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Protein

Uncharacterized protein C10orf82

Gene

C10orf82

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C10orf82
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:28500. C10orf82.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134919914.

Polymorphism and mutation databases

BioMutaiC10orf82.
DMDMi221222443.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 230230Uncharacterized protein C10orf82PRO_0000089807Add
BLAST

Proteomic databases

PaxDbiQ8WW14.
PRIDEiQ8WW14.

Expressioni

Gene expression databases

BgeeiQ8WW14.
CleanExiHS_C10orf82.
ExpressionAtlasiQ8WW14. baseline and differential.
GenevisibleiQ8WW14. HS.

Organism-specific databases

HPAiHPA043022.

Interactioni

Protein-protein interaction databases

BioGridi126799. 1 interaction.
IntActiQ8WW14. 1 interaction.
MINTiMINT-1443845.

Structurei

3D structure databases

ProteinModelPortaliQ8WW14.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IZQ2. Eukaryota.
ENOG4112A7G. LUCA.
GeneTreeiENSGT00390000017460.
HOGENOMiHOG000111692.
HOVERGENiHBG107693.
InParanoidiQ8WW14.
PhylomeDBiQ8WW14.
TreeFamiTF337656.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WW14-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPSKTFMRN LPITPGYSGF VPFLSCQGMS KEDDMNHCVK TFQEKTQRYK
60 70 80 90 100
EQLRELCCAV ATAPKLKPVN SEETVLQALH QYNLQYHPLI LECKYVKKPL
110 120 130 140 150
QEPPIPGWAG YLPRAKVTEF GCGTRYTVMA KNCYKDFLEI TERAKKAHLK
160 170 180 190 200
PYEEIYGVSS TKTSAPSPKV LQHEELLPKY PDFSIPDGSC PALGRPLRED
210 220 230
PKTPLTCGCA QRPSIPCSGK MYLEPLSSAK
Length:230
Mass (Da):25,923
Last modified:January 20, 2009 - v2
Checksum:i4800822A81935930
GO
Isoform 2 (identifier: Q8WW14-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     155-230: Missing.

Show »
Length:154
Mass (Da):17,797
Checksum:i38C00B1F8780EED1
GO
Isoform 3 (identifier: Q8WW14-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     92-110: ECKYVKKPLQEPPIPGWAG → GSSALKPFPLTPGHPCRFS
     111-230: Missing.

Show »
Length:110
Mass (Da):12,473
Checksum:iE0C48F433EE875BD
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti124 – 1241T → M.
Corresponds to variant rs11551267 [ dbSNP | Ensembl ].
VAR_050854

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei92 – 11019ECKYV…PGWAG → GSSALKPFPLTPGHPCRFS in isoform 3. 1 PublicationVSP_036117Add
BLAST
Alternative sequencei111 – 230120Missing in isoform 3. 1 PublicationVSP_036118Add
BLAST
Alternative sequencei155 – 23076Missing in isoform 2. 1 PublicationVSP_036119Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097587 mRNA. Translation: BAG53491.1.
AC016825 Genomic DNA. No translation available.
CH471066 Genomic DNA. Translation: EAW49444.1.
CH471066 Genomic DNA. Translation: EAW49445.1.
BC021737 mRNA. Translation: AAH21737.1.
CCDSiCCDS7596.1. [Q8WW14-2]
RefSeqiNP_653262.1. NM_144661.2. [Q8WW14-2]
UniGeneiHs.121347.

Genome annotation databases

EnsembliENST00000369210; ENSP00000358212; ENSG00000165863. [Q8WW14-2]
GeneIDi143379.
KEGGihsa:143379.
UCSCiuc001lcr.3. human. [Q8WW14-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097587 mRNA. Translation: BAG53491.1.
AC016825 Genomic DNA. No translation available.
CH471066 Genomic DNA. Translation: EAW49444.1.
CH471066 Genomic DNA. Translation: EAW49445.1.
BC021737 mRNA. Translation: AAH21737.1.
CCDSiCCDS7596.1. [Q8WW14-2]
RefSeqiNP_653262.1. NM_144661.2. [Q8WW14-2]
UniGeneiHs.121347.

3D structure databases

ProteinModelPortaliQ8WW14.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126799. 1 interaction.
IntActiQ8WW14. 1 interaction.
MINTiMINT-1443845.

Polymorphism and mutation databases

BioMutaiC10orf82.
DMDMi221222443.

Proteomic databases

PaxDbiQ8WW14.
PRIDEiQ8WW14.

Protocols and materials databases

DNASUi143379.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369210; ENSP00000358212; ENSG00000165863. [Q8WW14-2]
GeneIDi143379.
KEGGihsa:143379.
UCSCiuc001lcr.3. human. [Q8WW14-1]

Organism-specific databases

CTDi143379.
GeneCardsiC10orf82.
HGNCiHGNC:28500. C10orf82.
HPAiHPA043022.
neXtProtiNX_Q8WW14.
PharmGKBiPA134919914.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZQ2. Eukaryota.
ENOG4112A7G. LUCA.
GeneTreeiENSGT00390000017460.
HOGENOMiHOG000111692.
HOVERGENiHBG107693.
InParanoidiQ8WW14.
PhylomeDBiQ8WW14.
TreeFamiTF337656.

Miscellaneous databases

GenomeRNAii143379.
NextBioi84698.
PROiQ8WW14.

Gene expression databases

BgeeiQ8WW14.
CleanExiHS_C10orf82.
ExpressionAtlasiQ8WW14. baseline and differential.
GenevisibleiQ8WW14. HS.

Family and domain databases

ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Testis.
  2. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.

Entry informationi

Entry nameiCJ082_HUMAN
AccessioniPrimary (citable) accession number: Q8WW14
Secondary accession number(s): B3KUM9, D3DRC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: January 20, 2009
Last modified: March 16, 2016
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.