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Protein

Glycosylated lysosomal membrane protein

Gene

GLMP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • ligand-dependent nuclear receptor transcription coactivator activity Source: BHF-UCL
  • RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding Source: BHF-UCL
  • transcription factor activity, sequence-specific DNA binding Source: BHF-UCL
  • transcription regulatory region DNA binding Source: BHF-UCL

GO - Biological processi

  • positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:G66-30709-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycosylated lysosomal membrane proteinImported
Alternative name(s):
Lysosomal protein NCU-G1Curated
Gene namesi
Name:GLMPImported
Synonyms:C1orf85Imported
ORF Names:PSEC0030, UNQ2553/PRO6182
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:29436. GLMP.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini36 – 372LumenalSequence analysisAdd BLAST337
Transmembranei373 – 393HelicalSequence analysisAdd BLAST21
Topological domaini394 – 406CytoplasmicSequence analysisAdd BLAST13

GO - Cellular componenti

  • cytosol Source: BHF-UCL
  • integral component of membrane Source: UniProtKB
  • lysosomal membrane Source: UniProtKB-SubCell
  • lysosome Source: UniProtKB
  • nucleus Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Lysosome, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000198715.
PharmGKBiPA142672533.

Polymorphism and mutation databases

BioMutaiC1orf85.
DMDMi74760578.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 35Sequence analysisAdd BLAST35
ChainiPRO_000028448436 – 406Glycosylated lysosomal membrane proteinCuratedAdd BLAST371

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi65N-linked (GlcNAc...)Sequence analysis1
Glycosylationi134N-linked (GlcNAc...)Sequence analysis1
Glycosylationi159N-linked (GlcNAc...)Sequence analysis1
Glycosylationi187N-linked (GlcNAc...)Sequence analysis1
Glycosylationi230N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

Highly N-glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8WWB7.
PaxDbiQ8WWB7.
PeptideAtlasiQ8WWB7.
PRIDEiQ8WWB7.

PTM databases

iPTMnetiQ8WWB7.
PhosphoSitePlusiQ8WWB7.
UniCarbKBiQ8WWB7.

Expressioni

Inductioni

Transcription is activated by TFEB.1 Publication

Gene expression databases

BgeeiENSG00000198715.
CleanExiHS_C1orf85.
ExpressionAtlasiQ8WWB7. baseline and differential.
GenevisibleiQ8WWB7. HS.

Organism-specific databases

HPAiHPA029121.

Interactioni

Protein-protein interaction databases

BioGridi125204. 65 interactors.
IntActiQ8WWB7. 3 interactors.
STRINGi9606.ENSP00000354553.

Structurei

3D structure databases

ProteinModelPortaliQ8WWB7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GLMP family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGRY. Eukaryota.
ENOG4111F22. LUCA.
GeneTreeiENSGT00390000005131.
InParanoidiQ8WWB7.
OMAiFSWNNIT.
OrthoDBiEOG091G0R4Q.
PhylomeDBiQ8WWB7.
TreeFamiTF324431.

Family and domain databases

InterProiIPR029382. NCU-G1.
[Graphical view]
PfamiPF15065. NCU-G1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WWB7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRGSVECTWG WGHCAPSPLL LWTLLLFAAP FGLLGEKTRQ VSLEVIPNWL
60 70 80 90 100
GPLQNLLHIR AVGTNSTLHY VWSSLGPLAV VMVATNTPHS TLSVNWSLLL
110 120 130 140 150
SPEPDGGLMV LPKDSIQFSS ALVFTRLLEF DSTNVSDTAA KPLGRPYPPY
160 170 180 190 200
SLADFSWNNI TDSLDPATLS ATFQGHPMND PTRTFANGSL AFRVQAFSRS
210 220 230 240 250
SRPAQPPRLL HTADTCQLEV ALIGASPRGN RSLFGLEVAT LGQGPDCPSM
260 270 280 290 300
QEQHSIDDEY APAVFQLDQL LWGSLPSGFA QWRPVAYSQK PGGRESALPC
310 320 330 340 350
QASPLHPALA YSLPQSPIVR AFFGSQNNFC AFNLTFGAST GPGYWDQHYL
360 370 380 390 400
SWSMLLGVGF PPVDGLSPLV LGIMAVALGA PGLMLLGGGL VLLLHHKKYS

EYQSIN
Length:406
Mass (Da):43,864
Last modified:March 1, 2002 - v1
Checksum:i9FB23252A6FE9163
GO
Isoform 2 (identifier: Q8WWB7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-81: Missing.

Note: No experimental confirmation available.
Show »
Length:325
Mass (Da):34,991
Checksum:iB76B9C86EC6CAB76
GO

Sequence cautioni

The sequence AAH11575 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAI14165 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03174294V → I.1 PublicationCorresponds to variant rs1570805dbSNPEnsembl.1
Natural variantiVAR_031743203P → S.1 PublicationCorresponds to variant rs10908496dbSNPEnsembl.1
Natural variantiVAR_031744223I → V.1 PublicationCorresponds to variant rs10908495dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0378421 – 81Missing in isoform 2. 1 PublicationAdd BLAST81

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358450 mRNA. Translation: AAQ88815.1.
AK075349 mRNA. Translation: BAC11561.1.
AK296157 mRNA. Translation: BAG58896.1.
AL589685 Genomic DNA. Translation: CAI14164.1.
AL589685 Genomic DNA. Translation: CAI14165.1. Sequence problems.
BC018757 mRNA. Translation: AAH18757.1.
BC011575 mRNA. Translation: AAH11575.1. Different initiation.
BC036340 mRNA. Translation: AAH36340.1.
CCDSiCCDS1139.1. [Q8WWB7-1]
CCDS72947.1. [Q8WWB7-2]
RefSeqiNP_001243538.1. NM_001256609.1. [Q8WWB7-2]
NP_653181.1. NM_144580.2. [Q8WWB7-1]
UniGeneiHs.202522.

Genome annotation databases

EnsembliENST00000362007; ENSP00000354553; ENSG00000198715. [Q8WWB7-1]
ENST00000614643; ENSP00000480936; ENSG00000198715. [Q8WWB7-2]
GeneIDi112770.
KEGGihsa:112770.
UCSCiuc001foh.5. human. [Q8WWB7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358450 mRNA. Translation: AAQ88815.1.
AK075349 mRNA. Translation: BAC11561.1.
AK296157 mRNA. Translation: BAG58896.1.
AL589685 Genomic DNA. Translation: CAI14164.1.
AL589685 Genomic DNA. Translation: CAI14165.1. Sequence problems.
BC018757 mRNA. Translation: AAH18757.1.
BC011575 mRNA. Translation: AAH11575.1. Different initiation.
BC036340 mRNA. Translation: AAH36340.1.
CCDSiCCDS1139.1. [Q8WWB7-1]
CCDS72947.1. [Q8WWB7-2]
RefSeqiNP_001243538.1. NM_001256609.1. [Q8WWB7-2]
NP_653181.1. NM_144580.2. [Q8WWB7-1]
UniGeneiHs.202522.

3D structure databases

ProteinModelPortaliQ8WWB7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125204. 65 interactors.
IntActiQ8WWB7. 3 interactors.
STRINGi9606.ENSP00000354553.

PTM databases

iPTMnetiQ8WWB7.
PhosphoSitePlusiQ8WWB7.
UniCarbKBiQ8WWB7.

Polymorphism and mutation databases

BioMutaiC1orf85.
DMDMi74760578.

Proteomic databases

MaxQBiQ8WWB7.
PaxDbiQ8WWB7.
PeptideAtlasiQ8WWB7.
PRIDEiQ8WWB7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000362007; ENSP00000354553; ENSG00000198715. [Q8WWB7-1]
ENST00000614643; ENSP00000480936; ENSG00000198715. [Q8WWB7-2]
GeneIDi112770.
KEGGihsa:112770.
UCSCiuc001foh.5. human. [Q8WWB7-1]

Organism-specific databases

CTDi112770.
GeneCardsiGLMP.
HGNCiHGNC:29436. GLMP.
HPAiHPA029121.
neXtProtiNX_Q8WWB7.
OpenTargetsiENSG00000198715.
PharmGKBiPA142672533.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGRY. Eukaryota.
ENOG4111F22. LUCA.
GeneTreeiENSGT00390000005131.
InParanoidiQ8WWB7.
OMAiFSWNNIT.
OrthoDBiEOG091G0R4Q.
PhylomeDBiQ8WWB7.
TreeFamiTF324431.

Enzyme and pathway databases

BioCyciZFISH:G66-30709-MONOMER.

Miscellaneous databases

ChiTaRSiC1orf85. human.
GenomeRNAii112770.
PROiQ8WWB7.

Gene expression databases

BgeeiENSG00000198715.
CleanExiHS_C1orf85.
ExpressionAtlasiQ8WWB7. baseline and differential.
GenevisibleiQ8WWB7. HS.

Family and domain databases

InterProiIPR029382. NCU-G1.
[Graphical view]
PfamiPF15065. NCU-G1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGLMP_HUMAN
AccessioniPrimary (citable) accession number: Q8WWB7
Secondary accession number(s): A6NH16
, B4DJN4, Q5SZX4, Q6UX96, Q8IV07, Q96F65
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: March 1, 2002
Last modified: November 2, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

According to PubMed:18021396, it binds DNA and acts as a transcription factor. However, the localization in lysosomes which was confirmed by different groups and the presence of transmembrane region strongly suggests that it does not have coactivator activity.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.