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Q8WWF8 (CAPSL_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Calcyphosin-like protein
Gene names
Name:CAPSL
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length208 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Cytoplasm Potential.

Sequence similarities

Contains 4 EF-hand domains.

Sequence caution

The sequence AAH17586.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
   Cellular componentCytoplasm
   Coding sequence diversityPolymorphism
   DomainRepeat
   LigandCalcium
Metal-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncalcium ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 208208Calcyphosin-like protein
PRO_0000264473

Regions

Domain39 – 7436EF-hand 1
Domain75 – 11036EF-hand 2
Domain111 – 14636EF-hand 3
Domain154 – 19138EF-hand 4
Calcium binding52 – 63121 Potential
Calcium binding88 – 99122 Potential

Natural variations

Natural variant851R → Q.
Corresponds to variant rs1445898 [ dbSNP | Ensembl ].
VAR_029631
Natural variant2011M → V.
Corresponds to variant rs1345826 [ dbSNP | Ensembl ].
VAR_029632

Experimental info

Sequence conflict241D → N in AAH17586. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q8WWF8 [UniParc].

Last modified May 18, 2010. Version 4.
Checksum: 4F1C9D89F13C538E

FASTA20824,229
        10         20         30         40         50         60 
MAGTARHDRE MAIQAKKKLT TATDPIERLR LQCLARGSAG IKGLGRVFRI MDDDNNRTLD 

        70         80         90        100        110        120 
FKEFMKGLND YAVVMEKEEV EELFRRFDKD GNGTIDFNEF LLTLRPPMSR ARKEVIMQAF 

       130        140        150        160        170        180 
RKLDKTGDGV ITIEDLREVY NAKHHPKYQN GEWSEEQVFR KFLDNFDSPY DKDGLVTPEE 

       190        200 
FMNYYAGVSA SIDTDVYFII MMRTAWKL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC112204 Genomic DNA. No translation available.
BC017586 mRNA. Translation: AAH17586.2. Different initiation.
RefSeqNP_001036090.1. NM_001042625.1.
NP_653248.3. NM_144647.3.
UniGeneHs.55150.

3D structure databases

ProteinModelPortalQ8WWF8.
SMRQ8WWF8. Positions 14-208.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid126371. 1 interaction.
STRING9606.ENSP00000380523.

PTM databases

PhosphoSiteQ8WWF8.

Polymorphism databases

DMDM296439463.

Proteomic databases

PaxDbQ8WWF8.
PRIDEQ8WWF8.

Protocols and materials databases

DNASU133690.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000397366; ENSP00000380523; ENSG00000152611.
ENST00000397367; ENSP00000380524; ENSG00000152611.
GeneID133690.
KEGGhsa:133690.
UCSCuc003jjt.1. human.

Organism-specific databases

CTD133690.
GeneCardsGC05M035905.
HGNCHGNC:28375. CAPSL.
HPAHPA046811.
HPA058495.
neXtProtNX_Q8WWF8.
PharmGKBPA142672204.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG256371.
HOGENOMHOG000008004.
HOVERGENHBG050808.
InParanoidQ8WWF8.
OMATLDFKEF.
OrthoDBEOG7992SK.
PhylomeDBQ8WWF8.
TreeFamTF318191.

Gene expression databases

ArrayExpressQ8WWF8.
BgeeQ8WWF8.
CleanExHS_CAPSL.
GenevestigatorQ8WWF8.

Family and domain databases

Gene3D1.10.238.10. 3 hits.
InterProIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001125. Recoverin_like.
[Graphical view]
PfamPF13499. EF-hand_7. 2 hits.
[Graphical view]
PRINTSPR00450. RECOVERIN.
SMARTSM00054. EFh. 4 hits.
[Graphical view]
PROSITEPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi133690.
NextBio83270.
PROQ8WWF8.

Entry information

Entry nameCAPSL_HUMAN
AccessionPrimary (citable) accession number: Q8WWF8
Entry history
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: May 18, 2010
Last modified: April 16, 2014
This is version 96 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM