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Protein

SPRY domain-containing protein 4

Gene

SPRYD4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
SPRY domain-containing protein 4
Gene namesi
Name:SPRYD4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000176422.12
HGNCiHGNC:27468 SPRYD4
neXtProtiNX_Q8WW59

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485622

Polymorphism and mutation databases

BioMutaiSPRYD4
DMDMi296452842

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002408561 – 207SPRY domain-containing protein 4Add BLAST207

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei53N6-acetyllysineBy similarity1
Modified residuei130N6-acetyllysineCombined sources1
Modified residuei139N6-succinyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8WW59
MaxQBiQ8WW59
PaxDbiQ8WW59
PeptideAtlasiQ8WW59
PRIDEiQ8WW59

PTM databases

iPTMnetiQ8WW59
PhosphoSitePlusiQ8WW59

Expressioni

Gene expression databases

BgeeiENSG00000176422
CleanExiHS_SPRYD4
GenevisibleiQ8WW59 HS

Organism-specific databases

HPAiHPA053469

Interactioni

Protein-protein interaction databases

BioGridi129542, 19 interactors
IntActiQ8WW59, 7 interactors
MINTiQ8WW59
STRINGi9606.ENSP00000338034

Structurei

3D structure databases

ProteinModelPortaliQ8WW59
SMRiQ8WW59
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 206B30.2/SPRYPROSITE-ProRule annotationAdd BLAST195

Phylogenomic databases

eggNOGiENOG410ITFJ Eukaryota
ENOG4111G9C LUCA
HOGENOMiHOG000013130
HOVERGENiHBG069004
InParanoidiQ8WW59
OrthoDBiEOG091G0N07
PhylomeDBiQ8WW59
TreeFamiTF317532

Family and domain databases

InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR003879 Butyrophylin_SPRY
IPR013320 ConA-like_dom_sf
IPR003877 SPRY_dom
PfamiView protein in Pfam
PF00622 SPRY, 1 hit
PRINTSiPR01407 BUTYPHLNCDUF
SMARTiView protein in SMART
SM00449 SPRY, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit

Sequencei

Sequence statusi: Complete.

Q8WW59-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALLFARSLR LCRWGAKRLG VASTEAQRGV SFKLEEKTAH SSLALFRDDM
60 70 80 90 100
GVKYGLVGLE PTKVALNVER FREWAVVLAD TAVTSGRHYW EVTVKRSQQF
110 120 130 140 150
RIGVADVDMS RDSCIGVDDR SWVFTYAQRK WYTMLANEKA PVEGIGQPEK
160 170 180 190 200
VGLLLEYEAQ KLSLVDVSQV SVVHTLQTDF RGPVVPAFAL WDGELLTHSG

LEVPEGL
Length:207
Mass (Da):23,129
Last modified:May 18, 2010 - v2
Checksum:i11D3262956B1D10E
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05138150M → T4 PublicationsCorresponds to variant dbSNP:rs2657881Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF451989 mRNA Translation: AAP97688.1
AK291920 mRNA Translation: BAF84609.1
AC097104 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW96941.1
BC020844 mRNA Translation: AAH20844.1
CCDSiCCDS8920.1
RefSeqiNP_997227.1, NM_207344.3
UniGeneiHs.128676

Genome annotation databases

EnsembliENST00000338146; ENSP00000338034; ENSG00000176422
GeneIDi283377
KEGGihsa:283377
UCSCiuc001sli.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSPRY4_HUMAN
AccessioniPrimary (citable) accession number: Q8WW59
Secondary accession number(s): A8K7A5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: May 18, 2010
Last modified: May 23, 2018
This is version 111 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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