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Protein

Kelch repeat and BTB domain-containing protein 7

Gene

KBTBD7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-5658442. Regulation of RAS by GAPs.
R-HSA-8951664. Neddylation.
R-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch repeat and BTB domain-containing protein 7
Gene namesi
Name:KBTBD7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000120696.8.
HGNCiHGNC:25266. KBTBD7.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi84078.
OpenTargetsiENSG00000120696.
PharmGKBiPA134934036.

Polymorphism and mutation databases

BioMutaiKBTBD7.
DMDMi45477155.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001190851 – 684Kelch repeat and BTB domain-containing protein 7Add BLAST684

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei29PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8WVZ9.
MaxQBiQ8WVZ9.
PaxDbiQ8WVZ9.
PeptideAtlasiQ8WVZ9.
PRIDEiQ8WVZ9.

PTM databases

iPTMnetiQ8WVZ9.
PhosphoSitePlusiQ8WVZ9.

Expressioni

Gene expression databases

BgeeiENSG00000120696.
CleanExiHS_KBTBD7.
GenevisibleiQ8WVZ9. HS.

Organism-specific databases

HPAiHPA043709.
HPA046861.
HPA048914.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi123873. 165 interactors.
IntActiQ8WVZ9. 63 interactors.
MINTiMINT-3978892.
STRINGi9606.ENSP00000368797.

Structurei

3D structure databases

ProteinModelPortaliQ8WVZ9.
SMRiQ8WVZ9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini63 – 138BTBPROSITE-ProRule annotationAdd BLAST76
Repeati386 – 435Kelch 1Add BLAST50
Repeati436 – 484Kelch 2Add BLAST49
Repeati486 – 523Kelch 3Add BLAST38
Repeati524 – 564Kelch 4Add BLAST41
Repeati567 – 616Kelch 5Add BLAST50

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IJ96. Eukaryota.
ENOG4110S2H. LUCA.
GeneTreeiENSGT00880000137845.
HOGENOMiHOG000074585.
HOVERGENiHBG052214.
InParanoidiQ8WVZ9.
KOiK10474.
OMAiTSLAHTK.
OrthoDBiEOG091G033H.
PhylomeDBiQ8WVZ9.
TreeFamiTF332672.

Family and domain databases

Gene3Di2.120.10.80. 1 hit.
InterProiView protein in InterPro
IPR011705. BACK.
IPR017096. BTB-kelch_protein.
IPR000210. BTB/POZ_dom.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
IPR011333. SKP1/BTB/POZ.
PfamiView protein in Pfam
PF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 1 hit.
PIRSFiPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTiView protein in SMART
SM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 2 hits.
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiView protein in PROSITE
PS50097. BTB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8WVZ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQSREDVPRS RRLASPRGGR RPKRISKPSV SAFFTGPEEL KDTAHSAALL
60 70 80 90 100
AQLKSFYDAR LLCDVTIEVV TPGSGPGTGR LFSCNRNVLA AACPYFKSMF
110 120 130 140 150
TGGMYESQQA SVTMHDVDAE SFEVLVDYCY TGRVSLSEAN VQRLYAASDM
160 170 180 190 200
LQLEYVREAC ASFLARRLDL TNCTAILKFA DAFDHHKLRS QAQSYIAHNF
210 220 230 240 250
KQLSRMGSIR EETLADLTLA QLLAVLRLDS LDIESERTVC HVAVQWLEAA
260 270 280 290 300
AKERGPSAAE VFKCVRWMHF TEEDQDYLEG LLTKPIVKKY CLDVIEGALQ
310 320 330 340 350
MRYGDLLYKS LVPVPNSSSS SSSSNSLVSA AENPPQRLGM CAKEMVIFFG
360 370 380 390 400
HPRDPFLCYD PYSGDIYTMP SPLTSFAHTK TVTSSAVCVS PDHDIYLAAQ
410 420 430 440 450
PRKDLWVYKP AQNSWQQLAD RLLCREGMDV AYLNGYIYIL GGRDPITGVK
460 470 480 490 500
LKEVECYSVQ RNQWALVAPV PHSFYSFELI VVQNYLYAVN SKRMLCYDPS
510 520 530 540 550
HNMWLNCASL KRSDFQEACV FNDEIYCICD IPVMKVYNPA RGEWRRISNI
560 570 580 590 600
PLDSETHNYQ IVNHDQKLLL ITSTTPQWKK NRVTVYEYDT REDQWINIGT
610 620 630 640 650
MLGLLQFDSG FICLCARVYP SCLEPGQSFI TEEDDARSES STEWDLDGFS
660 670 680
ELDSESGSSS SFSDDEVWVQ VAPQRNAQDQ QGSL
Length:684
Mass (Da):77,163
Last modified:March 1, 2002 - v1
Checksum:iB2D8B6969A1AE5E9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti361P → S in CAB66716 (PubMed:11230166).Curated1
Sequence conflicti602L → S in BAC03641 (PubMed:14702039).Curated1
Sequence conflicti622C → Y in BAC03641 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136782 mRNA. Translation: CAB66716.1.
FJ150424 mRNA. Translation: ACH92650.1.
AK091344 mRNA. Translation: BAC03641.1.
AL354696 Genomic DNA. No translation available.
CH471075 Genomic DNA. Translation: EAX08647.1.
BC022033 mRNA. Translation: AAH22033.1.
CCDSiCCDS9377.1.
RefSeqiNP_115514.2. NM_032138.5.
UniGeneiHs.594902.
Hs.63841.

Genome annotation databases

EnsembliENST00000379483; ENSP00000368797; ENSG00000120696.
GeneIDi84078.
KEGGihsa:84078.
UCSCiuc001uxw.2. human.

Similar proteinsi

Entry informationi

Entry nameiKBTB7_HUMAN
AccessioniPrimary (citable) accession number: Q8WVZ9
Secondary accession number(s): B5TZ86
, Q5T6Y7, Q8NB99, Q9H0I6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: March 1, 2002
Last modified: September 27, 2017
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM