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Protein

High mobility group protein B4

Gene

HMGB4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi9 – 7971HMG box 1PROSITE-ProRule annotationAdd
BLAST
DNA bindingi93 – 16169HMG box 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
High mobility group protein B4
Gene namesi
Name:HMGB4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:24954. HMGB4.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation
  • Chromosome By similarity

GO - Cellular componenti

  • chromosome Source: UniProtKB-SubCell
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

Pathology & Biotechi

Polymorphism and mutation databases

BioMutaiHMGB4.
DMDMi387912835.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 186186High mobility group protein B4PRO_0000269180Add
BLAST

Proteomic databases

PRIDEiQ8WW32.

PTM databases

PhosphoSiteiQ8WW32.

Expressioni

Gene expression databases

BgeeiQ8WW32.
CleanExiHS_HMGB4.

Organism-specific databases

HPAiHPA035699.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CEP70Q8NHQ13EBI-10277297,EBI-739624
KRTAP12-4P603293EBI-10277297,EBI-10176396

Protein-protein interaction databases

BioGridi126064. 3 interactions.
IntActiQ8WW32. 2 interactions.
STRINGi9606.ENSP00000429214.

Structurei

3D structure databases

ProteinModelPortaliQ8WW32.
SMRiQ8WW32. Positions 1-163.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HMGB family.Curated
Contains 2 HMG box DNA-binding domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

GeneTreeiENSGT00760000119164.
HOGENOMiHOG000197861.
HOVERGENiHBG009000.
InParanoidiQ8WW32.
KOiK11297.
OMAiRYQEEMM.
OrthoDBiEOG7WHHBQ.
PhylomeDBiQ8WW32.
TreeFamiTF105371.

Family and domain databases

Gene3Di1.10.30.10. 2 hits.
InterProiIPR009071. HMG_box_dom.
[Graphical view]
PfamiPF00505. HMG_box. 1 hit.
PF09011. HMG_box_2. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 2 hits.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 2 hits.
PROSITEiPS50118. HMG_BOX_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8WW32-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKEIQLKPK ANVSSYVHFL LNYRNKFKEQ QPNTYVGFKE FSRKCSEKWR
60 70 80 90 100
SISKHEKAKY EALAKLDKAR YQEEMMNYVG KRKKRRKRDP QEPRRPPSSF
110 120 130 140 150
LLFCQDHYAQ LKRENPNWSV VQVAKATGKM WSTATDLEKH PYEQRVALLR
160 170 180
AKYFEELELY RKQCNARKKY RMSARNRCRG KRVRQS
Length:186
Mass (Da):22,490
Last modified:May 16, 2012 - v2
Checksum:iE7F941ABBC8D3025
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti33 – 331N → S in AAH21180 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti59 – 591K → R.
Corresponds to variant rs11542686 [ dbSNP | Ensembl ].
VAR_055951
Natural varianti92 – 921E → A.2 Publications
Corresponds to variant rs10379 [ dbSNP | Ensembl ].
VAR_067467
Natural varianti170 – 1701Y → H.
Corresponds to variant rs57068937 [ dbSNP | Ensembl ].
VAR_067468

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ207367 mRNA. Translation: ABB22048.1.
AK311985 mRNA. Translation: BAG34924.1.
AL121980 Genomic DNA. No translation available.
BC021180 mRNA. Translation: AAH21180.1.
CH471059 Genomic DNA. Translation: EAX07453.1.
CCDSiCCDS30668.1.
RefSeqiNP_660206.2. NM_145205.5.
UniGeneiHs.568628.
Hs.667683.

Genome annotation databases

EnsembliENST00000519684; ENSP00000429214; ENSG00000176256.
ENST00000522796; ENSP00000430919; ENSG00000176256.
GeneIDi127540.
KEGGihsa:127540.
UCSCiuc001bxp.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ207367 mRNA. Translation: ABB22048.1.
AK311985 mRNA. Translation: BAG34924.1.
AL121980 Genomic DNA. No translation available.
BC021180 mRNA. Translation: AAH21180.1.
CH471059 Genomic DNA. Translation: EAX07453.1.
CCDSiCCDS30668.1.
RefSeqiNP_660206.2. NM_145205.5.
UniGeneiHs.568628.
Hs.667683.

3D structure databases

ProteinModelPortaliQ8WW32.
SMRiQ8WW32. Positions 1-163.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126064. 3 interactions.
IntActiQ8WW32. 2 interactions.
STRINGi9606.ENSP00000429214.

PTM databases

PhosphoSiteiQ8WW32.

Polymorphism and mutation databases

BioMutaiHMGB4.
DMDMi387912835.

Proteomic databases

PRIDEiQ8WW32.

Protocols and materials databases

DNASUi127540.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000519684; ENSP00000429214; ENSG00000176256.
ENST00000522796; ENSP00000430919; ENSG00000176256.
GeneIDi127540.
KEGGihsa:127540.
UCSCiuc001bxp.3. human.

Organism-specific databases

CTDi127540.
GeneCardsiGC01P034326.
HGNCiHGNC:24954. HMGB4.
HPAiHPA035699.
neXtProtiNX_Q8WW32.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00760000119164.
HOGENOMiHOG000197861.
HOVERGENiHBG009000.
InParanoidiQ8WW32.
KOiK11297.
OMAiRYQEEMM.
OrthoDBiEOG7WHHBQ.
PhylomeDBiQ8WW32.
TreeFamiTF105371.

Miscellaneous databases

GeneWikiiHMGB4.
GenomeRNAii127540.
NextBioi82109.
PROiQ8WW32.

Gene expression databases

BgeeiQ8WW32.
CleanExiHS_HMGB4.

Family and domain databases

Gene3Di1.10.30.10. 2 hits.
InterProiIPR009071. HMG_box_dom.
[Graphical view]
PfamiPF00505. HMG_box. 1 hit.
PF09011. HMG_box_2. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 2 hits.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 2 hits.
PROSITEiPS50118. HMG_BOX_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a novel H. sapiens protein with two high-mobility group domains."
    Zhou C., Xiao X.W., Zhou J.L., Zhang J.
    Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ALA-92.
    Tissue: Testis.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-92.
    Tissue: Testis.

Entry informationi

Entry nameiHMGB4_HUMAN
AccessioniPrimary (citable) accession number: Q8WW32
Secondary accession number(s): B2R4X7, Q0QWA4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: May 16, 2012
Last modified: June 24, 2015
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.