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Q8WWG9 (KCNE4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Potassium voltage-gated channel subfamily E member 4
Alternative name(s):
MinK-related peptide 3
Minimum potassium ion channel-related peptide 3
Potassium channel subunit beta MiRP3
Gene names
Name:KCNE4
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length170 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. May associate with KCNQ1/KVLTQ1 and inhibit potassium current.

Subunit structure

Associates with KCNQ1/KVLQT1 Probable.

Subcellular location

Membrane; Single-pass type I membrane protein.

Tissue specificity

Predominantly expressed in embryo and adult uterus. Low expression found in kidney, small intestine, lung and heart. Ref.4

Sequence similarities

Belongs to the potassium channel KCNE family.

Ontologies

Keywords
   Biological processIon transport
Potassium transport
Transport
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
Transmembrane helix
   LigandPotassium
   Molecular functionIon channel
Potassium channel
Voltage-gated channel
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionvoltage-gated potassium channel activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 170170Potassium voltage-gated channel subfamily E member 4
PRO_0000144292

Regions

Transmembrane36 – 5621Helical; Potential
Topological domain57 – 170114Cytoplasmic Potential

Amino acid modifications

Glycosylation81N-linked (GlcNAc...) Potential

Natural variations

Natural variant471G → S.
Corresponds to variant rs13409084 [ dbSNP | Ensembl ].
VAR_030620
Natural variant1451D → E. Ref.1 Ref.3
Corresponds to variant rs12621643 [ dbSNP | Ensembl ].
VAR_024411

Experimental info

Sequence conflict541M → V in AAL49979. Ref.1
Sequence conflict861P → S in AAL49979. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q8WWG9 [UniParc].

Last modified November 2, 2010. Version 3.
Checksum: 4F6D84E97BF71B52

FASTA17018,425
        10         20         30         40         50         60 
MLKMEPLNST HPGTAASSSP LESRAAGGGS GNGNEYFYIL VVMSFYGIFL IGIMLGYMKS 

        70         80         90        100        110        120 
KRREKKSSLL LLYKDEERLW GEAMKPLPVV SGLRSVQVPL MLNMLQESVA PALSCTLCSM 

       130        140        150        160        170 
EGDSVSSESS SPDVHLTIQE EGADDELEET SETPLNESSE GSSENIHQNS 

« Hide

References

« Hide 'large scale' references
[1]Hui R., Teng S., Lin C., Ma L., Zhen Y.
Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLU-145.
Tissue: Heart and Kidney.
[2]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLU-145.
Tissue: Lung.
[4]"KCNE4 is an inhibitory subunit to the KCNQ1 channel."
Grunnet M., Jespersen T., Rasmussen H.B., Ljungstroem T., Jorgensen N.K., Olesen S.-P., Klaerke D.A.
J. Physiol. (Lond.) 542:119-130(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: ASSOCIATION WITH KCNQ1, TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY065987 mRNA. Translation: AAL49979.1.
AC017014 Genomic DNA. Translation: AAX93228.1.
BC014429 mRNA. Translation: AAH14429.1.
UniGeneHs.348522.

3D structure databases

ProteinModelPortalQ8WWG9.
SMRQ8WWG9. Positions 5-87.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid117217. 5 interactions.
STRING9606.ENSP00000281830.

Polymorphism databases

DMDM311033433.

Proteomic databases

PaxDbQ8WWG9.
PRIDEQ8WWG9.

Protocols and materials databases

DNASU23704.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000604125; ENSP00000473755; ENSG00000152049.
UCSCuc021vxi.1. human.

Organism-specific databases

GeneCardsGC02P223880.
HGNCHGNC:6244. KCNE4.
HPAHPA011420.
MIM607775. gene.
neXtProtNX_Q8WWG9.
PharmGKBPA30032.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG42046.
HOVERGENHBG052229.
InParanoidQ8WWG9.
OMALWGEAMK.
OrthoDBEOG74XS89.
PhylomeDBQ8WWG9.
TreeFamTF333025.

Gene expression databases

ArrayExpressQ8WWG9.
BgeeQ8WWG9.
CleanExHS_KCNE4.
GenevestigatorQ8WWG9.

Family and domain databases

InterProIPR000369. K_chnl_volt-dep_bsu_KCNE.
[Graphical view]
PfamPF02060. ISK_Channel. 1 hit.
[Graphical view]
PRINTSPR00168. KCNECHANNEL.
ProtoNetSearch...

Other

NextBio46593.
PROQ8WWG9.
SOURCESearch...

Entry information

Entry nameKCNE4_HUMAN
AccessionPrimary (citable) accession number: Q8WWG9
Secondary accession number(s): Q53SM4, Q96CC4
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: November 2, 2010
Last modified: February 19, 2014
This is version 98 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM