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Protein

DnaJ homolog subfamily B member 3

Gene

DNAJB3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May operate as a co-chaperone of the male germ cell- and haploid stage-specific Hsp70 proteins.Curated

Keywordsi

Molecular functionChaperone

Names & Taxonomyi

Protein namesi
Recommended name:
DnaJ homolog subfamily B member 3
Gene namesi
Name:DNAJB3
Synonyms:HCG3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:32397. DNAJB3.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162383828.

Polymorphism and mutation databases

BioMutaiDNAJB3.
DMDMi74730976.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003864721 – 145DnaJ homolog subfamily B member 3Add BLAST145

Proteomic databases

EPDiQ8WWF6.
MaxQBiQ8WWF6.
PeptideAtlasiQ8WWF6.
PRIDEiQ8WWF6.

PTM databases

iPTMnetiQ8WWF6.
PhosphoSitePlusiQ8WWF6.

Expressioni

Tissue specificityi

Expressed in sperm (at protein level).1 Publication

Interactioni

Protein-protein interaction databases

BioGridi135928. 3 interactors.
IntActiQ8WWF6. 7 interactors.
MINTiMINT-1434458.

Structurei

Secondary structure

1145
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 7Combined sources4
Helixi16 – 27Combined sources12
Turni32 – 34Combined sources3
Helixi39 – 56Combined sources18
Helixi61 – 67Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EJ7NMR-A1-69[»]
ProteinModelPortaliQ8WWF6.
SMRiQ8WWF6.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8WWF6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 69JPROSITE-ProRule annotationAdd BLAST69

Phylogenomic databases

InParanoidiQ8WWF6.
KOiK09509.
PhylomeDBiQ8WWF6.

Family and domain databases

CDDicd06257. DnaJ. 1 hit.
Gene3Di1.10.287.110. 1 hit.
InterProiView protein in InterPro
IPR001623. DnaJ_domain.
IPR018253. DnaJ_domain_CS.
IPR026901. DNAJC3.
PANTHERiPTHR24078:SF350. PTHR24078:SF350. 1 hit.
PfamiView protein in Pfam
PF00226. DnaJ. 1 hit.
PRINTSiPR00625. JDOMAIN.
SMARTiView protein in SMART
SM00271. DnaJ. 1 hit.
SUPFAMiSSF46565. SSF46565. 1 hit.
PROSITEiView protein in PROSITE
PS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8WWF6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVDYYEVLDV PRQASSEAIK KAYRKLALKW HPDKNPENKE EAERRFKQVA
60 70 80 90 100
EAYEVLSDAK KRDIYDRYGE AGAEGGCTGG RPFEDPFEYV FSFRDPADVF
110 120 130 140
REFFGGQDPF SFDLLGNPLE NILGGSEELL GKQKQSVCTP FLCLQ
Length:145
Mass (Da):16,559
Last modified:March 1, 2002 - v1
Checksum:i065CD71109B6F0DE
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06114285D → E. Corresponds to variant dbSNP:rs34622615Ensembl.1
Natural variantiVAR_06114398D → E. Corresponds to variant dbSNP:rs34150486Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY083665 mRNA. Translation: AAM08934.1.
AC114812 Genomic DNA. Translation: AAY24024.1.
BC017590 mRNA. Translation: AAH17590.1.
BC024013 mRNA. Translation: AAH24013.1.
RefSeqiNP_001001394.1. NM_001001394.3.
UniGeneiHs.725533.

Genome annotation databases

GeneIDi414061.
KEGGihsa:414061.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiDNJB3_HUMAN
AccessioniPrimary (citable) accession number: Q8WWF6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 13, 2009
Last sequence update: March 1, 2002
Last modified: July 5, 2017
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Due to a premature stop codon, the human protein is truncated and lacks the DNAJB3 canonical C-terminal domain. However, expression studies suggest the existence of the mRNA and protein in human.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references