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Protein

Ubiquitin-like domain-containing CTD phosphatase 1

Gene

UBLCP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The dephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S proteasome.1 Publication

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.1 Publication

Cofactori

Mg2+1 Publication

pH dependencei

Optimum pH is 5.0.1 Publication

GO - Molecular functioni

  • protein serine/threonine phosphatase activity Source: FlyBase

GO - Biological processi

  • protein dephosphorylation Source: FlyBase

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-like domain-containing CTD phosphatase 1 (EC:3.1.3.16)
Alternative name(s):
Nuclear proteasome inhibitor UBLCP1
Gene namesi
Name:UBLCP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000164332.7
HGNCiHGNC:28110 UBLCP1
MIMi609867 gene
neXtProtiNX_Q8WVY7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi44K → A: No binding to proteasome. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000164332
PharmGKBiPA142670646

Chemistry databases

ChEMBLiCHEMBL3317333

Polymorphism and mutation databases

BioMutaiUBLCP1
DMDMi74751564

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002426402 – 318Ubiquitin-like domain-containing CTD phosphatase 1Add BLAST317

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei117N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8WVY7
MaxQBiQ8WVY7
PaxDbiQ8WVY7
PeptideAtlasiQ8WVY7
PRIDEiQ8WVY7

PTM databases

DEPODiQ8WVY7
iPTMnetiQ8WVY7
PhosphoSitePlusiQ8WVY7

Expressioni

Tissue specificityi

Broadly expressed, with highest levels in placenta, lung, testis and ovary. Up-regulated in tumor tissues.1 Publication

Gene expression databases

BgeeiENSG00000164332
CleanExiHS_UBLCP1
GenevisibleiQ8WVY7 HS

Organism-specific databases

HPAiHPA039615

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PSMD2Q1320010EBI-750011,EBI-357648

Protein-protein interaction databases

BioGridi126404, 35 interactors
IntActiQ8WVY7, 3 interactors
MINTiQ8WVY7
STRINGi9606.ENSP00000296786

Chemistry databases

BindingDBiQ8WVY7

Structurei

Secondary structure

1318
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi5 – 9Combined sources5
Beta strandi12 – 16Combined sources5
Turni21 – 23Combined sources3
Helixi25 – 35Combined sources11
Turni39 – 41Combined sources3
Beta strandi46 – 49Combined sources4
Beta strandi57 – 59Combined sources3
Helixi61 – 64Combined sources4
Helixi68 – 70Combined sources3
Beta strandi71 – 76Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KX3NMR-A1-81[»]
2LGDNMR-A1-81[»]
2M17NMR-A1-81[»]
ProteinModelPortaliQ8WVY7
SMRiQ8WVY7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 81Ubiquitin-likePROSITE-ProRule annotationAdd BLAST79
Domaini133 – 294FCP1 homologyPROSITE-ProRule annotationAdd BLAST162

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni133 – 294PhosphataseAdd BLAST162

Domaini

The Ubiquitin-like domain mediates interaction with proteasomes.

Phylogenomic databases

eggNOGiKOG1605 Eukaryota
KOG1872 Eukaryota
COG5190 LUCA
GeneTreeiENSGT00390000010107
HOGENOMiHOG000231279
HOVERGENiHBG080207
InParanoidiQ8WVY7
KOiK17618
OMAiFKLMMVG
OrthoDBiEOG091G0CRH
PhylomeDBiQ8WVY7
TreeFamiTF323786

Family and domain databases

Gene3Di3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR004274 FCP1_dom
IPR036412 HAD-like_sf
IPR011943 HAD-SF_hydro_IIID
IPR023214 HAD_sf
IPR029071 Ubiquitin-like_domsf
IPR000626 Ubiquitin_dom
PfamiView protein in Pfam
PF03031 NIF, 1 hit
PF00240 ubiquitin, 1 hit
SMARTiView protein in SMART
SM00577 CPDc, 1 hit
SM00213 UBQ, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit
SSF56784 SSF56784, 1 hit
TIGRFAMsiTIGR02245 HAD_IIID1, 1 hit
PROSITEiView protein in PROSITE
PS50969 FCP1, 1 hit
PS50053 UBIQUITIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8WVY7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALPIIVKWG GQEYSVTTLS EDDTVLDLKQ FLKTLTGVLP ERQKLLGLKV
60 70 80 90 100
KGKPAENDVK LGALKLKPNT KIMMMGTREE SLEDVLGPPP DNDDVVNDFD
110 120 130 140 150
IEDEVVEVEN REENLLKISR RVKEYKVEIL NPPREGKKLL VLDVDYTLFD
160 170 180 190 200
HRSCAETGVE LMRPYLHEFL TSAYEDYDIV IWSATNMKWI EAKMKELGVS
210 220 230 240 250
TNANYKITFM LDSAAMITVH TPRRGLIDVK PLGVIWGKFS EFYSKKNTIM
260 270 280 290 300
FDDIGRNFLM NPQNGLKIRP FMKAHLNRDK DKELLKLTQY LKEIAKLDDF
310
LDLNHKYWER YLSKKQGQ
Length:318
Mass (Da):36,805
Last modified:October 1, 2002 - v2
Checksum:i21CB4DB22C3B0E0F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti83E → G in BAB71628 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY444562 mRNA Translation: AAS68538.1
AK057996 mRNA Translation: BAB71628.1
CH471062 Genomic DNA Translation: EAW61577.1
CH471062 Genomic DNA Translation: EAW61578.1
BC013425 mRNA Translation: AAH13425.2
CCDSiCCDS4345.1
RefSeqiNP_659486.2, NM_145049.4
UniGeneiHs.591733

Genome annotation databases

EnsembliENST00000296786; ENSP00000296786; ENSG00000164332
GeneIDi134510
KEGGihsa:134510
UCSCiuc003lxq.2 human

Similar proteinsi

Entry informationi

Entry nameiUBCP1_HUMAN
AccessioniPrimary (citable) accession number: Q8WVY7
Secondary accession number(s): D3DQJ7, Q96DK5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: October 1, 2002
Last modified: May 23, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health