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Q8WWA0

- ITLN1_HUMAN

UniProt

Q8WWA0 - ITLN1_HUMAN

Protein

Intelectin-1

Gene

ITLN1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Has no effect on basal glucose uptake but enhances insulin-stimulated glucose uptake in adipocytes. Increases AKT phosphorylation in the absence and presence of insulin. May play a role in the defense system against microorganisms. May specifically recognize carbohydrate chains of pathogens and bacterial components containing galactofuranosyl residues, in a calcium-dependent manner. May be involved in iron metabolism.2 Publications

    GO - Biological processi

    1. positive regulation of glucose import Source: UniProtKB
    2. positive regulation of protein phosphorylation Source: UniProtKB
    3. response to nematode Source: UniProtKB

    Keywords - Ligandi

    Lectin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Intelectin-1
    Short name:
    ITLN-1
    Alternative name(s):
    Endothelial lectin HL-1
    Galactofuranose-binding lectin
    Intestinal lactoferrin receptor
    Omentin
    Gene namesi
    Name:ITLN1
    Synonyms:INTL, ITLN, LFR
    ORF Names:UNQ640/PRO1270
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:18259. ITLN1.

    Subcellular locationi

    Cell membrane; Lipid-anchorGPI-anchor. Secreted
    Note: Enriched in lipid rafts.By similarity

    GO - Cellular componenti

    1. anchored component of membrane Source: UniProtKB-KW
    2. brush border membrane Source: UniProtKB
    3. extracellular vesicular exosome Source: UniProt
    4. membrane raft Source: UniProtKB
    5. receptor complex Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Membrane, Secreted

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi31 – 311C → S: Forms mainly monomers; when associated with S-48. 1 Publication
    Mutagenesisi48 – 481C → S: Forms mainly dimers. Forms mainly monomers; when associated with S-31. 1 Publication

    Organism-specific databases

    PharmGKBiPA134870726.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 18181 PublicationAdd
    BLAST
    Chaini19 – 298280Intelectin-1PRO_0000009143Add
    BLAST
    Propeptidei299 – 31315Sequence AnalysisPRO_0000009144Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi31 ↔ 481 PublicationPROSITE-ProRule annotation
    Glycosylationi163 – 1631N-linked (GlcNAc...)Curated
    Lipidationi298 – 2981GPI-anchor amidated serineSequence Analysis

    Post-translational modificationi

    N-glycosylated.2 Publications

    Keywords - PTMi

    Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

    Proteomic databases

    PaxDbiQ8WWA0.
    PRIDEiQ8WWA0.

    PTM databases

    PhosphoSiteiQ8WWA0.

    Expressioni

    Tissue specificityi

    Highly expressed in omental adipose tissue where it is found in stromal vascular cells but not in fat cells but is barely detectable in subcutaneous adipose tissue (at protein level). Highly expressed in the small intestine. Also found in the heart, testis, colon, salivary gland, skeletal muscle, pancreas and thyroid and, to a lesser degree, in the uterus, spleen, prostate, lymph node and thymus.4 Publications

    Developmental stagei

    Found in fetal small intestine and thymus.

    Gene expression databases

    BgeeiQ8WWA0.
    CleanExiHS_ITLN1.
    GenevestigatoriQ8WWA0.

    Organism-specific databases

    HPAiCAB012652.

    Interactioni

    Subunit structurei

    Homotrimer; disulfide-linked.2 Publications

    Protein-protein interaction databases

    BioGridi120741. 2 interactions.
    STRINGi9606.ENSP00000323587.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8WWA0.
    SMRiQ8WWA0. Positions 36-162.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini32 – 255224Fibrinogen C-terminalPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 fibrinogen C-terminal domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG25076.
    HOGENOMiHOG000026788.
    HOVERGENiHBG052157.
    InParanoidiQ8WWA0.
    KOiK17527.
    OMAiCPSAFDG.
    OrthoDBiEOG76739X.
    PhylomeDBiQ8WWA0.
    TreeFamiTF328530.

    Family and domain databases

    Gene3Di3.90.215.10. 1 hit.
    InterProiIPR014716. Fibrinogen_a/b/g_C_1.
    IPR002181. Fibrinogen_a/b/g_C_dom.
    [Graphical view]
    SMARTiSM00186. FBG. 1 hit.
    [Graphical view]
    SUPFAMiSSF56496. SSF56496. 1 hit.
    PROSITEiPS51406. FIBRINOGEN_C_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8WWA0-1 [UniParc]FASTAAdd to Basket

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    MNQLSFLLFL IATTRGWSTD EANTYFKEWT CSSSPSLPRS CKEIKDECPS    50
    AFDGLYFLRT ENGVIYQTFC DMTSGGGGWT LVASVHENDM RGKCTVGDRW 100
    SSQQGSKAVY PEGDGNWANY NTFGSAEAAT SDDYKNPGYY DIQAKDLGIW 150
    HVPNKSPMQH WRNSSLLRYR TDTGFLQTLG HNLFGIYQKY PVKYGEGKCW 200
    TDNGPVIPVV YDFGDAQKTA SYYSPYGQRE FTAGFVQFRV FNNERAANAL 250
    CAGMRVTGCN TEHHCIGGGG YFPEASPQQC GDFSGFDWSG YGTHVGYSSS 300
    REITEAAVLL FYR 313
    Length:313
    Mass (Da):34,962
    Last modified:March 1, 2002 - v1
    Checksum:i56219FE937FC802E
    GO

    Mass spectrometryi

    Molecular mass is 35500 Da from positions 19 - 298. Determined by MALDI. 1 Publication

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti109 – 1091V → D.1 Publication
    Corresponds to variant rs2274907 [ dbSNP | Ensembl ].
    VAR_019924
    Natural varianti313 – 3131R → P.2 Publications
    Corresponds to variant rs8144 [ dbSNP | Ensembl ].
    VAR_019925

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF271386 mRNA. Translation: AAM20741.1.
    AY065972 mRNA. Translation: AAL58073.1.
    AB036706 mRNA. Translation: BAA96094.1.
    AY157361 mRNA. Translation: AAO17800.1.
    AY157362 mRNA. Translation: AAO17801.1.
    AY549722 mRNA. Translation: AAS49907.1.
    AY619692 mRNA. Translation: AAU88048.1.
    AY358359 mRNA. Translation: AAQ88725.1.
    AK000029 mRNA. Translation: BAA90893.1.
    CR457224 mRNA. Translation: CAG33505.1.
    AL354714 Genomic DNA. Translation: CAH72357.1.
    CH471121 Genomic DNA. Translation: EAW52690.1.
    BC020664 mRNA. Translation: AAH20664.1.
    CCDSiCCDS1211.1.
    RefSeqiNP_060095.2. NM_017625.2.
    UniGeneiHs.50813.

    Genome annotation databases

    EnsembliENST00000326245; ENSP00000323587; ENSG00000179914.
    GeneIDi55600.
    KEGGihsa:55600.
    UCSCiuc001fxc.3. human.

    Polymorphism databases

    DMDMi55976553.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF271386 mRNA. Translation: AAM20741.1 .
    AY065972 mRNA. Translation: AAL58073.1 .
    AB036706 mRNA. Translation: BAA96094.1 .
    AY157361 mRNA. Translation: AAO17800.1 .
    AY157362 mRNA. Translation: AAO17801.1 .
    AY549722 mRNA. Translation: AAS49907.1 .
    AY619692 mRNA. Translation: AAU88048.1 .
    AY358359 mRNA. Translation: AAQ88725.1 .
    AK000029 mRNA. Translation: BAA90893.1 .
    CR457224 mRNA. Translation: CAG33505.1 .
    AL354714 Genomic DNA. Translation: CAH72357.1 .
    CH471121 Genomic DNA. Translation: EAW52690.1 .
    BC020664 mRNA. Translation: AAH20664.1 .
    CCDSi CCDS1211.1.
    RefSeqi NP_060095.2. NM_017625.2.
    UniGenei Hs.50813.

    3D structure databases

    ProteinModelPortali Q8WWA0.
    SMRi Q8WWA0. Positions 36-162.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120741. 2 interactions.
    STRINGi 9606.ENSP00000323587.

    PTM databases

    PhosphoSitei Q8WWA0.

    Polymorphism databases

    DMDMi 55976553.

    Proteomic databases

    PaxDbi Q8WWA0.
    PRIDEi Q8WWA0.

    Protocols and materials databases

    DNASUi 55600.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000326245 ; ENSP00000323587 ; ENSG00000179914 .
    GeneIDi 55600.
    KEGGi hsa:55600.
    UCSCi uc001fxc.3. human.

    Organism-specific databases

    CTDi 55600.
    GeneCardsi GC01M160846.
    HGNCi HGNC:18259. ITLN1.
    HPAi CAB012652.
    MIMi 609873. gene.
    neXtProti NX_Q8WWA0.
    PharmGKBi PA134870726.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG25076.
    HOGENOMi HOG000026788.
    HOVERGENi HBG052157.
    InParanoidi Q8WWA0.
    KOi K17527.
    OMAi CPSAFDG.
    OrthoDBi EOG76739X.
    PhylomeDBi Q8WWA0.
    TreeFami TF328530.

    Miscellaneous databases

    ChiTaRSi ITLN1. human.
    GeneWikii ITLN1.
    GenomeRNAii 55600.
    NextBioi 60138.
    PROi Q8WWA0.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8WWA0.
    CleanExi HS_ITLN1.
    Genevestigatori Q8WWA0.

    Family and domain databases

    Gene3Di 3.90.215.10. 1 hit.
    InterProi IPR014716. Fibrinogen_a/b/g_C_1.
    IPR002181. Fibrinogen_a/b/g_C_dom.
    [Graphical view ]
    SMARTi SM00186. FBG. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56496. SSF56496. 1 hit.
    PROSITEi PS51406. FIBRINOGEN_C_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and functional expression of a human intestinal lactoferrin receptor."
      Suzuki Y.A., Shin K., Loennerdal B.
      Biochemistry 40:15771-15779(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], GPI-ANCHOR, TISSUE SPECIFICITY.
      Tissue: Small intestine.
    2. "Human homologs of the Xenopus oocyte cortical granule lectin XL35."
      Lee J.K., Schnee J., Pang M., Wolfert M., Baum L.G., Moremen K.W., Pierce M.
      Glycobiology 11:65-73(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Small intestine.
    3. "Human intelectin is a novel soluble lectin that recognizes galactofuranose in carbohydrate chains of bacterial cell wall."
      Tsuji S., Uehori J., Matsumoto M., Suzuki Y., Matsuhisa A., Toyoshima K., Seya T.
      J. Biol. Chem. 276:23456-23463(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 19-28, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, SUBUNIT, GLYCOSYLATION, VARIANT ASP-109.
      Tissue: Placenta.
    4. "The Xenopus laevis cortical granule lectin: cDNA cloning, developmental expression, and identification of the eglectin family of lectins."
      Chang B.Y., Peavy T.R., Wardrip N.J., Hedrick J.L.
      Comp. Biochem. Physiol. 137A:115-129(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT PRO-313.
    5. "Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action."
      Yang R.-Z., Lee M.-J., Hu H., Pray J., Wu H.-B., Hansen B.C., Shuldiner A.R., Fried S.K., McLenithan J.C., Gong D.-W.
      Am. J. Physiol. 290:E1253-E1261(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: Adipose tissue.
    6. "Human homolog of the Xenopus laevis egg cortical granule lectin."
      Peavy T.R., Hedrick J.L.
      Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT PRO-313.
      Tissue: Ovary.
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    8. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Adipose tissue.
    9. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    10. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    11. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    12. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    13. "Differential structure and activity between human and mouse intelectin-1: human intelectin-1 is a disulfide-linked trimer, whereas mouse homologue is a monomer."
      Tsuji S., Yamashita M., Nishiyama A., Shinohara T., Li Z., Myrvik Q.N., Hoffman D.R., Henriksen R.A., Shibata Y.
      Glycobiology 17:1045-1051(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBUNIT, MASS SPECTROMETRY, GLYCOSYLATION, DISULFIDE BOND, MUTAGENESIS OF CYS-31 AND CYS-48.

    Entry informationi

    Entry nameiITLN1_HUMAN
    AccessioniPrimary (citable) accession number: Q8WWA0
    Secondary accession number(s): Q5IWS4
    , Q5VYI4, Q6YDJ3, Q9NP67
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 23, 2004
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3