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Protein

L-selectin

Gene

SELL

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell adhesionUniRule annotation
LigandCalciumUniRule annotation, LectinImported

Names & Taxonomyi

Protein namesi
Recommended name:
L-selectinUniRule annotation
Gene namesi
Name:SELLImported
ORF Names:hCG_37088Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei347 – 368HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi70 ↔ 168UniRule annotation
Disulfide bondi141 ↔ 160UniRule annotation
Disulfide bondi173 ↔ 184UniRule annotation
Disulfide bondi178 ↔ 193UniRule annotation
Disulfide bondi195 ↔ 204UniRule annotation
Disulfide bondi210 ↔ 254UniRule annotation
Disulfide bondi240 ↔ 267UniRule annotation
Disulfide bondi272 ↔ 316UniRule annotation
Disulfide bondi302 ↔ 329UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini47 – 169C-type lectinInterPro annotationAdd BLAST123
Domaini169 – 205EGF-likeInterPro annotationAdd BLAST37
Domaini208 – 269SushiInterPro annotationAdd BLAST62
Domaini270 – 331SushiInterPro annotationAdd BLAST62

Sequence similaritiesi

Belongs to the selectin/LECAM family.UniRule annotation

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotationSAAS annotation, RepeatSAAS annotation, SushiPROSITE-ProRule annotationSAAS annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IS3T Eukaryota
ENOG410YB82 LUCA
HOVERGENiHBG052375

Family and domain databases

CDDicd00033 CCP, 2 hits
cd03592 CLECT_selectins_like, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR016187 CTDL_fold
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR016348 L-selectin
IPR033991 Selectin_CTLD
IPR002396 Selectin_superfamily
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
PF00084 Sushi, 2 hits
PIRSFiPIRSF002421 L-selectin, 1 hit
PRINTSiPR00343 SELECTIN
SMARTiView protein in SMART
SM00032 CCP, 2 hits
SM00034 CLECT, 1 hit
SM00181 EGF, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
SSF57535 SSF57535, 2 hits
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 1 hit
PS50923 SUSHI, 2 hits

Sequencei

Sequence statusi: Complete.

Q8WW79-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGCRRTREGP SKAMIFPWKC QSTQRDLWNI FKLWGWTMLC CDFLAHHGTD
60 70 80 90 100
CWTYHYSEKP MNWQRARRFC RDNYTDLVAI QNKAEIEYLE KTLPFSRSYY
110 120 130 140 150
WIGIRKIGGI WTWVGTNKSL TEEAENWGDG EPNNKKNKED CVEIYIKRNK
160 170 180 190 200
DAGKWNDDAC HKLKAALCYT ASCQPWSCSG HGECVEIINN YTCNCDVGYY
210 220 230 240 250
GPQCQFVIQC EPLEAPELGT MDCTHPLGNF SFSSQCAFSC SEGTNLTGIE
260 270 280 290 300
ETTCGPFGNW SSPEPTCQVI QCEPLSAPDL GIMNCSHPLA SFSFTSACTF
310 320 330 340 350
ICSEGTELIG KKKTICESSG IWSNPSPICQ KLDKSFSMIK EGDYNPLFIP
360 370
VAVMVTAFSG LAFIIWLARR LKKGM
Length:375
Mass (Da):42,413
Last modified:March 1, 2002 - v1
Checksum:i87CBD2E729918C60
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC020758 mRNA Translation: AAH20758.1
CH471067 Genomic DNA Translation: EAW90859.1
PIRiS09702
UniGeneiHs.728756

Similar proteinsi

Entry informationi

Entry nameiQ8WW79_HUMAN
AccessioniPrimary (citable) accession number: Q8WW79
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: March 28, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health