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Protein

Transmembrane protein 239

Gene

TMEM239

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 239
Gene namesi
Name:TMEM239
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:40044. TMEM239.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei105 – 125HelicalSequence analysisAdd BLAST21
Transmembranei145 – 171HelicalSequence analysisAdd BLAST27

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000198326.

Polymorphism and mutation databases

BioMutaiTMEM239.
DMDMi353558900.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004136941 – 195Transmembrane protein 239Add BLAST195

Proteomic databases

PaxDbiQ8WW34.
PeptideAtlasiQ8WW34.
PRIDEiQ8WW34.

Expressioni

Gene expression databases

BgeeiENSG00000198326.
GenevisibleiQ8WW34. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ADCK3Q8NI605EBI-9675724,EBI-745535
ATF7P175443EBI-9675724,EBI-765623
C12orf10Q86UA33EBI-9675724,EBI-10258793
FGD2Q7Z6J43EBI-9675724,EBI-1057190
LENG1Q96BZ83EBI-9675724,EBI-726510
POLIQ9UNA43EBI-9675724,EBI-741774
SDCBPO005603EBI-9675724,EBI-727004
SENP2Q9HC623EBI-9675724,EBI-714881
USP5P459743EBI-9675724,EBI-741277
WDYHV1Q96HA83EBI-9675724,EBI-741158

Protein-protein interaction databases

BioGridi940453. 11 interactors.
IntActiQ8WW34. 28 interactors.
STRINGi9606.ENSP00000369959.

Structurei

3D structure databases

ProteinModelPortaliQ8WW34.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi67 – 97Trp-richAdd BLAST31
Compositional biasi101 – 181Leu-richAdd BLAST81

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J4S4. Eukaryota.
ENOG41117DD. LUCA.
GeneTreeiENSGT00390000005090.
HOGENOMiHOG000138203.
HOVERGENiHBG056425.
InParanoidiQ8WW34.
OMAiLLTSMTH.
OrthoDBiEOG091G1334.
PhylomeDBiQ8WW34.
TreeFamiTF337840.

Family and domain databases

InterProiIPR031694. TMEM239.
[Graphical view]
PfamiPF15841. TMEM239. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WW34-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRVGTWICLP GRPGRCRKQH DLGNCPEVPG IFKTLALSPG APDMMQQPRV
60 70 80 90 100
ETDTIGAGEG PQQAVPWSAW VTRHGWVRWW VSHMPPSWIQ WWSTSNWRQP
110 120 130 140 150
LQRLLWGLEG ILYLLLALML CHALFTTGSH LLSSLWPVVA AVWRHLLPAL
160 170 180 190
LLLVLSALPA LLFTASFLLL FSTLLSLVGL LTSMTHPGDT QDLDQ
Length:195
Mass (Da):21,842
Last modified:February 19, 2014 - v3
Checksum:i56A1F7799411E2A4
GO
Isoform 2 (identifier: Q8WW34-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-43: Missing.

Note: No experimental confirmation available.
Show »
Length:152
Mass (Da):17,214
Checksum:i960DEC18B387FC24
GO

Sequence cautioni

The sequence AAH21178 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0537371 – 43Missing in isoform 2. 1 PublicationAdd BLAST43

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK126033 mRNA. Translation: BAC86404.1.
AL035460 Genomic DNA. Translation: CAI23039.1.
AL161656 Genomic DNA. No translation available.
CH471133 Genomic DNA. Translation: EAX10573.1.
BC021178 mRNA. Translation: AAH21178.1. Different initiation.
CCDSiCCDS54444.1. [Q8WW34-2]
CCDS82595.1. [Q8WW34-1]
RefSeqiNP_001161142.1. NM_001167670.2. [Q8WW34-2]
NP_001305136.1. NM_001318207.1. [Q8WW34-1]
XP_011527431.1. XM_011529129.2. [Q8WW34-2]
UniGeneiHs.664180.

Genome annotation databases

EnsembliENST00000361033; ENSP00000354312; ENSG00000198326. [Q8WW34-1]
ENST00000380585; ENSP00000369959; ENSG00000198326. [Q8WW34-2]
GeneIDi100288797.
KEGGihsa:100288797.
UCSCiuc002wgx.3. human. [Q8WW34-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK126033 mRNA. Translation: BAC86404.1.
AL035460 Genomic DNA. Translation: CAI23039.1.
AL161656 Genomic DNA. No translation available.
CH471133 Genomic DNA. Translation: EAX10573.1.
BC021178 mRNA. Translation: AAH21178.1. Different initiation.
CCDSiCCDS54444.1. [Q8WW34-2]
CCDS82595.1. [Q8WW34-1]
RefSeqiNP_001161142.1. NM_001167670.2. [Q8WW34-2]
NP_001305136.1. NM_001318207.1. [Q8WW34-1]
XP_011527431.1. XM_011529129.2. [Q8WW34-2]
UniGeneiHs.664180.

3D structure databases

ProteinModelPortaliQ8WW34.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi940453. 11 interactors.
IntActiQ8WW34. 28 interactors.
STRINGi9606.ENSP00000369959.

Polymorphism and mutation databases

BioMutaiTMEM239.
DMDMi353558900.

Proteomic databases

PaxDbiQ8WW34.
PeptideAtlasiQ8WW34.
PRIDEiQ8WW34.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361033; ENSP00000354312; ENSG00000198326. [Q8WW34-1]
ENST00000380585; ENSP00000369959; ENSG00000198326. [Q8WW34-2]
GeneIDi100288797.
KEGGihsa:100288797.
UCSCiuc002wgx.3. human. [Q8WW34-1]

Organism-specific databases

CTDi100288797.
GeneCardsiTMEM239.
HGNCiHGNC:40044. TMEM239.
neXtProtiNX_Q8WW34.
OpenTargetsiENSG00000198326.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J4S4. Eukaryota.
ENOG41117DD. LUCA.
GeneTreeiENSGT00390000005090.
HOGENOMiHOG000138203.
HOVERGENiHBG056425.
InParanoidiQ8WW34.
OMAiLLTSMTH.
OrthoDBiEOG091G1334.
PhylomeDBiQ8WW34.
TreeFamiTF337840.

Miscellaneous databases

GenomeRNAii100288797.
PROiQ8WW34.

Gene expression databases

BgeeiENSG00000198326.
GenevisibleiQ8WW34. HS.

Family and domain databases

InterProiIPR031694. TMEM239.
[Graphical view]
PfamiPF15841. TMEM239. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTM239_HUMAN
AccessioniPrimary (citable) accession number: Q8WW34
Secondary accession number(s): Q5JY54, Q6ZU23
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: February 19, 2014
Last modified: November 30, 2016
This is version 90 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.