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Q8WW32

- HMGB4_HUMAN

UniProt

Q8WW32 - HMGB4_HUMAN

Protein

High mobility group protein B4

Gene

HMGB4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 2 (16 May 2012)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi9 – 7971HMG box 1PROSITE-ProRule annotationAdd
    BLAST
    DNA bindingi93 – 16169HMG box 2PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    High mobility group protein B4
    Gene namesi
    Name:HMGB4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:24954. HMGB4.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation. Chromosome By similarity

    GO - Cellular componenti

    1. chromosome Source: UniProtKB-SubCell
    2. nucleus Source: UniProt

    Keywords - Cellular componenti

    Chromosome, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 186186High mobility group protein B4PRO_0000269180Add
    BLAST

    Proteomic databases

    PRIDEiQ8WW32.

    PTM databases

    PhosphoSiteiQ8WW32.

    Expressioni

    Gene expression databases

    BgeeiQ8WW32.
    CleanExiHS_HMGB4.
    GenevestigatoriQ8WW32.

    Organism-specific databases

    HPAiHPA035699.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8WW32.
    SMRiQ8WW32. Positions 1-163.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the HMGB family.Curated
    Contains 2 HMG box DNA-binding domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    HOGENOMiHOG000197861.
    HOVERGENiHBG009000.
    InParanoidiQ8WW32.
    KOiK11297.
    OMAiHEKAKYE.
    OrthoDBiEOG7WHHBQ.
    PhylomeDBiQ8WW32.
    TreeFamiTF105371.

    Family and domain databases

    Gene3Di1.10.30.10. 2 hits.
    InterProiIPR009071. HMG_box_dom.
    [Graphical view]
    PfamiPF00505. HMG_box. 1 hit.
    PF09011. HMG_box_2. 1 hit.
    [Graphical view]
    SMARTiSM00398. HMG. 2 hits.
    [Graphical view]
    SUPFAMiSSF47095. SSF47095. 2 hits.
    PROSITEiPS50118. HMG_BOX_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8WW32-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGKEIQLKPK ANVSSYVHFL LNYRNKFKEQ QPNTYVGFKE FSRKCSEKWR    50
    SISKHEKAKY EALAKLDKAR YQEEMMNYVG KRKKRRKRDP QEPRRPPSSF 100
    LLFCQDHYAQ LKRENPNWSV VQVAKATGKM WSTATDLEKH PYEQRVALLR 150
    AKYFEELELY RKQCNARKKY RMSARNRCRG KRVRQS 186
    Length:186
    Mass (Da):22,490
    Last modified:May 16, 2012 - v2
    Checksum:iE7F941ABBC8D3025
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti33 – 331N → S in AAH21180. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti59 – 591K → R.
    Corresponds to variant rs11542686 [ dbSNP | Ensembl ].
    VAR_055951
    Natural varianti92 – 921E → A.2 Publications
    Corresponds to variant rs10379 [ dbSNP | Ensembl ].
    VAR_067467
    Natural varianti170 – 1701Y → H.
    Corresponds to variant rs57068937 [ dbSNP | Ensembl ].
    VAR_067468

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ207367 mRNA. Translation: ABB22048.1.
    AK311985 mRNA. Translation: BAG34924.1.
    AL121980 Genomic DNA. No translation available.
    BC021180 mRNA. Translation: AAH21180.1.
    CH471059 Genomic DNA. Translation: EAX07453.1.
    CCDSiCCDS30668.1.
    RefSeqiNP_660206.2. NM_145205.5.
    UniGeneiHs.568628.
    Hs.667683.

    Genome annotation databases

    EnsembliENST00000519684; ENSP00000429214; ENSG00000176256.
    ENST00000522796; ENSP00000430919; ENSG00000176256.
    GeneIDi127540.
    KEGGihsa:127540.
    UCSCiuc001bxp.3. human.

    Polymorphism databases

    DMDMi387912835.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ207367 mRNA. Translation: ABB22048.1 .
    AK311985 mRNA. Translation: BAG34924.1 .
    AL121980 Genomic DNA. No translation available.
    BC021180 mRNA. Translation: AAH21180.1 .
    CH471059 Genomic DNA. Translation: EAX07453.1 .
    CCDSi CCDS30668.1.
    RefSeqi NP_660206.2. NM_145205.5.
    UniGenei Hs.568628.
    Hs.667683.

    3D structure databases

    ProteinModelPortali Q8WW32.
    SMRi Q8WW32. Positions 1-163.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8WW32.

    Polymorphism databases

    DMDMi 387912835.

    Proteomic databases

    PRIDEi Q8WW32.

    Protocols and materials databases

    DNASUi 127540.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000519684 ; ENSP00000429214 ; ENSG00000176256 .
    ENST00000522796 ; ENSP00000430919 ; ENSG00000176256 .
    GeneIDi 127540.
    KEGGi hsa:127540.
    UCSCi uc001bxp.3. human.

    Organism-specific databases

    CTDi 127540.
    GeneCardsi GC01P034326.
    HGNCi HGNC:24954. HMGB4.
    HPAi HPA035699.
    neXtProti NX_Q8WW32.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000197861.
    HOVERGENi HBG009000.
    InParanoidi Q8WW32.
    KOi K11297.
    OMAi HEKAKYE.
    OrthoDBi EOG7WHHBQ.
    PhylomeDBi Q8WW32.
    TreeFami TF105371.

    Miscellaneous databases

    GeneWikii HMGB4.
    GenomeRNAii 127540.
    NextBioi 82109.
    PROi Q8WW32.

    Gene expression databases

    Bgeei Q8WW32.
    CleanExi HS_HMGB4.
    Genevestigatori Q8WW32.

    Family and domain databases

    Gene3Di 1.10.30.10. 2 hits.
    InterProi IPR009071. HMG_box_dom.
    [Graphical view ]
    Pfami PF00505. HMG_box. 1 hit.
    PF09011. HMG_box_2. 1 hit.
    [Graphical view ]
    SMARTi SM00398. HMG. 2 hits.
    [Graphical view ]
    SUPFAMi SSF47095. SSF47095. 2 hits.
    PROSITEi PS50118. HMG_BOX_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a novel H. sapiens protein with two high-mobility group domains."
      Zhou C., Xiao X.W., Zhou J.L., Zhang J.
      Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ALA-92.
      Tissue: Testis.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    3. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-92.
      Tissue: Testis.

    Entry informationi

    Entry nameiHMGB4_HUMAN
    AccessioniPrimary (citable) accession number: Q8WW32
    Secondary accession number(s): B2R4X7, Q0QWA4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 12, 2006
    Last sequence update: May 16, 2012
    Last modified: October 1, 2014
    This is version 94 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3