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Protein

E3 ubiquitin-protein ligase RNF133

Gene

RNF133

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Has E3 ubiquitin-protein ligase activity.By similarity

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri256 – 297RING-type; atypicalPROSITE-ProRule annotationAdd BLAST42

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase RNF133 (EC:2.3.2.27)
Alternative name(s):
RING finger protein 133
RING-type E3 ubiquitin transferase RNF133Curated
Gene namesi
Name:RNF133
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:21154. RNF133.

Subcellular locationi

  • Endoplasmic reticulum membrane By similarity; Single-pass membrane protein By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei190 – 210HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi168433.
OpenTargetsiENSG00000188050.
PharmGKBiPA134991267.

Polymorphism and mutation databases

BioMutaiRNF133.
DMDMi74730905.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002478371 – 376E3 ubiquitin-protein ligase RNF133Add BLAST376

Post-translational modificationi

Auto-ubiquitinated.By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiQ8WVZ7.
PRIDEiQ8WVZ7.

PTM databases

iPTMnetiQ8WVZ7.
PhosphoSitePlusiQ8WVZ7.

Expressioni

Gene expression databases

BgeeiENSG00000188050.
CleanExiHS_RNF133.
GenevisibleiQ8WVZ7. HS.

Interactioni

Protein-protein interaction databases

BioGridi127962. 2 interactors.
IntActiQ8WVZ7. 2 interactors.
STRINGi9606.ENSP00000344489.

Structurei

3D structure databases

ProteinModelPortaliQ8WVZ7.
SMRiQ8WVZ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini65 – 167PAAdd BLAST103

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri256 – 297RING-type; atypicalPROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiKOG4628. Eukaryota.
ENOG410Z5DF. LUCA.
GeneTreeiENSGT00760000119057.
HOGENOMiHOG000231432.
HOVERGENiHBG057659.
InParanoidiQ8WVZ7.
KOiK15702.
OMAiNCIDPWI.
OrthoDBiEOG090B07N0.
PhylomeDBiQ8WVZ7.
TreeFamiTF317486.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR003137. PA_domain.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
PfamiView protein in Pfam
PF02225. PA. 1 hit.
PF13639. zf-RING_2. 1 hit.
SMARTiView protein in SMART
SM00184. RING. 1 hit.
PROSITEiView protein in PROSITE
PS50089. ZF_RING_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8WVZ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHLLKVGTWR NNTASSWLMK FSVLWLVSQN CCRASVVWMA YMNISFHVGN
60 70 80 90 100
HVLSELGETG VFGRSSTLKR VAGVIVPPEG KIQNACNPNT IFSRSKYSET
110 120 130 140 150
WLALIERGGC TFTQKIKVAT EKGASGVIIY NVPGTGNQVF PMFHQAFEDV
160 170 180 190 200
VVVMIGNLKG TEIFHLIKKG VLITAVVEVG RKHIIWMNHY LVSFVIVTTA
210 220 230 240 250
TLAYFIFYHI HRLCLARIQN RRWQRLTTDL QNTFGQLQLR VVKEGDEEIN
260 270 280 290 300
PNGDSCVICF ERYKPNDIVR ILTCKHFFHK NCIDPWILPH GTCPICKCDI
310 320 330 340 350
LKVLGIQVVV ENGTEPLQVL MSNELPETLS PSEEETNNEV SPAGTSDKVI
360 370
HVEENPTSQN NDIQPHSVVE DVHPSP
Length:376
Mass (Da):42,294
Last modified:March 1, 2002 - v1
Checksum:i7C0446D1FB0981F1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10R → G in BAC05321 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF447589 mRNA. Translation: AAM22872.1.
AK098524 mRNA. Translation: BAC05321.1.
AC006463 Genomic DNA. Translation: AAQ96858.1.
CH236947 Genomic DNA. Translation: EAL24341.1.
CH471070 Genomic DNA. Translation: EAW83577.1.
BC022038 mRNA. Translation: AAH22038.1.
CCDSiCCDS5784.1.
RefSeqiNP_631914.1. NM_139175.1.
UniGeneiHs.126730.

Genome annotation databases

EnsembliENST00000340112; ENSP00000344489; ENSG00000188050.
GeneIDi168433.
KEGGihsa:168433.
UCSCiuc003vkj.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF447589 mRNA. Translation: AAM22872.1.
AK098524 mRNA. Translation: BAC05321.1.
AC006463 Genomic DNA. Translation: AAQ96858.1.
CH236947 Genomic DNA. Translation: EAL24341.1.
CH471070 Genomic DNA. Translation: EAW83577.1.
BC022038 mRNA. Translation: AAH22038.1.
CCDSiCCDS5784.1.
RefSeqiNP_631914.1. NM_139175.1.
UniGeneiHs.126730.

3D structure databases

ProteinModelPortaliQ8WVZ7.
SMRiQ8WVZ7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127962. 2 interactors.
IntActiQ8WVZ7. 2 interactors.
STRINGi9606.ENSP00000344489.

PTM databases

iPTMnetiQ8WVZ7.
PhosphoSitePlusiQ8WVZ7.

Polymorphism and mutation databases

BioMutaiRNF133.
DMDMi74730905.

Proteomic databases

PaxDbiQ8WVZ7.
PRIDEiQ8WVZ7.

Protocols and materials databases

DNASUi168433.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340112; ENSP00000344489; ENSG00000188050.
GeneIDi168433.
KEGGihsa:168433.
UCSCiuc003vkj.2. human.

Organism-specific databases

CTDi168433.
DisGeNETi168433.
GeneCardsiRNF133.
HGNCiHGNC:21154. RNF133.
neXtProtiNX_Q8WVZ7.
OpenTargetsiENSG00000188050.
PharmGKBiPA134991267.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4628. Eukaryota.
ENOG410Z5DF. LUCA.
GeneTreeiENSGT00760000119057.
HOGENOMiHOG000231432.
HOVERGENiHBG057659.
InParanoidiQ8WVZ7.
KOiK15702.
OMAiNCIDPWI.
OrthoDBiEOG090B07N0.
PhylomeDBiQ8WVZ7.
TreeFamiTF317486.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

GenomeRNAii168433.
PROiQ8WVZ7.

Gene expression databases

BgeeiENSG00000188050.
CleanExiHS_RNF133.
GenevisibleiQ8WVZ7. HS.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR003137. PA_domain.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
PfamiView protein in Pfam
PF02225. PA. 1 hit.
PF13639. zf-RING_2. 1 hit.
SMARTiView protein in SMART
SM00184. RING. 1 hit.
PROSITEiView protein in PROSITE
PS50089. ZF_RING_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRN133_HUMAN
AccessioniPrimary (citable) accession number: Q8WVZ7
Secondary accession number(s): A4D0W2, Q8N7G7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: March 1, 2002
Last modified: February 15, 2017
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.