ID DNJA4_HUMAN Reviewed; 397 AA. AC Q8WW22; Q6AW87; Q8N7P2; DT 17-JAN-2003, integrated into UniProtKB/Swiss-Prot. DT 01-MAR-2002, sequence version 1. DT 25-JAN-2012, entry version 87. DE RecName: Full=DnaJ homolog subfamily A member 4; DE Flags: Precursor; GN Name=DNAJA4; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). RC TISSUE=Brain, and Trachea; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). RC TISSUE=Endometrial tumor; RX PubMed=17974005; DOI=10.1186/1471-2164-8-399; RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., RA Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., RA Ottenwaelder B., Poustka A., Wiemann S., Schupp I.; RT "The full-ORF clone resource of the German cDNA consortium."; RL BMC Genomics 8:399-399(2007). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16572171; DOI=10.1038/nature04601; RA Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., RA Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., RA FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., RA Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S., RA Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., RA DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., RA Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., RA Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., RA Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., RA Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., RA Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., RA Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., RA Nusbaum C.; RT "Analysis of the DNA sequence and duplication history of human RT chromosome 15."; RL Nature 440:671-675(2006). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., RA Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RC TISSUE=Testis; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- SUBCELLULAR LOCATION: Membrane; Lipid-anchor (Potential). CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; CC IsoId=Q8WW22-1; Sequence=Displayed; CC Name=2; CC IsoId=Q8WW22-2; Sequence=VSP_038965; CC -!- SIMILARITY: Contains 1 CR-type zinc finger. CC -!- SIMILARITY: Contains 1 J domain. CC -!- SEQUENCE CAUTION: CC Sequence=AAH21720.1; Type=Erroneous initiation; Note=Translation N-terminally extended; CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AK096616; BAC04828.1; -; mRNA. DR EMBL; AK098079; BAC05229.1; -; mRNA. DR EMBL; BX648710; CAH10558.1; -; mRNA. DR EMBL; AC092755; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471136; EAW99177.1; -; Genomic_DNA. DR EMBL; BC021720; AAH21720.1; ALT_INIT; mRNA. DR IPI; IPI00465105; -. DR IPI; IPI00853174; -. DR RefSeq; NP_001123654.1; NM_001130182.1. DR RefSeq; NP_001123655.1; NM_001130183.1. DR RefSeq; NP_061072.3; NM_018602.3. DR UniGene; Hs.513053; -. DR ProteinModelPortal; Q8WW22; -. DR SMR; Q8WW22; 3-68, 102-370. DR IntAct; Q8WW22; 2. DR STRING; Q8WW22; -. DR PhosphoSite; Q8WW22; -. DR DMDM; 27805462; -. DR PRIDE; Q8WW22; -. DR Ensembl; ENST00000343789; ENSP00000339581; ENSG00000140403. DR Ensembl; ENST00000394852; ENSP00000378321; ENSG00000140403. DR Ensembl; ENST00000394855; ENSP00000378324; ENSG00000140403. DR GeneID; 55466; -. DR KEGG; hsa:55466; -. DR UCSC; uc002bdj.1; human. DR CTD; 55466; -. DR GeneCards; GC15P078556; -. DR HGNC; HGNC:14885; DNAJA4. DR HPA; CAB004646; -. DR neXtProt; NX_Q8WW22; -. DR GeneTree; ENSGT00490000043321; -. DR HOVERGEN; HBG066727; -. DR InParanoid; Q8WW22; -. DR OMA; VIFPEKH; -. DR OrthoDB; EOG4RJG1R; -. DR PhylomeDB; Q8WW22; -. DR NextBio; 59854; -. DR ArrayExpress; Q8WW22; -. DR Bgee; Q8WW22; -. DR CleanEx; HS_DNAJA4; -. DR Genevestigator; Q8WW22; -. DR GermOnline; ENSG00000140403; Homo sapiens. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005524; F:ATP binding; IEA:InterPro. DR GO; GO:0031072; F:heat shock protein binding; IEA:InterPro. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0051082; F:unfolded protein binding; IEA:InterPro. DR GO; GO:0006457; P:protein folding; IEA:InterPro. DR GO; GO:0009408; P:response to heat; IEA:InterPro. DR InterPro; IPR012724; DnaJ. DR InterPro; IPR002939; DnaJ_C. DR InterPro; IPR001623; DnaJ_N. DR InterPro; IPR018253; Heat_shock_DnaJ_CS. DR InterPro; IPR008971; HSP40/DnaJ_pept-bd. DR InterPro; IPR003095; Hsp_DnaJ. DR InterPro; IPR001305; HSP_DnaJ_Cys-rich_dom. DR Gene3D; G3DSA:1.10.287.110; DnaJ_N; 1. DR Gene3D; G3DSA:2.10.230.10; HSP_DnaJ_cys-rich; 1. DR KO; K09505; -. DR Pfam; PF00226; DnaJ; 1. DR Pfam; PF01556; DnaJ_C; 1. DR Pfam; PF00684; DnaJ_CXXCXGXG; 1. DR PRINTS; PR00625; JDOMAIN. DR SMART; SM00271; DnaJ; 1. DR SUPFAM; SSF46565; DnaJ_N; 1. DR SUPFAM; SSF49493; HSP40_DnaJ_pep; 2. DR SUPFAM; SSF57938; HSP_DnaJ_cys-rich; 1. DR PROSITE; PS00636; DNAJ_1; 1. DR PROSITE; PS50076; DNAJ_2; 1. DR PROSITE; PS51188; ZF_CR; 1. PE 1: Evidence at protein level; KW Alternative splicing; Chaperone; Complete proteome; Lipoprotein; KW Membrane; Metal-binding; Methylation; Prenylation; Reference proteome; KW Repeat; Zinc; Zinc-finger. FT CHAIN 1 394 DnaJ homolog subfamily A member 4. FT /FTId=PRO_0000071014. FT PROPEP 395 397 Removed in mature form (By similarity). FT /FTId=PRO_0000396760. FT DOMAIN 4 70 J. FT REPEAT 135 142 CXXCXGXG motif. FT REPEAT 151 158 CXXCXGXG motif. FT REPEAT 178 185 CXXCXGXG motif. FT REPEAT 194 201 CXXCXGXG motif. FT ZN_FING 122 206 CR-type. FT COMPBIAS 75 96 Gly-rich. FT METAL 135 135 Zinc 1 (By similarity). FT METAL 138 138 Zinc 1 (By similarity). FT METAL 151 151 Zinc 2 (By similarity). FT METAL 154 154 Zinc 2 (By similarity). FT METAL 178 178 Zinc 2 (By similarity). FT METAL 181 181 Zinc 2 (By similarity). FT METAL 194 194 Zinc 1 (By similarity). FT METAL 197 197 Zinc 1 (By similarity). FT MOD_RES 394 394 Cysteine methyl ester (By similarity). FT LIPID 394 394 S-farnesyl cysteine (By similarity). FT VAR_SEQ 1 1 M -> MARGGSQSWSSGESDGQPKEQTPEKPRHKM (in FT isoform 2). FT /FTId=VSP_038965. FT CONFLICT 33 33 Y -> C (in Ref. 1; BAC05229). SQ SEQUENCE 397 AA; 44798 MW; 60D6AAD12C9B2529 CRC64; MVKETQYYDI LGVKPSASPE EIKKAYRKLA LKYHPDKNPD EGEKFKLISQ AYEVLSDPKK RDVYDQGGEQ AIKEGGSGSP SFSSPMDIFD MFFGGGGRMA RERRGKNVVH QLSVTLEDLY NGVTKKLALQ KNVICEKCEG VGGKKGSVEK CPLCKGRGMQ IHIQQIGPGM VQQIQTVCIE CKGQGERINP KDRCESCSGA KVIREKKIIE VHVEKGMKDG QKILFHGEGD QEPELEPGDV IIVLDQKDHS VFQRRGHDLI MKMKIQLSEA LCGFKKTIKT LDNRILVITS KAGEVIKHGD LRCVRDEGMP IYKAPLEKGI LIIQFLVIFP EKHWLSLEKL PQLEALLPPR QKVRITDDMD QVELKEFCPN EQNWRQHREA YEEDEDGPQA GVQCQTA //