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Protein

Calcyphosin-like protein

Gene

CAPSL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi52 – 63121PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi88 – 99122PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calcyphosin-like protein
Gene namesi
Name:CAPSL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:28375. CAPSL.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672204.

Polymorphism and mutation databases

BioMutaiCAPSL.
DMDMi296439463.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 208208Calcyphosin-like proteinPRO_0000264473Add
BLAST

Proteomic databases

MaxQBiQ8WWF8.
PaxDbiQ8WWF8.
PeptideAtlasiQ8WWF8.
PRIDEiQ8WWF8.

PTM databases

iPTMnetiQ8WWF8.
PhosphoSiteiQ8WWF8.

Expressioni

Gene expression databases

BgeeiQ8WWF8.
CleanExiHS_CAPSL.
ExpressionAtlasiQ8WWF8. baseline and differential.
GenevisibleiQ8WWF8. HS.

Organism-specific databases

HPAiHPA046811.
HPA058495.

Interactioni

Protein-protein interaction databases

BioGridi126371. 1 interaction.
STRINGi9606.ENSP00000380523.

Structurei

3D structure databases

ProteinModelPortaliQ8WWF8.
SMRiQ8WWF8. Positions 14-208.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini39 – 7436EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini75 – 11036EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini111 – 14636EF-hand 3PROSITE-ProRule annotationAdd
BLAST
Domaini154 – 19138EF-hand 4PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 4 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0032. Eukaryota.
ENOG410XRMJ. LUCA.
GeneTreeiENSGT00390000000679.
HOGENOMiHOG000008004.
HOVERGENiHBG050808.
InParanoidiQ8WWF8.
OMAiFDEFLIT.
OrthoDBiEOG7992SK.
PhylomeDBiQ8WWF8.
TreeFamiTF318191.

Family and domain databases

Gene3Di1.10.238.10. 3 hits.
InterProiIPR029633. CAPSL.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PANTHERiPTHR10891:SF551. PTHR10891:SF551. 1 hit.
PfamiPF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8WWF8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGTARHDRE MAIQAKKKLT TATDPIERLR LQCLARGSAG IKGLGRVFRI
60 70 80 90 100
MDDDNNRTLD FKEFMKGLND YAVVMEKEEV EELFRRFDKD GNGTIDFNEF
110 120 130 140 150
LLTLRPPMSR ARKEVIMQAF RKLDKTGDGV ITIEDLREVY NAKHHPKYQN
160 170 180 190 200
GEWSEEQVFR KFLDNFDSPY DKDGLVTPEE FMNYYAGVSA SIDTDVYFII

MMRTAWKL
Length:208
Mass (Da):24,229
Last modified:May 18, 2010 - v4
Checksum:i4F1C9D89F13C538E
GO

Sequence cautioni

The sequence AAH17586.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti24 – 241D → N in AAH17586 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti85 – 851R → Q.
Corresponds to variant rs1445898 [ dbSNP | Ensembl ].
VAR_029631
Natural varianti201 – 2011M → V.
Corresponds to variant rs1345826 [ dbSNP | Ensembl ].
VAR_029632

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC112204 Genomic DNA. No translation available.
BC017586 mRNA. Translation: AAH17586.2. Different initiation.
CCDSiCCDS3912.2.
RefSeqiNP_001036090.1. NM_001042625.1.
NP_653248.3. NM_144647.3.
UniGeneiHs.55150.

Genome annotation databases

EnsembliENST00000397366; ENSP00000380523; ENSG00000152611.
ENST00000397367; ENSP00000380524; ENSG00000152611.
GeneIDi133690.
KEGGihsa:133690.
UCSCiuc003jjt.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC112204 Genomic DNA. No translation available.
BC017586 mRNA. Translation: AAH17586.2. Different initiation.
CCDSiCCDS3912.2.
RefSeqiNP_001036090.1. NM_001042625.1.
NP_653248.3. NM_144647.3.
UniGeneiHs.55150.

3D structure databases

ProteinModelPortaliQ8WWF8.
SMRiQ8WWF8. Positions 14-208.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126371. 1 interaction.
STRINGi9606.ENSP00000380523.

PTM databases

iPTMnetiQ8WWF8.
PhosphoSiteiQ8WWF8.

Polymorphism and mutation databases

BioMutaiCAPSL.
DMDMi296439463.

Proteomic databases

MaxQBiQ8WWF8.
PaxDbiQ8WWF8.
PeptideAtlasiQ8WWF8.
PRIDEiQ8WWF8.

Protocols and materials databases

DNASUi133690.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000397366; ENSP00000380523; ENSG00000152611.
ENST00000397367; ENSP00000380524; ENSG00000152611.
GeneIDi133690.
KEGGihsa:133690.
UCSCiuc003jjt.2. human.

Organism-specific databases

CTDi133690.
GeneCardsiCAPSL.
HGNCiHGNC:28375. CAPSL.
HPAiHPA046811.
HPA058495.
neXtProtiNX_Q8WWF8.
PharmGKBiPA142672204.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0032. Eukaryota.
ENOG410XRMJ. LUCA.
GeneTreeiENSGT00390000000679.
HOGENOMiHOG000008004.
HOVERGENiHBG050808.
InParanoidiQ8WWF8.
OMAiFDEFLIT.
OrthoDBiEOG7992SK.
PhylomeDBiQ8WWF8.
TreeFamiTF318191.

Miscellaneous databases

GenomeRNAii133690.
PROiQ8WWF8.

Gene expression databases

BgeeiQ8WWF8.
CleanExiHS_CAPSL.
ExpressionAtlasiQ8WWF8. baseline and differential.
GenevisibleiQ8WWF8. HS.

Family and domain databases

Gene3Di1.10.238.10. 3 hits.
InterProiIPR029633. CAPSL.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PANTHERiPTHR10891:SF551. PTHR10891:SF551. 1 hit.
PfamiPF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiCAPSL_HUMAN
AccessioniPrimary (citable) accession number: Q8WWF8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: May 18, 2010
Last modified: July 6, 2016
This is version 111 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.