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Q8WWG9

- KCNE4_HUMAN

UniProt

Q8WWG9 - KCNE4_HUMAN

Protein

Potassium voltage-gated channel subfamily E member 4

Gene

KCNE4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 4 (03 Sep 2014)
      Previous versions | rss
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    Functioni

    Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. May associate with KCNQ1/KVLTQ1 and inhibit potassium current.

    GO - Molecular functioni

    1. voltage-gated potassium channel activity Source: InterPro

    Keywords - Molecular functioni

    Ion channel, Potassium channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    Potassium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium voltage-gated channel subfamily E member 4
    Alternative name(s):
    MinK-related peptide 3
    Minimum potassium ion channel-related peptide 3
    Potassium channel subunit beta MiRP3
    Gene namesi
    Name:KCNE4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:6244. KCNE4.

    Subcellular locationi

    GO - Cellular componenti

    1. apical plasma membrane Source: Ensembl
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30032.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 221221Potassium voltage-gated channel subfamily E member 4PRO_0000144292Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi9 – 91N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ8WWG9.
    PRIDEiQ8WWG9.

    Expressioni

    Tissue specificityi

    Predominantly expressed in embryo and adult uterus. Low expression found in kidney, small intestine, lung and heart.1 Publication

    Gene expression databases

    ArrayExpressiQ8WWG9.
    BgeeiQ8WWG9.
    CleanExiHS_KCNE4.
    GenevestigatoriQ8WWG9.

    Organism-specific databases

    HPAiHPA011420.

    Interactioni

    Subunit structurei

    Associates with KCNQ1/KVLQT1.Curated

    Protein-protein interaction databases

    BioGridi117217. 5 interactions.
    STRINGi9606.ENSP00000281830.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8WWG9.
    SMRiQ8WWG9. Positions 5-87.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 8686ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini108 – 221114CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei87 – 10721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi120 – 1234Poly-Leu

    Sequence similaritiesi

    Belongs to the potassium channel KCNE family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG42046.
    HOVERGENiHBG052229.
    InParanoidiQ8WWG9.
    OrthoDBiEOG74XS89.
    PhylomeDBiQ8WWG9.
    TreeFamiTF333025.

    Family and domain databases

    InterProiIPR000369. K_chnl_volt-dep_bsu_KCNE.
    [Graphical view]
    PfamiPF02060. ISK_Channel. 1 hit.
    [Graphical view]
    PRINTSiPR00168. KCNECHANNEL.

    Sequencei

    Sequence statusi: Complete.

    Q8WWG9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHFLTIYPNC SSGVVRAQSR TEQKNPLGLD DLGIQNLGQT VSLAPAVEAA    50
    SMLKMEPLNS THPGTAASSS PLESRAAGGG SGNGNEYFYI LVVMSFYGIF 100
    LIGIMLGYMK SKRREKKSSL LLLYKDEERL WGEAMKPLPV VSGLRSVQVP 150
    LMLNMLQESV APALSCTLCS MEGDSVSSES SSPDVHLTIQ EEGADDELEE 200
    TSETPLNESS EGSSENIHQN S 221
    Length:221
    Mass (Da):23,806
    Last modified:September 3, 2014 - v4
    Checksum:iF601434C18E82CFE
    GO

    Sequence cautioni

    The sequence AAH14429.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence AAL49979.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti47 – 471V → A in BAH11761. (PubMed:14702039)Curated
    Sequence conflicti105 – 1051M → V in AAL49979. 1 PublicationCurated
    Sequence conflicti137 – 1371P → S in AAL49979. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti98 – 981G → S.
    Corresponds to variant rs13409084 [ dbSNP | Ensembl ].
    VAR_030620
    Natural varianti196 – 1961D → E.2 Publications
    Corresponds to variant rs12621643 [ dbSNP | Ensembl ].
    VAR_024411

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK294423 mRNA. Translation: BAH11761.1.
    AC017014 Genomic DNA. Translation: AAX93228.1.
    BC014429 mRNA. Translation: AAH14429.1. Different initiation.
    AY065987 mRNA. Translation: AAL49979.1. Different initiation.
    UniGeneiHs.348522.

    Genome annotation databases

    EnsembliENST00000281830; ENSP00000281830; ENSG00000152049.
    GeneIDi23704.

    Polymorphism databases

    DMDMi311033433.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK294423 mRNA. Translation: BAH11761.1 .
    AC017014 Genomic DNA. Translation: AAX93228.1 .
    BC014429 mRNA. Translation: AAH14429.1 . Different initiation.
    AY065987 mRNA. Translation: AAL49979.1 . Different initiation.
    UniGenei Hs.348522.

    3D structure databases

    ProteinModelPortali Q8WWG9.
    SMRi Q8WWG9. Positions 5-87.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117217. 5 interactions.
    STRINGi 9606.ENSP00000281830.

    Polymorphism databases

    DMDMi 311033433.

    Proteomic databases

    PaxDbi Q8WWG9.
    PRIDEi Q8WWG9.

    Protocols and materials databases

    DNASUi 23704.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000281830 ; ENSP00000281830 ; ENSG00000152049 .
    GeneIDi 23704.

    Organism-specific databases

    CTDi 23704.
    GeneCardsi GC02P223880.
    HGNCi HGNC:6244. KCNE4.
    HPAi HPA011420.
    MIMi 607775. gene.
    neXtProti NX_Q8WWG9.
    PharmGKBi PA30032.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG42046.
    HOVERGENi HBG052229.
    InParanoidi Q8WWG9.
    OrthoDBi EOG74XS89.
    PhylomeDBi Q8WWG9.
    TreeFami TF333025.

    Miscellaneous databases

    GeneWikii KCNE4.
    NextBioi 35478924.
    PROi Q8WWG9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8WWG9.
    Bgeei Q8WWG9.
    CleanExi HS_KCNE4.
    Genevestigatori Q8WWG9.

    Family and domain databases

    InterProi IPR000369. K_chnl_volt-dep_bsu_KCNE.
    [Graphical view ]
    Pfami PF02060. ISK_Channel. 1 hit.
    [Graphical view ]
    PRINTSi PR00168. KCNECHANNEL.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Amygdala.
    2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 23-221, VARIANT GLU-196.
      Tissue: Lung.
    4. Hui R., Teng S., Lin C., Ma L., Zhen Y.
      Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 25-221, VARIANT GLU-196.
      Tissue: Heart and Kidney.
    5. Cited for: ASSOCIATION WITH KCNQ1, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiKCNE4_HUMAN
    AccessioniPrimary (citable) accession number: Q8WWG9
    Secondary accession number(s): B7Z275, Q53SM4, Q96CC4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2002
    Last sequence update: September 3, 2014
    Last modified: October 1, 2014
    This is version 103 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3