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Q8WWG1 (NRG4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pro-neuregulin-4, membrane-bound isoform

Short name=Pro-NRG4

Cleaved into the following chain:

  1. Neuregulin-4
    Short name=NRG-4
Gene names
Name:NRG4
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length115 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors By similarity.

Subunit structure

Interacts with ERBB4 By similarity.

Subcellular location

Pro-neuregulin-4, membrane-bound isoform: Cell membrane; Single-pass type I membrane protein By similarity. Note: Does not seem to be active By similarity.

Neuregulin-4: Secreted By similarity.

Domain

The cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing involves initial intracellular domain dimerization By similarity.

ERBB receptor binding is elicited entirely by the EGF-like domain By similarity.

Post-translational modification

Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form By similarity.

Extensive glycosylation precedes the proteolytic cleavage By similarity.

Sequence similarities

Belongs to the neuregulin family.

Contains 1 EGF-like domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 115115Pro-neuregulin-4, membrane-bound isoform
PRO_0000019485
Chain1 – 6161Neuregulin-4
PRO_0000019486

Regions

Topological domain1 – 6262Extracellular Potential
Transmembrane63 – 8321Helical; Note=Internal signal sequence; Potential
Topological domain84 – 11532Cytoplasmic Potential
Domain5 – 4642EGF-like

Amino acid modifications

Glycosylation391N-linked (GlcNAc...) Potential
Disulfide bond9 ↔ 23 By similarity
Disulfide bond17 ↔ 34 By similarity
Disulfide bond36 ↔ 45 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8WWG1 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 72F962E2D0F37AC3

FASTA11512,722
        10         20         30         40         50         60 
MPTDHEEPCG PSHKSFCLNG GLCYVIPTIP SPFCRCVENY TGARCEEVFL PGSSIQTKSN 

        70         80         90        100        110 
LFEAFVALAV LVTLIIGAFY FLCRKGHFQR ASSVQYDINL VETSSTSAHH SHEQH 

« Hide

References

[1]"Analysis of the DNA sequence and duplication history of human chromosome 15."
Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A. expand/collapse author list , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC087456 Genomic DNA. No translation available.
CH471136 Genomic DNA. Translation: EAW99227.1.
BC017568 mRNA. Translation: AAH17568.1.
RefSeqNP_612640.1. NM_138573.3.
UniGeneHs.732438.

3D structure databases

ProteinModelPortalQ8WWG1.
SMRQ8WWG1. Positions 6-49.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ8WWG1. 2 interactions.
STRING9606.ENSP00000378367.

Polymorphism databases

DMDM28201832.

Proteomic databases

PRIDEQ8WWG1.

Protocols and materials databases

DNASU145957.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000394907; ENSP00000378367; ENSG00000169752.
ENST00000566417; ENSP00000457335; ENSG00000169752.
GeneID145957.
KEGGhsa:145957.
UCSCuc002bbo.3. human.

Organism-specific databases

CTD145957.
GeneCardsGC15M076233.
HGNCHGNC:29862. NRG4.
HPAHPA010957.
MIM610894. gene.
neXtProtNX_Q8WWG1.
PharmGKBPA142671246.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG42904.
HOGENOMHOG000113853.
HOVERGENHBG006533.
InParanoidQ8WWG1.
KOK05458.
OMACRCIENY.
OrthoDBEOG73806M.
PhylomeDBQ8WWG1.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.
REACT_116125. Disease.
REACT_6900. Immune System.
SignaLinkQ8WWG1.

Gene expression databases

ArrayExpressQ8WWG1.
BgeeQ8WWG1.
CleanExHS_NRG4.
GenevestigatorQ8WWG1.

Family and domain databases

InterProIPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
[Graphical view]
SMARTSM00181. EGF. 1 hit.
[Graphical view]
PROSITEPS00022. EGF_1. 1 hit.
PS50026. EGF_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiNRG4.
GenomeRNAi145957.
NextBio85235.
PROQ8WWG1.
SOURCESearch...

Entry information

Entry nameNRG4_HUMAN
AccessionPrimary (citable) accession number: Q8WWG1
Secondary accession number(s): A6NIE8
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: March 1, 2002
Last modified: March 19, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 15

Human chromosome 15: entries, gene names and cross-references to MIM