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Protein

Putative C->U-editing enzyme APOBEC-4

Gene

APOBEC4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Putative C to U editing enzyme whose physiological substrate is not yet known.By similarity

Cofactori

Zn2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi93 – 931Zinc; catalyticBy similarity
Active sitei95 – 951Proton donorBy similarity
Metal bindingi127 – 1271Zinc; catalyticBy similarity
Metal bindingi134 – 1341Zinc; catalyticBy similarity

GO - Molecular functioni

  1. hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines Source: InterPro
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. mRNA processing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

mRNA processing

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Putative C->U-editing enzyme APOBEC-4 (EC:3.5.4.-)
Alternative name(s):
Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 4
Gene namesi
Name:APOBEC4
Synonyms:C1orf169
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:32152. APOBEC4.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672597.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 367367Putative C->U-editing enzyme APOBEC-4PRO_0000239355Add
BLAST

Proteomic databases

PaxDbiQ8WW27.
PRIDEiQ8WW27.

Expressioni

Tissue specificityi

Predominantly expressed in testis.1 Publication

Gene expression databases

BgeeiQ8WW27.
CleanExiHS_APOBEC4.
GenevestigatoriQ8WW27.

Organism-specific databases

HPAiHPA015636.
HPA015637.

Interactioni

Protein-protein interaction databases

BioGridi135625. 2 interactions.
STRINGi9606.ENSP00000310622.

Structurei

3D structure databases

ProteinModelPortaliQ8WW27.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi299 – 31416Leu-richAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG43268.
GeneTreeiENSGT00390000014243.
HOGENOMiHOG000033767.
HOVERGENiHBG080811.
KOiK18773.
OMAiTIVKPYY.
OrthoDBiEOG7FV3QM.
PhylomeDBiQ8WW27.
TreeFamiTF338173.

Family and domain databases

InterProiIPR013158. APOBEC_N.
[Graphical view]
PfamiPF08210. APOBEC_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8WW27-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEPIYEEYLA NHGTIVKPYY WLSFSLDCSN CPYHIRTGEE ARVSLTEFCQ
60 70 80 90 100
IFGFPYGTTF PQTKHLTFYE LKTSSGSLVQ KGHASSCTGN YIHPESMLFE
110 120 130 140 150
MNGYLDSAIY NNDSIRHIIL YSNNSPCNEA NHCCISKMYN FLITYPGITL
160 170 180 190 200
SIYFSQLYHT EMDFPASAWN REALRSLASL WPRVVLSPIS GGIWHSVLHS
210 220 230 240 250
FISGVSGSHV FQPILTGRAL ADRHNAYEIN AITGVKPYFT DVLLQTKRNP
260 270 280 290 300
NTKAQEALES YPLNNAFPGQ FFQMPSGQLQ PNLPPDLRAP VVFVLVPLRD
310 320 330 340 350
LPPMHMGQNP NKPRNIVRHL NMPQMSFQET KDLGRLPTGR SVEIVEITEQ
360
FASSKEADEK KKKKGKK
Length:367
Mass (Da):41,581
Last modified:March 1, 2002 - v1
Checksum:iB5ACD9AB875482C6
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti75 – 751S → F.
Corresponds to variant rs16861394 [ dbSNP | Ensembl ].
VAR_026639
Natural varianti271 – 2711F → S.1 Publication
Corresponds to variant rs1174658 [ dbSNP | Ensembl ].
VAR_026640
Natural varianti275 – 2751P → S.
Corresponds to variant rs10911391 [ dbSNP | Ensembl ].
VAR_026641
Natural varianti300 – 3001D → G.
Corresponds to variant rs16861381 [ dbSNP | Ensembl ].
VAR_048724
Natural varianti331 – 3311K → E.1 Publication
Corresponds to variant rs1174657 [ dbSNP | Ensembl ].
VAR_026642
Natural varianti345 – 3451V → M.
Corresponds to variant rs10911390 [ dbSNP | Ensembl ].
VAR_026643

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK098557 mRNA. Translation: BAC05332.1.
AL137800 Genomic DNA. Translation: CAI19483.1.
BC021711 mRNA. Translation: AAH21711.1.
CCDSiCCDS1358.1.
RefSeqiNP_982279.1. NM_203454.2.
UniGeneiHs.97335.

Genome annotation databases

EnsembliENST00000308641; ENSP00000310622; ENSG00000173627.
GeneIDi403314.
KEGGihsa:403314.
UCSCiuc001gqn.3. human.

Polymorphism databases

DMDMi74751569.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK098557 mRNA. Translation: BAC05332.1.
AL137800 Genomic DNA. Translation: CAI19483.1.
BC021711 mRNA. Translation: AAH21711.1.
CCDSiCCDS1358.1.
RefSeqiNP_982279.1. NM_203454.2.
UniGeneiHs.97335.

3D structure databases

ProteinModelPortaliQ8WW27.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi135625. 2 interactions.
STRINGi9606.ENSP00000310622.

Polymorphism databases

DMDMi74751569.

Proteomic databases

PaxDbiQ8WW27.
PRIDEiQ8WW27.

Protocols and materials databases

DNASUi403314.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000308641; ENSP00000310622; ENSG00000173627.
GeneIDi403314.
KEGGihsa:403314.
UCSCiuc001gqn.3. human.

Organism-specific databases

CTDi403314.
GeneCardsiGC01M183615.
HGNCiHGNC:32152. APOBEC4.
HPAiHPA015636.
HPA015637.
MIMi609908. gene.
neXtProtiNX_Q8WW27.
PharmGKBiPA142672597.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG43268.
GeneTreeiENSGT00390000014243.
HOGENOMiHOG000033767.
HOVERGENiHBG080811.
KOiK18773.
OMAiTIVKPYY.
OrthoDBiEOG7FV3QM.
PhylomeDBiQ8WW27.
TreeFamiTF338173.

Miscellaneous databases

GeneWikiiAPOBEC4.
GenomeRNAii403314.
NextBioi107764.
PROiQ8WW27.
SOURCEiSearch...

Gene expression databases

BgeeiQ8WW27.
CleanExiHS_APOBEC4.
GenevestigatoriQ8WW27.

Family and domain databases

InterProiIPR013158. APOBEC_N.
[Graphical view]
PfamiPF08210. APOBEC_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS SER-271 AND GLU-331.
    Tissue: Testis.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  4. "APOBEC4, a new member of the AID/APOBEC family of polynucleotide (deoxy)cytidine deaminases predicted by computational analysis."
    Rogozin I.B., Basu M.K., Jordan I.K., Pavlov Y.I., Koonin E.V.
    Cell Cycle 4:1281-1285(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiABEC4_HUMAN
AccessioniPrimary (citable) accession number: Q8WW27
Secondary accession number(s): Q8N7F6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: March 1, 2002
Last modified: February 4, 2015
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.