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Protein

Zinc finger protein ZFPM2

Gene

ZFPM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA4, GATA5 and GATA6. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. Also required in gonadal differentiation, possibly be regulating expression of SRY. Probably acts a corepressor of NR2F2 (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri244 – 277CCHC FOG-type 1PROSITE-ProRule annotationAdd BLAST34
Zinc fingeri296 – 320C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri335 – 357C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri363 – 385C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri542 – 575CCHC FOG-type 2PROSITE-ProRule annotationAdd BLAST34
Zinc fingeri681 – 714CCHC FOG-type 3PROSITE-ProRule annotationAdd BLAST34
Zinc fingeri848 – 881CCHC FOG-type 4PROSITE-ProRule annotationAdd BLAST34
Zinc fingeri1113 – 1146CCHC FOG-type 5PROSITE-ProRule annotationAdd BLAST34

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • RNA polymerase II transcription coactivator activity Source: BHF-UCL
  • RNA polymerase II transcription factor binding Source: GO_Central
  • transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding Source: GO_Central
  • transcription corepressor activity Source: BHF-UCL
  • transcription factor binding Source: BHF-UCL
  • zinc ion binding Source: BHF-UCL

GO - Biological processi

  • blood coagulation Source: Reactome
  • embryonic organ development Source: Ensembl
  • gonadal mesoderm development Source: UniProtKB-KW
  • in utero embryonic development Source: Ensembl
  • lung development Source: Ensembl
  • negative regulation of cell death Source: Ensembl
  • negative regulation of fat cell differentiation Source: UniProtKB
  • negative regulation of female gonad development Source: Ensembl
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • outflow tract septum morphogenesis Source: BHF-UCL
  • positive regulation of cardiac muscle cell proliferation Source: Ensembl
  • positive regulation of male gonad development Source: Ensembl
  • positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  • right ventricular cardiac muscle tissue morphogenesis Source: BHF-UCL
  • vasculogenesis Source: Ensembl
  • ventricular septum morphogenesis Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Differentiation, Gonadal differentiation, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-983231. Factors involved in megakaryocyte development and platelet production.
SIGNORiQ8WW38.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein ZFPM2
Alternative name(s):
Friend of GATA protein 2
Short name:
FOG-2
Short name:
Friend of GATA 2
Short name:
hFOG-2
Zinc finger protein 89B
Zinc finger protein multitype 2
Gene namesi
Name:ZFPM2
Synonyms:FOG2, ZNF89B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:16700. ZFPM2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Tetralogy of Fallot (TOF)2 Publications
The disease may be caused by mutations affecting the gene represented in this entry.
Disease descriptionA congenital heart anomaly which consists of pulmonary stenosis, ventricular septal defect, dextroposition of the aorta (aorta is on the right side instead of the left) and hypertrophy of the right ventricle. In this condition, blood from both ventricles (oxygen-rich and oxygen-poor) is pumped into the body often causing cyanosis.
See also OMIM:187500
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01794230E → G in TOF and CTHM; does not affect its ability to interact with GATA4. 2 PublicationsCorresponds to variant rs121908601dbSNPEnsembl.1
Natural variantiVAR_072075544M → I in SRXY9 and TOF; reduced its ability to interact with GATA4. 2 PublicationsCorresponds to variant rs187043152dbSNPEnsembl.1
Natural variantiVAR_017943657S → G in TOF; slightly impairs its ability to interact with GATA4. 1 PublicationCorresponds to variant rs28374544dbSNPEnsembl.1
Diaphragmatic hernia 3 (DIH3)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionForm of congenital diaphragmatic hernia (CDH). CDH refers to a group of congenital defects in the structural integrity of the diaphragm associated with often lethal pulmonary hypoplasia and pulmonary hypertension.
See also OMIM:610187
46,XY sex reversal 9 (SRXY9)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder of sex development. Affected individuals have a 46,XY karyotype but present as phenotypically normal females or have ambiguous external genitalia.
See also OMIM:616067
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_071104260R → Q in SRXY9; results in reduced transactivation activity on the AMH promoter; does not affect its ability to interact with GATA4. 1 PublicationCorresponds to variant rs200834568dbSNPEnsembl.1
Natural variantiVAR_071105402S → R in SRXY9; results in reduced transactivation activity on the AMH promoter; abolished its ability to interact with GATA4. 1 PublicationCorresponds to variant rs606231252dbSNPEnsembl.1
Natural variantiVAR_072075544M → I in SRXY9 and TOF; reduced its ability to interact with GATA4. 2 PublicationsCorresponds to variant rs187043152dbSNPEnsembl.1
Conotruncal heart malformations (CTHM)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA group of congenital heart defects involving the outflow tracts. Examples include truncus arteriosus communis, double-outlet right ventricle and transposition of great arteries. Truncus arteriosus communis is characterized by a single outflow tract instead of a separate aorta and pulmonary artery. In transposition of the great arteries, the aorta arises from the right ventricle and the pulmonary artery from the left ventricle. In double outlet of the right ventricle, both the pulmonary artery and aorta arise from the right ventricle.
See also OMIM:217095
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01794230E → G in TOF and CTHM; does not affect its ability to interact with GATA4. 2 PublicationsCorresponds to variant rs121908601dbSNPEnsembl.1
Natural variantiVAR_072074227I → V in CTHM. 1 PublicationCorresponds to variant rs202204708dbSNPEnsembl.1

Keywords - Diseasei

Cardiomyopathy, Disease mutation

Organism-specific databases

DisGeNETi23414.
MalaCardsiZFPM2.
MIMi187500. phenotype.
217095. phenotype.
610187. phenotype.
616067. phenotype.
OpenTargetsiENSG00000169946.
Orphaneti251510. 46,XY partial gonadal dysgenesis.
2140. Congenital diaphragmatic hernia.
3303. Tetralogy of Fallot.
PharmGKBiPA134947303.

Polymorphism and mutation databases

BioMutaiZFPM2.
DMDMi126302543.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002210431 – 1151Zinc finger protein ZFPM2Add BLAST1151

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki324Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)1 Publication
Cross-linki471Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)1 Publication
Modified residuei532PhosphoserineCombined sources1
Modified residuei581PhosphoserineCombined sources1
Modified residuei904PhosphoserineCombined sources1
Cross-linki915Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)1 Publication
Cross-linki955Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)1 Publication
Modified residuei1014PhosphoserineCombined sources1

Post-translational modificationi

Sumoylation reduces transcriptional repression activity.1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ8WW38.
PaxDbiQ8WW38.
PeptideAtlasiQ8WW38.
PRIDEiQ8WW38.

PTM databases

iPTMnetiQ8WW38.
PhosphoSitePlusiQ8WW38.

Expressioni

Tissue specificityi

Widely expressed at low level.1 Publication

Gene expression databases

BgeeiENSG00000169946.
CleanExiHS_ZFPM2.
ExpressionAtlasiQ8WW38. baseline and differential.
GenevisibleiQ8WW38. HS.

Organism-specific databases

HPAiHPA004094.

Interactioni

Subunit structurei

Interacts with the N-terminal zinc-finger of GATA4, GATA5 and probably GATA6. Interacts with retinoid nuclear receptor RXRA when ligand bound (By similarity). Interacts with corepressor CTBP2; this interaction is however not essential for corepressor activity. Able to bind GATA1 in vitro. Interacts with NR2F2 and NR2F6 (By similarity). Interacts with ATOH8; mediates indirect interaction with GATA4 (By similarity).By similarity2 Publications

GO - Molecular functioni

  • RNA polymerase II transcription factor binding Source: GO_Central
  • transcription factor binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi116986. 14 interactors.
IntActiQ8WW38. 4 interactors.
STRINGi9606.ENSP00000384179.

Structurei

3D structure databases

ProteinModelPortaliQ8WW38.
SMRiQ8WW38.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni829 – 835Interaction with CTBP2Curated7

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi736 – 740Nuclear localization signalBy similarity5

Domaini

The CCHC FOG-type zinc fingers 1, 2, 3 and 5 directly bind to GATA-type zinc fingers. The Tyr residue adjacent to the last Cys of the CCHC FOG-type zinc finger is essential for the interaction with GATA-type zinc fingers (By similarity).By similarity

Sequence similaritiesi

Belongs to the FOG (Friend of GATA) family.PROSITE-ProRule annotation
Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 5 CCHC FOG-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri244 – 277CCHC FOG-type 1PROSITE-ProRule annotationAdd BLAST34
Zinc fingeri296 – 320C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri335 – 357C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri363 – 385C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri542 – 575CCHC FOG-type 2PROSITE-ProRule annotationAdd BLAST34
Zinc fingeri681 – 714CCHC FOG-type 3PROSITE-ProRule annotationAdd BLAST34
Zinc fingeri848 – 881CCHC FOG-type 4PROSITE-ProRule annotationAdd BLAST34
Zinc fingeri1113 – 1146CCHC FOG-type 5PROSITE-ProRule annotationAdd BLAST34

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063823.
HOGENOMiHOG000057275.
HOVERGENiHBG048953.
InParanoidiQ8WW38.
KOiK17442.
OMAiIYSPLMP.
OrthoDBiEOG091G00RC.
PhylomeDBiQ8WW38.
TreeFamiTF331342.

Family and domain databases

Gene3Di3.30.160.60. 1 hit.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 8 hits.
[Graphical view]
PROSITEiPS51810. ZF_CCHC_FOG. 5 hits.
PS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WW38-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSRRKQSKPR QIKRPLEDAI EDEEEECPSE ETDIISKGDF PLEESFSTEF
60 70 80 90 100
GPENLSCEEV EYFCNKGDDE GIQETAESDG DTQSEKPGQP GVETDDWDGP
110 120 130 140 150
GELEVFQKDG ERKIQSRQQL PVGTTWGPFP GKMDLNNNSL KTKAQVPMVL
160 170 180 190 200
TAGPKWLLDV TWQGVEDNKN NCIVYSKGGQ LWCTTTKAIS EGEELIAFVV
210 220 230 240 250
DFDSRLQAAS QMTLTEGMYP ARLLDSIQLL PQQAAMASIL PTAIVNKDIF
260 270 280 290 300
PCKSCGIWYR SERNLQAHLM YYCSGRQREA APVSEENEDS AHQISSLCPF
310 320 330 340 350
PQCTKSFSNA RALEMHLNSH SGVKMEEFLP PGASLKCTVC SYTADSVINF
360 370 380 390 400
HQHLFSHLTQ AAFRCNHCHF GFQTQRELLQ HQELHVPSGK LPRESDMEHS
410 420 430 440 450
PSATEDSLQP ATDLLTRSEL PQSQKAMQTK DASSDTELDK CEKKTQLFLT
460 470 480 490 500
NQRPEIQPTT NKQSFSYTKI KSEPSSPRLA SSPVQPNIGP SFPVGPFLSQ
510 520 530 540 550
FSFPQDITMV PQASEILAKM SELVHRRLRH GSSSYPPVIY SPLMPKGATC
560 570 580 590 600
FECNITFNNL DNYLVHKKHY CSSRWQQMAK SPEFPSVSEK MPEALSPNTG
610 620 630 640 650
QTSINLLNPA AHSADPENPL LQTSCINSST VLDLIGPNGK GHDKDFSTQT
660 670 680 690 700
KKLSTSSNND DKINGKPVDV KNPSVPLVDG ESDPNKTTCE ACNITFSRHE
710 720 730 740 750
TYMVHKQYYC ATRHDPPLKR SASNKVPAMQ RTMRTRKRRK MYEMCLPEQE
760 770 780 790 800
QRPPLVQQRF LDVANLNNPC TSTQEPTEGL GECYHPRCDI FPGIVSKHLE
810 820 830 840 850
TSLTINKCVP VSKCDTTHSS VSCLEMDVPI DLSKKCLSQS ERTTTSPKRL
860 870 880 890 900
LDYHECTVCK ISFNKVENYL AHKQNFCPVT AHQRNDLGQL DGKVFPNPES
910 920 930 940 950
ERNSPDVSYE RSIIKCEKNG NLKQPSPNGN LFSSHLATLQ GLKVFSEAAQ
960 970 980 990 1000
LIATKEENRH LFLPQCLYPG AIKKAKGADQ LSPYYGIKPS DYISGSLVIH
1010 1020 1030 1040 1050
NTDIEQSRNA ENESPKGQAS SNGCAALKKD SLPLLPKNRG MVIVNGGLKQ
1060 1070 1080 1090 1100
DERPAANPQQ ENISQNPQHE DDHKSPSWIS ENPLAANENV SPGIPSAEEQ
1110 1120 1130 1140 1150
LSSIAKGVNG SSQAPTSGKY CRLCDIQFNN LSNFITHKKF YCSSHAAEHV

K
Length:1,151
Mass (Da):128,159
Last modified:February 20, 2007 - v3
Checksum:i680E31BA1D044C35
GO
Isoform 2 (identifier: Q8WW38-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-132: Missing.
     247-287: KDIFPCKSCG...REAAPVSEEN → SKCSVLCSPA...FFLQKKKKKK

Note: Sequence incomplete. No experimental confirmation available.
Show »
Length:1,019
Mass (Da):113,229
Checksum:iA4365593BE3B4476
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti198F → L in CAB97541 (Ref. 3) Curated1
Sequence conflicti939L → P in AAD49558 (PubMed:10438528).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01794230E → G in TOF and CTHM; does not affect its ability to interact with GATA4. 2 PublicationsCorresponds to variant rs121908601dbSNPEnsembl.1
Natural variantiVAR_072074227I → V in CTHM. 1 PublicationCorresponds to variant rs202204708dbSNPEnsembl.1
Natural variantiVAR_071104260R → Q in SRXY9; results in reduced transactivation activity on the AMH promoter; does not affect its ability to interact with GATA4. 1 PublicationCorresponds to variant rs200834568dbSNPEnsembl.1
Natural variantiVAR_071105402S → R in SRXY9; results in reduced transactivation activity on the AMH promoter; abolished its ability to interact with GATA4. 1 PublicationCorresponds to variant rs606231252dbSNPEnsembl.1
Natural variantiVAR_024178403A → G.1 PublicationCorresponds to variant rs11993776dbSNPEnsembl.1
Natural variantiVAR_072075544M → I in SRXY9 and TOF; reduced its ability to interact with GATA4. 2 PublicationsCorresponds to variant rs187043152dbSNPEnsembl.1
Natural variantiVAR_017943657S → G in TOF; slightly impairs its ability to interact with GATA4. 1 PublicationCorresponds to variant rs28374544dbSNPEnsembl.1
Natural variantiVAR_017944782E → D.1 PublicationCorresponds to variant rs2920048dbSNPEnsembl.1
Natural variantiVAR_0307601055A → V.Corresponds to variant rs16873741dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0097011 – 132Missing in isoform 2. 1 PublicationAdd BLAST132
Alternative sequenceiVSP_009702247 – 287KDIFP…VSEEN → SKCSVLCSPALEVMGIYGRK KCLLTRNQEQTFFLQKKKKK K in isoform 2. 1 PublicationAdd BLAST41

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF119334 mRNA. Translation: AAD49558.1.
BC020928 mRNA. Translation: AAH20928.1.
BC109222 mRNA. Translation: AAI09223.1.
AL389987 mRNA. Translation: CAB97539.1.
AL389989 mRNA. Translation: CAB97541.1.
CCDSiCCDS47908.1. [Q8WW38-1]
RefSeqiNP_036214.2. NM_012082.3. [Q8WW38-1]
UniGeneiHs.431009.

Genome annotation databases

EnsembliENST00000407775; ENSP00000384179; ENSG00000169946. [Q8WW38-1]
GeneIDi23414.
KEGGihsa:23414.
UCSCiuc003ymd.4. human. [Q8WW38-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF119334 mRNA. Translation: AAD49558.1.
BC020928 mRNA. Translation: AAH20928.1.
BC109222 mRNA. Translation: AAI09223.1.
AL389987 mRNA. Translation: CAB97539.1.
AL389989 mRNA. Translation: CAB97541.1.
CCDSiCCDS47908.1. [Q8WW38-1]
RefSeqiNP_036214.2. NM_012082.3. [Q8WW38-1]
UniGeneiHs.431009.

3D structure databases

ProteinModelPortaliQ8WW38.
SMRiQ8WW38.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116986. 14 interactors.
IntActiQ8WW38. 4 interactors.
STRINGi9606.ENSP00000384179.

PTM databases

iPTMnetiQ8WW38.
PhosphoSitePlusiQ8WW38.

Polymorphism and mutation databases

BioMutaiZFPM2.
DMDMi126302543.

Proteomic databases

MaxQBiQ8WW38.
PaxDbiQ8WW38.
PeptideAtlasiQ8WW38.
PRIDEiQ8WW38.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000407775; ENSP00000384179; ENSG00000169946. [Q8WW38-1]
GeneIDi23414.
KEGGihsa:23414.
UCSCiuc003ymd.4. human. [Q8WW38-1]

Organism-specific databases

CTDi23414.
DisGeNETi23414.
GeneCardsiZFPM2.
HGNCiHGNC:16700. ZFPM2.
HPAiHPA004094.
MalaCardsiZFPM2.
MIMi187500. phenotype.
217095. phenotype.
603693. gene.
610187. phenotype.
616067. phenotype.
neXtProtiNX_Q8WW38.
OpenTargetsiENSG00000169946.
Orphaneti251510. 46,XY partial gonadal dysgenesis.
2140. Congenital diaphragmatic hernia.
3303. Tetralogy of Fallot.
PharmGKBiPA134947303.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063823.
HOGENOMiHOG000057275.
HOVERGENiHBG048953.
InParanoidiQ8WW38.
KOiK17442.
OMAiIYSPLMP.
OrthoDBiEOG091G00RC.
PhylomeDBiQ8WW38.
TreeFamiTF331342.

Enzyme and pathway databases

ReactomeiR-HSA-983231. Factors involved in megakaryocyte development and platelet production.
SIGNORiQ8WW38.

Miscellaneous databases

ChiTaRSiZFPM2. human.
GeneWikiiZFPM2.
GenomeRNAii23414.
PROiQ8WW38.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000169946.
CleanExiHS_ZFPM2.
ExpressionAtlasiQ8WW38. baseline and differential.
GenevisibleiQ8WW38. HS.

Family and domain databases

Gene3Di3.30.160.60. 1 hit.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 8 hits.
[Graphical view]
PROSITEiPS51810. ZF_CCHC_FOG. 5 hits.
PS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFOG2_HUMAN
AccessioniPrimary (citable) accession number: Q8WW38
Secondary accession number(s): Q32MA6
, Q9NPL7, Q9NPS4, Q9UNI5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: February 20, 2007
Last modified: November 30, 2016
This is version 127 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.