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Q8WVZ9

- KBTB7_HUMAN

UniProt

Q8WVZ9 - KBTB7_HUMAN

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Protein
Kelch repeat and BTB domain-containing protein 7
Gene
KBTBD7
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. protein binding Source: IntAct
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch repeat and BTB domain-containing protein 7
Gene namesi
Name:KBTBD7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 13

Organism-specific databases

HGNCiHGNC:25266. KBTBD7.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134934036.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 684684Kelch repeat and BTB domain-containing protein 7
PRO_0000119085Add
BLAST

Proteomic databases

MaxQBiQ8WVZ9.
PaxDbiQ8WVZ9.
PRIDEiQ8WVZ9.

PTM databases

PhosphoSiteiQ8WVZ9.

Expressioni

Gene expression databases

ArrayExpressiQ8WVZ9.
BgeeiQ8WVZ9.
CleanExiHS_KBTBD7.
GenevestigatoriQ8WVZ9.

Organism-specific databases

HPAiHPA043709.
HPA046861.
HPA048914.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
GABARAPO951662EBI-473695,EBI-712001
GABARAPL1Q9H0R83EBI-473695,EBI-746969
GABARAPL2P605203EBI-473695,EBI-720116
MAP1LC3BQ9GZQ84EBI-473695,EBI-373144
MAP1LC3CQ9BXW42EBI-473695,EBI-2603996

Protein-protein interaction databases

BioGridi123873. 44 interactions.
IntActiQ8WVZ9. 41 interactions.
MINTiMINT-3978892.
STRINGi9606.ENSP00000368797.

Structurei

3D structure databases

ProteinModelPortaliQ8WVZ9.
SMRiQ8WVZ9. Positions 42-289, 334-602.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini63 – 13876BTB
Add
BLAST
Repeati386 – 43550Kelch 1
Add
BLAST
Repeati436 – 48449Kelch 2
Add
BLAST
Repeati486 – 52338Kelch 3
Add
BLAST
Repeati524 – 56441Kelch 4
Add
BLAST
Repeati567 – 61650Kelch 5
Add
BLAST

Sequence similaritiesi

Contains 1 BTB (POZ) domain.
Contains 5 Kelch repeats.

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiNOG146872.
HOGENOMiHOG000074585.
HOVERGENiHBG052214.
InParanoidiQ8WVZ9.
KOiK10474.
OMAiTSLAHTK.
OrthoDBiEOG7MSMNJ.
PhylomeDBiQ8WVZ9.
TreeFamiTF332672.

Family and domain databases

Gene3Di2.120.10.80. 1 hit.
3.30.710.10. 1 hit.
InterProiIPR011705. BACK.
IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR017096. Kelch-like_gigaxonin-typ.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
[Graphical view]
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 1 hit.
[Graphical view]
PIRSFiPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8WVZ9-1 [UniParc]FASTAAdd to Basket

« Hide

MQSREDVPRS RRLASPRGGR RPKRISKPSV SAFFTGPEEL KDTAHSAALL    50
AQLKSFYDAR LLCDVTIEVV TPGSGPGTGR LFSCNRNVLA AACPYFKSMF 100
TGGMYESQQA SVTMHDVDAE SFEVLVDYCY TGRVSLSEAN VQRLYAASDM 150
LQLEYVREAC ASFLARRLDL TNCTAILKFA DAFDHHKLRS QAQSYIAHNF 200
KQLSRMGSIR EETLADLTLA QLLAVLRLDS LDIESERTVC HVAVQWLEAA 250
AKERGPSAAE VFKCVRWMHF TEEDQDYLEG LLTKPIVKKY CLDVIEGALQ 300
MRYGDLLYKS LVPVPNSSSS SSSSNSLVSA AENPPQRLGM CAKEMVIFFG 350
HPRDPFLCYD PYSGDIYTMP SPLTSFAHTK TVTSSAVCVS PDHDIYLAAQ 400
PRKDLWVYKP AQNSWQQLAD RLLCREGMDV AYLNGYIYIL GGRDPITGVK 450
LKEVECYSVQ RNQWALVAPV PHSFYSFELI VVQNYLYAVN SKRMLCYDPS 500
HNMWLNCASL KRSDFQEACV FNDEIYCICD IPVMKVYNPA RGEWRRISNI 550
PLDSETHNYQ IVNHDQKLLL ITSTTPQWKK NRVTVYEYDT REDQWINIGT 600
MLGLLQFDSG FICLCARVYP SCLEPGQSFI TEEDDARSES STEWDLDGFS 650
ELDSESGSSS SFSDDEVWVQ VAPQRNAQDQ QGSL 684
Length:684
Mass (Da):77,163
Last modified:March 1, 2002 - v1
Checksum:iB2D8B6969A1AE5E9
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti361 – 3611P → S in CAB66716. 1 Publication
Sequence conflicti602 – 6021L → S in BAC03641. 1 Publication
Sequence conflicti622 – 6221C → Y in BAC03641. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL136782 mRNA. Translation: CAB66716.1.
FJ150424 mRNA. Translation: ACH92650.1.
AK091344 mRNA. Translation: BAC03641.1.
AL354696 Genomic DNA. Translation: CAI16613.1.
CH471075 Genomic DNA. Translation: EAX08647.1.
BC022033 mRNA. Translation: AAH22033.1.
CCDSiCCDS9377.1.
RefSeqiNP_115514.2. NM_032138.4.
UniGeneiHs.63841.

Genome annotation databases

EnsembliENST00000379483; ENSP00000368797; ENSG00000120696.
GeneIDi84078.
KEGGihsa:84078.
UCSCiuc001uxw.1. human.

Polymorphism databases

DMDMi45477155.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL136782 mRNA. Translation: CAB66716.1 .
FJ150424 mRNA. Translation: ACH92650.1 .
AK091344 mRNA. Translation: BAC03641.1 .
AL354696 Genomic DNA. Translation: CAI16613.1 .
CH471075 Genomic DNA. Translation: EAX08647.1 .
BC022033 mRNA. Translation: AAH22033.1 .
CCDSi CCDS9377.1.
RefSeqi NP_115514.2. NM_032138.4.
UniGenei Hs.63841.

3D structure databases

ProteinModelPortali Q8WVZ9.
SMRi Q8WVZ9. Positions 42-289, 334-602.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 123873. 44 interactions.
IntActi Q8WVZ9. 41 interactions.
MINTi MINT-3978892.
STRINGi 9606.ENSP00000368797.

PTM databases

PhosphoSitei Q8WVZ9.

Polymorphism databases

DMDMi 45477155.

Proteomic databases

MaxQBi Q8WVZ9.
PaxDbi Q8WVZ9.
PRIDEi Q8WVZ9.

Protocols and materials databases

DNASUi 84078.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000379483 ; ENSP00000368797 ; ENSG00000120696 .
GeneIDi 84078.
KEGGi hsa:84078.
UCSCi uc001uxw.1. human.

Organism-specific databases

CTDi 84078.
GeneCardsi GC13M041765.
HGNCi HGNC:25266. KBTBD7.
HPAi HPA043709.
HPA046861.
HPA048914.
neXtProti NX_Q8WVZ9.
PharmGKBi PA134934036.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG146872.
HOGENOMi HOG000074585.
HOVERGENi HBG052214.
InParanoidi Q8WVZ9.
KOi K10474.
OMAi TSLAHTK.
OrthoDBi EOG7MSMNJ.
PhylomeDBi Q8WVZ9.
TreeFami TF332672.

Miscellaneous databases

GeneWikii KBTBD7.
GenomeRNAii 84078.
NextBioi 73295.
PROi Q8WVZ9.

Gene expression databases

ArrayExpressi Q8WVZ9.
Bgeei Q8WVZ9.
CleanExi HS_KBTBD7.
Genevestigatori Q8WVZ9.

Family and domain databases

Gene3Di 2.120.10.80. 1 hit.
3.30.710.10. 1 hit.
InterProi IPR011705. BACK.
IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR017096. Kelch-like_gigaxonin-typ.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
[Graphical view ]
Pfami PF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 1 hit.
[Graphical view ]
PIRSFi PIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTi SM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
[Graphical view ]
SUPFAMi SSF54695. SSF54695. 1 hit.
PROSITEi PS50097. BTB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Hu J., Peng X., Yang Z., Yuan W., Wang Y., Li Y., Wu X.
    Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiKBTB7_HUMAN
AccessioniPrimary (citable) accession number: Q8WVZ9
Secondary accession number(s): B5TZ86
, Q5T6Y7, Q8NB99, Q9H0I6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: March 1, 2002
Last modified: July 9, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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