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Protein

High mobility group protein B4

Gene

HMGB4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi9 – 79HMG box 1PROSITE-ProRule annotationAdd BLAST71
DNA bindingi93 – 161HMG box 2PROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000176256-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
High mobility group protein B4
Gene namesi
Name:HMGB4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:24954. HMGB4.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation
  • Chromosome By similarity

GO - Cellular componenti

  • chromosome Source: UniProtKB-SubCell
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi127540.
OpenTargetsiENSG00000176256.

Polymorphism and mutation databases

BioMutaiHMGB4.
DMDMi387912835.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002691801 – 186High mobility group protein B4Add BLAST186

Proteomic databases

EPDiQ8WW32.
PaxDbiQ8WW32.
PeptideAtlasiQ8WW32.
PRIDEiQ8WW32.

PTM databases

iPTMnetiQ8WW32.
PhosphoSitePlusiQ8WW32.

Expressioni

Gene expression databases

BgeeiENSG00000176256.
CleanExiHS_HMGB4.
GenevisibleiQ8WW32. HS.

Organism-specific databases

HPAiHPA035699.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CEP70Q8NHQ15EBI-10277297,EBI-739624
KRTAP12-4P603293EBI-10277297,EBI-10176396

Protein-protein interaction databases

BioGridi126064. 3 interactors.
IntActiQ8WW32. 2 interactors.
STRINGi9606.ENSP00000429214.

Structurei

3D structure databases

ProteinModelPortaliQ8WW32.
SMRiQ8WW32.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HMGB family.Curated
Contains 2 HMG box DNA-binding domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0381. Eukaryota.
COG5648. LUCA.
GeneTreeiENSGT00760000119164.
HOGENOMiHOG000197861.
HOVERGENiHBG009000.
InParanoidiQ8WW32.
KOiK11297.
OMAiVDKQPYE.
OrthoDBiEOG091G0P81.
PhylomeDBiQ8WW32.
TreeFamiTF105371.

Family and domain databases

Gene3Di1.10.30.10. 2 hits.
InterProiIPR009071. HMG_box_dom.
[Graphical view]
PfamiPF00505. HMG_box. 1 hit.
PF09011. HMG_box_2. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 2 hits.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 2 hits.
PROSITEiPS50118. HMG_BOX_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8WW32-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKEIQLKPK ANVSSYVHFL LNYRNKFKEQ QPNTYVGFKE FSRKCSEKWR
60 70 80 90 100
SISKHEKAKY EALAKLDKAR YQEEMMNYVG KRKKRRKRDP QEPRRPPSSF
110 120 130 140 150
LLFCQDHYAQ LKRENPNWSV VQVAKATGKM WSTATDLEKH PYEQRVALLR
160 170 180
AKYFEELELY RKQCNARKKY RMSARNRCRG KRVRQS
Length:186
Mass (Da):22,490
Last modified:May 16, 2012 - v2
Checksum:iE7F941ABBC8D3025
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti33N → S in AAH21180 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05595159K → R.Corresponds to variant rs11542686dbSNPEnsembl.1
Natural variantiVAR_06746792E → A.2 PublicationsCorresponds to variant rs10379dbSNPEnsembl.1
Natural variantiVAR_067468170Y → H.Corresponds to variant rs57068937dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ207367 mRNA. Translation: ABB22048.1.
AK311985 mRNA. Translation: BAG34924.1.
AL121980 Genomic DNA. No translation available.
BC021180 mRNA. Translation: AAH21180.1.
CH471059 Genomic DNA. Translation: EAX07453.1.
CCDSiCCDS30668.1.
RefSeqiNP_660206.2. NM_145205.5.
UniGeneiHs.568628.
Hs.667683.

Genome annotation databases

EnsembliENST00000519684; ENSP00000429214; ENSG00000176256.
ENST00000522796; ENSP00000430919; ENSG00000176256.
GeneIDi127540.
KEGGihsa:127540.
UCSCiuc001bxp.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ207367 mRNA. Translation: ABB22048.1.
AK311985 mRNA. Translation: BAG34924.1.
AL121980 Genomic DNA. No translation available.
BC021180 mRNA. Translation: AAH21180.1.
CH471059 Genomic DNA. Translation: EAX07453.1.
CCDSiCCDS30668.1.
RefSeqiNP_660206.2. NM_145205.5.
UniGeneiHs.568628.
Hs.667683.

3D structure databases

ProteinModelPortaliQ8WW32.
SMRiQ8WW32.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126064. 3 interactors.
IntActiQ8WW32. 2 interactors.
STRINGi9606.ENSP00000429214.

PTM databases

iPTMnetiQ8WW32.
PhosphoSitePlusiQ8WW32.

Polymorphism and mutation databases

BioMutaiHMGB4.
DMDMi387912835.

Proteomic databases

EPDiQ8WW32.
PaxDbiQ8WW32.
PeptideAtlasiQ8WW32.
PRIDEiQ8WW32.

Protocols and materials databases

DNASUi127540.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000519684; ENSP00000429214; ENSG00000176256.
ENST00000522796; ENSP00000430919; ENSG00000176256.
GeneIDi127540.
KEGGihsa:127540.
UCSCiuc001bxp.3. human.

Organism-specific databases

CTDi127540.
DisGeNETi127540.
GeneCardsiHMGB4.
HGNCiHGNC:24954. HMGB4.
HPAiHPA035699.
neXtProtiNX_Q8WW32.
OpenTargetsiENSG00000176256.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0381. Eukaryota.
COG5648. LUCA.
GeneTreeiENSGT00760000119164.
HOGENOMiHOG000197861.
HOVERGENiHBG009000.
InParanoidiQ8WW32.
KOiK11297.
OMAiVDKQPYE.
OrthoDBiEOG091G0P81.
PhylomeDBiQ8WW32.
TreeFamiTF105371.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000176256-MONOMER.

Miscellaneous databases

GeneWikiiHMGB4.
GenomeRNAii127540.
PROiQ8WW32.

Gene expression databases

BgeeiENSG00000176256.
CleanExiHS_HMGB4.
GenevisibleiQ8WW32. HS.

Family and domain databases

Gene3Di1.10.30.10. 2 hits.
InterProiIPR009071. HMG_box_dom.
[Graphical view]
PfamiPF00505. HMG_box. 1 hit.
PF09011. HMG_box_2. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 2 hits.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 2 hits.
PROSITEiPS50118. HMG_BOX_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHMGB4_HUMAN
AccessioniPrimary (citable) accession number: Q8WW32
Secondary accession number(s): B2R4X7, Q0QWA4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: May 16, 2012
Last modified: November 30, 2016
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.