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Protein

Probable palmitoyltransferase ZDHHC19

Gene

ZDHHC19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Enzyme and pathway databases

BioCyciZFISH:ENSG00000163958-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable palmitoyltransferase ZDHHC19 (EC:2.3.1.225)
Alternative name(s):
Zinc finger DHHC domain-containing protein 19
Short name:
DHHC-19
Gene namesi
Name:ZDHHC19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:20713. ZDHHC19.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei29 – 49HelicalSequence analysisAdd BLAST21
Transmembranei59 – 79HelicalSequence analysisAdd BLAST21
Transmembranei160 – 180HelicalSequence analysisAdd BLAST21
Transmembranei193 – 213HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • endoplasmic reticulum Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000163958.
PharmGKBiPA134871748.

Polymorphism and mutation databases

BioMutaiZDHHC19.
DMDMi218511970.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002129041 – 309Probable palmitoyltransferase ZDHHC19Add BLAST309

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ8WVZ1.
PRIDEiQ8WVZ1.

PTM databases

PhosphoSitePlusiQ8WVZ1.

Expressioni

Gene expression databases

BgeeiENSG00000163958.
CleanExiHS_ZDHHC19.
ExpressionAtlasiQ8WVZ1. baseline and differential.
GenevisibleiQ8WVZ1. HS.

Interactioni

Protein-protein interaction databases

BioGridi126283. 1 interactor.
STRINGi9606.ENSP00000296326.

Structurei

3D structure databases

ProteinModelPortaliQ8WVZ1.
SMRiQ8WVZ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini112 – 162DHHCPROSITE-ProRule annotationAdd BLAST51

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family.Curated
Contains 1 DHHC domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1311. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00550000074293.
HOGENOMiHOG000065755.
HOVERGENiHBG067319.
InParanoidiQ8WVZ1.
KOiK18932.
OMAiEGKCRYL.
OrthoDBiEOG091G0GD9.
PhylomeDBiQ8WVZ1.
TreeFamiTF319798.

Family and domain databases

InterProiIPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view]
PfamiPF01529. zf-DHHC. 1 hit.
[Graphical view]
PROSITEiPS50216. DHHC. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WVZ1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTLLTDATPL VKEPHPLPLV PRPWFLPSLF AAFNVVLLVF FSGLFFAFPC
60 70 80 90 100
RWLAQNGEWA FPVITGSLFV LTFFSLVSLN FSDPGILHQG SAEQGPLTVH
110 120 130 140 150
VVWVNHGAFR LQWCPKCCFH RPPRTYHCPW CNICVEDFDH HCKWVNNCIG
160 170 180 190 200
HRNFRFFMLL VLSLCLYSGA MLVTCLIFLV RTTHLPFSTD KAIAIVVAVS
210 220 230 240 250
AAGLLVPLSL LLLIQALSVS SADRTYKGKC RHLQGYNPFD QGCASNWYLT
260 270 280 290 300
ICAPLGPKYM AEAVQLQRVV GPDWTSMPNL HPPMSPSALN PPAPTSGSLQ

SREGTPGAW
Length:309
Mass (Da):34,352
Last modified:December 16, 2008 - v2
Checksum:i645B007F74692FA1
GO
Isoform 2 (identifier: Q8WVZ1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     230-309: Missing.

Note: No experimental confirmation available.
Show »
Length:229
Mass (Da):25,718
Checksum:i143D96E744463D42
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05297966G → A.Corresponds to variant rs13315830dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_056001230 – 309Missing in isoform 2. 1 PublicationAdd BLAST80

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122907 mRNA. Translation: BAG53793.1.
AC069257 Genomic DNA. No translation available.
CH471191 Genomic DNA. Translation: EAW53668.1.
CCDSiCCDS43190.1. [Q8WVZ1-1]
RefSeqiNP_001034706.1. NM_001039617.1. [Q8WVZ1-1]
UniGeneiHs.111591.

Genome annotation databases

EnsembliENST00000296326; ENSP00000296326; ENSG00000163958. [Q8WVZ1-1]
ENST00000438232; ENSP00000393710; ENSG00000163958. [Q8WVZ1-2]
GeneIDi131540.
KEGGihsa:131540.
UCSCiuc003fwc.4. human. [Q8WVZ1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122907 mRNA. Translation: BAG53793.1.
AC069257 Genomic DNA. No translation available.
CH471191 Genomic DNA. Translation: EAW53668.1.
CCDSiCCDS43190.1. [Q8WVZ1-1]
RefSeqiNP_001034706.1. NM_001039617.1. [Q8WVZ1-1]
UniGeneiHs.111591.

3D structure databases

ProteinModelPortaliQ8WVZ1.
SMRiQ8WVZ1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126283. 1 interactor.
STRINGi9606.ENSP00000296326.

PTM databases

PhosphoSitePlusiQ8WVZ1.

Polymorphism and mutation databases

BioMutaiZDHHC19.
DMDMi218511970.

Proteomic databases

PaxDbiQ8WVZ1.
PRIDEiQ8WVZ1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296326; ENSP00000296326; ENSG00000163958. [Q8WVZ1-1]
ENST00000438232; ENSP00000393710; ENSG00000163958. [Q8WVZ1-2]
GeneIDi131540.
KEGGihsa:131540.
UCSCiuc003fwc.4. human. [Q8WVZ1-1]

Organism-specific databases

CTDi131540.
GeneCardsiZDHHC19.
HGNCiHGNC:20713. ZDHHC19.
neXtProtiNX_Q8WVZ1.
OpenTargetsiENSG00000163958.
PharmGKBiPA134871748.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1311. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00550000074293.
HOGENOMiHOG000065755.
HOVERGENiHBG067319.
InParanoidiQ8WVZ1.
KOiK18932.
OMAiEGKCRYL.
OrthoDBiEOG091G0GD9.
PhylomeDBiQ8WVZ1.
TreeFamiTF319798.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000163958-MONOMER.

Miscellaneous databases

GenomeRNAii131540.
PROiQ8WVZ1.

Gene expression databases

BgeeiENSG00000163958.
CleanExiHS_ZDHHC19.
ExpressionAtlasiQ8WVZ1. baseline and differential.
GenevisibleiQ8WVZ1. HS.

Family and domain databases

InterProiIPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view]
PfamiPF01529. zf-DHHC. 1 hit.
[Graphical view]
PROSITEiPS50216. DHHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZDH19_HUMAN
AccessioniPrimary (citable) accession number: Q8WVZ1
Secondary accession number(s): A8MSY6, B3KVI1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: December 16, 2008
Last modified: November 2, 2016
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.