Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8WW27

- ABEC4_HUMAN

UniProt

Q8WW27 - ABEC4_HUMAN

Protein

Putative C->U-editing enzyme APOBEC-4

Gene

APOBEC4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Putative C to U editing enzyme whose physiological substrate is not yet known.By similarity

    Cofactori

    Zinc.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi93 – 931Zinc; catalyticBy similarity
    Active sitei95 – 951Proton donorBy similarity
    Metal bindingi127 – 1271Zinc; catalyticBy similarity
    Metal bindingi134 – 1341Zinc; catalyticBy similarity

    GO - Molecular functioni

    1. hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines Source: InterPro
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. mRNA processing Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    mRNA processing

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative C->U-editing enzyme APOBEC-4 (EC:3.5.4.-)
    Alternative name(s):
    Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 4
    Gene namesi
    Name:APOBEC4
    Synonyms:C1orf169
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:32152. APOBEC4.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142672597.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 367367Putative C->U-editing enzyme APOBEC-4PRO_0000239355Add
    BLAST

    Proteomic databases

    PaxDbiQ8WW27.
    PRIDEiQ8WW27.

    Expressioni

    Tissue specificityi

    Predominantly expressed in testis.1 Publication

    Gene expression databases

    BgeeiQ8WW27.
    CleanExiHS_APOBEC4.
    GenevestigatoriQ8WW27.

    Organism-specific databases

    HPAiHPA015636.
    HPA015637.

    Interactioni

    Protein-protein interaction databases

    BioGridi135625. 2 interactions.
    STRINGi9606.ENSP00000310622.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8WW27.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi299 – 31416Leu-richAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG43268.
    HOGENOMiHOG000033767.
    HOVERGENiHBG080811.
    InParanoidiQ8WW27.
    KOiK01500.
    OMAiFSQLYHT.
    OrthoDBiEOG7FV3QM.
    PhylomeDBiQ8WW27.
    TreeFamiTF338173.

    Family and domain databases

    InterProiIPR013158. APOBEC_N.
    [Graphical view]
    PfamiPF08210. APOBEC_N. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8WW27-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEPIYEEYLA NHGTIVKPYY WLSFSLDCSN CPYHIRTGEE ARVSLTEFCQ    50
    IFGFPYGTTF PQTKHLTFYE LKTSSGSLVQ KGHASSCTGN YIHPESMLFE 100
    MNGYLDSAIY NNDSIRHIIL YSNNSPCNEA NHCCISKMYN FLITYPGITL 150
    SIYFSQLYHT EMDFPASAWN REALRSLASL WPRVVLSPIS GGIWHSVLHS 200
    FISGVSGSHV FQPILTGRAL ADRHNAYEIN AITGVKPYFT DVLLQTKRNP 250
    NTKAQEALES YPLNNAFPGQ FFQMPSGQLQ PNLPPDLRAP VVFVLVPLRD 300
    LPPMHMGQNP NKPRNIVRHL NMPQMSFQET KDLGRLPTGR SVEIVEITEQ 350
    FASSKEADEK KKKKGKK 367
    Length:367
    Mass (Da):41,581
    Last modified:March 1, 2002 - v1
    Checksum:iB5ACD9AB875482C6
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti75 – 751S → F.
    Corresponds to variant rs16861394 [ dbSNP | Ensembl ].
    VAR_026639
    Natural varianti271 – 2711F → S.1 Publication
    Corresponds to variant rs1174658 [ dbSNP | Ensembl ].
    VAR_026640
    Natural varianti275 – 2751P → S.
    Corresponds to variant rs10911391 [ dbSNP | Ensembl ].
    VAR_026641
    Natural varianti300 – 3001D → G.
    Corresponds to variant rs16861381 [ dbSNP | Ensembl ].
    VAR_048724
    Natural varianti331 – 3311K → E.1 Publication
    Corresponds to variant rs1174657 [ dbSNP | Ensembl ].
    VAR_026642
    Natural varianti345 – 3451V → M.
    Corresponds to variant rs10911390 [ dbSNP | Ensembl ].
    VAR_026643

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK098557 mRNA. Translation: BAC05332.1.
    AL137800 Genomic DNA. Translation: CAI19483.1.
    BC021711 mRNA. Translation: AAH21711.1.
    CCDSiCCDS1358.1.
    RefSeqiNP_982279.1. NM_203454.2.
    UniGeneiHs.97335.

    Genome annotation databases

    EnsembliENST00000308641; ENSP00000310622; ENSG00000173627.
    GeneIDi403314.
    KEGGihsa:403314.
    UCSCiuc001gqn.3. human.

    Polymorphism databases

    DMDMi74751569.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK098557 mRNA. Translation: BAC05332.1 .
    AL137800 Genomic DNA. Translation: CAI19483.1 .
    BC021711 mRNA. Translation: AAH21711.1 .
    CCDSi CCDS1358.1.
    RefSeqi NP_982279.1. NM_203454.2.
    UniGenei Hs.97335.

    3D structure databases

    ProteinModelPortali Q8WW27.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 135625. 2 interactions.
    STRINGi 9606.ENSP00000310622.

    Polymorphism databases

    DMDMi 74751569.

    Proteomic databases

    PaxDbi Q8WW27.
    PRIDEi Q8WW27.

    Protocols and materials databases

    DNASUi 403314.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000308641 ; ENSP00000310622 ; ENSG00000173627 .
    GeneIDi 403314.
    KEGGi hsa:403314.
    UCSCi uc001gqn.3. human.

    Organism-specific databases

    CTDi 403314.
    GeneCardsi GC01M183615.
    HGNCi HGNC:32152. APOBEC4.
    HPAi HPA015636.
    HPA015637.
    MIMi 609908. gene.
    neXtProti NX_Q8WW27.
    PharmGKBi PA142672597.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG43268.
    HOGENOMi HOG000033767.
    HOVERGENi HBG080811.
    InParanoidi Q8WW27.
    KOi K01500.
    OMAi FSQLYHT.
    OrthoDBi EOG7FV3QM.
    PhylomeDBi Q8WW27.
    TreeFami TF338173.

    Miscellaneous databases

    GeneWikii APOBEC4.
    GenomeRNAii 403314.
    NextBioi 107764.
    PROi Q8WW27.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8WW27.
    CleanExi HS_APOBEC4.
    Genevestigatori Q8WW27.

    Family and domain databases

    InterProi IPR013158. APOBEC_N.
    [Graphical view ]
    Pfami PF08210. APOBEC_N. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS SER-271 AND GLU-331.
      Tissue: Testis.
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    4. "APOBEC4, a new member of the AID/APOBEC family of polynucleotide (deoxy)cytidine deaminases predicted by computational analysis."
      Rogozin I.B., Basu M.K., Jordan I.K., Pavlov Y.I., Koonin E.V.
      Cell Cycle 4:1281-1285(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiABEC4_HUMAN
    AccessioniPrimary (citable) accession number: Q8WW27
    Secondary accession number(s): Q8N7F6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 13, 2006
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3