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Protein

Tektin-4

Gene

TEKT4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls of ciliary and flagellar microtubules (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cilium biogenesis/degradation

Enzyme and pathway databases

BioCyciZFISH:ENSG00000163060-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Tektin-4
Gene namesi
Name:TEKT4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:31012. TEKT4.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-KW
  • microtubule Source: UniProtKB-KW
  • motile cilium Source: UniProtKB-KW
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Flagellum, Microtubule

Pathology & Biotechi

Organism-specific databases

DisGeNETi150483.
OpenTargetsiENSG00000163060.
PharmGKBiPA142670819.

Polymorphism and mutation databases

BioMutaiTEKT4.
DMDMi74730916.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002611611 – 435Tektin-4Add BLAST435

Proteomic databases

PaxDbiQ8WW24.
PeptideAtlasiQ8WW24.
PRIDEiQ8WW24.

PTM databases

iPTMnetiQ8WW24.
PhosphoSitePlusiQ8WW24.

Expressioni

Gene expression databases

BgeeiENSG00000163060.
CleanExiHS_TEKT4.

Organism-specific databases

HPAiHPA048600.
HPA053929.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ALAS1P131965EBI-750487,EBI-3905054
ATG5A9UGY93EBI-750487,EBI-10175276
GSE1Q146873EBI-750487,EBI-372619
HNRNPMP522723EBI-750487,EBI-486809
IKZF3Q9UKT96EBI-750487,EBI-747204
KRTAP26-1Q6PEX33EBI-750487,EBI-3957672
MAGEA4P433583EBI-750487,EBI-743122
MAGEA4Q1RN333EBI-750487,EBI-10194128
PRDM14Q9GZV83EBI-750487,EBI-3957793
RARAP102763EBI-750487,EBI-413374
RARAP10276-23EBI-750487,EBI-10197061
RECKQ6P9E25EBI-750487,EBI-10253121
SLC25A6P122363EBI-750487,EBI-356254
SMAD3P840223EBI-750487,EBI-347161
TADA2AO754783EBI-750487,EBI-742268
TRIP6Q156543EBI-750487,EBI-742327

Protein-protein interaction databases

BioGridi127301. 27 interactors.
IntActiQ8WW24. 34 interactors.
MINTiMINT-1482504.
STRINGi9606.ENSP00000295201.

Structurei

3D structure databases

ProteinModelPortaliQ8WW24.
SMRiQ8WW24.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili102 – 180Sequence analysisAdd BLAST79
Coiled coili310 – 336Sequence analysisAdd BLAST27
Coiled coili363 – 411Sequence analysisAdd BLAST49

Sequence similaritiesi

Belongs to the tektin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2685. Eukaryota.
ENOG410XSCN. LUCA.
GeneTreeiENSGT00390000016344.
HOGENOMiHOG000246943.
HOVERGENiHBG056503.
InParanoidiQ8WW24.
KOiK18631.
OMAiNSSRTIM.
OrthoDBiEOG091G0AJL.
PhylomeDBiQ8WW24.
TreeFamiTF320754.

Family and domain databases

InterProiIPR000435. Tektin.
[Graphical view]
PANTHERiPTHR19960. PTHR19960. 1 hit.
PRINTSiPR00511. TEKTIN.

Sequencei

Sequence statusi: Complete.

Q8WW24-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQTVPPCEL PCKEYDVARN TGAYTSSGLA TASFRTSKYL LEEWFQNCYA
60 70 80 90 100
RYHQAFADRD QSERQRHESQ QLATETQALA QRTQQDSTRT VGERLQDTHS
110 120 130 140 150
WKSELQREME ALAAETNLLL AQKQRLERAL DATEVPFSIT TDNLQCRERR
160 170 180 190 200
EHPNLVRDHV ETELLKEAEL IRNIQELLKR TIMQAVSQIR LNREHKETCE
210 220 230 240 250
MDWSDKMEAY NIDETCGRHH SQSTEVQAHP YSTTFQESAS TPETRAKFTQ
260 270 280 290 300
DNLCRAQRER LASANLRVLV DCILRDTSED LRLQCDAVNL AFGRRCEELE
310 320 330 340 350
DARYKLHHHL HKTLREITDQ EHNVAALKQA IKDKEAPLHV AQTRLYLRSH
360 370 380 390 400
RPNMELCRDA AQFRLLSEVE ELNMSLTALR EKLLEAEQSL RNLEDIHMSL
410 420 430
EKDIAAMTNS LFIDRQKCMA HRTRYPTILQ LAGYQ
Length:435
Mass (Da):50,649
Last modified:March 1, 2002 - v1
Checksum:i90C16D8B0F782CED
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02908583T → M.Corresponds to variant rs4854235dbSNPEnsembl.1
Natural variantiVAR_062151100S → G.Corresponds to variant rs11164112dbSNPEnsembl.1
Natural variantiVAR_029086102K → N.Corresponds to variant rs17802433dbSNPEnsembl.1
Natural variantiVAR_035941272C → S in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_029087409N → K.Corresponds to variant rs17120062dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC097374 Genomic DNA. Translation: AAX88873.1.
BC021716 mRNA. Translation: AAH21716.1.
CCDSiCCDS2005.1.
RefSeqiNP_653306.1. NM_144705.3.
UniGeneiHs.631517.

Genome annotation databases

EnsembliENST00000295201; ENSP00000295201; ENSG00000163060.
GeneIDi150483.
KEGGihsa:150483.
UCSCiuc002stw.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC097374 Genomic DNA. Translation: AAX88873.1.
BC021716 mRNA. Translation: AAH21716.1.
CCDSiCCDS2005.1.
RefSeqiNP_653306.1. NM_144705.3.
UniGeneiHs.631517.

3D structure databases

ProteinModelPortaliQ8WW24.
SMRiQ8WW24.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127301. 27 interactors.
IntActiQ8WW24. 34 interactors.
MINTiMINT-1482504.
STRINGi9606.ENSP00000295201.

PTM databases

iPTMnetiQ8WW24.
PhosphoSitePlusiQ8WW24.

Polymorphism and mutation databases

BioMutaiTEKT4.
DMDMi74730916.

Proteomic databases

PaxDbiQ8WW24.
PeptideAtlasiQ8WW24.
PRIDEiQ8WW24.

Protocols and materials databases

DNASUi150483.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295201; ENSP00000295201; ENSG00000163060.
GeneIDi150483.
KEGGihsa:150483.
UCSCiuc002stw.3. human.

Organism-specific databases

CTDi150483.
DisGeNETi150483.
GeneCardsiTEKT4.
H-InvDBHIX0176446.
HGNCiHGNC:31012. TEKT4.
HPAiHPA048600.
HPA053929.
neXtProtiNX_Q8WW24.
OpenTargetsiENSG00000163060.
PharmGKBiPA142670819.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2685. Eukaryota.
ENOG410XSCN. LUCA.
GeneTreeiENSGT00390000016344.
HOGENOMiHOG000246943.
HOVERGENiHBG056503.
InParanoidiQ8WW24.
KOiK18631.
OMAiNSSRTIM.
OrthoDBiEOG091G0AJL.
PhylomeDBiQ8WW24.
TreeFamiTF320754.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000163060-MONOMER.

Miscellaneous databases

GenomeRNAii150483.
PROiQ8WW24.

Gene expression databases

BgeeiENSG00000163060.
CleanExiHS_TEKT4.

Family and domain databases

InterProiIPR000435. Tektin.
[Graphical view]
PANTHERiPTHR19960. PTHR19960. 1 hit.
PRINTSiPR00511. TEKTIN.
ProtoNetiSearch...

Entry informationi

Entry nameiTEKT4_HUMAN
AccessioniPrimary (citable) accession number: Q8WW24
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: March 1, 2002
Last modified: November 30, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.