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Protein

Putative C->U-editing enzyme APOBEC-4

Gene

APOBEC4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Putative C to U editing enzyme whose physiological substrate is not yet known.By similarity

Cofactori

Zn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi93Zinc; catalyticBy similarity1
Active sitei95Proton donorBy similarity1
Metal bindingi127Zinc; catalyticBy similarity1
Metal bindingi134Zinc; catalyticBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processmRNA processing
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-72200. mRNA Editing: C to U Conversion.
R-HSA-75094. Formation of the Editosome.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative C->U-editing enzyme APOBEC-4 (EC:3.5.4.-)
Alternative name(s):
Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 4
Gene namesi
Name:APOBEC4
Synonyms:C1orf169
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000173627.7.
HGNCiHGNC:32152. APOBEC4.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000173627.
PharmGKBiPA142672597.

Polymorphism and mutation databases

BioMutaiAPOBEC4.
DMDMi74751569.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002393551 – 367Putative C->U-editing enzyme APOBEC-4Add BLAST367

Proteomic databases

PaxDbiQ8WW27.
PeptideAtlasiQ8WW27.
PRIDEiQ8WW27.

PTM databases

iPTMnetiQ8WW27.
PhosphoSitePlusiQ8WW27.

Expressioni

Tissue specificityi

Predominantly expressed in testis.1 Publication

Gene expression databases

BgeeiENSG00000173627.
CleanExiHS_APOBEC4.
GenevisibleiQ8WW27. HS.

Organism-specific databases

HPAiHPA015636.
HPA015637.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000310622.

Structurei

3D structure databases

ProteinModelPortaliQ8WW27.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini61 – 177CMP/dCMP-type deaminasePROSITE-ProRule annotationAdd BLAST117

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi299 – 314Leu-richAdd BLAST16

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410II65. Eukaryota.
ENOG4111QES. LUCA.
GeneTreeiENSGT00390000014243.
HOGENOMiHOG000033767.
HOVERGENiHBG080811.
KOiK18773.
OMAiFSQLYHT.
OrthoDBiEOG091G0T9Y.
PhylomeDBiQ8WW27.
TreeFamiTF338173.

Family and domain databases

InterProiView protein in InterPro
IPR013158. APOBEC_N.
IPR002125. CMP_dCMP_dom.
PfamiView protein in Pfam
PF08210. APOBEC_N. 1 hit.
PROSITEiView protein in PROSITE
PS51747. CYT_DCMP_DEAMINASES_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8WW27-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPIYEEYLA NHGTIVKPYY WLSFSLDCSN CPYHIRTGEE ARVSLTEFCQ
60 70 80 90 100
IFGFPYGTTF PQTKHLTFYE LKTSSGSLVQ KGHASSCTGN YIHPESMLFE
110 120 130 140 150
MNGYLDSAIY NNDSIRHIIL YSNNSPCNEA NHCCISKMYN FLITYPGITL
160 170 180 190 200
SIYFSQLYHT EMDFPASAWN REALRSLASL WPRVVLSPIS GGIWHSVLHS
210 220 230 240 250
FISGVSGSHV FQPILTGRAL ADRHNAYEIN AITGVKPYFT DVLLQTKRNP
260 270 280 290 300
NTKAQEALES YPLNNAFPGQ FFQMPSGQLQ PNLPPDLRAP VVFVLVPLRD
310 320 330 340 350
LPPMHMGQNP NKPRNIVRHL NMPQMSFQET KDLGRLPTGR SVEIVEITEQ
360
FASSKEADEK KKKKGKK
Length:367
Mass (Da):41,581
Last modified:March 1, 2002 - v1
Checksum:iB5ACD9AB875482C6
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02663975S → F. Corresponds to variant dbSNP:rs16861394Ensembl.1
Natural variantiVAR_026640271F → S1 PublicationCorresponds to variant dbSNP:rs1174658Ensembl.1
Natural variantiVAR_026641275P → S. Corresponds to variant dbSNP:rs10911391Ensembl.1
Natural variantiVAR_048724300D → G. Corresponds to variant dbSNP:rs16861381Ensembl.1
Natural variantiVAR_026642331K → E1 PublicationCorresponds to variant dbSNP:rs1174657Ensembl.1
Natural variantiVAR_026643345V → M. Corresponds to variant dbSNP:rs10911390Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK098557 mRNA. Translation: BAC05332.1.
AL137800 Genomic DNA. No translation available.
BC021711 mRNA. Translation: AAH21711.1.
CCDSiCCDS1358.1.
RefSeqiNP_982279.1. NM_203454.2.
UniGeneiHs.97335.

Genome annotation databases

EnsembliENST00000308641; ENSP00000310622; ENSG00000173627.
GeneIDi403314.
KEGGihsa:403314.
UCSCiuc001gqn.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiABEC4_HUMAN
AccessioniPrimary (citable) accession number: Q8WW27
Secondary accession number(s): Q8N7F6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: March 1, 2002
Last modified: September 27, 2017
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families