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Q8WWA0

- ITLN1_HUMAN

UniProt

Q8WWA0 - ITLN1_HUMAN

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Protein

Intelectin-1

Gene
ITLN1, INTL, ITLN, LFR, UNQ640/PRO1270
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Has no effect on basal glucose uptake but enhances insulin-stimulated glucose uptake in adipocytes. Increases AKT phosphorylation in the absence and presence of insulin. May play a role in the defense system against microorganisms. May specifically recognize carbohydrate chains of pathogens and bacterial components containing galactofuranosyl residues, in a calcium-dependent manner. May be involved in iron metabolism.2 Publications

GO - Biological processi

  1. positive regulation of glucose import Source: UniProtKB
  2. positive regulation of protein phosphorylation Source: UniProtKB
  3. response to nematode Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Intelectin-1
Short name:
ITLN-1
Alternative name(s):
Endothelial lectin HL-1
Galactofuranose-binding lectin
Intestinal lactoferrin receptor
Omentin
Gene namesi
Name:ITLN1
Synonyms:INTL, ITLN, LFR
ORF Names:UNQ640/PRO1270
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:18259. ITLN1.

Subcellular locationi

Cell membrane; Lipid-anchorGPI-anchor. Secreted
Note: Enriched in lipid rafts By similarity.3 Publications

GO - Cellular componenti

  1. anchored component of membrane Source: UniProtKB-KW
  2. brush border membrane Source: UniProtKB
  3. extracellular vesicular exosome Source: UniProt
  4. membrane raft Source: UniProtKB
  5. receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi31 – 311C → S: Forms mainly monomers; when associated with S-48. 1 Publication
Mutagenesisi48 – 481C → S: Forms mainly dimers. Forms mainly monomers; when associated with S-31. 1 Publication

Organism-specific databases

PharmGKBiPA134870726.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 18181 PublicationAdd
BLAST
Chaini19 – 298280Intelectin-1PRO_0000009143Add
BLAST
Propeptidei299 – 31315 Reviewed predictionPRO_0000009144Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi31 ↔ 481 Publication
Glycosylationi163 – 1631N-linked (GlcNAc...) Inferred
Lipidationi298 – 2981GPI-anchor amidated serine Reviewed prediction

Post-translational modificationi

N-glycosylated.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ8WWA0.
PRIDEiQ8WWA0.

PTM databases

PhosphoSiteiQ8WWA0.

Expressioni

Tissue specificityi

Highly expressed in omental adipose tissue where it is found in stromal vascular cells but not in fat cells but is barely detectable in subcutaneous adipose tissue (at protein level). Highly expressed in the small intestine. Also found in the heart, testis, colon, salivary gland, skeletal muscle, pancreas and thyroid and, to a lesser degree, in the uterus, spleen, prostate, lymph node and thymus.4 Publications

Developmental stagei

Found in fetal small intestine and thymus.

Gene expression databases

BgeeiQ8WWA0.
CleanExiHS_ITLN1.
GenevestigatoriQ8WWA0.

Organism-specific databases

HPAiCAB012652.

Interactioni

Subunit structurei

Homotrimer; disulfide-linked.2 Publications

Protein-protein interaction databases

BioGridi120741. 2 interactions.
STRINGi9606.ENSP00000323587.

Structurei

3D structure databases

ProteinModelPortaliQ8WWA0.
SMRiQ8WWA0. Positions 36-162.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini32 – 255224Fibrinogen C-terminalAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG25076.
HOGENOMiHOG000026788.
HOVERGENiHBG052157.
InParanoidiQ8WWA0.
KOiK17527.
OMAiCPSAFDG.
OrthoDBiEOG76739X.
PhylomeDBiQ8WWA0.
TreeFamiTF328530.

Family and domain databases

Gene3Di3.90.215.10. 1 hit.
InterProiIPR014716. Fibrinogen_a/b/g_C_1.
IPR002181. Fibrinogen_a/b/g_C_dom.
[Graphical view]
SMARTiSM00186. FBG. 1 hit.
[Graphical view]
SUPFAMiSSF56496. SSF56496. 1 hit.
PROSITEiPS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8WWA0-1 [UniParc]FASTAAdd to Basket

« Hide

MNQLSFLLFL IATTRGWSTD EANTYFKEWT CSSSPSLPRS CKEIKDECPS    50
AFDGLYFLRT ENGVIYQTFC DMTSGGGGWT LVASVHENDM RGKCTVGDRW 100
SSQQGSKAVY PEGDGNWANY NTFGSAEAAT SDDYKNPGYY DIQAKDLGIW 150
HVPNKSPMQH WRNSSLLRYR TDTGFLQTLG HNLFGIYQKY PVKYGEGKCW 200
TDNGPVIPVV YDFGDAQKTA SYYSPYGQRE FTAGFVQFRV FNNERAANAL 250
CAGMRVTGCN TEHHCIGGGG YFPEASPQQC GDFSGFDWSG YGTHVGYSSS 300
REITEAAVLL FYR 313
Length:313
Mass (Da):34,962
Last modified:March 1, 2002 - v1
Checksum:i56219FE937FC802E
GO

Mass spectrometryi

Molecular mass is 35500 Da from positions 19 - 298. Determined by MALDI. 1 Publication

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti109 – 1091V → D.1 Publication
Corresponds to variant rs2274907 [ dbSNP | Ensembl ].
VAR_019924
Natural varianti313 – 3131R → P.2 Publications
Corresponds to variant rs8144 [ dbSNP | Ensembl ].
VAR_019925

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF271386 mRNA. Translation: AAM20741.1.
AY065972 mRNA. Translation: AAL58073.1.
AB036706 mRNA. Translation: BAA96094.1.
AY157361 mRNA. Translation: AAO17800.1.
AY157362 mRNA. Translation: AAO17801.1.
AY549722 mRNA. Translation: AAS49907.1.
AY619692 mRNA. Translation: AAU88048.1.
AY358359 mRNA. Translation: AAQ88725.1.
AK000029 mRNA. Translation: BAA90893.1.
CR457224 mRNA. Translation: CAG33505.1.
AL354714 Genomic DNA. Translation: CAH72357.1.
CH471121 Genomic DNA. Translation: EAW52690.1.
BC020664 mRNA. Translation: AAH20664.1.
CCDSiCCDS1211.1.
RefSeqiNP_060095.2. NM_017625.2.
UniGeneiHs.50813.

Genome annotation databases

EnsembliENST00000326245; ENSP00000323587; ENSG00000179914.
GeneIDi55600.
KEGGihsa:55600.
UCSCiuc001fxc.3. human.

Polymorphism databases

DMDMi55976553.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF271386 mRNA. Translation: AAM20741.1 .
AY065972 mRNA. Translation: AAL58073.1 .
AB036706 mRNA. Translation: BAA96094.1 .
AY157361 mRNA. Translation: AAO17800.1 .
AY157362 mRNA. Translation: AAO17801.1 .
AY549722 mRNA. Translation: AAS49907.1 .
AY619692 mRNA. Translation: AAU88048.1 .
AY358359 mRNA. Translation: AAQ88725.1 .
AK000029 mRNA. Translation: BAA90893.1 .
CR457224 mRNA. Translation: CAG33505.1 .
AL354714 Genomic DNA. Translation: CAH72357.1 .
CH471121 Genomic DNA. Translation: EAW52690.1 .
BC020664 mRNA. Translation: AAH20664.1 .
CCDSi CCDS1211.1.
RefSeqi NP_060095.2. NM_017625.2.
UniGenei Hs.50813.

3D structure databases

ProteinModelPortali Q8WWA0.
SMRi Q8WWA0. Positions 36-162.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120741. 2 interactions.
STRINGi 9606.ENSP00000323587.

PTM databases

PhosphoSitei Q8WWA0.

Polymorphism databases

DMDMi 55976553.

Proteomic databases

PaxDbi Q8WWA0.
PRIDEi Q8WWA0.

Protocols and materials databases

DNASUi 55600.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000326245 ; ENSP00000323587 ; ENSG00000179914 .
GeneIDi 55600.
KEGGi hsa:55600.
UCSCi uc001fxc.3. human.

Organism-specific databases

CTDi 55600.
GeneCardsi GC01M160846.
HGNCi HGNC:18259. ITLN1.
HPAi CAB012652.
MIMi 609873. gene.
neXtProti NX_Q8WWA0.
PharmGKBi PA134870726.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG25076.
HOGENOMi HOG000026788.
HOVERGENi HBG052157.
InParanoidi Q8WWA0.
KOi K17527.
OMAi CPSAFDG.
OrthoDBi EOG76739X.
PhylomeDBi Q8WWA0.
TreeFami TF328530.

Miscellaneous databases

ChiTaRSi ITLN1. human.
GeneWikii ITLN1.
GenomeRNAii 55600.
NextBioi 60138.
PROi Q8WWA0.
SOURCEi Search...

Gene expression databases

Bgeei Q8WWA0.
CleanExi HS_ITLN1.
Genevestigatori Q8WWA0.

Family and domain databases

Gene3Di 3.90.215.10. 1 hit.
InterProi IPR014716. Fibrinogen_a/b/g_C_1.
IPR002181. Fibrinogen_a/b/g_C_dom.
[Graphical view ]
SMARTi SM00186. FBG. 1 hit.
[Graphical view ]
SUPFAMi SSF56496. SSF56496. 1 hit.
PROSITEi PS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and functional expression of a human intestinal lactoferrin receptor."
    Suzuki Y.A., Shin K., Loennerdal B.
    Biochemistry 40:15771-15779(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], GPI-ANCHOR, TISSUE SPECIFICITY.
    Tissue: Small intestine.
  2. "Human homologs of the Xenopus oocyte cortical granule lectin XL35."
    Lee J.K., Schnee J., Pang M., Wolfert M., Baum L.G., Moremen K.W., Pierce M.
    Glycobiology 11:65-73(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Small intestine.
  3. "Human intelectin is a novel soluble lectin that recognizes galactofuranose in carbohydrate chains of bacterial cell wall."
    Tsuji S., Uehori J., Matsumoto M., Suzuki Y., Matsuhisa A., Toyoshima K., Seya T.
    J. Biol. Chem. 276:23456-23463(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 19-28, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, SUBUNIT, GLYCOSYLATION, VARIANT ASP-109.
    Tissue: Placenta.
  4. "The Xenopus laevis cortical granule lectin: cDNA cloning, developmental expression, and identification of the eglectin family of lectins."
    Chang B.Y., Peavy T.R., Wardrip N.J., Hedrick J.L.
    Comp. Biochem. Physiol. 137A:115-129(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT PRO-313.
  5. "Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action."
    Yang R.-Z., Lee M.-J., Hu H., Pray J., Wu H.-B., Hansen B.C., Shuldiner A.R., Fried S.K., McLenithan J.C., Gong D.-W.
    Am. J. Physiol. 290:E1253-E1261(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Adipose tissue.
  6. "Human homolog of the Xenopus laevis egg cortical granule lectin."
    Peavy T.R., Hedrick J.L.
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT PRO-313.
    Tissue: Ovary.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  8. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Adipose tissue.
  9. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  10. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  11. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  12. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  13. "Differential structure and activity between human and mouse intelectin-1: human intelectin-1 is a disulfide-linked trimer, whereas mouse homologue is a monomer."
    Tsuji S., Yamashita M., Nishiyama A., Shinohara T., Li Z., Myrvik Q.N., Hoffman D.R., Henriksen R.A., Shibata Y.
    Glycobiology 17:1045-1051(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT, MASS SPECTROMETRY, GLYCOSYLATION, DISULFIDE BOND, MUTAGENESIS OF CYS-31 AND CYS-48.

Entry informationi

Entry nameiITLN1_HUMAN
AccessioniPrimary (citable) accession number: Q8WWA0
Secondary accession number(s): Q5IWS4
, Q5VYI4, Q6YDJ3, Q9NP67
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: March 1, 2002
Last modified: July 9, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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