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Protein

Zinc finger CCHC domain-containing protein 13

Gene

ZCCHC13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri4 – 21CCHC-type 1; degeneratePROSITE-ProRule annotationAdd BLAST18
Zinc fingeri45 – 62CCHC-type 2; degeneratePROSITE-ProRule annotationAdd BLAST18
Zinc fingeri65 – 82CCHC-type 3PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri89 – 106CCHC-type 4PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri110 – 127CCHC-type 5PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri128 – 145CCHC-type 6PROSITE-ProRule annotationAdd BLAST18

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger CCHC domain-containing protein 13
Gene namesi
Name:ZCCHC13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:31749. ZCCHC13.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000187969.
PharmGKBiPA134926925.

Polymorphism and mutation databases

BioMutaiZCCHC13.
DMDMi71152962.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001509741 – 166Zinc finger CCHC domain-containing protein 13Add BLAST166

Proteomic databases

PaxDbiQ8WW36.
PeptideAtlasiQ8WW36.
PRIDEiQ8WW36.

PTM databases

iPTMnetiQ8WW36.
PhosphoSitePlusiQ8WW36.

Expressioni

Gene expression databases

BgeeiENSG00000187969.
CleanExiHS_ZCCHC13.
GenevisibleiQ8WW36. HS.

Organism-specific databases

HPAiHPA003382.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SIAH1Q8IUQ43EBI-954111,EBI-747107

Protein-protein interaction databases

BioGridi133309. 2 interactors.
IntActiQ8WW36. 7 interactors.
MINTiMINT-2879587.
STRINGi9606.ENSP00000345633.

Structurei

3D structure databases

ProteinModelPortaliQ8WW36.
SMRiQ8WW36.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri4 – 21CCHC-type 1; degeneratePROSITE-ProRule annotationAdd BLAST18
Zinc fingeri45 – 62CCHC-type 2; degeneratePROSITE-ProRule annotationAdd BLAST18
Zinc fingeri65 – 82CCHC-type 3PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri89 – 106CCHC-type 4PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri110 – 127CCHC-type 5PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri128 – 145CCHC-type 6PROSITE-ProRule annotationAdd BLAST18

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG4400. Eukaryota.
COG5082. LUCA.
GeneTreeiENSGT00510000047065.
HOGENOMiHOG000186262.
HOVERGENiHBG000397.
InParanoidiQ8WW36.
OMAiRERRQHC.
OrthoDBiEOG091G0LZK.
PhylomeDBiQ8WW36.
TreeFamiTF316974.

Family and domain databases

Gene3Di4.10.60.10. 6 hits.
InterProiView protein in InterPro
IPR001878. Znf_CCHC.
PfamiView protein in Pfam
PF00098. zf-CCHC. 4 hits.
SMARTiView protein in SMART
SM00343. ZnF_C2HC. 6 hits.
SUPFAMiSSF57756. SSF57756. 3 hits.
PROSITEiView protein in PROSITE
PS50158. ZF_CCHC. 4 hits.

Sequencei

Sequence statusi: Complete.

Q8WW36-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSKDFFACG HSGHWARGCP RGGAGGRRGG GHGRGSQCGS TTLSYTCYCC
60 70 80 90 100
GESGRNAKNC VLLGNICYNC GRSGHIAKDC KDPKRERRQH CYTCGRLGHL
110 120 130 140 150
ARDCDRQKEQ KCYSCGKLGH IQKDCAQVKC YRCGEIGHVA INCSKARPGQ
160
LLPLRQIPTS SQGMSQ
Length:166
Mass (Da):18,005
Last modified:March 1, 2002 - v1
Checksum:i40CC28B9FF3F64C3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC021176 mRNA. Translation: AAH21176.1.
CCDSiCCDS14425.1.
RefSeqiNP_976048.1. NM_203303.2.
UniGeneiHs.157231.

Genome annotation databases

EnsembliENST00000339534; ENSP00000345633; ENSG00000187969.
GeneIDi389874.
KEGGihsa:389874.
UCSCiuc004ebs.5. human.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiZCH13_HUMAN
AccessioniPrimary (citable) accession number: Q8WW36
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: March 1, 2002
Last modified: June 7, 2017
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM