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Q8WVZ9

- KBTB7_HUMAN

UniProt

Q8WVZ9 - KBTB7_HUMAN

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Protein

Kelch repeat and BTB domain-containing protein 7

Gene

KBTBD7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch repeat and BTB domain-containing protein 7
Gene namesi
Name:KBTBD7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 13

Organism-specific databases

HGNCiHGNC:25266. KBTBD7.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134934036.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 684684Kelch repeat and BTB domain-containing protein 7PRO_0000119085Add
BLAST

Proteomic databases

MaxQBiQ8WVZ9.
PaxDbiQ8WVZ9.
PRIDEiQ8WVZ9.

PTM databases

PhosphoSiteiQ8WVZ9.

Expressioni

Gene expression databases

BgeeiQ8WVZ9.
CleanExiHS_KBTBD7.
ExpressionAtlasiQ8WVZ9. baseline and differential.
GenevestigatoriQ8WVZ9.

Organism-specific databases

HPAiHPA043709.
HPA046861.
HPA048914.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
GABARAPO951662EBI-473695,EBI-712001
GABARAPL1Q9H0R83EBI-473695,EBI-746969
GABARAPL2P605203EBI-473695,EBI-720116
MAP1LC3BQ9GZQ84EBI-473695,EBI-373144
MAP1LC3CQ9BXW42EBI-473695,EBI-2603996

Protein-protein interaction databases

BioGridi123873. 57 interactions.
IntActiQ8WVZ9. 42 interactions.
MINTiMINT-3978892.
STRINGi9606.ENSP00000368797.

Structurei

3D structure databases

ProteinModelPortaliQ8WVZ9.
SMRiQ8WVZ9. Positions 42-289, 334-602.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini63 – 13876BTBPROSITE-ProRule annotationAdd
BLAST
Repeati386 – 43550Kelch 1Add
BLAST
Repeati436 – 48449Kelch 2Add
BLAST
Repeati486 – 52338Kelch 3Add
BLAST
Repeati524 – 56441Kelch 4Add
BLAST
Repeati567 – 61650Kelch 5Add
BLAST

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 5 Kelch repeats.Curated

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiNOG146872.
GeneTreeiENSGT00770000120450.
HOGENOMiHOG000074585.
HOVERGENiHBG052214.
InParanoidiQ8WVZ9.
KOiK10474.
OMAiTSLAHTK.
OrthoDBiEOG7MSMNJ.
PhylomeDBiQ8WVZ9.
TreeFamiTF332672.

Family and domain databases

Gene3Di2.120.10.80. 1 hit.
3.30.710.10. 1 hit.
InterProiIPR011705. BACK.
IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR017096. Kelch-like_gigaxonin-typ.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
[Graphical view]
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 1 hit.
[Graphical view]
PIRSFiPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8WVZ9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQSREDVPRS RRLASPRGGR RPKRISKPSV SAFFTGPEEL KDTAHSAALL
60 70 80 90 100
AQLKSFYDAR LLCDVTIEVV TPGSGPGTGR LFSCNRNVLA AACPYFKSMF
110 120 130 140 150
TGGMYESQQA SVTMHDVDAE SFEVLVDYCY TGRVSLSEAN VQRLYAASDM
160 170 180 190 200
LQLEYVREAC ASFLARRLDL TNCTAILKFA DAFDHHKLRS QAQSYIAHNF
210 220 230 240 250
KQLSRMGSIR EETLADLTLA QLLAVLRLDS LDIESERTVC HVAVQWLEAA
260 270 280 290 300
AKERGPSAAE VFKCVRWMHF TEEDQDYLEG LLTKPIVKKY CLDVIEGALQ
310 320 330 340 350
MRYGDLLYKS LVPVPNSSSS SSSSNSLVSA AENPPQRLGM CAKEMVIFFG
360 370 380 390 400
HPRDPFLCYD PYSGDIYTMP SPLTSFAHTK TVTSSAVCVS PDHDIYLAAQ
410 420 430 440 450
PRKDLWVYKP AQNSWQQLAD RLLCREGMDV AYLNGYIYIL GGRDPITGVK
460 470 480 490 500
LKEVECYSVQ RNQWALVAPV PHSFYSFELI VVQNYLYAVN SKRMLCYDPS
510 520 530 540 550
HNMWLNCASL KRSDFQEACV FNDEIYCICD IPVMKVYNPA RGEWRRISNI
560 570 580 590 600
PLDSETHNYQ IVNHDQKLLL ITSTTPQWKK NRVTVYEYDT REDQWINIGT
610 620 630 640 650
MLGLLQFDSG FICLCARVYP SCLEPGQSFI TEEDDARSES STEWDLDGFS
660 670 680
ELDSESGSSS SFSDDEVWVQ VAPQRNAQDQ QGSL
Length:684
Mass (Da):77,163
Last modified:March 1, 2002 - v1
Checksum:iB2D8B6969A1AE5E9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti361 – 3611P → S in CAB66716. (PubMed:11230166)Curated
Sequence conflicti602 – 6021L → S in BAC03641. (PubMed:14702039)Curated
Sequence conflicti622 – 6221C → Y in BAC03641. (PubMed:14702039)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136782 mRNA. Translation: CAB66716.1.
FJ150424 mRNA. Translation: ACH92650.1.
AK091344 mRNA. Translation: BAC03641.1.
AL354696 Genomic DNA. Translation: CAI16613.1.
CH471075 Genomic DNA. Translation: EAX08647.1.
BC022033 mRNA. Translation: AAH22033.1.
CCDSiCCDS9377.1.
RefSeqiNP_115514.2. NM_032138.4.
UniGeneiHs.63841.

Genome annotation databases

EnsembliENST00000379483; ENSP00000368797; ENSG00000120696.
GeneIDi84078.
KEGGihsa:84078.
UCSCiuc001uxw.1. human.

Polymorphism databases

DMDMi45477155.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136782 mRNA. Translation: CAB66716.1 .
FJ150424 mRNA. Translation: ACH92650.1 .
AK091344 mRNA. Translation: BAC03641.1 .
AL354696 Genomic DNA. Translation: CAI16613.1 .
CH471075 Genomic DNA. Translation: EAX08647.1 .
BC022033 mRNA. Translation: AAH22033.1 .
CCDSi CCDS9377.1.
RefSeqi NP_115514.2. NM_032138.4.
UniGenei Hs.63841.

3D structure databases

ProteinModelPortali Q8WVZ9.
SMRi Q8WVZ9. Positions 42-289, 334-602.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 123873. 57 interactions.
IntActi Q8WVZ9. 42 interactions.
MINTi MINT-3978892.
STRINGi 9606.ENSP00000368797.

PTM databases

PhosphoSitei Q8WVZ9.

Polymorphism databases

DMDMi 45477155.

Proteomic databases

MaxQBi Q8WVZ9.
PaxDbi Q8WVZ9.
PRIDEi Q8WVZ9.

Protocols and materials databases

DNASUi 84078.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000379483 ; ENSP00000368797 ; ENSG00000120696 .
GeneIDi 84078.
KEGGi hsa:84078.
UCSCi uc001uxw.1. human.

Organism-specific databases

CTDi 84078.
GeneCardsi GC13M041765.
HGNCi HGNC:25266. KBTBD7.
HPAi HPA043709.
HPA046861.
HPA048914.
neXtProti NX_Q8WVZ9.
PharmGKBi PA134934036.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG146872.
GeneTreei ENSGT00770000120450.
HOGENOMi HOG000074585.
HOVERGENi HBG052214.
InParanoidi Q8WVZ9.
KOi K10474.
OMAi TSLAHTK.
OrthoDBi EOG7MSMNJ.
PhylomeDBi Q8WVZ9.
TreeFami TF332672.

Miscellaneous databases

GeneWikii KBTBD7.
GenomeRNAii 84078.
NextBioi 73295.
PROi Q8WVZ9.

Gene expression databases

Bgeei Q8WVZ9.
CleanExi HS_KBTBD7.
ExpressionAtlasi Q8WVZ9. baseline and differential.
Genevestigatori Q8WVZ9.

Family and domain databases

Gene3Di 2.120.10.80. 1 hit.
3.30.710.10. 1 hit.
InterProi IPR011705. BACK.
IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR017096. Kelch-like_gigaxonin-typ.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
[Graphical view ]
Pfami PF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 1 hit.
[Graphical view ]
PIRSFi PIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTi SM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
[Graphical view ]
SUPFAMi SSF54695. SSF54695. 1 hit.
PROSITEi PS50097. BTB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Hu J., Peng X., Yang Z., Yuan W., Wang Y., Li Y., Wu X.
    Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiKBTB7_HUMAN
AccessioniPrimary (citable) accession number: Q8WVZ9
Secondary accession number(s): B5TZ86
, Q5T6Y7, Q8NB99, Q9H0I6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: March 1, 2002
Last modified: November 26, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3