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Q8WWA0 (ITLN1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Intelectin-1

Short name=ITLN-1
Alternative name(s):
Endothelial lectin HL-1
Galactofuranose-binding lectin
Intestinal lactoferrin receptor
Omentin
Gene names
Name:ITLN1
Synonyms:INTL, ITLN, LFR
ORF Names:UNQ640/PRO1270
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length313 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Has no effect on basal glucose uptake but enhances insulin-stimulated glucose uptake in adipocytes. Increases AKT phosphorylation in the absence and presence of insulin. May play a role in the defense system against microorganisms. May specifically recognize carbohydrate chains of pathogens and bacterial components containing galactofuranosyl residues, in a calcium-dependent manner. May be involved in iron metabolism. Ref.3 Ref.5

Subunit structure

Homotrimer; disulfide-linked. Ref.3 Ref.13

Subcellular location

Cell membrane; Lipid-anchorGPI-anchor. Secreted. Note: Enriched in lipid rafts By similarity. Ref.1 Ref.3 Ref.5

Tissue specificity

Highly expressed in omental adipose tissue where it is found in stromal vascular cells but not in fat cells but is barely detectable in subcutaneous adipose tissue (at protein level). Highly expressed in the small intestine. Also found in the heart, testis, colon, salivary gland, skeletal muscle, pancreas and thyroid and, to a lesser degree, in the uterus, spleen, prostate, lymph node and thymus. Ref.1 Ref.2 Ref.3 Ref.5

Developmental stage

Found in fetal small intestine and thymus.

Post-translational modification

N-glycosylated. Ref.3 Ref.13

Sequence similarities

Contains 1 fibrinogen C-terminal domain.

Mass spectrometry

Molecular mass is 35500 Da from positions 19 - 298. Determined by MALDI. Ref.13

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Ref.3
Chain19 – 298280Intelectin-1
PRO_0000009143
Propeptide299 – 31315 Potential
PRO_0000009144

Regions

Domain32 – 255224Fibrinogen C-terminal

Amino acid modifications

Lipidation2981GPI-anchor amidated serine Potential
Glycosylation1631N-linked (GlcNAc...) Probable
Disulfide bond31 ↔ 48 Ref.13

Natural variations

Natural variant1091V → D. Ref.3
Corresponds to variant rs2274907 [ dbSNP | Ensembl ].
VAR_019924
Natural variant3131R → P. Ref.4 Ref.6
Corresponds to variant rs8144 [ dbSNP | Ensembl ].
VAR_019925

Experimental info

Mutagenesis311C → S: Forms mainly monomers; when associated with S-48. Ref.13
Mutagenesis481C → S: Forms mainly dimers. Forms mainly monomers; when associated with S-31. Ref.13

Sequences

Sequence LengthMass (Da)Tools
Q8WWA0 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 56219FE937FC802E

FASTA31334,962
        10         20         30         40         50         60 
MNQLSFLLFL IATTRGWSTD EANTYFKEWT CSSSPSLPRS CKEIKDECPS AFDGLYFLRT 

        70         80         90        100        110        120 
ENGVIYQTFC DMTSGGGGWT LVASVHENDM RGKCTVGDRW SSQQGSKAVY PEGDGNWANY 

       130        140        150        160        170        180 
NTFGSAEAAT SDDYKNPGYY DIQAKDLGIW HVPNKSPMQH WRNSSLLRYR TDTGFLQTLG 

       190        200        210        220        230        240 
HNLFGIYQKY PVKYGEGKCW TDNGPVIPVV YDFGDAQKTA SYYSPYGQRE FTAGFVQFRV 

       250        260        270        280        290        300 
FNNERAANAL CAGMRVTGCN TEHHCIGGGG YFPEASPQQC GDFSGFDWSG YGTHVGYSSS 

       310 
REITEAAVLL FYR 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning and functional expression of a human intestinal lactoferrin receptor."
Suzuki Y.A., Shin K., Loennerdal B.
Biochemistry 40:15771-15779(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], GPI-ANCHOR, TISSUE SPECIFICITY.
Tissue: Small intestine.
[2]"Human homologs of the Xenopus oocyte cortical granule lectin XL35."
Lee J.K., Schnee J., Pang M., Wolfert M., Baum L.G., Moremen K.W., Pierce M.
Glycobiology 11:65-73(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Tissue: Small intestine.
[3]"Human intelectin is a novel soluble lectin that recognizes galactofuranose in carbohydrate chains of bacterial cell wall."
Tsuji S., Uehori J., Matsumoto M., Suzuki Y., Matsuhisa A., Toyoshima K., Seya T.
J. Biol. Chem. 276:23456-23463(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 19-28, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, SUBUNIT, GLYCOSYLATION, VARIANT ASP-109.
Tissue: Placenta.
[4]"The Xenopus laevis cortical granule lectin: cDNA cloning, developmental expression, and identification of the eglectin family of lectins."
Chang B.Y., Peavy T.R., Wardrip N.J., Hedrick J.L.
Comp. Biochem. Physiol. 137A:115-129(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT PRO-313.
[5]"Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action."
Yang R.-Z., Lee M.-J., Hu H., Pray J., Wu H.-B., Hansen B.C., Shuldiner A.R., Fried S.K., McLenithan J.C., Gong D.-W.
Am. J. Physiol. 290:E1253-E1261(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
Tissue: Adipose tissue.
[6]"Human homolog of the Xenopus laevis egg cortical granule lectin."
Peavy T.R., Hedrick J.L.
Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT PRO-313.
Tissue: Ovary.
[7]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[8]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Adipose tissue.
[9]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[10]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[11]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[12]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
[13]"Differential structure and activity between human and mouse intelectin-1: human intelectin-1 is a disulfide-linked trimer, whereas mouse homologue is a monomer."
Tsuji S., Yamashita M., Nishiyama A., Shinohara T., Li Z., Myrvik Q.N., Hoffman D.R., Henriksen R.A., Shibata Y.
Glycobiology 17:1045-1051(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBUNIT, MASS SPECTROMETRY, GLYCOSYLATION, DISULFIDE BOND, MUTAGENESIS OF CYS-31 AND CYS-48.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF271386 mRNA. Translation: AAM20741.1.
AY065972 mRNA. Translation: AAL58073.1.
AB036706 mRNA. Translation: BAA96094.1.
AY157361 mRNA. Translation: AAO17800.1.
AY157362 mRNA. Translation: AAO17801.1.
AY549722 mRNA. Translation: AAS49907.1.
AY619692 mRNA. Translation: AAU88048.1.
AY358359 mRNA. Translation: AAQ88725.1.
AK000029 mRNA. Translation: BAA90893.1.
CR457224 mRNA. Translation: CAG33505.1.
AL354714 Genomic DNA. Translation: CAH72357.1.
CH471121 Genomic DNA. Translation: EAW52690.1.
BC020664 mRNA. Translation: AAH20664.1.
RefSeqNP_060095.2. NM_017625.2.
UniGeneHs.50813.

3D structure databases

ProteinModelPortalQ8WWA0.
SMRQ8WWA0. Positions 36-151.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid120741. 2 interactions.
STRING9606.ENSP00000323587.

PTM databases

PhosphoSiteQ8WWA0.

Polymorphism databases

DMDM55976553.

Proteomic databases

PaxDbQ8WWA0.
PRIDEQ8WWA0.

Protocols and materials databases

DNASU55600.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000326245; ENSP00000323587; ENSG00000179914.
GeneID55600.
KEGGhsa:55600.
UCSCuc001fxc.3. human.

Organism-specific databases

CTD55600.
GeneCardsGC01M160846.
HGNCHGNC:18259. ITLN1.
HPACAB012652.
MIM609873. gene.
neXtProtNX_Q8WWA0.
PharmGKBPA134870726.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG25076.
HOGENOMHOG000026788.
HOVERGENHBG052157.
InParanoidQ8WWA0.
KOK17527.
OMACPSAFDG.
OrthoDBEOG76739X.
PhylomeDBQ8WWA0.
TreeFamTF328530.

Gene expression databases

BgeeQ8WWA0.
CleanExHS_ITLN1.
GenevestigatorQ8WWA0.

Family and domain databases

Gene3D3.90.215.10. 1 hit.
InterProIPR014716. Fibrinogen_a/b/g_C_1.
IPR002181. Fibrinogen_a/b/g_C_dom.
[Graphical view]
SMARTSM00186. FBG. 1 hit.
[Graphical view]
SUPFAMSSF56496. SSF56496. 1 hit.
PROSITEPS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSITLN1. human.
GeneWikiITLN1.
GenomeRNAi55600.
NextBio60138.
PROQ8WWA0.
SOURCESearch...

Entry information

Entry nameITLN1_HUMAN
AccessionPrimary (citable) accession number: Q8WWA0
Secondary accession number(s): Q5IWS4 expand/collapse secondary AC list , Q5VYI4, Q6YDJ3, Q9NP67
Entry history
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: March 1, 2002
Last modified: March 19, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM