKEPVS 

      1510       1520       1530       1540       1550       1560 
LPGIMRRGES LDNLDSPRSN SWRQPPWLNQ PTGFYASSSV QDFSRPPPQL VSTSNRAYMR 

      1570       1580       1590       1600       1610       1620 
NPSSSVPPPS AGSVKTSTTG VATTQSPTPR SHSPSASQSG SQLRNRSVSG KRICSYCNNI 

      1630       1640       1650       1660       1670       1680 
LGKGAAMIIE SLGLCYHLHC FKCVACECDL GGSSSGAEVR IRNHQLYCND CYLRFKSGRP 


TAM 

« Hide

Isoform 2 [UniParc].

Checksum: FC84DAB0587D1AB6
Show »

FASTA1,670190,876
Isoform 3 [UniParc].

Checksum: E5A0EBC6A4894751
Show »

FASTA1,349153,670
Isoform 4 [UniParc].

Checksum: E0212DE11E059A39
Show »

FASTA1,614185,216

References

« Hide 'large scale' references
[1]"A genomic map of a 6-Mb region at 13q21-q22 implicated in cancer development: identification and characterization of candidate genes."
Rozenblum E., Vahteristo P., Sandberg T., Bergthorsson J.T., Syrjakoski K., Weaver D., Haraldsson K., Johannsdottir H.K., Vehmanen P., Nigam S., Golberger N., Robbins C., Pak E., Dutra A., Gillander E., Stephan D.A., Bailey-Wilson J., Juo S.-H.H. expand/collapse author list , Kainu T., Arason A., Barkardottir R.B., Nevanlinna H., Borg A., Kallioniemi O.-P.
Hum. Genet. 110:111-121(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), TISSUE SPECIFICITY.
Tissue: Brain and Peripheral blood leukocyte.
[2]"The DNA sequence and analysis of human chromosome 13."
Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 123-1349 (ISOFORM 2).
Tissue: Brain.
[4]"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: SEQUENCE REVISION.
[5]"Identification of a family of human F-box proteins."
Cenciarelli C., Chiaur D.S., Guardavaccaro D., Parks W., Vidal M., Pagano M.
Curr. Biol. 9:1177-1179(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 504-758 (ISOFORM 2).
[6]"LOMP, a novel protein that contains a single LIM domain and PDZ domain."
Mu W., Burt D.R.
Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 763-1683 (ISOFORM 2).
Tissue: Brain.
[7]"Analysis of a human cDNA containing a tissue-specific alternatively spliced LIM domain."
Putilina T., Jaworski C., Gentleman S., McDonald B., Kadiri M., Wong P.
Biochem. Biophys. Res. Commun. 252:433-439(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 1343-1683 (ISOFORM 3), ALTERNATIVE SPLICING (ISOFORMS 2; 3 AND 4), TISSUE SPECIFICITY.
Tissue: Pancreas.
[8]"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-246; SER-1026 AND SER-1510, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[9]"A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-867; THR-949; THR-1048 AND SER-1586, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-342 (ISOFORM 3), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[10]"Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."
Yu L.R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.
J. Proteome Res. 6:4150-4162(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[11]"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[12]"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-873 AND SER-1510, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[13]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-246; SER-276; SER-709; SER-867; SER-873; SER-895; THR-913; SER-919; SER-926; THR-932; SER-988; SER-991; SER-995; SER-1026; SER-1044; THR-1048; SER-1423; SER-1563; SER-1586; SER-1593; SER-1595; SER-1597 AND SER-1601, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-342 AND SER-345 (ISOFORM 3), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[14]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-185; SER-704; SER-805; THR-956; SER-960; SER-988; SER-1026; SER-1423 AND SER-1586, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[15]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-246; SER-276; SER-704; SER-805; SER-867; SER-895; THR-913; SER-919; SER-960; SER-988; SER-991; SER-994; SER-1026; SER-1032; THR-1048; SER-1177; SER-1304; SER-1307; SER-1510; SER-1516; SER-1593 AND SER-1601, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-342 AND SER-345 (ISOFORM 3), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[16]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[17]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-246; SER-704; SER-751; SER-805; THR-1048; SER-1423 AND SER-1510, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-342 (ISOFORM 3), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[18]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[19]"Crystal structure of PDZ domain of KIAA0858 (LIM), ms0793 from homo sapiens."
RIKEN structural genomics initiative (RSGI)
Submitted (JUL-2007) to the PDB data bank
Cited for: X-RAY CRYSTALLOGRAPHY (1.46 ANGSTROMS) OF 1037-1126.
[20]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS [LARGE SCALE ANALYSIS] ALA-354 AND MET-785.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF330045 mRNA. Translation: AAL37480.1.
AL137244 expand/collapse EMBL AC list , AL137121, AL137782, AL359392 Genomic DNA. Translation: CAI12422.1.
AL137121 expand/collapse EMBL AC list , AL137244, AL137782, AL359392 Genomic DNA. Translation: CAI39480.1.
AL137782 expand/collapse EMBL AC list , AL137121, AL137244, AL359392 Genomic DNA. Translation: CAI40007.1.
AL359392 expand/collapse EMBL AC list , AL137121, AL137244, AL137782 Genomic DNA. Translation: CAI40209.1.
AB020665 mRNA. Translation: BAA74881.2. Sequence problems.
AF174600 mRNA. Translation: AAF04521.1.
AF144237 mRNA. Translation: AAD33924.1. Sequence problems.
U90654 mRNA. Translation: AAB86592.1.
AF092557 expand/collapse EMBL AC list , AF092554, AF092555, AF092556 Genomic DNA. Translation: AAC96299.1. Different initiation.
AF092557, AF092554 Genomic DNA. Translation: AAC96300.1. Different initiation.
CCDSCCDS9454.1. [Q8WWI1-3]
PIRJE0325.
RefSeqNP_005349.3. NM_005358.5. [Q8WWI1-3]
NP_056667.2. NM_015842.2.
UniGeneHs.207631.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2EAQX-ray1.46A1037-1126[»]
ProteinModelPortalQ8WWI1.
SMRQ8WWI1. Positions 86-158, 1037-1125, 1633-1675.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110193. 19 interactions.
DIPDIP-33107N.
IntActQ8WWI1. 11 interactions.
MINTMINT-3047522.
STRING9606.ENSP00000342112.

PTM databases

PhosphoSiteQ8WWI1.

Polymorphism databases

DMDM308153585.

Proteomic databases

MaxQBQ8WWI1.
PaxDbQ8WWI1.
PRIDEQ8WWI1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000341547; ENSP00000342112; ENSG00000136153. [Q8WWI1-3]
GeneID4008.
KEGGhsa:4008.
UCSCuc010thv.2. human. [Q8WWI1-3]

Organism-specific databases

CTD4008.
GeneCardsGC13P076194.
HGNCHGNC:6646. LMO7.
HPAHPA020923.
HPA050184.
MIM604362. gene.
neXtProtNX_Q8WWI1.
PharmGKBPA30412.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG241186.
HOVERGENHBG049143.
InParanoidQ8WWI1.
KOK06084.
OrthoDBEOG79SDWD.
PhylomeDBQ8WWI1.

Gene expression databases

ArrayExpressQ8WWI1.
BgeeQ8WWI1.
CleanExHS_LMO7.
GenevestigatorQ8WWI1.

Family and domain databases

Gene3D1.10.418.10. 1 hit.
2.10.110.10. 1 hit.
2.30.42.10. 1 hit.
InterProIPR001715. CH-domain.
IPR001478. PDZ.
IPR003096. SM22_calponin.
IPR001781. Znf_LIM.
[Graphical view]
PfamPF00307. CH. 1 hit.
PF00412. LIM. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view]
PRINTSPR00888. SM22CALPONIN.
SMARTSM00033. CH. 1 hit.
SM00132. LIM. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMSSF47576. SSF47576. 1 hit.
SSF50156. SSF50156. 1 hit.
PROSITEPS50021. CH. 1 hit.
PS00478. LIM_DOMAIN_1. 1 hit.
PS50023. LIM_DOMAIN_2. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSLMO7. human.
EvolutionaryTraceQ8WWI1.
GeneWikiLMO7.
GenomeRNAi4008.
NextBio15720.
PMAP-CutDBQ5TBK6.
PROQ8WWI1.
SOURCESearch...

Entry information

Entry nameLMO7_HUMAN
AccessionPrimary (citable) accession number: Q8WWI1
Secondary accession number(s): O15462 expand/collapse secondary AC list , O95346, Q5TBK6, Q9UKC1, Q9UQM5, Q9Y6A7
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: October 5, 2010
Last modified: July 9, 2014
This is version 124 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 13

Human chromosome 13: entries, gene names and cross-references to MIM