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Protein

Ubiquitin-like domain-containing CTD phosphatase 1

Gene

UBLCP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The dephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S proteasome.1 Publication

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.1 Publication

Cofactori

Mg2+1 Publication

pH dependencei

Optimum pH is 5.0.1 Publication

GO - Molecular functioni

  • protein serine/threonine phosphatase activity Source: FlyBase

GO - Biological processi

  • protein dephosphorylation Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Enzyme and pathway databases

BioCyciZFISH:HS09065-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-like domain-containing CTD phosphatase 1 (EC:3.1.3.16)
Alternative name(s):
Nuclear proteasome inhibitor UBLCP1
Gene namesi
Name:UBLCP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:28110. UBLCP1.

Subcellular locationi

GO - Cellular componenti

  • nucleolus Source: HPA
  • nucleus Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi44K → A: No binding to proteasome. 1 Publication1

Organism-specific databases

DisGeNETi134510.
OpenTargetsiENSG00000164332.
PharmGKBiPA142670646.

Chemistry databases

ChEMBLiCHEMBL3317333.

Polymorphism and mutation databases

BioMutaiUBLCP1.
DMDMi74751564.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002426402 – 318Ubiquitin-like domain-containing CTD phosphatase 1Add BLAST317

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei117N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8WVY7.
MaxQBiQ8WVY7.
PaxDbiQ8WVY7.
PeptideAtlasiQ8WVY7.
PRIDEiQ8WVY7.

PTM databases

DEPODiQ8WVY7.
iPTMnetiQ8WVY7.
PhosphoSitePlusiQ8WVY7.

Expressioni

Tissue specificityi

Broadly expressed, with highest levels in placenta, lung, testis and ovary. Up-regulated in tumor tissues.1 Publication

Gene expression databases

BgeeiENSG00000164332.
CleanExiHS_UBLCP1.
GenevisibleiQ8WVY7. HS.

Organism-specific databases

HPAiHPA039615.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PSMD2Q1320010EBI-750011,EBI-357648

Protein-protein interaction databases

BioGridi126404. 11 interactors.
IntActiQ8WVY7. 3 interactors.
MINTiMINT-1445291.
STRINGi9606.ENSP00000296786.

Chemistry databases

BindingDBiQ8WVY7.

Structurei

Secondary structure

1318
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi5 – 9Combined sources5
Beta strandi12 – 16Combined sources5
Turni21 – 23Combined sources3
Helixi25 – 35Combined sources11
Turni39 – 41Combined sources3
Beta strandi46 – 49Combined sources4
Beta strandi57 – 59Combined sources3
Helixi61 – 64Combined sources4
Helixi68 – 70Combined sources3
Beta strandi71 – 76Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KX3NMR-A1-81[»]
2LGDNMR-A1-81[»]
2M17NMR-A1-81[»]
ProteinModelPortaliQ8WVY7.
SMRiQ8WVY7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 81Ubiquitin-likePROSITE-ProRule annotationAdd BLAST79
Domaini133 – 294FCP1 homologyPROSITE-ProRule annotationAdd BLAST162

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni133 – 294PhosphataseAdd BLAST162

Domaini

The Ubiquitin-like domain mediates interaction with proteasomes.

Sequence similaritiesi

Contains 1 FCP1 homology domain.PROSITE-ProRule annotation
Contains 1 ubiquitin-like domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1605. Eukaryota.
KOG1872. Eukaryota.
COG5190. LUCA.
GeneTreeiENSGT00390000010107.
HOGENOMiHOG000231279.
HOVERGENiHBG080207.
InParanoidiQ8WVY7.
KOiK17618.
OMAiLFDHRSA.
OrthoDBiEOG091G0CRH.
PhylomeDBiQ8WVY7.
TreeFamiTF323786.

Family and domain databases

Gene3Di3.40.50.1000. 1 hit.
InterProiIPR004274. FCP1_dom.
IPR023214. HAD-like_dom.
IPR011943. HAD-SF_hydro_IIID.
IPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
[Graphical view]
PfamiPF03031. NIF. 1 hit.
PF00240. ubiquitin. 1 hit.
[Graphical view]
SMARTiSM00577. CPDc. 1 hit.
SM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
SSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR02245. HAD_IIID1. 1 hit.
PROSITEiPS50969. FCP1. 1 hit.
PS50053. UBIQUITIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8WVY7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALPIIVKWG GQEYSVTTLS EDDTVLDLKQ FLKTLTGVLP ERQKLLGLKV
60 70 80 90 100
KGKPAENDVK LGALKLKPNT KIMMMGTREE SLEDVLGPPP DNDDVVNDFD
110 120 130 140 150
IEDEVVEVEN REENLLKISR RVKEYKVEIL NPPREGKKLL VLDVDYTLFD
160 170 180 190 200
HRSCAETGVE LMRPYLHEFL TSAYEDYDIV IWSATNMKWI EAKMKELGVS
210 220 230 240 250
TNANYKITFM LDSAAMITVH TPRRGLIDVK PLGVIWGKFS EFYSKKNTIM
260 270 280 290 300
FDDIGRNFLM NPQNGLKIRP FMKAHLNRDK DKELLKLTQY LKEIAKLDDF
310
LDLNHKYWER YLSKKQGQ
Length:318
Mass (Da):36,805
Last modified:October 1, 2002 - v2
Checksum:i21CB4DB22C3B0E0F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti83E → G in BAB71628 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY444562 mRNA. Translation: AAS68538.1.
AK057996 mRNA. Translation: BAB71628.1.
CH471062 Genomic DNA. Translation: EAW61577.1.
CH471062 Genomic DNA. Translation: EAW61578.1.
BC013425 mRNA. Translation: AAH13425.2.
CCDSiCCDS4345.1.
RefSeqiNP_659486.2. NM_145049.4.
UniGeneiHs.591733.

Genome annotation databases

EnsembliENST00000296786; ENSP00000296786; ENSG00000164332.
GeneIDi134510.
KEGGihsa:134510.
UCSCiuc003lxq.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY444562 mRNA. Translation: AAS68538.1.
AK057996 mRNA. Translation: BAB71628.1.
CH471062 Genomic DNA. Translation: EAW61577.1.
CH471062 Genomic DNA. Translation: EAW61578.1.
BC013425 mRNA. Translation: AAH13425.2.
CCDSiCCDS4345.1.
RefSeqiNP_659486.2. NM_145049.4.
UniGeneiHs.591733.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KX3NMR-A1-81[»]
2LGDNMR-A1-81[»]
2M17NMR-A1-81[»]
ProteinModelPortaliQ8WVY7.
SMRiQ8WVY7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126404. 11 interactors.
IntActiQ8WVY7. 3 interactors.
MINTiMINT-1445291.
STRINGi9606.ENSP00000296786.

Chemistry databases

BindingDBiQ8WVY7.
ChEMBLiCHEMBL3317333.

PTM databases

DEPODiQ8WVY7.
iPTMnetiQ8WVY7.
PhosphoSitePlusiQ8WVY7.

Polymorphism and mutation databases

BioMutaiUBLCP1.
DMDMi74751564.

Proteomic databases

EPDiQ8WVY7.
MaxQBiQ8WVY7.
PaxDbiQ8WVY7.
PeptideAtlasiQ8WVY7.
PRIDEiQ8WVY7.

Protocols and materials databases

DNASUi134510.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296786; ENSP00000296786; ENSG00000164332.
GeneIDi134510.
KEGGihsa:134510.
UCSCiuc003lxq.2. human.

Organism-specific databases

CTDi134510.
DisGeNETi134510.
GeneCardsiUBLCP1.
HGNCiHGNC:28110. UBLCP1.
HPAiHPA039615.
MIMi609867. gene.
neXtProtiNX_Q8WVY7.
OpenTargetsiENSG00000164332.
PharmGKBiPA142670646.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1605. Eukaryota.
KOG1872. Eukaryota.
COG5190. LUCA.
GeneTreeiENSGT00390000010107.
HOGENOMiHOG000231279.
HOVERGENiHBG080207.
InParanoidiQ8WVY7.
KOiK17618.
OMAiLFDHRSA.
OrthoDBiEOG091G0CRH.
PhylomeDBiQ8WVY7.
TreeFamiTF323786.

Enzyme and pathway databases

BioCyciZFISH:HS09065-MONOMER.

Miscellaneous databases

ChiTaRSiUBLCP1. human.
GenomeRNAii134510.
PROiQ8WVY7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000164332.
CleanExiHS_UBLCP1.
GenevisibleiQ8WVY7. HS.

Family and domain databases

Gene3Di3.40.50.1000. 1 hit.
InterProiIPR004274. FCP1_dom.
IPR023214. HAD-like_dom.
IPR011943. HAD-SF_hydro_IIID.
IPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
[Graphical view]
PfamiPF03031. NIF. 1 hit.
PF00240. ubiquitin. 1 hit.
[Graphical view]
SMARTiSM00577. CPDc. 1 hit.
SM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
SSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR02245. HAD_IIID1. 1 hit.
PROSITEiPS50969. FCP1. 1 hit.
PS50053. UBIQUITIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUBCP1_HUMAN
AccessioniPrimary (citable) accession number: Q8WVY7
Secondary accession number(s): D3DQJ7, Q96DK5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: October 1, 2002
Last modified: November 30, 2016
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.