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Protein

DnaJ homolog subfamily B member 3

Gene

DNAJB3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May operate as a co-chaperone of the male germ cell- and haploid stage-specific Hsp70 proteins.Curated

Keywords - Molecular functioni

Chaperone

Names & Taxonomyi

Protein namesi
Recommended name:
DnaJ homolog subfamily B member 3
Gene namesi
Name:DNAJB3
Synonyms:HCG3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:32397. DNAJB3.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162383828.

Polymorphism and mutation databases

BioMutaiDNAJB3.
DMDMi74730976.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 145145DnaJ homolog subfamily B member 3PRO_0000386472Add
BLAST

Proteomic databases

MaxQBiQ8WWF6.
PRIDEiQ8WWF6.

PTM databases

iPTMnetiQ8WWF6.
PhosphoSiteiQ8WWF6.

Expressioni

Tissue specificityi

Expressed in sperm (at protein level).1 Publication

Interactioni

Protein-protein interaction databases

BioGridi135928. 2 interactions.
IntActiQ8WWF6. 1 interaction.
MINTiMINT-1434458.

Structurei

Secondary structure

1
145
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi4 – 74Combined sources
Helixi16 – 2712Combined sources
Turni32 – 343Combined sources
Helixi39 – 5618Combined sources
Helixi61 – 677Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2EJ7NMR-A1-69[»]
ProteinModelPortaliQ8WWF6.
SMRiQ8WWF6. Positions 1-105.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8WWF6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 6969JPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 J domain.PROSITE-ProRule annotation

Phylogenomic databases

InParanoidiQ8WWF6.
KOiK09509.
PhylomeDBiQ8WWF6.

Family and domain databases

Gene3Di1.10.287.110. 1 hit.
InterProiIPR001623. DnaJ_domain.
IPR018253. DnaJ_domain_CS.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
[Graphical view]
PRINTSiPR00625. JDOMAIN.
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
PROSITEiPS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8WWF6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVDYYEVLDV PRQASSEAIK KAYRKLALKW HPDKNPENKE EAERRFKQVA
60 70 80 90 100
EAYEVLSDAK KRDIYDRYGE AGAEGGCTGG RPFEDPFEYV FSFRDPADVF
110 120 130 140
REFFGGQDPF SFDLLGNPLE NILGGSEELL GKQKQSVCTP FLCLQ
Length:145
Mass (Da):16,559
Last modified:March 1, 2002 - v1
Checksum:i065CD71109B6F0DE
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti85 – 851D → E.
Corresponds to variant rs34622615 [ dbSNP | Ensembl ].
VAR_061142
Natural varianti98 – 981D → E.
Corresponds to variant rs34150486 [ dbSNP | Ensembl ].
VAR_061143

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY083665 mRNA. Translation: AAM08934.1.
AC114812 Genomic DNA. Translation: AAY24024.1.
BC017590 mRNA. Translation: AAH17590.1.
BC024013 mRNA. Translation: AAH24013.1.
RefSeqiNP_001001394.1. NM_001001394.3.
UniGeneiHs.725533.

Genome annotation databases

GeneIDi414061.
KEGGihsa:414061.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY083665 mRNA. Translation: AAM08934.1.
AC114812 Genomic DNA. Translation: AAY24024.1.
BC017590 mRNA. Translation: AAH17590.1.
BC024013 mRNA. Translation: AAH24013.1.
RefSeqiNP_001001394.1. NM_001001394.3.
UniGeneiHs.725533.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2EJ7NMR-A1-69[»]
ProteinModelPortaliQ8WWF6.
SMRiQ8WWF6. Positions 1-105.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi135928. 2 interactions.
IntActiQ8WWF6. 1 interaction.
MINTiMINT-1434458.

PTM databases

iPTMnetiQ8WWF6.
PhosphoSiteiQ8WWF6.

Polymorphism and mutation databases

BioMutaiDNAJB3.
DMDMi74730976.

Proteomic databases

MaxQBiQ8WWF6.
PRIDEiQ8WWF6.

Protocols and materials databases

DNASUi414061.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi414061.
KEGGihsa:414061.

Organism-specific databases

CTDi414061.
GeneCardsiDNAJB3.
HGNCiHGNC:32397. DNAJB3.
neXtProtiNX_Q8WWF6.
PharmGKBiPA162383828.
GenAtlasiSearch...

Phylogenomic databases

InParanoidiQ8WWF6.
KOiK09509.
PhylomeDBiQ8WWF6.

Miscellaneous databases

EvolutionaryTraceiQ8WWF6.
GenomeRNAii414061.
NextBioi108385.
PROiQ8WWF6.

Family and domain databases

Gene3Di1.10.287.110. 1 hit.
InterProiIPR001623. DnaJ_domain.
IPR018253. DnaJ_domain_CS.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
[Graphical view]
PRINTSiPR00625. JDOMAIN.
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
PROSITEiPS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and identification of genes which are differentially expressed in hepatocellular carcinoma."
    Xueyuan D., Weifeng C.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Hepatoma.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  4. "Structure of msj-1 gene in mice and humans: a possible role in the regulation of male reproduction."
    Meccariello R., Berruti G., Chianese R., De Santis R., Di Cunto F., Scarpa D., Cobellis G., Zucchetti I., Pierantoni R., Altruda F., Fasano S.
    Gen. Comp. Endocrinol. 156:91-103(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  5. "Solution structure of the DNAj domain of the human protein hcg3, a hypothetical protein tmp_locus_21."
    RIKEN structural genomics initiative (RSGI)
    Submitted (FEB-2009) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 1-69.

Entry informationi

Entry nameiDNJB3_HUMAN
AccessioniPrimary (citable) accession number: Q8WWF6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 13, 2009
Last sequence update: March 1, 2002
Last modified: March 16, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Due to a premature stop codon, the human protein is truncated and lacks the DNAJB3 canonical C-terminal domain. However, expression studies suggest the existence of the mRNA and protein in human.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.