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Q8WW27 (ABEC4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative C->U-editing enzyme APOBEC-4

EC=3.5.4.-
Alternative name(s):
Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 4
Gene names
Name:APOBEC4
Synonyms:C1orf169
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length367 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Putative C to U editing enzyme whose physiological substrate is not yet known By similarity.

Cofactor

Zinc By similarity.

Tissue specificity

Predominantly expressed in testis. Ref.4

Sequence similarities

Belongs to the cytidine and deoxycytidylate deaminase family.

Ontologies

Keywords
   Biological processmRNA processing
   Coding sequence diversityPolymorphism
   LigandMetal-binding
Zinc
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processmRNA processing

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionhydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines

Inferred from electronic annotation. Source: InterPro

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 367367Putative C->U-editing enzyme APOBEC-4
PRO_0000239355

Regions

Compositional bias299 – 31416Leu-rich

Sites

Active site951Proton donor By similarity
Metal binding931Zinc; catalytic By similarity
Metal binding1271Zinc; catalytic By similarity
Metal binding1341Zinc; catalytic By similarity

Natural variations

Natural variant751S → F.
Corresponds to variant rs16861394 [ dbSNP | Ensembl ].
VAR_026639
Natural variant2711F → S. Ref.1
Corresponds to variant rs1174658 [ dbSNP | Ensembl ].
VAR_026640
Natural variant2751P → S.
Corresponds to variant rs10911391 [ dbSNP | Ensembl ].
VAR_026641
Natural variant3001D → G.
Corresponds to variant rs16861381 [ dbSNP | Ensembl ].
VAR_048724
Natural variant3311K → E. Ref.1
Corresponds to variant rs1174657 [ dbSNP | Ensembl ].
VAR_026642
Natural variant3451V → M.
Corresponds to variant rs10911390 [ dbSNP | Ensembl ].
VAR_026643

Sequences

Sequence LengthMass (Da)Tools
Q8WW27 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: B5ACD9AB875482C6

FASTA36741,581
        10         20         30         40         50         60 
MEPIYEEYLA NHGTIVKPYY WLSFSLDCSN CPYHIRTGEE ARVSLTEFCQ IFGFPYGTTF 

        70         80         90        100        110        120 
PQTKHLTFYE LKTSSGSLVQ KGHASSCTGN YIHPESMLFE MNGYLDSAIY NNDSIRHIIL 

       130        140        150        160        170        180 
YSNNSPCNEA NHCCISKMYN FLITYPGITL SIYFSQLYHT EMDFPASAWN REALRSLASL 

       190        200        210        220        230        240 
WPRVVLSPIS GGIWHSVLHS FISGVSGSHV FQPILTGRAL ADRHNAYEIN AITGVKPYFT 

       250        260        270        280        290        300 
DVLLQTKRNP NTKAQEALES YPLNNAFPGQ FFQMPSGQLQ PNLPPDLRAP VVFVLVPLRD 

       310        320        330        340        350        360 
LPPMHMGQNP NKPRNIVRHL NMPQMSFQET KDLGRLPTGR SVEIVEITEQ FASSKEADEK 


KKKKGKK 

« Hide

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS SER-271 AND GLU-331.
Tissue: Testis.
[2]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[4]"APOBEC4, a new member of the AID/APOBEC family of polynucleotide (deoxy)cytidine deaminases predicted by computational analysis."
Rogozin I.B., Basu M.K., Jordan I.K., Pavlov Y.I., Koonin E.V.
Cell Cycle 4:1281-1285(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION, TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK098557 mRNA. Translation: BAC05332.1.
AL137800 Genomic DNA. Translation: CAI19483.1.
BC021711 mRNA. Translation: AAH21711.1.
RefSeqNP_982279.1. NM_203454.2.
UniGeneHs.97335.

3D structure databases

ProteinModelPortalQ8WW27.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid135625. 2 interactions.
STRING9606.ENSP00000310622.

Polymorphism databases

DMDM74751569.

Proteomic databases

PaxDbQ8WW27.
PRIDEQ8WW27.

Protocols and materials databases

DNASU403314.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000308641; ENSP00000310622; ENSG00000173627.
GeneID403314.
KEGGhsa:403314.
UCSCuc001gqn.3. human.

Organism-specific databases

CTD403314.
GeneCardsGC01M183615.
HGNCHGNC:32152. APOBEC4.
HPAHPA015636.
HPA015637.
MIM609908. gene.
neXtProtNX_Q8WW27.
PharmGKBPA142672597.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG43268.
HOGENOMHOG000033767.
HOVERGENHBG080811.
InParanoidQ8WW27.
KOK01500.
OMAFSQLYHT.
OrthoDBEOG7FV3QM.
PhylomeDBQ8WW27.
TreeFamTF338173.

Gene expression databases

BgeeQ8WW27.
CleanExHS_APOBEC4.
GenevestigatorQ8WW27.

Family and domain databases

InterProIPR013158. APOBEC_N.
[Graphical view]
PfamPF08210. APOBEC_N. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiAPOBEC4.
GenomeRNAi403314.
NextBio107764.
PROQ8WW27.
SOURCESearch...

Entry information

Entry nameABEC4_HUMAN
AccessionPrimary (citable) accession number: Q8WW27
Secondary accession number(s): Q8N7F6
Entry history
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: March 1, 2002
Last modified: February 19, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM