ID CAPSL_HUMAN Reviewed; 208 AA. AC Q8WWF8; DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot. DT 18-MAY-2010, sequence version 4. DT 24-JAN-2024, entry version 155. DE RecName: Full=Calcyphosin-like protein; GN Name=CAPSL; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15372022; DOI=10.1038/nature02919; RA Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., RA Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., RA She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S., RA Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., RA Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., RA Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., RA Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., RA Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., RA Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., RA Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., RA Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., RA Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., RA Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.; RT "The DNA sequence and comparative analysis of human chromosome 5."; RL Nature 431:268-274(2004). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Testis; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=AAH17586.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC112204; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC017586; AAH17586.2; ALT_INIT; mRNA. DR CCDS; CCDS3912.2; -. DR RefSeq; NP_001036090.1; NM_001042625.1. DR RefSeq; NP_653248.3; NM_144647.3. DR AlphaFoldDB; Q8WWF8; -. DR SMR; Q8WWF8; -. DR BioGRID; 126371; 15. DR STRING; 9606.ENSP00000380524; -. DR iPTMnet; Q8WWF8; -. DR MetOSite; Q8WWF8; -. DR PhosphoSitePlus; Q8WWF8; -. DR BioMuta; CAPSL; -. DR DMDM; 296439463; -. DR MassIVE; Q8WWF8; -. DR PaxDb; 9606-ENSP00000380524; -. DR PeptideAtlas; Q8WWF8; -. DR ProteomicsDB; 74883; -. DR Antibodypedia; 43514; 43 antibodies from 19 providers. DR DNASU; 133690; -. DR Ensembl; ENST00000397366.5; ENSP00000380523.1; ENSG00000152611.12. DR Ensembl; ENST00000397367.6; ENSP00000380524.2; ENSG00000152611.12. DR Ensembl; ENST00000651391.1; ENSP00000498465.1; ENSG00000152611.12. DR GeneID; 133690; -. DR KEGG; hsa:133690; -. DR MANE-Select; ENST00000651391.1; ENSP00000498465.1; NM_001042625.2; NP_001036090.1. DR UCSC; uc003jjt.2; human. DR AGR; HGNC:28375; -. DR CTD; 133690; -. DR DisGeNET; 133690; -. DR GeneCards; CAPSL; -. DR HGNC; HGNC:28375; CAPSL. DR HPA; ENSG00000152611; Group enriched (choroid plexus, fallopian tube). DR MIM; 618799; gene. DR neXtProt; NX_Q8WWF8; -. DR OpenTargets; ENSG00000152611; -. DR PharmGKB; PA142672204; -. DR VEuPathDB; HostDB:ENSG00000152611; -. DR eggNOG; KOG0032; Eukaryota. DR GeneTree; ENSGT00940000156466; -. DR HOGENOM; CLU_036726_1_0_1; -. DR InParanoid; Q8WWF8; -. DR OMA; DYAVMID; -. DR OrthoDB; 52418at2759; -. DR PhylomeDB; Q8WWF8; -. DR TreeFam; TF318191; -. DR PathwayCommons; Q8WWF8; -. DR SignaLink; Q8WWF8; -. DR BioGRID-ORCS; 133690; 13 hits in 1132 CRISPR screens. DR GenomeRNAi; 133690; -. DR Pharos; Q8WWF8; Tdark. DR PRO; PR:Q8WWF8; -. DR Proteomes; UP000005640; Chromosome 5. DR RNAct; Q8WWF8; Protein. DR Bgee; ENSG00000152611; Expressed in bronchial epithelial cell and 95 other cell types or tissues. DR ExpressionAtlas; Q8WWF8; baseline and differential. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro. DR Gene3D; 1.10.238.10; EF-hand; 2. DR InterPro; IPR011992; EF-hand-dom_pair. DR InterPro; IPR018247; EF_Hand_1_Ca_BS. DR InterPro; IPR002048; EF_hand_dom. DR PANTHER; PTHR34524; CALCYPHOSIN; 1. DR PANTHER; PTHR34524:SF5; CALCYPHOSIN-LIKE PROTEIN; 1. DR Pfam; PF13499; EF-hand_7; 2. DR PRINTS; PR00450; RECOVERIN. DR SMART; SM00054; EFh; 4. DR SUPFAM; SSF47473; EF-hand; 1. DR PROSITE; PS00018; EF_HAND_1; 2. DR PROSITE; PS50222; EF_HAND_2; 4. DR Genevisible; Q8WWF8; HS. PE 2: Evidence at transcript level; KW Calcium; Cytoplasm; Metal-binding; Reference proteome; Repeat. FT CHAIN 1..208 FT /note="Calcyphosin-like protein" FT /id="PRO_0000264473" FT DOMAIN 39..74 FT /note="EF-hand 1" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448" FT DOMAIN 75..110 FT /note="EF-hand 2" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448" FT DOMAIN 111..146 FT /note="EF-hand 3" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448" FT DOMAIN 154..191 FT /note="EF-hand 4" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448" FT BINDING 52 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /ligand_label="1" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448" FT BINDING 54 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /ligand_label="1" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448" FT BINDING 56 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /ligand_label="1" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448" FT BINDING 58 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /ligand_label="1" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448" FT BINDING 63 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /ligand_label="1" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448" FT BINDING 88 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /ligand_label="2" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448" FT BINDING 90 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /ligand_label="2" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448" FT BINDING 92 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /ligand_label="2" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448" FT BINDING 94 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /ligand_label="2" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448" FT BINDING 99 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /ligand_label="2" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448" FT VARIANT 85 FT /note="R -> Q (in dbSNP:rs1445898)" FT /id="VAR_029631" FT VARIANT 201 FT /note="M -> V (in dbSNP:rs1345826)" FT /id="VAR_029632" FT CONFLICT 24 FT /note="D -> N (in Ref. 2; AAH17586)" FT /evidence="ECO:0000305" SQ SEQUENCE 208 AA; 24229 MW; 4F1C9D89F13C538E CRC64; MAGTARHDRE MAIQAKKKLT TATDPIERLR LQCLARGSAG IKGLGRVFRI MDDDNNRTLD FKEFMKGLND YAVVMEKEEV EELFRRFDKD GNGTIDFNEF LLTLRPPMSR ARKEVIMQAF RKLDKTGDGV ITIEDLREVY NAKHHPKYQN GEWSEEQVFR KFLDNFDSPY DKDGLVTPEE FMNYYAGVSA SIDTDVYFII MMRTAWKL //