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Protein

Glycosylated lysosomal membrane protein

Gene

GLMP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • ligand-dependent nuclear receptor transcription coactivator activity Source: BHF-UCL
  • RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding Source: BHF-UCL
  • transcription factor activity, sequence-specific DNA binding Source: BHF-UCL
  • transcription regulatory region DNA binding Source: BHF-UCL

GO - Biological processi

  • intracellular receptor signaling pathway Source: GOC
  • positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Glycosylated lysosomal membrane proteinImported
Alternative name(s):
Lysosomal protein NCU-G1Curated
Gene namesi
Name:GLMPImported
Synonyms:C1orf85Imported
ORF Names:PSEC0030, UNQ2553/PRO6182
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:29436. GLMP.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini36 – 372337LumenalSequence analysisAdd
BLAST
Transmembranei373 – 39321HelicalSequence analysisAdd
BLAST
Topological domaini394 – 40613CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • cytosol Source: BHF-UCL
  • integral component of membrane Source: UniProtKB
  • lysosomal membrane Source: UniProtKB-SubCell
  • lysosome Source: UniProtKB
  • nucleus Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Lysosome, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672533.

Polymorphism and mutation databases

BioMutaiC1orf85.
DMDMi74760578.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3535Sequence analysisAdd
BLAST
Chaini36 – 406371Glycosylated lysosomal membrane proteinCuratedPRO_0000284484Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi65 – 651N-linked (GlcNAc...)Sequence analysis
Glycosylationi134 – 1341N-linked (GlcNAc...)Sequence analysis
Glycosylationi159 – 1591N-linked (GlcNAc...)Sequence analysis
Glycosylationi187 – 1871N-linked (GlcNAc...)Sequence analysis
Glycosylationi230 – 2301N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

Highly N-glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8WWB7.
PaxDbiQ8WWB7.
PRIDEiQ8WWB7.

PTM databases

iPTMnetiQ8WWB7.
UniCarbKBiQ8WWB7.

Expressioni

Inductioni

Transcription is activated by TFEB.1 Publication

Gene expression databases

BgeeiQ8WWB7.
CleanExiHS_C1orf85.
ExpressionAtlasiQ8WWB7. baseline and differential.
GenevisibleiQ8WWB7. HS.

Organism-specific databases

HPAiHPA029121.

Interactioni

Protein-protein interaction databases

BioGridi125204. 65 interactions.
IntActiQ8WWB7. 3 interactions.
STRINGi9606.ENSP00000354553.

Structurei

3D structure databases

ProteinModelPortaliQ8WWB7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GLMP family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGRY. Eukaryota.
ENOG4111F22. LUCA.
GeneTreeiENSGT00390000005131.
InParanoidiQ8WWB7.
OMAiFSWNNIT.
OrthoDBiEOG7D85WK.
PhylomeDBiQ8WWB7.
TreeFamiTF324431.

Family and domain databases

InterProiIPR029382. NCU-G1.
[Graphical view]
PfamiPF15065. NCU-G1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WWB7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRGSVECTWG WGHCAPSPLL LWTLLLFAAP FGLLGEKTRQ VSLEVIPNWL
60 70 80 90 100
GPLQNLLHIR AVGTNSTLHY VWSSLGPLAV VMVATNTPHS TLSVNWSLLL
110 120 130 140 150
SPEPDGGLMV LPKDSIQFSS ALVFTRLLEF DSTNVSDTAA KPLGRPYPPY
160 170 180 190 200
SLADFSWNNI TDSLDPATLS ATFQGHPMND PTRTFANGSL AFRVQAFSRS
210 220 230 240 250
SRPAQPPRLL HTADTCQLEV ALIGASPRGN RSLFGLEVAT LGQGPDCPSM
260 270 280 290 300
QEQHSIDDEY APAVFQLDQL LWGSLPSGFA QWRPVAYSQK PGGRESALPC
310 320 330 340 350
QASPLHPALA YSLPQSPIVR AFFGSQNNFC AFNLTFGAST GPGYWDQHYL
360 370 380 390 400
SWSMLLGVGF PPVDGLSPLV LGIMAVALGA PGLMLLGGGL VLLLHHKKYS

EYQSIN
Length:406
Mass (Da):43,864
Last modified:March 1, 2002 - v1
Checksum:i9FB23252A6FE9163
GO
Isoform 2 (identifier: Q8WWB7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-81: Missing.

Note: No experimental confirmation available.
Show »
Length:325
Mass (Da):34,991
Checksum:iB76B9C86EC6CAB76
GO

Sequence cautioni

The sequence AAH11575.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAI14165.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti94 – 941V → I.1 Publication
Corresponds to variant rs1570805 [ dbSNP | Ensembl ].
VAR_031742
Natural varianti203 – 2031P → S.1 Publication
Corresponds to variant rs10908496 [ dbSNP | Ensembl ].
VAR_031743
Natural varianti223 – 2231I → V.1 Publication
Corresponds to variant rs10908495 [ dbSNP | Ensembl ].
VAR_031744

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8181Missing in isoform 2. 1 PublicationVSP_037842Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358450 mRNA. Translation: AAQ88815.1.
AK075349 mRNA. Translation: BAC11561.1.
AK296157 mRNA. Translation: BAG58896.1.
AL589685 Genomic DNA. Translation: CAI14164.1.
AL589685 Genomic DNA. Translation: CAI14165.1. Sequence problems.
BC018757 mRNA. Translation: AAH18757.1.
BC011575 mRNA. Translation: AAH11575.1. Different initiation.
BC036340 mRNA. Translation: AAH36340.1.
CCDSiCCDS1139.1. [Q8WWB7-1]
CCDS72947.1. [Q8WWB7-2]
RefSeqiNP_001243538.1. NM_001256609.1. [Q8WWB7-2]
NP_653181.1. NM_144580.2. [Q8WWB7-1]
UniGeneiHs.202522.

Genome annotation databases

EnsembliENST00000362007; ENSP00000354553; ENSG00000198715. [Q8WWB7-1]
ENST00000614643; ENSP00000480936; ENSG00000198715. [Q8WWB7-2]
GeneIDi112770.
KEGGihsa:112770.
UCSCiuc001foh.5. human. [Q8WWB7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358450 mRNA. Translation: AAQ88815.1.
AK075349 mRNA. Translation: BAC11561.1.
AK296157 mRNA. Translation: BAG58896.1.
AL589685 Genomic DNA. Translation: CAI14164.1.
AL589685 Genomic DNA. Translation: CAI14165.1. Sequence problems.
BC018757 mRNA. Translation: AAH18757.1.
BC011575 mRNA. Translation: AAH11575.1. Different initiation.
BC036340 mRNA. Translation: AAH36340.1.
CCDSiCCDS1139.1. [Q8WWB7-1]
CCDS72947.1. [Q8WWB7-2]
RefSeqiNP_001243538.1. NM_001256609.1. [Q8WWB7-2]
NP_653181.1. NM_144580.2. [Q8WWB7-1]
UniGeneiHs.202522.

3D structure databases

ProteinModelPortaliQ8WWB7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125204. 65 interactions.
IntActiQ8WWB7. 3 interactions.
STRINGi9606.ENSP00000354553.

PTM databases

iPTMnetiQ8WWB7.
UniCarbKBiQ8WWB7.

Polymorphism and mutation databases

BioMutaiC1orf85.
DMDMi74760578.

Proteomic databases

MaxQBiQ8WWB7.
PaxDbiQ8WWB7.
PRIDEiQ8WWB7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000362007; ENSP00000354553; ENSG00000198715. [Q8WWB7-1]
ENST00000614643; ENSP00000480936; ENSG00000198715. [Q8WWB7-2]
GeneIDi112770.
KEGGihsa:112770.
UCSCiuc001foh.5. human. [Q8WWB7-1]

Organism-specific databases

CTDi112770.
GeneCardsiGLMP.
HGNCiHGNC:29436. GLMP.
HPAiHPA029121.
neXtProtiNX_Q8WWB7.
PharmGKBiPA142672533.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGRY. Eukaryota.
ENOG4111F22. LUCA.
GeneTreeiENSGT00390000005131.
InParanoidiQ8WWB7.
OMAiFSWNNIT.
OrthoDBiEOG7D85WK.
PhylomeDBiQ8WWB7.
TreeFamiTF324431.

Miscellaneous databases

ChiTaRSiC1orf85. human.
GenomeRNAii112770.
PROiQ8WWB7.

Gene expression databases

BgeeiQ8WWB7.
CleanExiHS_C1orf85.
ExpressionAtlasiQ8WWB7. baseline and differential.
GenevisibleiQ8WWB7. HS.

Family and domain databases

InterProiIPR029382. NCU-G1.
[Graphical view]
PfamiPF15065. NCU-G1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ILE-94.
  2. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
    Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
    , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
    DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Teratocarcinoma.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Thalamus.
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS SER-203 AND VAL-223.
    Tissue: Colon, Skin and Spleen.
  6. "Human NCU-G1 can function as a transcription factor and as a nuclear receptor co-activator."
    Steffensen K.R., Bouzga M., Skjeldal F., Kasi C., Karahasan A., Matre V., Bakke O., Guerin S., Eskild W.
    BMC Mol. Biol. 8:106-106(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PUTATIVE FUNCTION.
  7. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Tissue: Placenta.
  8. Cited for: SUBCELLULAR LOCATION, INDUCTION.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiGLMP_HUMAN
AccessioniPrimary (citable) accession number: Q8WWB7
Secondary accession number(s): A6NH16
, B4DJN4, Q5SZX4, Q6UX96, Q8IV07, Q96F65
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: March 1, 2002
Last modified: June 8, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

According to PubMed:18021396, it binds DNA and acts as a transcription factor. However, the localization in lysosomes which was confirmed by different groups and the presence of transmembrane region strongly suggests that it does not have coactivator activity.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.