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Protein

L-selectin

Gene

SELL

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Cell surface adhesion protein. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesionUniRule annotation

Keywords - Ligandi

LectinImported

Names & Taxonomyi

Protein namesi
Recommended name:
L-selectinUniRule annotation
Gene namesi
Name:SELLImported
ORF Names:hCG_37088Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei347 – 368HelicalSequence analysisAdd BLAST22

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi70 ↔ 168UniRule annotation
Disulfide bondi141 ↔ 160UniRule annotation
Disulfide bondi173 ↔ 184UniRule annotation
Disulfide bondi178 ↔ 193UniRule annotation
Disulfide bondi195 ↔ 204UniRule annotation
Disulfide bondi210 ↔ 254UniRule annotation
Disulfide bondi240 ↔ 267UniRule annotation
Disulfide bondi272 ↔ 316UniRule annotation
Disulfide bondi302 ↔ 329UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000236147.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini47 – 169C-type lectinInterPro annotationAdd BLAST123
Domaini169 – 205EGF-likeInterPro annotationAdd BLAST37
Domaini208 – 269Sushi (CCP/SCR)InterPro annotationAdd BLAST62
Domaini270 – 331Sushi (CCP/SCR)InterPro annotationAdd BLAST62

Sequence similaritiesi

Belongs to the selectin/LECAM family.UniRule annotation

Keywords - Domaini

EGF-like domainSAAS annotation, RepeatSAAS annotation, SushiSAAS annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IS3T. Eukaryota.
ENOG410YB82. LUCA.
HOVERGENiHBG052375.

Family and domain databases

CDDicd00033. CCP. 2 hits.
Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR018378. C-type_lectin_CS.
IPR016187. CTDL_fold.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR016348. L-selectin.
IPR002396. Selectin_superfamily.
IPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PANTHERiPTHR19325:SF352. PTHR19325:SF352. 1 hit.
PfamiPF00059. Lectin_C. 1 hit.
PF00084. Sushi. 2 hits.
[Graphical view]
PIRSFiPIRSF002421. L-selectin. 1 hit.
PRINTSiPR00343. SELECTIN.
SMARTiSM00032. CCP. 2 hits.
SM00034. CLECT. 1 hit.
SM00181. EGF. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
SSF57535. SSF57535. 2 hits.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS50923. SUSHI. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8WW79-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGCRRTREGP SKAMIFPWKC QSTQRDLWNI FKLWGWTMLC CDFLAHHGTD
60 70 80 90 100
CWTYHYSEKP MNWQRARRFC RDNYTDLVAI QNKAEIEYLE KTLPFSRSYY
110 120 130 140 150
WIGIRKIGGI WTWVGTNKSL TEEAENWGDG EPNNKKNKED CVEIYIKRNK
160 170 180 190 200
DAGKWNDDAC HKLKAALCYT ASCQPWSCSG HGECVEIINN YTCNCDVGYY
210 220 230 240 250
GPQCQFVIQC EPLEAPELGT MDCTHPLGNF SFSSQCAFSC SEGTNLTGIE
260 270 280 290 300
ETTCGPFGNW SSPEPTCQVI QCEPLSAPDL GIMNCSHPLA SFSFTSACTF
310 320 330 340 350
ICSEGTELIG KKKTICESSG IWSNPSPICQ KLDKSFSMIK EGDYNPLFIP
360 370
VAVMVTAFSG LAFIIWLARR LKKGM
Length:375
Mass (Da):42,413
Last modified:March 1, 2002 - v1
Checksum:i87CBD2E729918C60
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC020758 mRNA. Translation: AAH20758.1.
CH471067 Genomic DNA. Translation: EAW90859.1.
PIRiS09702.
UniGeneiHs.728756.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC020758 mRNA. Translation: AAH20758.1.
CH471067 Genomic DNA. Translation: EAW90859.1.
PIRiS09702.
UniGeneiHs.728756.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000236147.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG410IS3T. Eukaryota.
ENOG410YB82. LUCA.
HOVERGENiHBG052375.

Family and domain databases

CDDicd00033. CCP. 2 hits.
Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR018378. C-type_lectin_CS.
IPR016187. CTDL_fold.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR016348. L-selectin.
IPR002396. Selectin_superfamily.
IPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PANTHERiPTHR19325:SF352. PTHR19325:SF352. 1 hit.
PfamiPF00059. Lectin_C. 1 hit.
PF00084. Sushi. 2 hits.
[Graphical view]
PIRSFiPIRSF002421. L-selectin. 1 hit.
PRINTSiPR00343. SELECTIN.
SMARTiSM00032. CCP. 2 hits.
SM00034. CLECT. 1 hit.
SM00181. EGF. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
SSF57535. SSF57535. 2 hits.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS50923. SUSHI. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ8WW79_HUMAN
AccessioniPrimary (citable) accession number: Q8WW79
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: November 30, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.