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Q8WVZ9

- KBTB7_HUMAN

UniProt

Q8WVZ9 - KBTB7_HUMAN

Protein

Kelch repeat and BTB domain-containing protein 7

Gene

KBTBD7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. protein binding Source: IntAct

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Kelch repeat and BTB domain-containing protein 7
    Gene namesi
    Name:KBTBD7
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 13

    Organism-specific databases

    HGNCiHGNC:25266. KBTBD7.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134934036.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 684684Kelch repeat and BTB domain-containing protein 7PRO_0000119085Add
    BLAST

    Proteomic databases

    MaxQBiQ8WVZ9.
    PaxDbiQ8WVZ9.
    PRIDEiQ8WVZ9.

    PTM databases

    PhosphoSiteiQ8WVZ9.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8WVZ9.
    BgeeiQ8WVZ9.
    CleanExiHS_KBTBD7.
    GenevestigatoriQ8WVZ9.

    Organism-specific databases

    HPAiHPA043709.
    HPA046861.
    HPA048914.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    GABARAPO951662EBI-473695,EBI-712001
    GABARAPL1Q9H0R83EBI-473695,EBI-746969
    GABARAPL2P605203EBI-473695,EBI-720116
    MAP1LC3BQ9GZQ84EBI-473695,EBI-373144
    MAP1LC3CQ9BXW42EBI-473695,EBI-2603996

    Protein-protein interaction databases

    BioGridi123873. 44 interactions.
    IntActiQ8WVZ9. 42 interactions.
    MINTiMINT-3978892.
    STRINGi9606.ENSP00000368797.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8WVZ9.
    SMRiQ8WVZ9. Positions 42-289, 334-602.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini63 – 13876BTBPROSITE-ProRule annotationAdd
    BLAST
    Repeati386 – 43550Kelch 1Add
    BLAST
    Repeati436 – 48449Kelch 2Add
    BLAST
    Repeati486 – 52338Kelch 3Add
    BLAST
    Repeati524 – 56441Kelch 4Add
    BLAST
    Repeati567 – 61650Kelch 5Add
    BLAST

    Sequence similaritiesi

    Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
    Contains 5 Kelch repeats.Curated

    Keywords - Domaini

    Kelch repeat, Repeat

    Phylogenomic databases

    eggNOGiNOG146872.
    HOGENOMiHOG000074585.
    HOVERGENiHBG052214.
    InParanoidiQ8WVZ9.
    KOiK10474.
    OMAiTSLAHTK.
    OrthoDBiEOG7MSMNJ.
    PhylomeDBiQ8WVZ9.
    TreeFamiTF332672.

    Family and domain databases

    Gene3Di2.120.10.80. 1 hit.
    3.30.710.10. 1 hit.
    InterProiIPR011705. BACK.
    IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR013069. BTB_POZ.
    IPR017096. Kelch-like_gigaxonin-typ.
    IPR015915. Kelch-typ_b-propeller.
    IPR006652. Kelch_1.
    [Graphical view]
    PfamiPF07707. BACK. 1 hit.
    PF00651. BTB. 1 hit.
    PF01344. Kelch_1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
    SMARTiSM00875. BACK. 1 hit.
    SM00225. BTB. 1 hit.
    [Graphical view]
    SUPFAMiSSF54695. SSF54695. 1 hit.
    PROSITEiPS50097. BTB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8WVZ9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQSREDVPRS RRLASPRGGR RPKRISKPSV SAFFTGPEEL KDTAHSAALL    50
    AQLKSFYDAR LLCDVTIEVV TPGSGPGTGR LFSCNRNVLA AACPYFKSMF 100
    TGGMYESQQA SVTMHDVDAE SFEVLVDYCY TGRVSLSEAN VQRLYAASDM 150
    LQLEYVREAC ASFLARRLDL TNCTAILKFA DAFDHHKLRS QAQSYIAHNF 200
    KQLSRMGSIR EETLADLTLA QLLAVLRLDS LDIESERTVC HVAVQWLEAA 250
    AKERGPSAAE VFKCVRWMHF TEEDQDYLEG LLTKPIVKKY CLDVIEGALQ 300
    MRYGDLLYKS LVPVPNSSSS SSSSNSLVSA AENPPQRLGM CAKEMVIFFG 350
    HPRDPFLCYD PYSGDIYTMP SPLTSFAHTK TVTSSAVCVS PDHDIYLAAQ 400
    PRKDLWVYKP AQNSWQQLAD RLLCREGMDV AYLNGYIYIL GGRDPITGVK 450
    LKEVECYSVQ RNQWALVAPV PHSFYSFELI VVQNYLYAVN SKRMLCYDPS 500
    HNMWLNCASL KRSDFQEACV FNDEIYCICD IPVMKVYNPA RGEWRRISNI 550
    PLDSETHNYQ IVNHDQKLLL ITSTTPQWKK NRVTVYEYDT REDQWINIGT 600
    MLGLLQFDSG FICLCARVYP SCLEPGQSFI TEEDDARSES STEWDLDGFS 650
    ELDSESGSSS SFSDDEVWVQ VAPQRNAQDQ QGSL 684
    Length:684
    Mass (Da):77,163
    Last modified:March 1, 2002 - v1
    Checksum:iB2D8B6969A1AE5E9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti361 – 3611P → S in CAB66716. (PubMed:11230166)Curated
    Sequence conflicti602 – 6021L → S in BAC03641. (PubMed:14702039)Curated
    Sequence conflicti622 – 6221C → Y in BAC03641. (PubMed:14702039)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL136782 mRNA. Translation: CAB66716.1.
    FJ150424 mRNA. Translation: ACH92650.1.
    AK091344 mRNA. Translation: BAC03641.1.
    AL354696 Genomic DNA. Translation: CAI16613.1.
    CH471075 Genomic DNA. Translation: EAX08647.1.
    BC022033 mRNA. Translation: AAH22033.1.
    CCDSiCCDS9377.1.
    RefSeqiNP_115514.2. NM_032138.4.
    UniGeneiHs.63841.

    Genome annotation databases

    EnsembliENST00000379483; ENSP00000368797; ENSG00000120696.
    GeneIDi84078.
    KEGGihsa:84078.
    UCSCiuc001uxw.1. human.

    Polymorphism databases

    DMDMi45477155.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL136782 mRNA. Translation: CAB66716.1 .
    FJ150424 mRNA. Translation: ACH92650.1 .
    AK091344 mRNA. Translation: BAC03641.1 .
    AL354696 Genomic DNA. Translation: CAI16613.1 .
    CH471075 Genomic DNA. Translation: EAX08647.1 .
    BC022033 mRNA. Translation: AAH22033.1 .
    CCDSi CCDS9377.1.
    RefSeqi NP_115514.2. NM_032138.4.
    UniGenei Hs.63841.

    3D structure databases

    ProteinModelPortali Q8WVZ9.
    SMRi Q8WVZ9. Positions 42-289, 334-602.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123873. 44 interactions.
    IntActi Q8WVZ9. 42 interactions.
    MINTi MINT-3978892.
    STRINGi 9606.ENSP00000368797.

    PTM databases

    PhosphoSitei Q8WVZ9.

    Polymorphism databases

    DMDMi 45477155.

    Proteomic databases

    MaxQBi Q8WVZ9.
    PaxDbi Q8WVZ9.
    PRIDEi Q8WVZ9.

    Protocols and materials databases

    DNASUi 84078.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000379483 ; ENSP00000368797 ; ENSG00000120696 .
    GeneIDi 84078.
    KEGGi hsa:84078.
    UCSCi uc001uxw.1. human.

    Organism-specific databases

    CTDi 84078.
    GeneCardsi GC13M041765.
    HGNCi HGNC:25266. KBTBD7.
    HPAi HPA043709.
    HPA046861.
    HPA048914.
    neXtProti NX_Q8WVZ9.
    PharmGKBi PA134934036.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG146872.
    HOGENOMi HOG000074585.
    HOVERGENi HBG052214.
    InParanoidi Q8WVZ9.
    KOi K10474.
    OMAi TSLAHTK.
    OrthoDBi EOG7MSMNJ.
    PhylomeDBi Q8WVZ9.
    TreeFami TF332672.

    Miscellaneous databases

    GeneWikii KBTBD7.
    GenomeRNAii 84078.
    NextBioi 73295.
    PROi Q8WVZ9.

    Gene expression databases

    ArrayExpressi Q8WVZ9.
    Bgeei Q8WVZ9.
    CleanExi HS_KBTBD7.
    Genevestigatori Q8WVZ9.

    Family and domain databases

    Gene3Di 2.120.10.80. 1 hit.
    3.30.710.10. 1 hit.
    InterProi IPR011705. BACK.
    IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR013069. BTB_POZ.
    IPR017096. Kelch-like_gigaxonin-typ.
    IPR015915. Kelch-typ_b-propeller.
    IPR006652. Kelch_1.
    [Graphical view ]
    Pfami PF07707. BACK. 1 hit.
    PF00651. BTB. 1 hit.
    PF01344. Kelch_1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
    SMARTi SM00875. BACK. 1 hit.
    SM00225. BTB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54695. SSF54695. 1 hit.
    PROSITEi PS50097. BTB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Hu J., Peng X., Yang Z., Yuan W., Wang Y., Li Y., Wu X.
      Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    4. "The DNA sequence and analysis of human chromosome 13."
      Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
      Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.

    Entry informationi

    Entry nameiKBTB7_HUMAN
    AccessioniPrimary (citable) accession number: Q8WVZ9
    Secondary accession number(s): B5TZ86
    , Q5T6Y7, Q8NB99, Q9H0I6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2004
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 13
      Human chromosome 13: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3