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Q8WWG9

- KCNE4_HUMAN

UniProt

Q8WWG9 - KCNE4_HUMAN

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Protein

Potassium voltage-gated channel subfamily E member 4

Gene
KCNE4
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. May associate with KCNQ1/KVLTQ1 and inhibit potassium current.

GO - Molecular functioni

  1. voltage-gated potassium channel activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily E member 4
Alternative name(s):
MinK-related peptide 3
Minimum potassium ion channel-related peptide 3
Potassium channel subunit beta MiRP3
Gene namesi
Name:KCNE4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:6244. KCNE4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 8686Extracellular Reviewed predictionAdd
BLAST
Transmembranei87 – 10721Helical; Reviewed predictionAdd
BLAST
Topological domaini108 – 221114Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. apical plasma membrane Source: Ensembl
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30032.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 221221Potassium voltage-gated channel subfamily E member 4PRO_0000144292Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi9 – 91N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8WWG9.
PRIDEiQ8WWG9.

Expressioni

Tissue specificityi

Predominantly expressed in embryo and adult uterus. Low expression found in kidney, small intestine, lung and heart.1 Publication

Gene expression databases

ArrayExpressiQ8WWG9.
BgeeiQ8WWG9.
CleanExiHS_KCNE4.
GenevestigatoriQ8WWG9.

Organism-specific databases

HPAiHPA011420.

Interactioni

Subunit structurei

Associates with KCNQ1/KVLQT1 Inferred.

Protein-protein interaction databases

BioGridi117217. 5 interactions.
STRINGi9606.ENSP00000281830.

Structurei

3D structure databases

ProteinModelPortaliQ8WWG9.
SMRiQ8WWG9. Positions 5-87.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi120 – 1234Poly-Leu

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG42046.
HOVERGENiHBG052229.
InParanoidiQ8WWG9.
OrthoDBiEOG74XS89.
PhylomeDBiQ8WWG9.
TreeFamiTF333025.

Family and domain databases

InterProiIPR000369. K_chnl_volt-dep_bsu_KCNE.
[Graphical view]
PfamiPF02060. ISK_Channel. 1 hit.
[Graphical view]
PRINTSiPR00168. KCNECHANNEL.

Sequencei

Sequence statusi: Complete.

Q8WWG9-1 [UniParc]FASTAAdd to Basket

« Hide

MHFLTIYPNC SSGVVRAQSR TEQKNPLGLD DLGIQNLGQT VSLAPAVEAA    50
SMLKMEPLNS THPGTAASSS PLESRAAGGG SGNGNEYFYI LVVMSFYGIF 100
LIGIMLGYMK SKRREKKSSL LLLYKDEERL WGEAMKPLPV VSGLRSVQVP 150
LMLNMLQESV APALSCTLCS MEGDSVSSES SSPDVHLTIQ EEGADDELEE 200
TSETPLNESS EGSSENIHQN S 221
Length:221
Mass (Da):23,806
Last modified:September 3, 2014 - v4
Checksum:iF601434C18E82CFE
GO

Sequence cautioni

The sequence AAH14429.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence AAL49979.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti98 – 981G → S.
Corresponds to variant rs13409084 [ dbSNP | Ensembl ].
VAR_030620
Natural varianti196 – 1961D → E.
Corresponds to variant rs12621643 [ dbSNP | Ensembl ].
VAR_024411

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti47 – 471V → A in BAH11761. 1 Publication
Sequence conflicti105 – 1051M → V in AAL49979. 1 Publication
Sequence conflicti137 – 1371P → S in AAL49979. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK294423 mRNA. Translation: BAH11761.1.
AC017014 Genomic DNA. Translation: AAX93228.1.
BC014429 mRNA. Translation: AAH14429.1. Different initiation.
AY065987 mRNA. Translation: AAL49979.1. Different initiation.
UniGeneiHs.348522.

Genome annotation databases

EnsembliENST00000604125; ENSP00000473755; ENSG00000152049.
GeneIDi23704.

Polymorphism databases

DMDMi311033433.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK294423 mRNA. Translation: BAH11761.1 .
AC017014 Genomic DNA. Translation: AAX93228.1 .
BC014429 mRNA. Translation: AAH14429.1 . Different initiation.
AY065987 mRNA. Translation: AAL49979.1 . Different initiation.
UniGenei Hs.348522.

3D structure databases

ProteinModelPortali Q8WWG9.
SMRi Q8WWG9. Positions 5-87.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117217. 5 interactions.
STRINGi 9606.ENSP00000281830.

Polymorphism databases

DMDMi 311033433.

Proteomic databases

PaxDbi Q8WWG9.
PRIDEi Q8WWG9.

Protocols and materials databases

DNASUi 23704.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000604125 ; ENSP00000473755 ; ENSG00000152049 .
GeneIDi 23704.

Organism-specific databases

GeneCardsi GC02P223880.
HGNCi HGNC:6244. KCNE4.
HPAi HPA011420.
MIMi 607775. gene.
neXtProti NX_Q8WWG9.
PharmGKBi PA30032.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG42046.
HOVERGENi HBG052229.
InParanoidi Q8WWG9.
OrthoDBi EOG74XS89.
PhylomeDBi Q8WWG9.
TreeFami TF333025.

Miscellaneous databases

GeneWikii KCNE4.
NextBioi 35478924.
PROi Q8WWG9.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8WWG9.
Bgeei Q8WWG9.
CleanExi HS_KCNE4.
Genevestigatori Q8WWG9.

Family and domain databases

InterProi IPR000369. K_chnl_volt-dep_bsu_KCNE.
[Graphical view ]
Pfami PF02060. ISK_Channel. 1 hit.
[Graphical view ]
PRINTSi PR00168. KCNECHANNEL.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Amygdala.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 23-221, VARIANT GLU-196.
    Tissue: Lung.
  4. Hui R., Teng S., Lin C., Ma L., Zhen Y.
    Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 25-221, VARIANT GLU-196.
    Tissue: Heart and Kidney.
  5. Cited for: ASSOCIATION WITH KCNQ1, TISSUE SPECIFICITY.

Entry informationi

Entry nameiKCNE4_HUMAN
AccessioniPrimary (citable) accession number: Q8WWG9
Secondary accession number(s): B7Z275, Q53SM4, Q96CC4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: September 3, 2014
Last modified: September 3, 2014
This is version 102 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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