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Reviewed, UniProtKB/Swiss-Prot Q8WW22 (DNJA4_HUMAN)

Last modified October 13, 2009. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    DnaJ homolog subfamily A member 4
Gene names
Name: DNAJA4
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length397 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Subcellular location

Membrane; Lipid-anchor Potential.

Sequence similarities

Contains 1 CR-type zinc finger.

Contains 1 J domain.

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Ontologies

Keywords
   Cellular componentMembrane
   DomainRepeat
Zinc-finger
   LigandMetal-binding
Zinc
   Molecular functionChaperone
   PTMLipoprotein
Prenylation
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processprotein folding

Inferred from electronic annotation. Source: InterPro

   Cellular componentanchored to membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionheat shock protein binding

Inferred from electronic annotation. Source: InterPro

unfolded protein binding

Inferred from electronic annotation. Source: InterPro

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 397397DnaJ homolog subfamily A member 4
PRO_0000071014

Regions

Domain4 – 7067J
Repeat135 – 1428CXXCXGXG motif
Repeat151 – 1588CXXCXGXG motif
Repeat178 – 1858CXXCXGXG motif
Repeat194 – 2018CXXCXGXG motif
Zinc finger122 – 20685CR-type
Compositional bias75 – 9622Gly-rich

Sites

Metal binding1351Zinc 1 By similarity
Metal binding1381Zinc 1 By similarity
Metal binding1511Zinc 2 By similarity
Metal binding1541Zinc 2 By similarity
Metal binding1781Zinc 2 By similarity
Metal binding1811Zinc 2 By similarity
Metal binding1941Zinc 1 By similarity
Metal binding1971Zinc 1 By similarity

Amino acid modifications

Lipidation3941S-farnesyl cysteine By similarity

Experimental info

Sequence conflict331Y → C in BAC05229. Ref.1

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Sequences

Sequence LengthMass (Da)Tools
Q8WW22-1 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 60D6AAD12C9B2529

FASTA39744,798
        10         20         30         40         50         60 
MVKETQYYDI LGVKPSASPE EIKKAYRKLA LKYHPDKNPD EGEKFKLISQ AYEVLSDPKK 

        70         80         90        100        110        120 
RDVYDQGGEQ AIKEGGSGSP SFSSPMDIFD MFFGGGGRMA RERRGKNVVH QLSVTLEDLY 

       130        140        150        160        170        180 
NGVTKKLALQ KNVICEKCEG VGGKKGSVEK CPLCKGRGMQ IHIQQIGPGM VQQIQTVCIE 

       190        200        210        220        230        240 
CKGQGERINP KDRCESCSGA KVIREKKIIE VHVEKGMKDG QKILFHGEGD QEPELEPGDV 

       250        260        270        280        290        300 
IIVLDQKDHS VFQRRGHDLI MKMKIQLSEA LCGFKKTIKT LDNRILVITS KAGEVIKHGD 

       310        320        330        340        350        360 
LRCVRDEGMP IYKAPLEKGI LIIQFLVIFP EKHWLSLEKL PQLEALLPPR QKVRITDDMD 

       370        380        390 
QVELKEFCPN EQNWRQHREA YEEDEDGPQA GVQCQTA

« Hide

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References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain and Trachea.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.

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Cross-references

Sequence databases

AK096616 mRNA. Translation: BAC04828.1.
AK098079 mRNA. Translation: BAC05229.1. Different initiation.
BC021720 mRNA. Translation: AAH21720.1.
IPIIPI00853174.
RefSeqNP_001123654.1.
NP_001123655.1.
NP_061072.3.
UniGeneHs.513053

3D structure databases

HSSPHSSP built from PDB template 1HDJ based on UniProtKB P25685.
SMRQ8WW22. Positions 3-68.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ8WW22.

Proteomic databases

PRIDEQ8WW22.

Genome annotation databases

EnsemblENST00000343789; ENSP00000339581; ENSG00000140403; Homo sapiens. [Genome view]
ENST00000394852; ENSP00000378321; ENSG00000140403; Homo sapiens. [Genome view]
ENST00000394855; ENSP00000378324; ENSG00000140403; Homo sapiens. [Genome view]
ENST00000419495; ENSP00000401069; ENSG00000140403; Homo sapiens. [Genome view]
ENST00000423642; ENSP00000407136; ENSG00000140403; Homo sapiens. [Genome view]
ENST00000440911; ENSP00000395191; ENSG00000140403; Homo sapiens. [Genome view]
ENST00000446172; ENSP00000413499; ENSG00000140403; Homo sapiens. [Genome view]
GeneID55466.
KEGGhsa:55466.
UCSCuc002bdj.1. human.

Organism-specific databases

CTD55466.
GeneCardsGC15P076343.
HGNCHGNC:14885. DNAJA4.
HPACAB004646.
PharmGKBPA27411.
GenAtlasSearch...

Phylogenomic databases

HOVERGENQ8WW22.

Gene expression databases

ArrayExpressQ8WW22.
BgeeQ8WW22.
CleanExHS_DNAJA4.
GenevestigatorQ8WW22.
GermOnlineENSG00000140403. Homo sapiens.

Family and domain databases

InterProIPR002939. DnaJ_C.
IPR001623. DnaJ_N.
IPR018253. Heat_shock_DnaJ_CS.
IPR015609. Hsp40/DnaJ_Rel.
IPR003095. Hsp_DnaJ.
IPR001305. HSP_DnaJ_cys-rich.
[Graphical view]
Gene3DG3DSA:1.10.287.110. DnaJ_N. 1 hit.
PANTHERPTHR11821. Hsp40/DnaJ_Rel. 1 hit.
PfamPF00226. DnaJ. 1 hit.
PF01556. DnaJ_C. 1 hit.
PF00684. DnaJ_CXXCXGXG. 1 hit.
[Graphical view]
PRINTSPR00625. DNAJPROTEIN.
SMARTSM00271. DnaJ. 1 hit.
[Graphical view]
PROSITEPS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.
PS51188. ZF_CR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio59854.

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Entry information

Entry nameDNJA4_HUMAN
AccessionPrimary (citable) accession number: Q8WW22
Secondary accession number(s): Q8N7P2
Entry history
Integrated into UniProtKB/Swiss-Prot: January 17, 2003
Last sequence update: March 1, 2002
Last modified: October 13, 2009
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Human chromosome 15: entries, gene names and cross-references to MIM

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents