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Protein

Kelch repeat and BTB domain-containing protein 7

Gene

KBTBD7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000120696-MONOMER.
ReactomeiR-HSA-5658442. Regulation of RAS by GAPs.
R-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch repeat and BTB domain-containing protein 7
Gene namesi
Name:KBTBD7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:25266. KBTBD7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000120696.
PharmGKBiPA134934036.

Polymorphism and mutation databases

BioMutaiKBTBD7.
DMDMi45477155.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001190851 – 684Kelch repeat and BTB domain-containing protein 7Add BLAST684

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei29PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8WVZ9.
MaxQBiQ8WVZ9.
PaxDbiQ8WVZ9.
PeptideAtlasiQ8WVZ9.
PRIDEiQ8WVZ9.

PTM databases

iPTMnetiQ8WVZ9.
PhosphoSitePlusiQ8WVZ9.

Expressioni

Gene expression databases

BgeeiENSG00000120696.
CleanExiHS_KBTBD7.
GenevisibleiQ8WVZ9. HS.

Organism-specific databases

HPAiHPA043709.
HPA046861.
HPA048914.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
GABARAPO951662EBI-473695,EBI-712001
GABARAPL1Q9H0R86EBI-473695,EBI-746969
GABARAPL2P605203EBI-473695,EBI-720116
MAP1LC3BQ9GZQ84EBI-473695,EBI-373144
MAP1LC3CQ9BXW42EBI-473695,EBI-2603996
PHC2Q8IXK03EBI-473695,EBI-713786

Protein-protein interaction databases

BioGridi123873. 146 interactors.
IntActiQ8WVZ9. 63 interactors.
MINTiMINT-3978892.
STRINGi9606.ENSP00000368797.

Structurei

3D structure databases

ProteinModelPortaliQ8WVZ9.
SMRiQ8WVZ9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini63 – 138BTBPROSITE-ProRule annotationAdd BLAST76
Repeati386 – 435Kelch 1Add BLAST50
Repeati436 – 484Kelch 2Add BLAST49
Repeati486 – 523Kelch 3Add BLAST38
Repeati524 – 564Kelch 4Add BLAST41
Repeati567 – 616Kelch 5Add BLAST50

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 5 Kelch repeats.Curated

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IJ96. Eukaryota.
ENOG4110S2H. LUCA.
GeneTreeiENSGT00850000132244.
HOGENOMiHOG000074585.
HOVERGENiHBG052214.
InParanoidiQ8WVZ9.
KOiK10474.
OMAiTSLAHTK.
OrthoDBiEOG091G033H.
PhylomeDBiQ8WVZ9.
TreeFamiTF332672.

Family and domain databases

Gene3Di2.120.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR017096. BTB-kelch_protein.
IPR000210. BTB/POZ_dom.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 1 hit.
[Graphical view]
PIRSFiPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 2 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8WVZ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQSREDVPRS RRLASPRGGR RPKRISKPSV SAFFTGPEEL KDTAHSAALL
60 70 80 90 100
AQLKSFYDAR LLCDVTIEVV TPGSGPGTGR LFSCNRNVLA AACPYFKSMF
110 120 130 140 150
TGGMYESQQA SVTMHDVDAE SFEVLVDYCY TGRVSLSEAN VQRLYAASDM
160 170 180 190 200
LQLEYVREAC ASFLARRLDL TNCTAILKFA DAFDHHKLRS QAQSYIAHNF
210 220 230 240 250
KQLSRMGSIR EETLADLTLA QLLAVLRLDS LDIESERTVC HVAVQWLEAA
260 270 280 290 300
AKERGPSAAE VFKCVRWMHF TEEDQDYLEG LLTKPIVKKY CLDVIEGALQ
310 320 330 340 350
MRYGDLLYKS LVPVPNSSSS SSSSNSLVSA AENPPQRLGM CAKEMVIFFG
360 370 380 390 400
HPRDPFLCYD PYSGDIYTMP SPLTSFAHTK TVTSSAVCVS PDHDIYLAAQ
410 420 430 440 450
PRKDLWVYKP AQNSWQQLAD RLLCREGMDV AYLNGYIYIL GGRDPITGVK
460 470 480 490 500
LKEVECYSVQ RNQWALVAPV PHSFYSFELI VVQNYLYAVN SKRMLCYDPS
510 520 530 540 550
HNMWLNCASL KRSDFQEACV FNDEIYCICD IPVMKVYNPA RGEWRRISNI
560 570 580 590 600
PLDSETHNYQ IVNHDQKLLL ITSTTPQWKK NRVTVYEYDT REDQWINIGT
610 620 630 640 650
MLGLLQFDSG FICLCARVYP SCLEPGQSFI TEEDDARSES STEWDLDGFS
660 670 680
ELDSESGSSS SFSDDEVWVQ VAPQRNAQDQ QGSL
Length:684
Mass (Da):77,163
Last modified:March 1, 2002 - v1
Checksum:iB2D8B6969A1AE5E9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti361P → S in CAB66716 (PubMed:11230166).Curated1
Sequence conflicti602L → S in BAC03641 (PubMed:14702039).Curated1
Sequence conflicti622C → Y in BAC03641 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136782 mRNA. Translation: CAB66716.1.
FJ150424 mRNA. Translation: ACH92650.1.
AK091344 mRNA. Translation: BAC03641.1.
AL354696 Genomic DNA. Translation: CAI16613.1.
CH471075 Genomic DNA. Translation: EAX08647.1.
BC022033 mRNA. Translation: AAH22033.1.
CCDSiCCDS9377.1.
RefSeqiNP_115514.2. NM_032138.5.
UniGeneiHs.63841.

Genome annotation databases

EnsembliENST00000379483; ENSP00000368797; ENSG00000120696.
GeneIDi84078.
KEGGihsa:84078.
UCSCiuc001uxw.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136782 mRNA. Translation: CAB66716.1.
FJ150424 mRNA. Translation: ACH92650.1.
AK091344 mRNA. Translation: BAC03641.1.
AL354696 Genomic DNA. Translation: CAI16613.1.
CH471075 Genomic DNA. Translation: EAX08647.1.
BC022033 mRNA. Translation: AAH22033.1.
CCDSiCCDS9377.1.
RefSeqiNP_115514.2. NM_032138.5.
UniGeneiHs.63841.

3D structure databases

ProteinModelPortaliQ8WVZ9.
SMRiQ8WVZ9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123873. 146 interactors.
IntActiQ8WVZ9. 63 interactors.
MINTiMINT-3978892.
STRINGi9606.ENSP00000368797.

PTM databases

iPTMnetiQ8WVZ9.
PhosphoSitePlusiQ8WVZ9.

Polymorphism and mutation databases

BioMutaiKBTBD7.
DMDMi45477155.

Proteomic databases

EPDiQ8WVZ9.
MaxQBiQ8WVZ9.
PaxDbiQ8WVZ9.
PeptideAtlasiQ8WVZ9.
PRIDEiQ8WVZ9.

Protocols and materials databases

DNASUi84078.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000379483; ENSP00000368797; ENSG00000120696.
GeneIDi84078.
KEGGihsa:84078.
UCSCiuc001uxw.2. human.

Organism-specific databases

CTDi84078.
GeneCardsiKBTBD7.
HGNCiHGNC:25266. KBTBD7.
HPAiHPA043709.
HPA046861.
HPA048914.
neXtProtiNX_Q8WVZ9.
OpenTargetsiENSG00000120696.
PharmGKBiPA134934036.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJ96. Eukaryota.
ENOG4110S2H. LUCA.
GeneTreeiENSGT00850000132244.
HOGENOMiHOG000074585.
HOVERGENiHBG052214.
InParanoidiQ8WVZ9.
KOiK10474.
OMAiTSLAHTK.
OrthoDBiEOG091G033H.
PhylomeDBiQ8WVZ9.
TreeFamiTF332672.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000120696-MONOMER.
ReactomeiR-HSA-5658442. Regulation of RAS by GAPs.
R-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

GeneWikiiKBTBD7.
GenomeRNAii84078.
PROiQ8WVZ9.

Gene expression databases

BgeeiENSG00000120696.
CleanExiHS_KBTBD7.
GenevisibleiQ8WVZ9. HS.

Family and domain databases

Gene3Di2.120.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR017096. BTB-kelch_protein.
IPR000210. BTB/POZ_dom.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 1 hit.
[Graphical view]
PIRSFiPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 2 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKBTB7_HUMAN
AccessioniPrimary (citable) accession number: Q8WVZ9
Secondary accession number(s): B5TZ86
, Q5T6Y7, Q8NB99, Q9H0I6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: March 1, 2002
Last modified: November 30, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.