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Protein

DPY30 domain-containing protein 1

Gene

DYDC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a crucial role during acrosome biogenesis.1 Publication

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
DPY30 domain-containing protein 1
Gene namesi
Name:DYDC1
Synonyms:DPY30D1
ORF Names:RSD-9, RSD9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:23460. DYDC1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134972260.

Polymorphism and mutation databases

BioMutaiDYDC1.
DMDMi74751572.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 177177DPY30 domain-containing protein 1PRO_0000247556Add
BLAST

Proteomic databases

PaxDbiQ8WWB3.
PeptideAtlasiQ8WWB3.
PRIDEiQ8WWB3.

PTM databases

PhosphoSiteiQ8WWB3.

Expressioni

Tissue specificityi

Brain and testis. Accumulates during late stage of spermiogenesis.1 Publication

Gene expression databases

BgeeiENSG00000170788.
CleanExiHS_DYDC1.
ExpressionAtlasiQ8WWB3. baseline and differential.
GenevisibleiQ8WWB3. HS.

Organism-specific databases

HPAiHPA037790.
HPA037791.

Interactioni

Subunit structurei

Interacts with SH3GL3.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CCNCP248633EBI-740680,EBI-395261
CEP57L1Q8IYX8-23EBI-740680,EBI-10181988
DKFZp451B226Q5HYH73EBI-740680,EBI-10173842
MOSP005403EBI-740680,EBI-1757866
NME5P565974EBI-740680,EBI-740667
PIK3R2O004593EBI-740680,EBI-346930
TCHPQ9BT923EBI-740680,EBI-740781
TFPTG5E9B53EBI-740680,EBI-10178002
TXNDC9O145303EBI-740680,EBI-707554
USHBP1Q8N6Y04EBI-740680,EBI-739895
WACQ9BTA93EBI-740680,EBI-749118
ZGPATQ8N5A53EBI-740680,EBI-3439227

Protein-protein interaction databases

BioGridi126791. 15 interactions.
IntActiQ8WWB3. 14 interactions.
MINTiMINT-1483490.
STRINGi9606.ENSP00000361276.

Structurei

3D structure databases

ProteinModelPortaliQ8WWB3.
SMRiQ8WWB3. Positions 4-44.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dpy-30 family.Curated

Phylogenomic databases

eggNOGiENOG410J0SH. Eukaryota.
ENOG410XYYJ. LUCA.
GeneTreeiENSGT00530000063857.
HOGENOMiHOG000013181.
HOVERGENiHBG081469.
InParanoidiQ8WWB3.
OMAiDEPMFSD.
OrthoDBiEOG091G17ZL.
PhylomeDBiQ8WWB3.
TreeFamiTF330747.

Family and domain databases

InterProiIPR007858. Dpy-30_motif.
[Graphical view]
PfamiPF05186. Dpy-30. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WWB3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MESIYLQKHL GACLTQGLAE VARVRPVDPI EYLALWIYKY KENVTMEQLR
60 70 80 90 100
QKEMAKLERE RELALMEQEM MERLKAEELL LQQQQLALQL ELEMQEKERQ
110 120 130 140 150
RIQELQRAQE QLGKEMRMNM ENLVRNEDIL HSEEATLDSG KTLAEISDRY
160 170
GAPNLSRVEE LDEPMFSDIA LNIDQDL
Length:177
Mass (Da):20,893
Last modified:March 1, 2002 - v1
Checksum:iFB3DA4290972C623
GO
Isoform 2 (identifier: Q8WWB3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     169-177: IALNIDQDL → VSISVFCEKTRFCFCF

Note: No experimental confirmation available.
Show »
Length:184
Mass (Da):21,795
Checksum:iB8559B607228C22D
GO

Sequence cautioni

The sequence BAC86339 differs from that shown.Intron retention.Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei169 – 1779IALNIDQDL → VSISVFCEKTRFCFCF in isoform 2. 1 PublicationVSP_056983

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY278322 mRNA. Translation: AAQ84766.1.
AK125908 mRNA. Translation: BAC86339.1. Sequence problems.
AK292542 mRNA. Translation: BAF85231.1.
AL359195 Genomic DNA. Translation: CAI13699.1.
AL359195 Genomic DNA. Translation: CAI13701.1.
AL359195 Genomic DNA. Translation: CAI13702.1.
BC019250 mRNA. Translation: AAH19250.1.
CCDSiCCDS7366.1. [Q8WWB3-1]
RefSeqiNP_001255982.1. NM_001269053.1. [Q8WWB3-1]
NP_620167.1. NM_138812.3. [Q8WWB3-1]
XP_005269606.1. XM_005269549.4. [Q8WWB3-2]
XP_005269607.1. XM_005269550.4. [Q8WWB3-2]
XP_011537636.1. XM_011539334.2. [Q8WWB3-2]
XP_011537637.1. XM_011539335.1. [Q8WWB3-1]
UniGeneiHs.407751.

Genome annotation databases

EnsembliENST00000372202; ENSP00000361276; ENSG00000170788. [Q8WWB3-1]
ENST00000372204; ENSP00000361278; ENSG00000170788. [Q8WWB3-1]
ENST00000421924; ENSP00000402890; ENSG00000170788. [Q8WWB3-1]
GeneIDi143241.
KEGGihsa:143241.
UCSCiuc001kbx.6. human. [Q8WWB3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY278322 mRNA. Translation: AAQ84766.1.
AK125908 mRNA. Translation: BAC86339.1. Sequence problems.
AK292542 mRNA. Translation: BAF85231.1.
AL359195 Genomic DNA. Translation: CAI13699.1.
AL359195 Genomic DNA. Translation: CAI13701.1.
AL359195 Genomic DNA. Translation: CAI13702.1.
BC019250 mRNA. Translation: AAH19250.1.
CCDSiCCDS7366.1. [Q8WWB3-1]
RefSeqiNP_001255982.1. NM_001269053.1. [Q8WWB3-1]
NP_620167.1. NM_138812.3. [Q8WWB3-1]
XP_005269606.1. XM_005269549.4. [Q8WWB3-2]
XP_005269607.1. XM_005269550.4. [Q8WWB3-2]
XP_011537636.1. XM_011539334.2. [Q8WWB3-2]
XP_011537637.1. XM_011539335.1. [Q8WWB3-1]
UniGeneiHs.407751.

3D structure databases

ProteinModelPortaliQ8WWB3.
SMRiQ8WWB3. Positions 4-44.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126791. 15 interactions.
IntActiQ8WWB3. 14 interactions.
MINTiMINT-1483490.
STRINGi9606.ENSP00000361276.

PTM databases

PhosphoSiteiQ8WWB3.

Polymorphism and mutation databases

BioMutaiDYDC1.
DMDMi74751572.

Proteomic databases

PaxDbiQ8WWB3.
PeptideAtlasiQ8WWB3.
PRIDEiQ8WWB3.

Protocols and materials databases

DNASUi143241.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372202; ENSP00000361276; ENSG00000170788. [Q8WWB3-1]
ENST00000372204; ENSP00000361278; ENSG00000170788. [Q8WWB3-1]
ENST00000421924; ENSP00000402890; ENSG00000170788. [Q8WWB3-1]
GeneIDi143241.
KEGGihsa:143241.
UCSCiuc001kbx.6. human. [Q8WWB3-1]

Organism-specific databases

CTDi143241.
GeneCardsiDYDC1.
HGNCiHGNC:23460. DYDC1.
HPAiHPA037790.
HPA037791.
MIMi615154. gene.
neXtProtiNX_Q8WWB3.
PharmGKBiPA134972260.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J0SH. Eukaryota.
ENOG410XYYJ. LUCA.
GeneTreeiENSGT00530000063857.
HOGENOMiHOG000013181.
HOVERGENiHBG081469.
InParanoidiQ8WWB3.
OMAiDEPMFSD.
OrthoDBiEOG091G17ZL.
PhylomeDBiQ8WWB3.
TreeFamiTF330747.

Miscellaneous databases

GenomeRNAii143241.
PROiQ8WWB3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000170788.
CleanExiHS_DYDC1.
ExpressionAtlasiQ8WWB3. baseline and differential.
GenevisibleiQ8WWB3. HS.

Family and domain databases

InterProiIPR007858. Dpy-30_motif.
[Graphical view]
PfamiPF05186. Dpy-30. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDYDC1_HUMAN
AccessioniPrimary (citable) accession number: Q8WWB3
Secondary accession number(s): A8K927
, Q5QP03, Q5QP04, Q6WNP4, Q6ZU87
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: March 1, 2002
Last modified: September 7, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Sequence AAQ84766 was incorrectly indicated as originating from mouse.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.