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Protein

SPRY domain-containing protein 4

Gene

SPRYD4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
SPRY domain-containing protein 4
Gene namesi
Name:SPRYD4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:27468. SPRYD4.

Subcellular locationi

GO - Cellular componenti

  • mitochondrion Source: Ensembl
  • nucleus Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485622.

Polymorphism and mutation databases

BioMutaiSPRYD4.
DMDMi296452842.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 207207SPRY domain-containing protein 4PRO_0000240856Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei53 – 531N6-acetyllysineBy similarity
Modified residuei130 – 1301N6-acetyllysineCombined sources
Modified residuei139 – 1391N6-succinyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8WW59.
MaxQBiQ8WW59.
PaxDbiQ8WW59.
PRIDEiQ8WW59.

PTM databases

iPTMnetiQ8WW59.
PhosphoSiteiQ8WW59.

Expressioni

Gene expression databases

BgeeiQ8WW59.
CleanExiHS_SPRYD4.
ExpressionAtlasiQ8WW59. baseline and differential.
GenevisibleiQ8WW59. HS.

Organism-specific databases

HPAiHPA053469.

Interactioni

Protein-protein interaction databases

BioGridi129542. 5 interactions.
IntActiQ8WW59. 2 interactions.
STRINGi9606.ENSP00000338034.

Structurei

3D structure databases

ProteinModelPortaliQ8WW59.
SMRiQ8WW59. Positions 34-190.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini12 – 206195B30.2/SPRYPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410ITFJ. Eukaryota.
ENOG4111G9C. LUCA.
HOGENOMiHOG000013130.
HOVERGENiHBG069004.
InParanoidiQ8WW59.
OrthoDBiEOG73BVDS.
PhylomeDBiQ8WW59.
TreeFamiTF317532.

Family and domain databases

InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR003877. SPRY_dom.
[Graphical view]
PfamiPF00622. SPRY. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8WW59-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALLFARSLR LCRWGAKRLG VASTEAQRGV SFKLEEKTAH SSLALFRDDM
60 70 80 90 100
GVKYGLVGLE PTKVALNVER FREWAVVLAD TAVTSGRHYW EVTVKRSQQF
110 120 130 140 150
RIGVADVDMS RDSCIGVDDR SWVFTYAQRK WYTMLANEKA PVEGIGQPEK
160 170 180 190 200
VGLLLEYEAQ KLSLVDVSQV SVVHTLQTDF RGPVVPAFAL WDGELLTHSG

LEVPEGL
Length:207
Mass (Da):23,129
Last modified:May 18, 2010 - v2
Checksum:i11D3262956B1D10E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti50 – 501M → T.4 Publications
Corresponds to variant rs2657881 [ dbSNP | Ensembl ].
VAR_051381

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF451989 mRNA. Translation: AAP97688.1.
AK291920 mRNA. Translation: BAF84609.1.
AC097104 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW96941.1.
BC020844 mRNA. Translation: AAH20844.1.
CCDSiCCDS8920.1.
RefSeqiNP_997227.1. NM_207344.3.
UniGeneiHs.128676.

Genome annotation databases

EnsembliENST00000338146; ENSP00000338034; ENSG00000176422.
GeneIDi283377.
KEGGihsa:283377.
UCSCiuc001sli.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF451989 mRNA. Translation: AAP97688.1.
AK291920 mRNA. Translation: BAF84609.1.
AC097104 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW96941.1.
BC020844 mRNA. Translation: AAH20844.1.
CCDSiCCDS8920.1.
RefSeqiNP_997227.1. NM_207344.3.
UniGeneiHs.128676.

3D structure databases

ProteinModelPortaliQ8WW59.
SMRiQ8WW59. Positions 34-190.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129542. 5 interactions.
IntActiQ8WW59. 2 interactions.
STRINGi9606.ENSP00000338034.

PTM databases

iPTMnetiQ8WW59.
PhosphoSiteiQ8WW59.

Polymorphism and mutation databases

BioMutaiSPRYD4.
DMDMi296452842.

Proteomic databases

EPDiQ8WW59.
MaxQBiQ8WW59.
PaxDbiQ8WW59.
PRIDEiQ8WW59.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000338146; ENSP00000338034; ENSG00000176422.
GeneIDi283377.
KEGGihsa:283377.
UCSCiuc001sli.5. human.

Organism-specific databases

CTDi283377.
GeneCardsiSPRYD4.
HGNCiHGNC:27468. SPRYD4.
HPAiHPA053469.
neXtProtiNX_Q8WW59.
PharmGKBiPA143485622.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ITFJ. Eukaryota.
ENOG4111G9C. LUCA.
HOGENOMiHOG000013130.
HOVERGENiHBG069004.
InParanoidiQ8WW59.
OrthoDBiEOG73BVDS.
PhylomeDBiQ8WW59.
TreeFamiTF317532.

Miscellaneous databases

ChiTaRSiSPRYD4. human.
GenomeRNAii283377.
NextBioi93850.
PROiQ8WW59.

Gene expression databases

BgeeiQ8WW59.
CleanExiHS_SPRYD4.
ExpressionAtlasiQ8WW59. baseline and differential.
GenevisibleiQ8WW59. HS.

Family and domain databases

InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR003877. SPRY_dom.
[Graphical view]
PfamiPF00622. SPRY. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Guo J.H., Zan Q., She X.Y., Li D., Yu L.
    Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-50.
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-50.
  3. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT THR-50.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-50.
    Tissue: Placenta.
  6. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-130, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSPRY4_HUMAN
AccessioniPrimary (citable) accession number: Q8WW59
Secondary accession number(s): A8K7A5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: May 18, 2010
Last modified: May 11, 2016
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.