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Protein

Potassium voltage-gated channel subfamily E member 4

Gene

KCNE4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. May associate with KCNQ1/KVLTQ1 and inhibit potassium current.

GO - Molecular functioni

  1. voltage-gated potassium channel activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily E member 4
Alternative name(s):
MinK-related peptide 3
Minimum potassium ion channel-related peptide 3
Potassium channel subunit beta MiRP3
Gene namesi
Name:KCNE4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:6244. KCNE4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 8686ExtracellularSequence AnalysisAdd
BLAST
Transmembranei87 – 10721HelicalSequence AnalysisAdd
BLAST
Topological domaini108 – 221114CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. apical plasma membrane Source: Ensembl
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30032.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 221221Potassium voltage-gated channel subfamily E member 4PRO_0000144292Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi9 – 91N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8WWG9.
PRIDEiQ8WWG9.

Expressioni

Tissue specificityi

Predominantly expressed in embryo and adult uterus. Low expression found in kidney, small intestine, lung and heart.1 Publication

Gene expression databases

BgeeiQ8WWG9.
CleanExiHS_KCNE4.
ExpressionAtlasiQ8WWG9. baseline and differential.
GenevestigatoriQ8WWG9.

Organism-specific databases

HPAiHPA011420.

Interactioni

Subunit structurei

Associates with KCNQ1/KVLQT1.Curated

Protein-protein interaction databases

BioGridi117217. 5 interactions.
STRINGi9606.ENSP00000281830.

Structurei

3D structure databases

ProteinModelPortaliQ8WWG9.
SMRiQ8WWG9. Positions 56-138.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi120 – 1234Poly-Leu

Sequence similaritiesi

Belongs to the potassium channel KCNE family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG42046.
GeneTreeiENSGT00390000013776.
HOVERGENiHBG052229.
InParanoidiQ8WWG9.
KOiK04898.
OMAiLWGEAMK.
OrthoDBiEOG74XS89.
TreeFamiTF333025.

Family and domain databases

InterProiIPR000369. K_chnl_volt-dep_bsu_KCNE.
[Graphical view]
PfamiPF02060. ISK_Channel. 1 hit.
[Graphical view]
PRINTSiPR00168. KCNECHANNEL.

Sequencei

Sequence statusi: Complete.

Q8WWG9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHFLTIYPNC SSGVVRAQSR TEQKNPLGLD DLGIQNLGQT VSLAPAVEAA
60 70 80 90 100
SMLKMEPLNS THPGTAASSS PLESRAAGGG SGNGNEYFYI LVVMSFYGIF
110 120 130 140 150
LIGIMLGYMK SKRREKKSSL LLLYKDEERL WGEAMKPLPV VSGLRSVQVP
160 170 180 190 200
LMLNMLQESV APALSCTLCS MEGDSVSSES SSPDVHLTIQ EEGADDELEE
210 220
TSETPLNESS EGSSENIHQN S
Length:221
Mass (Da):23,806
Last modified:September 3, 2014 - v4
Checksum:iF601434C18E82CFE
GO

Sequence cautioni

The sequence AAH14429.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAL49979.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti47 – 471V → A in BAH11761. (PubMed:14702039)Curated
Sequence conflicti105 – 1051M → V in AAL49979. 1 PublicationCurated
Sequence conflicti137 – 1371P → S in AAL49979. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti98 – 981G → S.
Corresponds to variant rs13409084 [ dbSNP | Ensembl ].
VAR_030620
Natural varianti196 – 1961D → E.2 Publications
Corresponds to variant rs12621643 [ dbSNP | Ensembl ].
VAR_024411

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK294423 mRNA. Translation: BAH11761.1.
AC017014 Genomic DNA. Translation: AAX93228.1.
BC014429 mRNA. Translation: AAH14429.1. Different initiation.
AY065987 mRNA. Translation: AAL49979.1. Different initiation.
CCDSiCCDS2456.2.
RefSeqiNP_542402.3. NM_080671.3.
UniGeneiHs.348522.

Genome annotation databases

EnsembliENST00000281830; ENSP00000281830; ENSG00000152049.
GeneIDi23704.
KEGGihsa:23704.
UCSCiuc021vxi.1. human.

Polymorphism databases

DMDMi311033433.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK294423 mRNA. Translation: BAH11761.1.
AC017014 Genomic DNA. Translation: AAX93228.1.
BC014429 mRNA. Translation: AAH14429.1. Different initiation.
AY065987 mRNA. Translation: AAL49979.1. Different initiation.
CCDSiCCDS2456.2.
RefSeqiNP_542402.3. NM_080671.3.
UniGeneiHs.348522.

3D structure databases

ProteinModelPortaliQ8WWG9.
SMRiQ8WWG9. Positions 56-138.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117217. 5 interactions.
STRINGi9606.ENSP00000281830.

Polymorphism databases

DMDMi311033433.

Proteomic databases

PaxDbiQ8WWG9.
PRIDEiQ8WWG9.

Protocols and materials databases

DNASUi23704.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000281830; ENSP00000281830; ENSG00000152049.
GeneIDi23704.
KEGGihsa:23704.
UCSCiuc021vxi.1. human.

Organism-specific databases

CTDi23704.
GeneCardsiGC02P223880.
HGNCiHGNC:6244. KCNE4.
HPAiHPA011420.
MIMi607775. gene.
neXtProtiNX_Q8WWG9.
PharmGKBiPA30032.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG42046.
GeneTreeiENSGT00390000013776.
HOVERGENiHBG052229.
InParanoidiQ8WWG9.
KOiK04898.
OMAiLWGEAMK.
OrthoDBiEOG74XS89.
TreeFamiTF333025.

Miscellaneous databases

GeneWikiiKCNE4.
NextBioi35478924.
PROiQ8WWG9.
SOURCEiSearch...

Gene expression databases

BgeeiQ8WWG9.
CleanExiHS_KCNE4.
ExpressionAtlasiQ8WWG9. baseline and differential.
GenevestigatoriQ8WWG9.

Family and domain databases

InterProiIPR000369. K_chnl_volt-dep_bsu_KCNE.
[Graphical view]
PfamiPF02060. ISK_Channel. 1 hit.
[Graphical view]
PRINTSiPR00168. KCNECHANNEL.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Amygdala.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 23-221, VARIANT GLU-196.
    Tissue: Lung.
  4. Hui R., Teng S., Lin C., Ma L., Zhen Y.
    Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 25-221, VARIANT GLU-196.
    Tissue: Heart and Kidney.
  5. Cited for: ASSOCIATION WITH KCNQ1, TISSUE SPECIFICITY.

Entry informationi

Entry nameiKCNE4_HUMAN
AccessioniPrimary (citable) accession number: Q8WWG9
Secondary accession number(s): B7Z275, Q53SM4, Q96CC4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: September 3, 2014
Last modified: January 7, 2015
This is version 106 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.