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Protein

PEST proteolytic signal-containing nuclear protein

Gene

PCNP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in cell cycle regulation.

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • proteasome-mediated ubiquitin-dependent protein catabolic process Source: HGNC
  • protein ubiquitination Source: HGNC
Complete GO annotation...

Keywords - Biological processi

Cell cycle

Names & Taxonomyi

Protein namesi
Recommended name:
PEST proteolytic signal-containing nuclear protein
Short name:
PCNP
Short name:
PEST-containing nuclear protein
Gene namesi
Name:PCNP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:30023. PCNP.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000081154.
PharmGKBiPA143485572.

Polymorphism and mutation databases

BioMutaiPCNP.
DMDMi67460963.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000582532 – 178PEST proteolytic signal-containing nuclear proteinAdd BLAST177

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine1 Publication1
Modified residuei53PhosphoserineCombined sources1
Modified residuei64N6-acetyllysineCombined sources1
Modified residuei77PhosphoserineCombined sources1
Modified residuei87PhosphoserineCombined sources1
Modified residuei119PhosphoserineCombined sources1
Modified residuei139PhosphothreonineCombined sources1
Modified residuei147PhosphoserineCombined sources1
Modified residuei150N6-acetyllysineCombined sources1
Modified residuei152N6-acetyllysineCombined sources1

Post-translational modificationi

Ubiquitinated; mediated by UHRF2 and leading to its subsequent proteasomal degradation.1 Publication
N-terminally acetylated in a HYPK-dependent manner by the NatA acetyltransferase complex which is composed of NAA10 and NAA15.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8WW12.
MaxQBiQ8WW12.
PaxDbiQ8WW12.
PeptideAtlasiQ8WW12.
PRIDEiQ8WW12.
TopDownProteomicsiQ8WW12-1. [Q8WW12-1]
Q8WW12-2. [Q8WW12-2]
Q8WW12-3. [Q8WW12-3]

PTM databases

iPTMnetiQ8WW12.
PhosphoSitePlusiQ8WW12.

Expressioni

Gene expression databases

BgeeiENSG00000081154.
CleanExiHS_PCNP.
ExpressionAtlasiQ8WW12. baseline and differential.
GenevisibleiQ8WW12. HS.

Organism-specific databases

HPAiHPA035011.
HPA063861.

Interactioni

Subunit structurei

Interacts with UHRF2/NIRF.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
TERF2IPQ9NYB02EBI-10972020,EBI-750109

Protein-protein interaction databases

BioGridi121360. 19 interactors.
IntActiQ8WW12. 11 interactors.
STRINGi9606.ENSP00000265260.

Structurei

3D structure databases

ProteinModelPortaliQ8WW12.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IWUJ. Eukaryota.
ENOG4111S9J. LUCA.
GeneTreeiENSGT00390000010218.
HOGENOMiHOG000088639.
HOVERGENiHBG059581.
InParanoidiQ8WW12.
OMAiPAKMSKF.
OrthoDBiEOG091G14A2.
PhylomeDBiQ8WW12.
TreeFamiTF333058.

Family and domain databases

InterProiIPR029169. PCNP.
[Graphical view]
PANTHERiPTHR16523. PTHR16523. 1 hit.
PfamiPF15473. PCNP. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WW12-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADGKAGDEK PEKSQRAGAA GGPEEEAEKP VKTKTVSSSN GGESSSRSAE
60 70 80 90 100
KRSAEEEAAD LPTKPTKISK FGFAIGSQTT KKASAISIKL GSSKPKETVP
110 120 130 140 150
TLAPKTLSVA AAFNEDEDSE PEEMPPEAKM RMKNIGRDTP TSAGPNSFNK
160 170
GKHGFSDNQK LWERNIKSHL GNVHDQDN
Length:178
Mass (Da):18,925
Last modified:June 7, 2005 - v2
Checksum:iB79D49B362892AE1
GO
Isoform 2 (identifier: Q8WW12-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     119-130: SEPEEMPPEAKM → GYTNISWTKLLQ
     131-178: Missing.

Note: No experimental confirmation available.
Show »
Length:130
Mass (Da):13,544
Checksum:i60256023D3435196
GO
Isoform 3 (identifier: Q8WW12-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-123: Missing.

Show »
Length:55
Mass (Da):6,233
Checksum:iC95818E33C1461F0
GO

Sequence cautioni

The sequence EAW79790 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence EAW79792 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti126P → Q in AAH22001 (PubMed:15489334).Curated1
Sequence conflicti150K → E in BAD96698 (Ref. 3) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0138791 – 123Missing in isoform 3. 1 PublicationAdd BLAST123
Alternative sequenceiVSP_013880119 – 130SEPEE…PEAKM → GYTNISWTKLLQ in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_013881131 – 178Missing in isoform 2. 1 PublicationAdd BLAST48

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037675 mRNA. Translation: BAB03501.1.
AK314629 mRNA. Translation: BAG37194.1.
AK222978 mRNA. Translation: BAD96698.1.
CR627371 mRNA. Translation: CAH10470.1.
CH471052 Genomic DNA. Translation: EAW79790.1. Different initiation.
CH471052 Genomic DNA. Translation: EAW79792.1. Different initiation.
BC013916 mRNA. Translation: AAH13916.1.
BC022001 mRNA. Translation: AAH22001.1.
CCDSiCCDS2942.1. [Q8WW12-1]
RefSeqiNP_001307324.1. NM_001320395.1. [Q8WW12-2]
NP_001307326.1. NM_001320397.1.
NP_001307327.1. NM_001320398.1.
NP_001307328.1. NM_001320399.1.
NP_001307329.1. NM_001320400.1.
NP_001307330.1. NM_001320401.1.
NP_065090.1. NM_020357.2. [Q8WW12-1]
UniGeneiHs.732633.
Hs.744968.

Genome annotation databases

EnsembliENST00000265260; ENSP00000265260; ENSG00000081154. [Q8WW12-1]
ENST00000469941; ENSP00000470810; ENSG00000081154. [Q8WW12-3]
GeneIDi57092.
KEGGihsa:57092.
UCSCiuc003dva.4. human. [Q8WW12-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037675 mRNA. Translation: BAB03501.1.
AK314629 mRNA. Translation: BAG37194.1.
AK222978 mRNA. Translation: BAD96698.1.
CR627371 mRNA. Translation: CAH10470.1.
CH471052 Genomic DNA. Translation: EAW79790.1. Different initiation.
CH471052 Genomic DNA. Translation: EAW79792.1. Different initiation.
BC013916 mRNA. Translation: AAH13916.1.
BC022001 mRNA. Translation: AAH22001.1.
CCDSiCCDS2942.1. [Q8WW12-1]
RefSeqiNP_001307324.1. NM_001320395.1. [Q8WW12-2]
NP_001307326.1. NM_001320397.1.
NP_001307327.1. NM_001320398.1.
NP_001307328.1. NM_001320399.1.
NP_001307329.1. NM_001320400.1.
NP_001307330.1. NM_001320401.1.
NP_065090.1. NM_020357.2. [Q8WW12-1]
UniGeneiHs.732633.
Hs.744968.

3D structure databases

ProteinModelPortaliQ8WW12.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121360. 19 interactors.
IntActiQ8WW12. 11 interactors.
STRINGi9606.ENSP00000265260.

PTM databases

iPTMnetiQ8WW12.
PhosphoSitePlusiQ8WW12.

Polymorphism and mutation databases

BioMutaiPCNP.
DMDMi67460963.

Proteomic databases

EPDiQ8WW12.
MaxQBiQ8WW12.
PaxDbiQ8WW12.
PeptideAtlasiQ8WW12.
PRIDEiQ8WW12.
TopDownProteomicsiQ8WW12-1. [Q8WW12-1]
Q8WW12-2. [Q8WW12-2]
Q8WW12-3. [Q8WW12-3]

Protocols and materials databases

DNASUi57092.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265260; ENSP00000265260; ENSG00000081154. [Q8WW12-1]
ENST00000469941; ENSP00000470810; ENSG00000081154. [Q8WW12-3]
GeneIDi57092.
KEGGihsa:57092.
UCSCiuc003dva.4. human. [Q8WW12-1]

Organism-specific databases

CTDi57092.
GeneCardsiPCNP.
HGNCiHGNC:30023. PCNP.
HPAiHPA035011.
HPA063861.
MIMi615210. gene.
neXtProtiNX_Q8WW12.
OpenTargetsiENSG00000081154.
PharmGKBiPA143485572.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWUJ. Eukaryota.
ENOG4111S9J. LUCA.
GeneTreeiENSGT00390000010218.
HOGENOMiHOG000088639.
HOVERGENiHBG059581.
InParanoidiQ8WW12.
OMAiPAKMSKF.
OrthoDBiEOG091G14A2.
PhylomeDBiQ8WW12.
TreeFamiTF333058.

Miscellaneous databases

ChiTaRSiPCNP. human.
GenomeRNAii57092.
PROiQ8WW12.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000081154.
CleanExiHS_PCNP.
ExpressionAtlasiQ8WW12. baseline and differential.
GenevisibleiQ8WW12. HS.

Family and domain databases

InterProiIPR029169. PCNP.
[Graphical view]
PANTHERiPTHR16523. PTHR16523. 1 hit.
PfamiPF15473. PCNP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPCNP_HUMAN
AccessioniPrimary (citable) accession number: Q8WW12
Secondary accession number(s): B2RBE7
, D3DN52, Q53GF3, Q6AI44, Q96CU3, Q9NS81
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 7, 2005
Last modified: November 2, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.