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Protein

Potassium voltage-gated channel subfamily E member 4

Gene

KCNE4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. May associate with KCNQ1/KVLTQ1 and inhibit potassium current.

GO - Molecular functioni

  • ion channel binding Source: UniProtKB
  • voltage-gated potassium channel activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

BioCyciZFISH:ENSG00000152049-MONOMER.
ReactomeiR-HSA-5576890. Phase 3 - rapid repolarisation.
R-HSA-5576893. Phase 2 - plateau phase.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily E member 4
Alternative name(s):
MinK-related peptide 3
Minimum potassium ion channel-related peptide 3
Potassium channel subunit beta MiRP3
Gene namesi
Name:KCNE4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:6244. KCNE4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 86ExtracellularSequence analysisAdd BLAST86
Transmembranei87 – 107HelicalSequence analysisAdd BLAST21
Topological domaini108 – 221CytoplasmicSequence analysisAdd BLAST114

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi23704.
OpenTargetsiENSG00000152049.
PharmGKBiPA30032.

Polymorphism and mutation databases

DMDMi311033433.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001442921 – 221Potassium voltage-gated channel subfamily E member 4Add BLAST221

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi9N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8WWG9.
PeptideAtlasiQ8WWG9.
PRIDEiQ8WWG9.

Expressioni

Tissue specificityi

Predominantly expressed in embryo and adult uterus. Low expression found in kidney, small intestine, lung and heart.1 Publication

Gene expression databases

BgeeiENSG00000152049.
CleanExiHS_KCNE4.
GenevisibleiQ8WWG9. HS.

Organism-specific databases

HPAiHPA011420.

Interactioni

Subunit structurei

Interacts with KCNQ1; impairs KCNQ1 localization in lipid rafts and inhibits voltage-gated potassium channel activity.3 Publications

GO - Molecular functioni

  • ion channel binding Source: UniProtKB

Protein-protein interaction databases

BioGridi117217. 5 interactors.
IntActiQ8WWG9. 1 interactor.
STRINGi9606.ENSP00000281830.

Structurei

3D structure databases

ProteinModelPortaliQ8WWG9.
SMRiQ8WWG9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi120 – 123Poly-Leu4

Sequence similaritiesi

Belongs to the potassium channel KCNE family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWSX. Eukaryota.
ENOG41129VY. LUCA.
GeneTreeiENSGT00390000013776.
HOGENOMiHOG000237340.
HOVERGENiHBG052229.
InParanoidiQ8WWG9.
KOiK04898.
OMAiLWGEAMK.
OrthoDBiEOG091G0QZW.
TreeFamiTF333025.

Family and domain databases

InterProiIPR000369. K_chnl_KCNE.
[Graphical view]
PfamiPF02060. ISK_Channel. 1 hit.
[Graphical view]
PRINTSiPR00168. KCNECHANNEL.

Sequencei

Sequence statusi: Complete.

Q8WWG9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHFLTIYPNC SSGVVRAQSR TEQKNPLGLD DLGIQNLGQT VSLAPAVEAA
60 70 80 90 100
SMLKMEPLNS THPGTAASSS PLESRAAGGG SGNGNEYFYI LVVMSFYGIF
110 120 130 140 150
LIGIMLGYMK SKRREKKSSL LLLYKDEERL WGEAMKPLPV VSGLRSVQVP
160 170 180 190 200
LMLNMLQESV APALSCTLCS MEGDSVSSES SSPDVHLTIQ EEGADDELEE
210 220
TSETPLNESS EGSSENIHQN S
Length:221
Mass (Da):23,806
Last modified:September 3, 2014 - v4
Checksum:iF601434C18E82CFE
GO

Sequence cautioni

The sequence AAH14429 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAL49979 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti47V → A in BAH11761 (PubMed:14702039).Curated1
Sequence conflicti105M → V in AAL49979 (Ref. 4) Curated1
Sequence conflicti137P → S in AAL49979 (Ref. 4) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03062098G → S.Corresponds to variant rs13409084dbSNPEnsembl.1
Natural variantiVAR_024411196D → E.2 PublicationsCorresponds to variant rs12621643dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK294423 mRNA. Translation: BAH11761.1.
AC017014 Genomic DNA. Translation: AAX93228.1.
BC014429 mRNA. Translation: AAH14429.1. Different initiation.
AY065987 mRNA. Translation: AAL49979.1. Different initiation.
CCDSiCCDS2456.2.
RefSeqiNP_542402.3. NM_080671.3.
UniGeneiHs.348522.

Genome annotation databases

EnsembliENST00000281830; ENSP00000281830; ENSG00000152049.
GeneIDi23704.
KEGGihsa:23704.
UCSCiuc002vnl.7. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK294423 mRNA. Translation: BAH11761.1.
AC017014 Genomic DNA. Translation: AAX93228.1.
BC014429 mRNA. Translation: AAH14429.1. Different initiation.
AY065987 mRNA. Translation: AAL49979.1. Different initiation.
CCDSiCCDS2456.2.
RefSeqiNP_542402.3. NM_080671.3.
UniGeneiHs.348522.

3D structure databases

ProteinModelPortaliQ8WWG9.
SMRiQ8WWG9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117217. 5 interactors.
IntActiQ8WWG9. 1 interactor.
STRINGi9606.ENSP00000281830.

Polymorphism and mutation databases

DMDMi311033433.

Proteomic databases

PaxDbiQ8WWG9.
PeptideAtlasiQ8WWG9.
PRIDEiQ8WWG9.

Protocols and materials databases

DNASUi23704.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000281830; ENSP00000281830; ENSG00000152049.
GeneIDi23704.
KEGGihsa:23704.
UCSCiuc002vnl.7. human.

Organism-specific databases

CTDi23704.
DisGeNETi23704.
GeneCardsiKCNE4.
HGNCiHGNC:6244. KCNE4.
HPAiHPA011420.
MIMi607775. gene.
neXtProtiNX_Q8WWG9.
OpenTargetsiENSG00000152049.
PharmGKBiPA30032.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWSX. Eukaryota.
ENOG41129VY. LUCA.
GeneTreeiENSGT00390000013776.
HOGENOMiHOG000237340.
HOVERGENiHBG052229.
InParanoidiQ8WWG9.
KOiK04898.
OMAiLWGEAMK.
OrthoDBiEOG091G0QZW.
TreeFamiTF333025.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000152049-MONOMER.
ReactomeiR-HSA-5576890. Phase 3 - rapid repolarisation.
R-HSA-5576893. Phase 2 - plateau phase.

Miscellaneous databases

GeneWikiiKCNE4.
GenomeRNAii23704.
PROiQ8WWG9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000152049.
CleanExiHS_KCNE4.
GenevisibleiQ8WWG9. HS.

Family and domain databases

InterProiIPR000369. K_chnl_KCNE.
[Graphical view]
PfamiPF02060. ISK_Channel. 1 hit.
[Graphical view]
PRINTSiPR00168. KCNECHANNEL.
ProtoNetiSearch...

Entry informationi

Entry nameiKCNE4_HUMAN
AccessioniPrimary (citable) accession number: Q8WWG9
Secondary accession number(s): B7Z275, Q53SM4, Q96CC4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: September 3, 2014
Last modified: November 30, 2016
This is version 122 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.