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Protein

Kelch repeat and BTB domain-containing protein 7

Gene

KBTBD7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-5658442 Regulation of RAS by GAPs
R-HSA-8951664 Neddylation
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch repeat and BTB domain-containing protein 7
Gene namesi
Name:KBTBD7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000120696.8
HGNCiHGNC:25266 KBTBD7
MIMi617739 gene
neXtProtiNX_Q8WVZ9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi84078
OpenTargetsiENSG00000120696
PharmGKBiPA134934036

Polymorphism and mutation databases

BioMutaiKBTBD7
DMDMi45477155

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001190851 – 684Kelch repeat and BTB domain-containing protein 7Add BLAST684

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei29PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8WVZ9
MaxQBiQ8WVZ9
PaxDbiQ8WVZ9
PeptideAtlasiQ8WVZ9
PRIDEiQ8WVZ9
ProteomicsDBi74839

PTM databases

iPTMnetiQ8WVZ9
PhosphoSitePlusiQ8WVZ9

Expressioni

Gene expression databases

BgeeiENSG00000120696
CleanExiHS_KBTBD7
GenevisibleiQ8WVZ9 HS

Organism-specific databases

HPAiHPA043709
HPA046861
HPA048914

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi123873, 165 interactors
IntActiQ8WVZ9, 63 interactors
MINTiQ8WVZ9
STRINGi9606.ENSP00000368797

Structurei

3D structure databases

ProteinModelPortaliQ8WVZ9
SMRiQ8WVZ9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini63 – 138BTBPROSITE-ProRule annotationAdd BLAST76
Repeati386 – 435Kelch 1Add BLAST50
Repeati436 – 484Kelch 2Add BLAST49
Repeati486 – 523Kelch 3Add BLAST38
Repeati524 – 564Kelch 4Add BLAST41
Repeati567 – 616Kelch 5Add BLAST50

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IJ96 Eukaryota
ENOG4110S2H LUCA
GeneTreeiENSGT00910000143979
HOGENOMiHOG000074585
HOVERGENiHBG052214
InParanoidiQ8WVZ9
KOiK10474
OMAiTSLAHTK
OrthoDBiEOG091G033H
PhylomeDBiQ8WVZ9
TreeFamiTF332672

Family and domain databases

Gene3Di2.120.10.80, 2 hits
InterProiView protein in InterPro
IPR011705 BACK
IPR017096 BTB-kelch_protein
IPR000210 BTB/POZ_dom
IPR015915 Kelch-typ_b-propeller
IPR006652 Kelch_1
IPR011333 SKP1/BTB/POZ_sf
PfamiView protein in Pfam
PF07707 BACK, 1 hit
PF00651 BTB, 1 hit
PF01344 Kelch_1, 1 hit
PIRSFiPIRSF037037 Kelch-like_protein_gigaxonin, 1 hit
SMARTiView protein in SMART
SM00875 BACK, 1 hit
SM00225 BTB, 1 hit
SM00612 Kelch, 2 hits
SUPFAMiSSF117281 SSF117281, 1 hit
SSF54695 SSF54695, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit

Sequencei

Sequence statusi: Complete.

Q8WVZ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQSREDVPRS RRLASPRGGR RPKRISKPSV SAFFTGPEEL KDTAHSAALL
60 70 80 90 100
AQLKSFYDAR LLCDVTIEVV TPGSGPGTGR LFSCNRNVLA AACPYFKSMF
110 120 130 140 150
TGGMYESQQA SVTMHDVDAE SFEVLVDYCY TGRVSLSEAN VQRLYAASDM
160 170 180 190 200
LQLEYVREAC ASFLARRLDL TNCTAILKFA DAFDHHKLRS QAQSYIAHNF
210 220 230 240 250
KQLSRMGSIR EETLADLTLA QLLAVLRLDS LDIESERTVC HVAVQWLEAA
260 270 280 290 300
AKERGPSAAE VFKCVRWMHF TEEDQDYLEG LLTKPIVKKY CLDVIEGALQ
310 320 330 340 350
MRYGDLLYKS LVPVPNSSSS SSSSNSLVSA AENPPQRLGM CAKEMVIFFG
360 370 380 390 400
HPRDPFLCYD PYSGDIYTMP SPLTSFAHTK TVTSSAVCVS PDHDIYLAAQ
410 420 430 440 450
PRKDLWVYKP AQNSWQQLAD RLLCREGMDV AYLNGYIYIL GGRDPITGVK
460 470 480 490 500
LKEVECYSVQ RNQWALVAPV PHSFYSFELI VVQNYLYAVN SKRMLCYDPS
510 520 530 540 550
HNMWLNCASL KRSDFQEACV FNDEIYCICD IPVMKVYNPA RGEWRRISNI
560 570 580 590 600
PLDSETHNYQ IVNHDQKLLL ITSTTPQWKK NRVTVYEYDT REDQWINIGT
610 620 630 640 650
MLGLLQFDSG FICLCARVYP SCLEPGQSFI TEEDDARSES STEWDLDGFS
660 670 680
ELDSESGSSS SFSDDEVWVQ VAPQRNAQDQ QGSL
Length:684
Mass (Da):77,163
Last modified:March 1, 2002 - v1
Checksum:iB2D8B6969A1AE5E9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti361P → S in CAB66716 (PubMed:11230166).Curated1
Sequence conflicti602L → S in BAC03641 (PubMed:14702039).Curated1
Sequence conflicti622C → Y in BAC03641 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136782 mRNA Translation: CAB66716.1
FJ150424 mRNA Translation: ACH92650.1
AK091344 mRNA Translation: BAC03641.1
AL354696 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08647.1
BC022033 mRNA Translation: AAH22033.1
CCDSiCCDS9377.1
RefSeqiNP_115514.2, NM_032138.5
UniGeneiHs.594902
Hs.63841

Genome annotation databases

EnsembliENST00000379483; ENSP00000368797; ENSG00000120696
GeneIDi84078
KEGGihsa:84078
UCSCiuc001uxw.2 human

Similar proteinsi

Entry informationi

Entry nameiKBTB7_HUMAN
AccessioniPrimary (citable) accession number: Q8WVZ9
Secondary accession number(s): B5TZ86
, Q5T6Y7, Q8NB99, Q9H0I6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: March 1, 2002
Last modified: June 20, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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